CN1039086C - 制备低剂量的干药物制剂的方法 - Google Patents
制备低剂量的干药物制剂的方法 Download PDFInfo
- Publication number
- CN1039086C CN1039086C CN92101566A CN92101566A CN1039086C CN 1039086 C CN1039086 C CN 1039086C CN 92101566 A CN92101566 A CN 92101566A CN 92101566 A CN92101566 A CN 92101566A CN 1039086 C CN1039086 C CN 1039086C
- Authority
- CN
- China
- Prior art keywords
- mixture
- weight
- tablet
- excipient
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
赋形剂 | 结合百分数 | 最大值 | 最小值 | 差 值 | 反混合趋势% |
abcd | 96.789.897.483.5 | 104.7100.7104.594.8 | 100.78371.267 | 417.733.327.8 | 1.65.87.46.4 |
efghijkl | 5563.580.388.482.561.470.664.7 | 96132.3154.9201.2163.3205.5221.1240.8 | 787486.166.325.251.957.657 | 1858.368.8134.9138.1153.6163.5183.8 | 9.423.920.722.4395538.951.4 |
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91200524 | 1991-03-12 | ||
EP91200524.6 | 1991-03-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1064810A CN1064810A (zh) | 1992-09-30 |
CN1039086C true CN1039086C (zh) | 1998-07-15 |
Family
ID=8207548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN92101566A Expired - Lifetime CN1039086C (zh) | 1991-03-12 | 1992-03-11 | 制备低剂量的干药物制剂的方法 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5382434A (zh) |
EP (1) | EP0503521B2 (zh) |
JP (1) | JP3474210B2 (zh) |
KR (1) | KR100198017B1 (zh) |
CN (1) | CN1039086C (zh) |
AT (1) | ATE125155T1 (zh) |
AU (1) | AU651869B2 (zh) |
CA (1) | CA2062428C (zh) |
DE (1) | DE69203488T3 (zh) |
DK (1) | DK0503521T4 (zh) |
ES (1) | ES2077897T5 (zh) |
FI (1) | FI100770B (zh) |
GR (1) | GR3017737T3 (zh) |
HK (1) | HK1002018A1 (zh) |
IE (1) | IE67345B1 (zh) |
NO (1) | NO305055B1 (zh) |
NZ (1) | NZ241915A (zh) |
ZA (1) | ZA921659B (zh) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA924617B (en) | 1991-03-25 | 1994-05-27 | Boart International S A Pty Lt | A percussion drill bit |
US5928668A (en) * | 1993-12-21 | 1999-07-27 | Applied Analytical Industries, Inc. | Method for dry blend compression of medicaments |
ZA939566B (en) * | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for dry blend compression od medicaments. |
ZA939565B (en) * | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for preparing low dose pharmaceutical products. |
US5976570A (en) * | 1993-12-21 | 1999-11-02 | Applied Analytical Industries, Inc. | Method for preparing low dose pharmaceutical products |
ZA949929B (en) * | 1993-12-23 | 1995-08-23 | Akzo Nobel Nv | Sugar-coated pharmaceutical dosage unit. |
US6077533A (en) * | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
PT782449E (pt) * | 1994-09-22 | 2003-07-31 | Akzo Nobel Nv | Processo de fabrico de unidades de dosagem por granulacao humida |
IL115445A (en) * | 1994-10-17 | 1999-08-17 | Akzo Nobel Nv | Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation |
WO1997026798A1 (en) * | 1995-01-25 | 1997-07-31 | Wm. Wrigley Jr. Company | Improved rolling compound and methods of manufacturing chewing gum using same |
US6063403A (en) * | 1995-06-22 | 2000-05-16 | Akzo Nobel N.V. | Compressed dry-granulation desogestrel tablets |
DE19652196A1 (de) | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
WO2000050041A1 (en) * | 1999-02-24 | 2000-08-31 | Akzo Nobel N.V. | Pharmaceutical compositions containing a crystalline form of the progestagen-(17alpha)-17-hydroxy-11-methylene-19-nor-pregna-4,15-dien-20-yn-3-one (org 30659) and lactose |
KR20010006835A (ko) * | 1999-03-25 | 2001-01-26 | 김선진 | 경구용 속붕해정 |
DE19917347A1 (de) * | 1999-04-16 | 2000-11-09 | Gsf Forschungszentrum Umwelt | Verfahren und Vorrichtung zum trockenen Anbringen von Substanzen an inhalierbare pulverförmige Trägerstoffe |
ITMI991582A1 (it) * | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
FR2796840B1 (fr) * | 1999-07-26 | 2003-06-20 | Ethypharm Lab Prod Ethiques | Comprimes faiblement doses et procede de preparation |
US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
FR2801218B1 (fr) * | 1999-11-23 | 2001-12-28 | Hoechst Marion Roussel Inc | Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant |
