EA200900625A1 - О-замещенные производные дибензилмочевины в качестве антагонистов рецепторов trpv1 - Google Patents

О-замещенные производные дибензилмочевины в качестве антагонистов рецепторов trpv1

Info

Publication number
EA200900625A1
EA200900625A1 EA200900625A EA200900625A EA200900625A1 EA 200900625 A1 EA200900625 A1 EA 200900625A1 EA 200900625 A EA200900625 A EA 200900625A EA 200900625 A EA200900625 A EA 200900625A EA 200900625 A1 EA200900625 A1 EA 200900625A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxypropyl
antagonists
dihydroxypropyl
hydroxymethyl
carboxy
Prior art date
Application number
EA200900625A
Other languages
English (en)
Other versions
EA015152B1 (ru
Inventor
Пьер Джованни Баральди
Пьер Андреа Бореа
Пьеранджело Джеппетти
Франческа Фруттароло
Мария Джованна Павани
Марчелло Тревизани
Original Assignee
Фарместе С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фарместе С.Р.Л. filed Critical Фарместе С.Р.Л.
Publication of EA200900625A1 publication Critical patent/EA200900625A1/ru
Publication of EA015152B1 publication Critical patent/EA015152B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/06Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретение относится к соединениям формулы (I), где R выбран из галогена, алкила, алкокси, арила и гетероарила; Rвыбран из 2-гидроксиэтила, 2,3-дигидроксипропила, 3-гидроксипропила, 2,2-дигидроксиэтила, 3,3-дигидроксипропила, 1,3-диоксаланэтила, 1,3-диоксанметила, 1,3-диоксаланметила, 1,3-диоксанэтила, 3-фтор-2-гидроксипропила, 3-карбокси-2-гидроксипропила, 3-хлор-2-гидроксипропила, 2-гидроксипропила, 2-гидроксипропен-2-ила, морфолиноэтила, пиперазиноэтила, гидроксиметила, бензила, 4-(гидроксиметил)бензила, 4-хлорбензила, 4-фторбензила и 4-гидроксибензила. Rпредставляет собой трет-бутил или трифторметил; Rнезависимо выбран из водорода, карбокси, циано, алкила или гидроксиалкила. Соединения формулы (I) могут быть использованы для изготовления фармацевтических композиций для лечения воспалительных состояний, таких как хроническая невропатическая боль, синдром гиперактивного мочевого пузыря, боль при опухоли, геморрой, воспалительная гипералгезия, послеоперационная боль, удаление зубов, заболевания дыхательных путей и желудочно-кишечные заболевания.
EA200900625A 2006-12-21 2007-12-06 О-замещенные производные дибензилмочевины в качестве антагонистов рецепторов trpv1 EA015152B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06026533A EP1939173A1 (en) 2006-12-21 2006-12-21 O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists
PCT/IB2007/003784 WO2008075150A1 (en) 2006-12-21 2007-12-06 O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists

Publications (2)

Publication Number Publication Date
EA200900625A1 true EA200900625A1 (ru) 2009-12-30
EA015152B1 EA015152B1 (ru) 2011-06-30

Family

ID=38139789

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900625A EA015152B1 (ru) 2006-12-21 2007-12-06 О-замещенные производные дибензилмочевины в качестве антагонистов рецепторов trpv1

Country Status (25)

Country Link
US (1) US7750049B2 (ru)
EP (2) EP1939173A1 (ru)
JP (1) JP5302214B2 (ru)
KR (1) KR101460177B1 (ru)
CN (1) CN101563317B (ru)
AT (1) ATE479652T1 (ru)
BR (1) BRPI0720421A2 (ru)
CA (1) CA2673219C (ru)
CY (1) CY1110833T1 (ru)
DE (1) DE602007008942D1 (ru)
DK (1) DK2094653T3 (ru)
EA (1) EA015152B1 (ru)
ES (1) ES2347492T3 (ru)
HR (1) HRP20100588T1 (ru)
IL (1) IL199422A (ru)
MX (1) MX2009006582A (ru)
NO (1) NO20092336L (ru)
NZ (1) NZ577796A (ru)
PL (1) PL2094653T3 (ru)
PT (1) PT2094653E (ru)
RS (1) RS51555B (ru)
SI (1) SI2094653T1 (ru)
UA (1) UA95986C2 (ru)
WO (1) WO2008075150A1 (ru)
ZA (1) ZA200904278B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
EP3547991A1 (en) 2016-12-02 2019-10-09 Symrise AG Cosmetic blends
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8715357D0 (en) * 1987-06-30 1987-08-05 Sandoz Inst For Medical Resear Organic compounds
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
CA2417507A1 (en) * 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP2003192660A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
ITMI20041231A1 (it) * 2004-06-18 2004-09-18 Pharmeste Srl Antagonisti del recettore dei vanilloidi trpv1

Also Published As

Publication number Publication date
PT2094653E (pt) 2010-09-23
BRPI0720421A2 (pt) 2013-12-31
MX2009006582A (es) 2009-07-02
CA2673219A1 (en) 2008-06-26
CY1110833T1 (el) 2015-06-10
IL199422A (en) 2015-01-29
KR101460177B1 (ko) 2014-11-10
EP2094653A1 (en) 2009-09-02
ATE479652T1 (de) 2010-09-15
CA2673219C (en) 2015-04-14
JP5302214B2 (ja) 2013-10-02
UA95986C2 (ru) 2011-09-26
HRP20100588T1 (hr) 2010-12-31
US20100105740A1 (en) 2010-04-29
SI2094653T1 (sl) 2011-01-31
CN101563317B (zh) 2012-12-12
NO20092336L (no) 2009-06-18
PL2094653T3 (pl) 2011-02-28
JP2010513455A (ja) 2010-04-30
DK2094653T3 (da) 2010-10-25
EP1939173A1 (en) 2008-07-02
WO2008075150A1 (en) 2008-06-26
ZA200904278B (en) 2010-08-25
EA015152B1 (ru) 2011-06-30
US7750049B2 (en) 2010-07-06
EP2094653B1 (en) 2010-09-01
DE602007008942D1 (de) 2010-10-14
NZ577796A (en) 2011-10-28
ES2347492T3 (es) 2010-10-29
KR20090090347A (ko) 2009-08-25
RS51555B (en) 2011-06-30
CN101563317A (zh) 2009-10-21

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU