NO300980B1 - Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin - Google Patents
Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulinInfo
- Publication number
- NO300980B1 NO300980B1 NO913474A NO913474A NO300980B1 NO 300980 B1 NO300980 B1 NO 300980B1 NO 913474 A NO913474 A NO 913474A NO 913474 A NO913474 A NO 913474A NO 300980 B1 NO300980 B1 NO 300980B1
- Authority
- NO
- Norway
- Prior art keywords
- amino acid
- clostripain
- preproinsulin
- carboxypeptidase
- insulin
- Prior art date
Links
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- 230000007062 hydrolysis Effects 0.000 title claims abstract description 9
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 9
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- 150000002835 noble gases Chemical class 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013587 production medium Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000016491 selenocysteine Nutrition 0.000 description 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 1
- 229940055619 selenocysteine Drugs 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4028118 | 1990-09-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO913474D0 NO913474D0 (no) | 1991-09-04 |
| NO913474L NO913474L (no) | 1992-03-06 |
| NO300980B1 true NO300980B1 (no) | 1997-08-25 |
Family
ID=6413629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO913474A NO300980B1 (no) | 1990-09-05 | 1991-09-04 | Fremgangsmåte for hydrolyse av aminosyrekjeden til preproinsulin |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5728543A (ja) |
| EP (1) | EP0474212B1 (ja) |
| JP (1) | JP3005335B2 (ja) |
| KR (1) | KR100188800B1 (ja) |
| AT (1) | ATE145922T1 (ja) |
| AU (1) | AU637254B2 (ja) |
| CA (1) | CA2050606C (ja) |
| CZ (1) | CZ283234B6 (ja) |
| DE (1) | DE59108392D1 (ja) |
| DK (1) | DK0474212T3 (ja) |
| ES (1) | ES2095891T3 (ja) |
| FI (1) | FI103805B (ja) |
| GR (1) | GR3021909T3 (ja) |
| HR (1) | HRP940766A2 (ja) |
| HU (1) | HU214676B (ja) |
| IE (1) | IE75723B1 (ja) |
| IL (1) | IL99383A (ja) |
| LT (1) | LT3328B (ja) |
| LV (1) | LV10508B (ja) |
| NO (1) | NO300980B1 (ja) |
| NZ (1) | NZ239652A (ja) |
| PL (1) | PL167810B1 (ja) |
| RU (1) | RU2062301C1 (ja) |
| SK (1) | SK279686B6 (ja) |
| YU (1) | YU147491A (ja) |
| ZA (1) | ZA917008B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6461834B1 (en) * | 1998-11-06 | 2002-10-08 | Bionebraska, Inc. | Clostripain catalyzed amidation of peptides |
| DE19915938A1 (de) * | 1999-04-09 | 2000-10-19 | Aventis Pharma Gmbh | Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung |
| WO2003099847A2 (en) * | 2002-05-24 | 2003-12-04 | Restoragen, Inc. | Method for enzymatic production of glp-1 (7-36) amide peptides |
| CA2485695A1 (en) * | 2002-05-24 | 2003-12-04 | Fred W. Wagner | Method for universal enzymatic production of bioactive peptides |
| EP1572720A4 (en) * | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES |
| PL1704234T3 (pl) * | 2003-11-21 | 2012-06-29 | Nps Pharma Inc | Wytwarzanie glukagonopodobnego peptydu 2 i analogów |
| WO2013015697A1 (en) * | 2011-07-28 | 2013-01-31 | Mabion S.A. | A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue |
| KR102646845B1 (ko) * | 2018-08-08 | 2024-03-14 | 주식회사 대웅제약 | 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU81606A1 (de) | 1979-08-14 | 1981-03-24 | Arbed | Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten |
| DE3209184A1 (de) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen |
| EP0095691B1 (de) | 1982-05-27 | 1986-01-22 | Neiman S.A. | Zylinderschloss, insbesondere Lenkschloss für ein Kraftfahrzeug |
| JPS60217894A (ja) * | 1984-04-14 | 1985-10-31 | Suntory Ltd | 新規プロテア−ゼ及びその製造方法 |
| DE3440988A1 (de) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| CA1339955C (en) | 1986-10-14 | 1998-07-14 | Richard Eugene Heiney | Process for transforming a human insulin precursor to human insulin |
| DE4012818A1 (de) * | 1990-04-21 | 1991-10-24 | Hoechst Ag | Verfahren zur herstellung von fremdproteinen in streptomyceten |
| ATE101620T1 (de) | 1988-06-23 | 1994-03-15 | Hoechst Ag | Mini-proinsulin, seine herstellung und verwendung. |
| DE3919852A1 (de) * | 1988-06-23 | 1989-12-28 | Hoechst Ag | Mini-proinsulin, seine herstellung und verwendung |
| DE58909556D1 (de) | 1988-11-03 | 1996-02-15 | Hoechst Ag | Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten |
| US5617606A (en) | 1996-02-29 | 1997-04-08 | Baracuda International Corp. | Fluted swimming pool cleaner discs |
-
1991
- 1991-09-03 NZ NZ239652A patent/NZ239652A/xx not_active IP Right Cessation
- 1991-09-03 FI FI914151A patent/FI103805B/fi not_active IP Right Cessation
- 1991-09-03 KR KR1019910015314A patent/KR100188800B1/ko not_active IP Right Cessation
- 1991-09-03 CZ CS912711A patent/CZ283234B6/cs not_active IP Right Cessation
- 1991-09-03 IL IL9938391A patent/IL99383A/en not_active IP Right Cessation
- 1991-09-03 SK SK2711-91A patent/SK279686B6/sk not_active IP Right Cessation
- 1991-09-04 ZA ZA917008A patent/ZA917008B/xx unknown
- 1991-09-04 PL PL91291617A patent/PL167810B1/pl unknown
- 1991-09-04 IE IE311791A patent/IE75723B1/en not_active IP Right Cessation
- 1991-09-04 JP JP3223243A patent/JP3005335B2/ja not_active Expired - Lifetime
- 1991-09-04 DK DK91114934.2T patent/DK0474212T3/da active
- 1991-09-04 EP EP91114934A patent/EP0474212B1/de not_active Expired - Lifetime
- 1991-09-04 ES ES91114934T patent/ES2095891T3/es not_active Expired - Lifetime
- 1991-09-04 RU SU915001486A patent/RU2062301C1/ru active
- 1991-09-04 CA CA002050606A patent/CA2050606C/en not_active Expired - Lifetime
- 1991-09-04 NO NO913474A patent/NO300980B1/no not_active IP Right Cessation
- 1991-09-04 AU AU83567/91A patent/AU637254B2/en not_active Expired
- 1991-09-04 YU YU147491A patent/YU147491A/sh unknown
- 1991-09-04 DE DE59108392T patent/DE59108392D1/de not_active Expired - Lifetime
- 1991-09-04 AT AT91114934T patent/ATE145922T1/de not_active IP Right Cessation
- 1991-09-05 HU HU912875A patent/HU214676B/hu unknown
-
1993
- 1993-05-05 LV LVP-93-288A patent/LV10508B/xx unknown
- 1993-06-25 LT LTIP712A patent/LT3328B/lt not_active IP Right Cessation
-
1994
- 1994-08-08 US US08/291,060 patent/US5728543A/en not_active Expired - Lifetime
- 1994-10-25 HR HRP-1474/91A patent/HRP940766A2/hr not_active Application Discontinuation
-
1996
- 1996-12-05 GR GR960403067T patent/GR3021909T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |