NO301193B1 - Testmetode og reagenssett for denne - Google Patents
Testmetode og reagenssett for denne Download PDFInfo
- Publication number
- NO301193B1 NO301193B1 NO903124A NO903124A NO301193B1 NO 301193 B1 NO301193 B1 NO 301193B1 NO 903124 A NO903124 A NO 903124A NO 903124 A NO903124 A NO 903124A NO 301193 B1 NO301193 B1 NO 301193B1
- Authority
- NO
- Norway
- Prior art keywords
- gold
- analyte
- reagent
- porous material
- nanometers
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 48
- 238000010998 test method Methods 0.000 title 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 92
- 239000002245 particle Substances 0.000 claims abstract description 75
- 239000012491 analyte Substances 0.000 claims abstract description 71
- 229910052737 gold Inorganic materials 0.000 claims abstract description 61
- 239000010931 gold Substances 0.000 claims abstract description 61
- 238000000034 method Methods 0.000 claims abstract description 46
- 230000027455 binding Effects 0.000 claims abstract description 26
- 239000007790 solid phase Substances 0.000 claims abstract description 22
- 230000009870 specific binding Effects 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 10
- 239000011148 porous material Substances 0.000 claims description 21
- 239000007787 solid Substances 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 239000002250 absorbent Substances 0.000 claims description 10
- 230000002745 absorbent Effects 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000123 paper Substances 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229920001778 nylon Polymers 0.000 claims description 5
- 239000000020 Nitrocellulose Substances 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 229920002301 cellulose acetate Polymers 0.000 claims description 3
- 229920001220 nitrocellulos Polymers 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims 2
- 150000002343 gold Chemical class 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 12
- 239000012528 membrane Substances 0.000 description 42
- 239000008279 sol Substances 0.000 description 24
- 239000000084 colloidal system Substances 0.000 description 22
- 239000000523 sample Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000427 antigen Substances 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 108010074051 C-Reactive Protein Proteins 0.000 description 4
- 102100032752 C-reactive protein Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 3
- 102000007562 Serum Albumin Human genes 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001493 electron microscopy Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000012064 sodium phosphate buffer Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 2
- 239000001263 FEMA 3042 Substances 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 101000942118 Homo sapiens C-reactive protein Proteins 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
- 229940033123 tannic acid Drugs 0.000 description 2
- 235000015523 tannic acid Nutrition 0.000 description 2
- 229920002258 tannic acid Polymers 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229910000960 colored gold Inorganic materials 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001803 electron scattering Methods 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- -1 nucleoside triphosphate Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000006894 reductive elimination reaction Methods 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888800702A GB8800702D0 (en) | 1988-01-13 | 1988-01-13 | Test method & reagent kit therefor |
| PCT/EP1989/000050 WO1989006801A1 (fr) | 1988-01-13 | 1989-01-11 | Procede de test et kit de reactif associe |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO903124D0 NO903124D0 (no) | 1990-07-13 |
| NO903124L NO903124L (no) | 1990-07-13 |
| NO301193B1 true NO301193B1 (no) | 1997-09-22 |
Family
ID=10629878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO903124A NO301193B1 (no) | 1988-01-13 | 1990-07-13 | Testmetode og reagenssett for denne |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5556756A (fr) |
| EP (1) | EP0398913B1 (fr) |
| JP (1) | JP2701949B2 (fr) |
| AT (1) | ATE99060T1 (fr) |