JP2003518038A (ja) * | 1999-12-20 | 2003-06-03 | ニコラス, ジェイ カークホフ, | 流動床噴霧乾燥によるナノ粒子製造方法 |
US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
ATE374261T1 (de) | 2000-07-20 | 2007-10-15 | Campina Nederland Holding Bv | Methode zur herstellung eines kristallinen tablettierungshilfstoffes, der so erhaltene hilfsstoff und seine verwendung |
ES2253451T3 (es) * | 2000-12-14 | 2006-06-01 | Ortho-Mcneil Pharmaceutical, Inc. | Productos a base de hormona esteroide y sus procedimientos de fabricacion. |
US20040121006A1 (en) * | 2001-03-06 | 2004-06-24 | Shoichi Narita | Utilization of spray-dried powder containing sugar alcohol |
KR20030081472A (ko) * | 2001-03-06 | 2003-10-17 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내 속붕괴성 제제 |
OA12596A (en) * | 2001-05-01 | 2006-06-08 | Pfizer Prod Inc | Method for manufacturing a low dose pharmaceuticalcomposition. |
US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
US6962908B2 (en) | 2001-12-21 | 2005-11-08 | Warner Chilcott Company Inc. | Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation |
EP1620060B1 (en) | 2003-04-29 | 2010-03-24 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7799273B2 (en) | 2004-05-06 | 2010-09-21 | Smp Logic Systems Llc | Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes |
US7444197B2 (en) | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
TWI428271B (zh) * | 2004-06-09 | 2014-03-01 | Smithkline Beecham Corp | 生產藥物之裝置及方法 |
US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
EP2178540A4 (en) * | 2007-08-01 | 2012-01-04 | Stellan Hjerten | PHARMACEUTICAL COMPOSITION FOR ADSORBED ON THE CELL SURFACE OF PATHOGENIC MICROBES |
BRPI0914024A2 (pt) * | 2008-10-10 | 2015-11-03 | Teva Womens Health Inc | formas de dosagem farmacêutica, embalagens e uso de acetato de ciproterona |
WO2010104563A2 (en) | 2009-03-09 | 2010-09-16 | Spi Pharma, Inc. | Highly compactable and durable direct compression excipients and excipient systems |
HUP0900698A2 (en) | 2009-11-06 | 2011-06-28 | Richter Gedeon Nyrt | Pharmaceutical compositions of enhanced stability containing drospirenone and ethynyl estradiol and process for their preparation |
EP2354150A1 (en) * | 2010-02-09 | 2011-08-10 | Laboratoire Theramex | Process for the preparation of gestodene |
WO2012120365A1 (en) | 2011-03-07 | 2012-09-13 | Aurobindo Pharma Limited | Stable pharmaceutical composition comprising ethinyl estradiol |
CN102416003A (zh) * | 2011-12-08 | 2012-04-18 | 南京优科生物医药有限公司 | 一种制备恩替卡韦片剂的方法 |
ES2804702T3 (es) * | 2013-03-04 | 2021-02-09 | Besins Healthcare Lu Sarl | Composiciones farmacéuticas secas que comprenden nanopartículas de agente activo unidas a partículas de portador |
CZ309820B6 (cs) * | 2021-04-23 | 2023-11-08 | Pro.Med.Cs Praha A.S. | Způsob přípravy pevné lékové formy obsahující kompozici s nízkým obsahem účinné látky |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3626063A (en) * | 1959-08-11 | 1971-12-07 | Upjohn Co | Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof |
US3344030A (en) * | 1964-06-15 | 1967-09-26 | American Home Prod | Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables |
US3423507A (en) * | 1966-02-25 | 1969-01-21 | Schering Corp | Method of treating benign prostratic hypertrophy |
US3568828A (en) * | 1967-03-01 | 1971-03-09 | Squibb & Sons Inc | Modified sequential oral contraceptive |
US3671633A (en) * | 1971-05-10 | 1972-06-20 | American Cyanamid Co | Process for tabletting acetazolamide |
US3802914A (en) * | 1972-04-10 | 1974-04-09 | Kraftco Corp | Method of treating lactose |
SE378109B (zh) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
DE2365103C3 (de) * | 1973-12-21 | 1980-08-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | V erwendung von Hormonen zur Kontrazeption |
DE2524902C2 (de) * | 1975-06-02 | 1984-10-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | Vorrichtung zur Inhalation von Arzneimitteln |
US4143136A (en) * | 1976-11-20 | 1979-03-06 | Akzona Incorporated | Method of contraception |
