CY1110833T1 - Ο-υποκατεστημενα παραγωγα διβενζυλουριας ως ανταγωνιστες του υποδοχεα trpv1 - Google Patents
Ο-υποκατεστημενα παραγωγα διβενζυλουριας ως ανταγωνιστες του υποδοχεα trpv1Info
- Publication number
- CY1110833T1 CY1110833T1 CY20101100925T CY101100925T CY1110833T1 CY 1110833 T1 CY1110833 T1 CY 1110833T1 CY 20101100925 T CY20101100925 T CY 20101100925T CY 101100925 T CY101100925 T CY 101100925T CY 1110833 T1 CY1110833 T1 CY 1110833T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxypropyl
- hydroxymethyl
- bivenzyluria
- trpv1
- competitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Η εφεύρεση αφορά ενώσεις του τύπου (I) εις τον οποίον το R εκλέγεται από αλογόνο αλκυλ, αλκόξυ, αρύλ και έτεροαρυλ· το R1 εκλέγεται από 2-υδροξυαιθύλ, 2,3-διυδροξυπροπύλ, 3-υδροξυπροπύλ, 2,2-διυδροξυαιθύλ, 3,3- διυδροξυπροπύλ, 1,3-διοξολάνο-αιθύλ, 1,3-διοξάνο-μεθύλ, 1,3-διοξολάνο-μεθύλ, 1,3-διοξάνο-αιθύλ, 3-φθόριο-2-υδροξυπροπύλ, 3-καρβοξυ-2-υδροξυ-προπυλ, 3-χλώριο-2-υδροξυπροπύλ, 2-υδροξυπροπύλ, 2-υδροξυ-προπεν-2-ύλ, μορφολίνοαιθύλ, πιπεραζίνοαιθύλ, υδροξυμεθύλ, βενζύλ, 4-υδροξυμεθύλ)βενζύλ, 4-χλώριοβενζύλ, 4-φθοριοβενζύλ, και 4-υδροξυβενζύλ. To R2 είναι τριτ-βουτύλ ή τριφθοριομεθύλ το R3 εκλέγεται ανεξαρτήτως από υδρογόνο, καρβόξυ, κυάνο, αλκύλ ή υδροξυαλκύλ. Οι ενώσεις του τύπου (I) μπορούν να χρησιμοποιηθούν για την παρασκευή φαρμακευτικών συνθέσεων για την θεραπευτική αγωγή φλεγμονωδών καταστάσεων όπως ο χρόνιος νευροπαθητικός πόνος, το σύνδρομο υπερδραστήριας ουροδόχου κύστης, ο πόνος από καρκίνωμα, οι αιμορροΐδες, η φλεγμονώδης υπεραλγησία, ο μετεγχειρητικός πόνος, η εξαγωγή οδόντος, οι ασθένειες των αναπνευστικών οδών και οι γαστρεντερικές ασθένειες.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06026533A EP1939173A1 (en) | 2006-12-21 | 2006-12-21 | O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists |
| EP07848984A EP2094653B1 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110833T1 true CY1110833T1 (el) | 2015-06-10 |
Family
ID=38139789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100925T CY1110833T1 (el) | 2006-12-21 | 2010-10-18 | Ο-υποκατεστημενα παραγωγα διβενζυλουριας ως ανταγωνιστες του υποδοχεα trpv1 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7750049B2 (el) |
| EP (2) | EP1939173A1 (el) |
| JP (1) | JP5302214B2 (el) |
| KR (1) | KR101460177B1 (el) |
| CN (1) | CN101563317B (el) |
| AT (1) | ATE479652T1 (el) |
| BR (1) | BRPI0720421A2 (el) |
| CA (1) | CA2673219C (el) |
| CY (1) | CY1110833T1 (el) |
| DE (1) | DE602007008942D1 (el) |
| DK (1) | DK2094653T3 (el) |
| EA (1) | EA015152B1 (el) |
| ES (1) | ES2347492T3 (el) |
| HR (1) | HRP20100588T1 (el) |
| IL (1) | IL199422A (el) |
| MX (1) | MX2009006582A (el) |
| NO (1) | NO20092336L (el) |
| NZ (1) | NZ577796A (el) |
| PL (1) | PL2094653T3 (el) |
| PT (1) | PT2094653E (el) |
| RS (1) | RS51555B (el) |
| SI (1) | SI2094653T1 (el) |
| UA (1) | UA95986C2 (el) |
| WO (1) | WO2008075150A1 (el) |
| ZA (1) | ZA200904278B (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2203411B1 (en) | 2007-09-20 | 2016-01-06 | Ramot at Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| EP3547991A1 (en) | 2016-12-02 | 2019-10-09 | Symrise AG | Cosmetic blends |
| RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8715357D0 (en) * | 1987-06-30 | 1987-08-05 | Sandoz Inst For Medical Resear | Organic compounds |
| GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
| CN100439332C (zh) * | 2000-08-21 | 2008-12-03 | 株式会社太平洋 | 硫脲衍生物以及包含该衍生物的药物组合物 |
| JP2003192660A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| ITMI20041231A1 (it) * | 2004-06-18 | 2004-09-18 | Pharmeste Srl | Antagonisti del recettore dei vanilloidi trpv1 |
-
2006
- 2006-12-21 EP EP06026533A patent/EP1939173A1/en not_active Withdrawn
-
2007
- 2007-06-12 UA UAA200904805A patent/UA95986C2/uk unknown
- 2007-12-06 MX MX2009006582A patent/MX2009006582A/es active IP Right Grant
- 2007-12-06 WO PCT/IB2007/003784 patent/WO2008075150A1/en active Application Filing
- 2007-12-06 CN CN2007800469258A patent/CN101563317B/zh active Active
- 2007-12-06 PL PL07848984T patent/PL2094653T3/pl unknown
- 2007-12-06 JP JP2009542247A patent/JP5302214B2/ja active Active
- 2007-12-06 DE DE602007008942T patent/DE602007008942D1/de active Active
- 2007-12-06 AT AT07848984T patent/ATE479652T1/de active
- 2007-12-06 DK DK07848984.6T patent/DK2094653T3/da active
- 2007-12-06 EP EP07848984A patent/EP2094653B1/en active Active
- 2007-12-06 EA EA200900625A patent/EA015152B1/ru not_active IP Right Cessation
- 2007-12-06 ZA ZA200904278A patent/ZA200904278B/xx unknown
- 2007-12-06 ES ES07848984T patent/ES2347492T3/es active Active
- 2007-12-06 US US12/519,753 patent/US7750049B2/en active Active
- 2007-12-06 CA CA2673219A patent/CA2673219C/en active Active
- 2007-12-06 SI SI200730412T patent/SI2094653T1/sl unknown
- 2007-12-06 PT PT07848984T patent/PT2094653E/pt unknown
- 2007-12-06 KR KR1020097012641A patent/KR101460177B1/ko active IP Right Grant
- 2007-12-06 RS RSP-2010/0441A patent/RS51555B/en unknown
- 2007-12-06 NZ NZ577796A patent/NZ577796A/en not_active IP Right Cessation
- 2007-12-06 BR BRPI0720421-3A patent/BRPI0720421A2/pt not_active IP Right Cessation
-
2009
- 2009-06-18 IL IL199422A patent/IL199422A/en active IP Right Grant
- 2009-06-18 NO NO20092336A patent/NO20092336L/no not_active Application Discontinuation
-
2010
- 2010-10-18 CY CY20101100925T patent/CY1110833T1/el unknown
- 2010-11-02 HR HR20100588T patent/HRP20100588T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602007008942D1 (de) | 2010-10-14 |
| US7750049B2 (en) | 2010-07-06 |
| CA2673219C (en) | 2015-04-14 |
| ES2347492T3 (es) | 2010-10-29 |
| IL199422A (en) | 2015-01-29 |
| PT2094653E (pt) | 2010-09-23 |
| KR101460177B1 (ko) | 2014-11-10 |
| SI2094653T1 (sl) | 2011-01-31 |
| EA200900625A1 (ru) | 2009-12-30 |
| DK2094653T3 (da) | 2010-10-25 |
| JP2010513455A (ja) | 2010-04-30 |
| WO2008075150A1 (en) | 2008-06-26 |
| ZA200904278B (en) | 2010-08-25 |
| EP1939173A1 (en) | 2008-07-02 |
| US20100105740A1 (en) | 2010-04-29 |
| CN101563317B (zh) | 2012-12-12 |
| EA015152B1 (ru) | 2011-06-30 |
| NO20092336L (no) | 2009-06-18 |
| MX2009006582A (es) | 2009-07-02 |
| NZ577796A (en) | 2011-10-28 |
| EP2094653A1 (en) | 2009-09-02 |
| HRP20100588T1 (hr) | 2010-12-31 |
| ATE479652T1 (de) | 2010-09-15 |
| CN101563317A (zh) | 2009-10-21 |
| CA2673219A1 (en) | 2008-06-26 |
| EP2094653B1 (en) | 2010-09-01 |
| PL2094653T3 (pl) | 2011-02-28 |
| RS51555B (en) | 2011-06-30 |
| JP5302214B2 (ja) | 2013-10-02 |
| UA95986C2 (uk) | 2011-09-26 |
| KR20090090347A (ko) | 2009-08-25 |
| BRPI0720421A2 (pt) | 2013-12-31 |
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