| AU (1) | AU614109B2 (fr) |
| CA (1) | CA1336393C (fr) |
| DE (1) | DE68911674T2 (fr) |
| DK (1) | DK172179B1 (fr) |
| FI (1) | FI92883C (fr) |
| GB (1) | GB8800702D0 (fr) |
| NO (1) | NO301193B1 (fr) |
| WO (1) | WO1989006801A1 (fr) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9028038D0 (en) * | 1990-12-24 | 1991-02-13 | Nycomed Pharma As | Test method and reagent kit therefor |
| EP0519250A3 (en) * | 1991-06-10 | 1993-06-02 | Miles Inc. | Microparticle-labeled binding assay analyzed by microwave spectroscopy |
| JPH0769326B2 (ja) * | 1992-01-14 | 1995-07-26 | 株式会社京都医科学研究所 | 生体防御機能の活性化状態検出用キット |
| AT399781B (de) * | 1992-11-23 | 1995-07-25 | Waldheim Pharmazeutika Gmbh | Verfahren und reaktionsgemisch zum nachweisen von antikörpern und verfahren zum herstellen des reaktionsgemisches |
| PT599803E (pt) * | 1992-11-23 | 2000-07-31 | Sanochemia Pharmazeutika Ag | Processo para a identificacao de anticorpos e antigenes |
| TW239881B (fr) * | 1992-12-22 | 1995-02-01 | Sienna Biotech Inc | |
| US6200820B1 (en) | 1992-12-22 | 2001-03-13 | Sienna Biotech, Inc. | Light scatter-based immunoassay |
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| US5851777A (en) * | 1996-02-05 | 1998-12-22 | Dade Behring Inc. | Homogeneous sol-sol assay |
| US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6767702B2 (en) | 1996-07-29 | 2004-07-27 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US7169556B2 (en) | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| US20030203394A1 (en) * | 1998-05-04 | 2003-10-30 | Yoav Eichen | Detection of a target in a sample |
| US7071005B1 (en) | 1998-08-24 | 2006-07-04 | Centrus International, Inc. | Method and device for concentrating selected groups of microorganisms |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| US6136610A (en) | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
| JP4402263B2 (ja) * | 1999-06-21 | 2010-01-20 | パナソニック株式会社 | クロマトグラフィー定量測定装置 |
| DE19943704C1 (de) * | 1999-09-08 | 2001-05-10 | Inst Physikalische Hochtech Ev | Affinitätssensor zum Nachweis biologischer und/oder chemischer Spezies und dessen Verwendung |
| US6365415B1 (en) * | 2000-01-06 | 2002-04-02 | Motorola Inc. | Method for characterization and quality control of porous media |
| JP3605607B2 (ja) | 2000-07-11 | 2004-12-22 | ノースウエスタン ユニバーシティ | 銀染色の増強による検出方法 |
| WO2002054052A1 (fr) * | 2001-01-08 | 2002-07-11 | Leonard Fish | Instruments et procedes de diagnostic permettant de detecter des analytes |
| DE10109777A1 (de) * | 2001-03-01 | 2002-09-19 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren |
| ATE431853T1 (de) * | 2001-03-28 | 2009-06-15 | Nanosphere Inc | Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes |
| DE10120349B4 (de) * | 2001-04-21 | 2004-10-28 | Michael Schwertner | Verfahren zur Erfassung molekularer Bindungsereignisse auf Affinitätssensoren |
| WO2002100444A1 (fr) * | 2001-06-08 | 2002-12-19 | Biosphere Medical Inc. | Microparticules marquees a l'aide d'un metal colloidal, production et utilisation de celles-ci |
| JP2003066047A (ja) * | 2001-06-14 | 2003-03-05 | Matsushita Electric Ind Co Ltd | 免疫反応測定方法及びそれに用いる免疫反応測定用試薬 |
| US7186814B2 (en) | 2001-11-09 | 2007-03-06 | Nanosphere, Inc. | Bioconjugate-nanoparticle probes |
| CA2473376A1 (fr) | 2002-01-16 | 2003-07-31 | Dynal Biotech Asa | Methode permettant d'isoler des acides nucleiques et des proteines contenus dans un echantillon unique |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| AU2003247788B2 (en) | 2002-07-02 | 2007-04-19 | Nanosphere Inc. | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
| GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
| AU2003296723A1 (en) * | 2002-12-23 | 2004-07-22 | Febit Ag | Incorporation of hapten groups during the production of carriers for the determination of analytes |
| WO2004102196A1 (fr) * | 2003-04-30 | 2004-11-25 | Chengdu Kuachang Medical Industrial Limited | Dispositif comprenant des nanostructures destine a une separation ou une analyse, et preparation et mise en oeuvre de ce dispositif |
| DE10323901A1 (de) * | 2003-05-26 | 2005-01-05 | Institut Virion/Serion Gmbh | Verfahren und Testmittel zur Untersuchung und/oder zum Nachweis von Biomolekülen und/oder Wirkstoffen in Flüssigkeitsproben |
