LT3328B - Process for the preparation of insulin - Google Patents

Process for the preparation of insulin Download PDF

Info

Publication number
LT3328B
LT3328B LTIP712A LTIP712A LT3328B LT 3328 B LT3328 B LT 3328B LT IP712 A LTIP712 A LT IP712A LT IP712 A LTIP712 A LT IP712A LT 3328 B LT3328 B LT 3328B
Authority
LT
Lithuania
Prior art keywords
amino acid
arginine
clostripan
insulin
process according
Prior art date
Application number
LTIP712A
Other languages
English (en)
Lithuanian (lt)
Inventor
Michael Doerschug
Klaus Peter Koller
Ruediger Marquardt
Johannes Meiwes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP712A publication Critical patent/LTIP712A/xx
Publication of LT3328B publication Critical patent/LT3328B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LTIP712A 1990-09-05 1993-06-25 Process for the preparation of insulin LT3328B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (2)

Publication Number Publication Date
LTIP712A LTIP712A (en) 1995-01-31
LT3328B true LT3328B (en) 1995-07-25

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP712A LT3328B (en) 1990-09-05 1993-06-25 Process for the preparation of insulin

Country Status (26)

Country Link
US (1) US5728543A (ja)
EP (1) EP0474212B1 (ja)
JP (1) JP3005335B2 (ja)
KR (1) KR100188800B1 (ja)
AT (1) ATE145922T1 (ja)
AU (1) AU637254B2 (ja)
CA (1) CA2050606C (ja)
CZ (1) CZ283234B6 (ja)
DE (1) DE59108392D1 (ja)
DK (1) DK0474212T3 (ja)
ES (1) ES2095891T3 (ja)
FI (1) FI103805B1 (ja)
GR (1) GR3021909T3 (ja)
HR (1) HRP940766A2 (ja)
HU (1) HU214676B (ja)
IE (1) IE75723B1 (ja)
IL (1) IL99383A (ja)
LT (1) LT3328B (ja)
LV (1) LV10508B (ja)
NO (1) NO300980B1 (ja)
NZ (1) NZ239652A (ja)
PL (1) PL167810B1 (ja)
RU (1) RU2062301C1 (ja)
SK (1) SK279686B6 (ja)
YU (1) YU147491A (ja)
ZA (1) ZA917008B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461834B1 (en) * 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
WO2003099848A2 (en) * 2002-05-24 2003-12-04 Restoragen Inc. Method for universal enzymatic production of bioactive peptides
CA2485703A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
EP1551435A4 (en) * 2002-05-24 2007-08-08 Restoragen Inc PROCESS FOR THE ENZYMATIC GENERATION OF GLP-1 (7-36) AMIDEPEPIDES
ES2380765T3 (es) * 2003-11-21 2012-05-18 Nps Pharmaceuticals, Inc. Producción del péptido 2 de tipo glucagón y análogos
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (ko) * 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024250A1 (de) 1979-08-14 1981-02-25 Arbed S.A. Verfahren und Einrichtung zur Wiederverwertung kohlenstoffreicher Abfälle
EP0095691A1 (de) 1982-05-27 1983-12-07 Neiman S.A. Zylinderschloss, insbesondere Lenkschloss für ein Kraftfahrzeug
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
EP0264250A2 (en) 1986-10-14 1988-04-20 Eli Lilly And Company Process for transforming a human insulin precursor to human insulin
EP0347781A2 (de) 1988-06-23 1989-12-27 Hoechst Aktiengesellschaft Mini-Proinsulin, seine Herstellung und Verwendung
EP0367163A2 (de) 1988-11-03 1990-05-09 Hoechst Aktiengesellschaft Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten
EP0890007A1 (en) 1996-02-29 1999-01-13 Sweepy International S.A. Fluted swimming pool cleaner discs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
JPS60217894A (ja) * 1984-04-14 1985-10-31 Suntory Ltd 新規プロテア−ゼ及びその製造方法
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3919852A1 (de) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024250A1 (de) 1979-08-14 1981-02-25 Arbed S.A. Verfahren und Einrichtung zur Wiederverwertung kohlenstoffreicher Abfälle
EP0095691A1 (de) 1982-05-27 1983-12-07 Neiman S.A. Zylinderschloss, insbesondere Lenkschloss für ein Kraftfahrzeug
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
EP0264250A2 (en) 1986-10-14 1988-04-20 Eli Lilly And Company Process for transforming a human insulin precursor to human insulin
EP0347781A2 (de) 1988-06-23 1989-12-27 Hoechst Aktiengesellschaft Mini-Proinsulin, seine Herstellung und Verwendung
EP0367163A2 (de) 1988-11-03 1990-05-09 Hoechst Aktiengesellschaft Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten
EP0890007A1 (en) 1996-02-29 1999-01-13 Sweepy International S.A. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
EP0474212B1 (de) 1996-12-04
DE59108392D1 (de) 1997-01-16
IL99383A (en) 1996-01-31
NZ239652A (en) 1992-09-25
YU147491A (sh) 1995-10-24
HUT58823A (en) 1992-03-30
AU637254B2 (en) 1993-05-20
ZA917008B (en) 1992-04-29
US5728543A (en) 1998-03-17
HU214676B (hu) 1998-04-28
CZ283234B6 (cs) 1998-02-18
CS271191A3 (en) 1992-03-18
HRP940766A2 (en) 1997-08-31
RU2062301C1 (ru) 1996-06-20
SK279686B6 (sk) 1999-02-11
KR920006504A (ko) 1992-04-27
FI914151A (fi) 1992-03-06
LV10508B (en) 1996-02-20
NO913474D0 (no) 1991-09-04
FI103805B (fi) 1999-09-30
NO300980B1 (no) 1997-08-25
LTIP712A (en) 1995-01-31
FI103805B1 (fi) 1999-09-30
JPH04258296A (ja) 1992-09-14
ES2095891T3 (es) 1997-03-01
JP3005335B2 (ja) 2000-01-31
DK0474212T3 (da) 1997-05-12
IL99383A0 (en) 1992-08-18
KR100188800B1 (ko) 1999-06-01
LV10508A (lv) 1995-02-20
NO913474L (no) 1992-03-06
HU912875D0 (en) 1992-01-28
CA2050606C (en) 2002-08-13
AU8356791A (en) 1992-03-12
ATE145922T1 (de) 1996-12-15
EP0474212A3 (de) 1992-04-08
PL167810B1 (pl) 1995-11-30
EP0474212A2 (de) 1992-03-11
IE913117A1 (en) 1992-03-11
GR3021909T3 (en) 1997-03-31
IE75723B1 (en) 1997-09-24
FI914151A0 (fi) 1991-09-03
PL291617A1 (en) 1992-03-09
CA2050606A1 (en) 1992-03-06

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Free format text: 20020812 * AVENTIS PHARMA DEUTSCHLAND GMBH,DE

MK9A Expiry of a patent

Effective date: 20130625