DE2716323C2 (de) * | 1977-04-07 | 1986-03-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | Vorrichtung zur Inhalation von Arzneimitteln |
NL8001593A (nl) * | 1980-03-18 | 1981-10-16 | Akzo Nv | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
US4628051A (en) * | 1983-09-26 | 1986-12-09 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
DE3506276C1 (de) * | 1985-02-22 | 1986-04-24 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Direkttablettiermittel |
US4916163A (en) * | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
-
1992
- 1992-02-27 IE IE920634A patent/IE67345B1/en not_active IP Right Cessation
- 1992-03-05 CA CA002062428A patent/CA2062428C/en not_active Expired - Lifetime
- 1992-03-05 ZA ZA921659A patent/ZA921659B/xx unknown
- 1992-03-06 AU AU12119/92A patent/AU651869B2/en not_active Expired
- 1992-03-09 DE DE69203488T patent/DE69203488T3/de not_active Expired - Lifetime
- 1992-03-09 ES ES92103963T patent/ES2077897T5/es not_active Expired - Lifetime
- 1992-03-09 FI FI921023A patent/FI100770B/fi not_active IP Right Cessation
- 1992-03-09 AT AT92103963T patent/ATE125155T1/de active
- 1992-03-09 DK DK92103963T patent/DK0503521T4/da active
- 1992-03-09 EP EP92103963A patent/EP0503521B2/en not_active Expired - Lifetime
- 1992-03-10 NZ NZ241915A patent/NZ241915A/en not_active IP Right Cessation
- 1992-03-11 KR KR1019920003956A patent/KR100198017B1/ko not_active IP Right Cessation
- 1992-03-11 NO NO920958A patent/NO305055B1/no not_active IP Right Cessation
- 1992-03-11 CN CN92101566A patent/CN1039086C/zh not_active Expired - Lifetime
- 1992-03-12 JP JP05393692A patent/JP3474210B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-22 US US08/216,236 patent/US5382434A/en not_active Expired - Lifetime
-
1995
- 1995-10-16 GR GR950402836T patent/GR3017737T3/el unknown
-
1998
- 1998-02-11 HK HK98101029A patent/HK1002018A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO920958D0 (no) | 1992-03-11 |
EP0503521B2 (en) | 2005-11-09 |
ES2077897T3 (es) | 1995-12-01 |
FI921023A0 (fi) | 1992-03-09 |
CN1064810A (zh) | 1992-09-30 |
DE69203488D1 (de) | 1995-08-24 |
FI100770B (fi) | 1998-02-27 |
KR100198017B1 (ko) | 1999-06-15 |
EP0503521A1 (en) | 1992-09-16 |
NO920958L (no) | 1992-09-14 |
CA2062428A1 (en) | 1992-09-13 |
ES2077897T5 (es) | 2006-06-16 |
CA2062428C (en) | 2002-07-30 |
JP3474210B2 (ja) | 2003-12-08 |
IE67345B1 (en) | 1996-03-20 |
DE69203488T2 (de) | 1996-01-11 |
NZ241915A (en) | 1994-04-27 |
HK1002018A1 (en) | 1998-07-24 |
IE920634A1 (en) | 1992-09-23 |
DK0503521T3 (da) | 1995-11-27 |
AU651869B2 (en) | 1994-08-04 |
KR920017656A (ko) | 1992-10-21 |
DK0503521T4 (da) | 2005-12-05 |
DE69203488T3 (de) | 2006-07-06 |
JPH0578251A (ja) | 1993-03-30 |
NO305055B1 (no) | 1999-03-29 |
FI921023A (fi) | 1992-09-13 |
AU1211992A (en) | 1992-09-17 |
GR3017737T3 (en) | 1996-01-31 |
US5382434A (en) | 1995-01-17 |
ZA921659B (en) | 1992-11-25 |
ATE125155T1 (de) | 1995-08-15 |
EP0503521B1 (en) | 1995-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
ASS | Succession or assignment of patent right |
Owner name: ORGANON NV Free format text: FORMER OWNER: AKZO NOVEL N.V. CORP. Effective date: 20070105 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: AKZO NOVEL N.V. CORP. Free format text: FORMER NAME OR ADDRESS: AKZO N. V. |
|
CP03 | Change of name, title or address |
Address after: Holland Arnhem Patentee after: AKZO NOBEL N.V. Address before: Holland Arnhem Patentee before: Akzo N |
|
TR01 | Transfer of patent right |
Effective date of registration: 20070105 Address after: Holland Patentee after: N.V. ORGANON Address before: Holland Arnhem Patentee before: AKZO NOBEL N.V. |
|
C56 | Change in the name or address of the patentee |
Owner name: MSD OS CO., LTD. Free format text: FORMER NAME: ORGANON NV |
|
CP01 | Change in the name or title of a patent holder |
Address after: Holland Patentee after: N.V. Organon Address before: Holland Patentee before: N.V. ORGANON |
|
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20120311 Granted publication date: 19980715 |