| ATE431854T1 (de) * | 2003-06-27 | 2009-06-15 | Nanosphere Inc | Auf bio-barcodes beruhender nachweis von zielanalyten |
| FI20040205A (fi) * | 2004-02-11 | 2005-08-12 | Reagena Ltd Oy | Menetelmä ja laite pikatestin valmistamiseksi |
| US7465587B2 (en) | 2004-12-03 | 2008-12-16 | Genzyme Corporation | Diagnostic assay device |
| WO2006098804A2 (fr) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dispositif de dosage immunologique a double trajet |
| US7189522B2 (en) * | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| KR101255400B1 (ko) * | 2005-05-23 | 2013-04-17 | 파디아 에이비 | 2 단계 횡 유동 검사 방법 및 장치 |
| US7736910B2 (en) * | 2005-10-04 | 2010-06-15 | Calypte Biomedical Corporation | One-step production of gold sols |
| ITUD20060177A1 (it) | 2006-07-14 | 2008-01-15 | Sire Analytical Systems Srl | Apparecchiatura integrata e metodo per la rilevazione di stati infiammatori presenti in un campione di sangue intero |
| US20100022916A1 (en) | 2008-07-24 | 2010-01-28 | Javanbakhsh Esfandiari | Method and Apparatus for Collecting and Preparing Biological Samples for Testing |
| CA2746128C (fr) | 2009-01-30 | 2020-07-28 | Pronota N.V. | Biomarqueur de diagnostic, prediction et/ou pronostic d'une insuffisance cardiaque aigue et ses utilisations |
| JP5810089B2 (ja) | 2009-10-21 | 2015-11-11 | マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ | 体液ホメオスタシスのバイオマーカーとしてのｍｃａｍ |
| AU2011231537B2 (en) | 2010-03-26 | 2016-05-12 | Mycartis Nv | LTBP2 as a biomarker for renal dysfunction, glomerular filtration rate, dyspnea, acute heart failure, left ventricular hypertrophy, cardiac fibrosis, preeclampsia, pregnancy-associated proteinuria |
| WO2011128357A2 (fr) | 2010-04-13 | 2011-10-20 | Pronota N.V. | Biomarqueurs de troubles liés à l'hypertension pendant la grossesse |
| AU2011275753A1 (en) | 2010-07-08 | 2013-01-10 | Pronota N.V. | Quiescin Q6 as biomarker for hypertensive disorders of pregnancy |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| EP2649454B1 (fr) | 2010-12-06 | 2018-06-20 | Mycartis N.V. | Biomarqueurs et paramètres des troubles d'hypertension de la grossesse |
| US8603835B2 (en) | 2011-02-10 | 2013-12-10 | Chembio Diagnostic Systems, Inc. | Reduced step dual path immunoassay device and method |
| FI20115285A0 (fi) * | 2011-03-24 | 2011-03-24 | Reagena Ltd Oy | Menetelmä pikatestin suorittamiseksi |
| WO2013083781A2 (fr) | 2011-12-08 | 2013-06-13 | Pronota N.V. | Biomarqueurs et panneaux d'essai utiles dans des conditions inflammatoires systémiques |
| WO2013087887A2 (fr) | 2011-12-15 | 2013-06-20 | Pronota N.V. | Biomarqueurs et paramètres pour troubles hypertensifs de grossesse |
| EP3578635B1 (fr) | 2014-04-02 | 2021-11-03 | Chembio Diagnostic Systems, Inc. | Immunoessai utilisant un conjugué de piégeage |
| US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
| KR102582297B1 (ko) | 2017-05-19 | 2023-09-25 | 필립모리스 프로덕츠 에스.에이. | 대상체의 흡연 상태를 구별하기 위한 진단 테스트 |
| KR20240045314A (ko) | 2021-08-18 | 2024-04-05 | 필립모리스 프로덕츠 에스.에이. | 항체 및 이의 항원 결합 단편 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299916A (en) * | 1979-12-26 | 1981-11-10 | Syva Company | Preferential signal production on a surface in immunoassays |
| US4459361A (en) * | 1982-06-04 | 1984-07-10 | Angenics, Inc. | Ligand assay with one or two particulate reagents and filter |
| GB8331514D0 (en) * | 1983-11-25 | 1984-01-04 | Janssen Pharmaceutica Nv | Visualization method |
| CA1224003A (fr) * | 1984-04-24 | 1987-07-14 | Robert S. Molday | Particules colloidales de metal-polysaccharide |
| USRE33581E (en) * | 1984-06-25 | 1991-04-30 | Immunoassay using optical interference detection | |
| US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
| US4760017A (en) * | 1985-12-23 | 1988-07-26 | E. I. Du Pont De Nemours And Company | Arabinonucleic acid probes for DNA/RNA assays |
| US4742000A (en) * | 1986-05-02 | 1988-05-03 | University Of Chicago | Antibody to human progesterone receptor and diagnostic materials and methods |
| AU7385387A (en) * | 1986-06-09 | 1987-12-10 | Ortho Diagnostic Systems Inc. | Immunoassay using detection of colloidal gold |
