NO20092336L - O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister - Google Patents

O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister

Info

Publication number
NO20092336L
NO20092336L NO20092336A NO20092336A NO20092336L NO 20092336 L NO20092336 L NO 20092336L NO 20092336 A NO20092336 A NO 20092336A NO 20092336 A NO20092336 A NO 20092336A NO 20092336 L NO20092336 L NO 20092336L
Authority
NO
Norway
Prior art keywords
hydroxypropyl
pain
trpv
substituted
dihydroxypropyl
Prior art date
Application number
NO20092336A
Other languages
English (en)
Inventor
Pier Giovanni Baraldi
Pier Andrea Borea
Pierangelo Geppetti
Francesca Fruttarolo
Maria Giovanna Pavani
Marcello Trevisani
Original Assignee
Pharmeste Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmeste Srl filed Critical Pharmeste Srl
Publication of NO20092336L publication Critical patent/NO20092336L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Oppfinnelsen angår forbindelser av formel (I) hvori R velges fra halogen, alkyl, alkoksy, aryl og heteroaryl; R1 velges fra 2-hydroksyetyl, 2,3-dihydroksypropyl, 3-hydroksypropyl, 2,2-dihydroksyetyl, 3,3-dihydroksypropyl, 1,3-dioksolane-etyl, 1,3-dioksan-metyl, 1,3-dioksolane-metyl, 1,3-dioksan-etyl, 3-fluor-2-hydroksypropyl, 3-karboksy-2-hydroksy-propyl, 3-klor-2-hydroksypropyl, 2-hydroksypropyl, 2-hydroksy-propen-2-yl, morfolinoetyl, piperazinoetyl, hydroksymetyl, benzyl, 4-(hydroksymetyl)benzyl, 4-klorbenzyl, 4-fluorbenzyl, og 4-hydroksybenzyl. R2 er tert-butyl eller trifluormetyl; R3 er uavhengig valgt fra hydrogen, karboksy, cyano, alkyl eller hydroksyalkyl. Forbindelsene av formel (I) kan anvendes for fremstillingen av farmasøytiske sammensetninger for behandling av inflammatoriske tilstander, slik som kronisk nevropatisk smerte, overaktiv blæresyndrom, tumorsmerte, hemoroider, inflammatorisk hyperalgesia, post-intervensjon smerte, tannuttrekking, luftvei og gastrointestinale lidelser.
NO20092336A 2006-12-21 2009-06-18 O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister NO20092336L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06026533A EP1939173A1 (en) 2006-12-21 2006-12-21 O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists
PCT/IB2007/003784 WO2008075150A1 (en) 2006-12-21 2007-12-06 O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists

Publications (1)

Publication Number Publication Date
NO20092336L true NO20092336L (no) 2009-06-18

Family

ID=38139789

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092336A NO20092336L (no) 2006-12-21 2009-06-18 O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister

Country Status (25)

Country Link
US (1) US7750049B2 (no)
EP (2) EP1939173A1 (no)
JP (1) JP5302214B2 (no)
KR (1) KR101460177B1 (no)
CN (1) CN101563317B (no)
AT (1) ATE479652T1 (no)
BR (1) BRPI0720421A2 (no)
CA (1) CA2673219C (no)
CY (1) CY1110833T1 (no)
DE (1) DE602007008942D1 (no)
DK (1) DK2094653T3 (no)
EA (1) EA015152B1 (no)
ES (1) ES2347492T3 (no)
HR (1) HRP20100588T1 (no)
IL (1) IL199422A (no)
MX (1) MX2009006582A (no)
NO (1) NO20092336L (no)
NZ (1) NZ577796A (no)
PL (1) PL2094653T3 (no)
PT (1) PT2094653E (no)
RS (1) RS51555B (no)
SI (1) SI2094653T1 (no)
UA (1) UA95986C2 (no)
WO (1) WO2008075150A1 (no)
ZA (1) ZA200904278B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2203411B1 (en) 2007-09-20 2016-01-06 Ramot at Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
EP3547991A1 (en) 2016-12-02 2019-10-09 Symrise AG Cosmetic blends
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8715357D0 (en) * 1987-06-30 1987-08-05 Sandoz Inst For Medical Resear Organic compounds
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
CN100439332C (zh) * 2000-08-21 2008-12-03 株式会社太平洋 硫脲衍生物以及包含该衍生物的药物组合物
JP2003192660A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
ITMI20041231A1 (it) * 2004-06-18 2004-09-18 Pharmeste Srl Antagonisti del recettore dei vanilloidi trpv1

Also Published As

Publication number Publication date
DE602007008942D1 (de) 2010-10-14
US7750049B2 (en) 2010-07-06
CA2673219C (en) 2015-04-14
ES2347492T3 (es) 2010-10-29
IL199422A (en) 2015-01-29
PT2094653E (pt) 2010-09-23
KR101460177B1 (ko) 2014-11-10
SI2094653T1 (sl) 2011-01-31
EA200900625A1 (ru) 2009-12-30
DK2094653T3 (da) 2010-10-25
JP2010513455A (ja) 2010-04-30
WO2008075150A1 (en) 2008-06-26
ZA200904278B (en) 2010-08-25
EP1939173A1 (en) 2008-07-02
US20100105740A1 (en) 2010-04-29
CN101563317B (zh) 2012-12-12
EA015152B1 (ru) 2011-06-30
CY1110833T1 (el) 2015-06-10
MX2009006582A (es) 2009-07-02
NZ577796A (en) 2011-10-28
EP2094653A1 (en) 2009-09-02
HRP20100588T1 (hr) 2010-12-31
ATE479652T1 (de) 2010-09-15
CN101563317A (zh) 2009-10-21
CA2673219A1 (en) 2008-06-26
EP2094653B1 (en) 2010-09-01
PL2094653T3 (pl) 2011-02-28
RS51555B (en) 2011-06-30
JP5302214B2 (ja) 2013-10-02
UA95986C2 (uk) 2011-09-26
KR20090090347A (ko) 2009-08-25
BRPI0720421A2 (pt) 2013-12-31

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