| AU602694B2 (en) * | 1986-06-09 | 1990-10-25 | Ortho Diagnostic Systems Inc. | Improved colloidal gold membrane assay |
| US4879220A (en) * | 1986-11-18 | 1989-11-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Crosslinking receptor-specific probes for electron microscopy |
| US4853335A (en) * | 1987-09-28 | 1989-08-01 | Olsen Duane A | Colloidal gold particle concentration immunoassay |
| US4874691A (en) * | 1987-10-16 | 1989-10-17 | Quadra Logic Technologies Inc. | Membrane-supported immunoassays |
| US5079172A (en) * | 1988-11-04 | 1992-01-07 | Board Of Trustees Operating Michigan State University | Method for detecting the presence of antibodies using gold-labeled antibodies and test kit |
-
1988
- 1988-01-13 GB GB888800702A patent/GB8800702D0/en active Pending
-
1989
- 1989-01-11 AU AU29359/89A patent/AU614109B2/en not_active Ceased
- 1989-01-11 JP JP1501456A patent/JP2701949B2/ja not_active Expired - Lifetime
- 1989-01-11 WO PCT/EP1989/000050 patent/WO1989006801A1/fr active IP Right Grant
- 1989-01-11 DE DE89901546T patent/DE68911674T2/de not_active Expired - Lifetime
- 1989-01-11 AT AT89901546T patent/ATE99060T1/de not_active IP Right Cessation
- 1989-01-11 EP EP89901546A patent/EP0398913B1/fr not_active Expired - Lifetime
- 1989-01-12 CA CA000588034A patent/CA1336393C/fr not_active Expired - Fee Related
-
1990
- 1990-07-09 DK DK164690A patent/DK172179B1/da not_active IP Right Cessation
- 1990-07-11 FI FI903515A patent/FI92883C/fi not_active IP Right Cessation
- 1990-07-13 NO NO903124A patent/NO301193B1/no not_active IP Right Cessation
-
1992
- 1992-06-05 US US07/895,244 patent/US5556756A/en not_active Expired - Fee Related
-
1995
- 1995-06-02 US US08/458,115 patent/US5616467A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB8800702D0 (en) | 1988-02-10 |
| DK172179B1 (da) | 1997-12-15 |
| JP2701949B2 (ja) | 1998-01-21 |
| NO903124D0 (no) | 1990-07-13 |
| EP0398913A1 (fr) | 1990-11-28 |
| JPH03502244A (ja) | 1991-05-23 |
| FI92883B (fi) | 1994-09-30 |
| AU614109B2 (en) | 1991-08-22 |
| FI903515A0 (fi) | 1990-07-11 |
| DK164690D0 (da) | 1990-07-09 |
| US5616467A (en) | 1997-04-01 |
| DE68911674D1 (de) | 1994-02-03 |
| FI92883C (fi) | 1995-01-10 |
| NO903124L (no) | 1990-07-13 |
| EP0398913B1 (fr) | 1993-12-22 |
| AU2935989A (en) | 1989-08-11 |
| DE68911674T2 (de) | 1994-04-07 |
| WO1989006801A1 (fr) | 1989-07-27 |
| ATE99060T1 (de) | 1994-01-15 |
| US5556756A (en) | 1996-09-17 |
| DK164690A (da) | 1990-07-09 |
| CA1336393C (fr) | 1995-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO301193B1 (no) | Testmetode og reagenssett for denne | |
| RU2025732C1 (ru) | Способ иммуноанализа аналита в водном образце | |
| US4853335A (en) | Colloidal gold particle concentration immunoassay | |
| JP4579414B2 (ja) | リガンド結合アッセイおよび阻害性分析物分離領域を有するキット | |
| US4960692A (en) | Assay employing binding pair members on particles and on a filter or membrane | |
| EP0564494B1 (fr) | Procede d'essai et kit reactif associe | |
| JPH03502246A (ja) | 物質の分析のための凝集方法 | |
| US5188939A (en) | Displacement immunoassay utilizing an oligavalent labelled antibody | |
| JPH11337553A (ja) | 免疫化学的標識およびこれを含有する水性懸濁液、ならびに該免疫化学的標識の製造方法 | |
| WO1997009620A1 (fr) | Procede et appareil destines a l'evaluation quantitative et semi-quantitative d'une substance a analyser | |
| FR2890173A1 (fr) | Dispositif de determination d'un analyte dans un echantillon liquide par un test sandwich et un test de competition | |
| EP0248892A1 (fr) | Immunoanalyse de composants de liaison lies a des particules | |
| JP3833358B2 (ja) | 被検体の亜集団の測定のための均一検出方法 | |
| JPH09504094A (ja) | 磁性ラテックス粒子および非磁性粒子を用いて免疫物質をアッセイする方法 | |
| EP0201211A1 (fr) | Méthode et compositions pour immuno-essais visuels à phase solide basés sur des particules microsphériques et luminescente | |
| EP0152254A2 (fr) | Immunoessai à base d'un support chromogénique utilisant des composants complémentaires marqués | |
| JP4771941B2 (ja) | 免疫学的定量法と試薬 | |
| JP2003262637A (ja) | 検査片及び検査方法 | |
| CA1336163C (fr) | Epreuve de dosage enzymatique par imbibition | |
| AU6782596A (en) | Method and apparatus for quantitative and semi-quantitative determination of an analyte |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |