NO20082215L - Ikke-kompetitive domene-antistofformater som binder interleukin 1 reseptortype 1 - Google Patents
Ikke-kompetitive domene-antistofformater som binder interleukin 1 reseptortype 1Info
- Publication number
- NO20082215L NO20082215L NO20082215A NO20082215A NO20082215L NO 20082215 L NO20082215 L NO 20082215L NO 20082215 A NO20082215 A NO 20082215A NO 20082215 A NO20082215 A NO 20082215A NO 20082215 L NO20082215 L NO 20082215L
- Authority
- NO
- Norway
- Prior art keywords
- dab
- domain antibody
- receptor type
- relates
- antibody formats
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SAMMENDRAG Oppfinnelsen angår dAb monomerer som binder IL-1R1 og hemmer binding av IL-1 (f.eks., IL-1a og/eller IL-1b) til reseptoren men ikke hemmer binding av IL-1ra til IL-1R1, og ligander omfattende slike dAb monomerer. Oppfinnelsen angår proteaseresistente dAb monomerer og ligander omfattende proteaseresistente dAb monomerer. Oppfinnelsen angår også nukleinsyrer omfattende vektorer som koder for dAb-monomerene og liganden, vertsceller som omfatter nukleinsyrene og fremgangsmåte for fremstiiling av en dAb monomer eller ligand. Oppfinnelsen angår også farmasøytiske sammensetninger som omfatter dAb-monomerene eller ligandene og terapeutiske fremgangsmåter som omfatter å administrere en dAb monomer av ligand.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74206205P | 2005-12-01 | 2005-12-01 | |
PCT/GB2006/004471 WO2007063308A2 (en) | 2005-12-01 | 2006-11-30 | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082215L true NO20082215L (no) | 2008-08-14 |
Family
ID=37885775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082215A NO20082215L (no) | 2005-12-01 | 2008-05-15 | Ikke-kompetitive domene-antistofformater som binder interleukin 1 reseptortype 1 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090155283A1 (no) |
EP (1) | EP1957536A2 (no) |
JP (1) | JP2009519011A (no) |
KR (1) | KR20080077238A (no) |
CN (1) | CN101454344A (no) |
AU (1) | AU2006321364B2 (no) |
BR (1) | BRPI0619225A2 (no) |
CA (1) | CA2632866A1 (no) |
CR (1) | CR10022A (no) |
EA (1) | EA200801170A1 (no) |
MA (1) | MA30300B1 (no) |
NO (1) | NO20082215L (no) |
TW (1) | TW200730539A (no) |
WO (1) | WO2007063308A2 (no) |
Families Citing this family (35)
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CA2411374C (en) | 2000-06-29 | 2012-10-30 | Abbott Laboratories | Dual specificity antibodies and methods of making and using |
EP2114443A4 (en) | 2006-12-29 | 2011-08-10 | Abbott Lab | IL-1A / IL-1B ANTIBODY WITH DOUBLE SPECIFICITY |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
CA2688433A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
GB0809069D0 (en) | 2008-05-19 | 2008-06-25 | Univ Leuven Kath | Gene signatures |
CN102089325A (zh) | 2008-04-17 | 2011-06-08 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽,以及包含其的化合物、构建体和多肽 |
US8298533B2 (en) | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
CA2744055A1 (en) * | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
CN102405236A (zh) * | 2009-02-19 | 2012-04-04 | 葛兰素集团有限公司 | 改进的抗-tnfr1多肽,抗体可变结构域和拮抗剂 |
CN102574914A (zh) * | 2009-07-16 | 2012-07-11 | 葛兰素集团有限公司 | 改进的抗血清清蛋白结合性单可变区 |
US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
HUE051913T2 (hu) * | 2009-09-18 | 2021-04-28 | Codexis Inc | Csökkentett kodon mutagenezis |
CA2788993A1 (en) | 2010-02-05 | 2011-08-11 | Ablynx N.V. | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
US20130149312A1 (en) * | 2010-04-16 | 2013-06-13 | Mcmaster University | Compositions and methods for treating copd exacerbation |
EP2721066A1 (en) * | 2011-06-17 | 2014-04-23 | Glaxo Group Limited | Tumour necrosis factor receptor 1 antagonists |
EP4350345A2 (en) | 2011-06-23 | 2024-04-10 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
BR112013032145B1 (pt) | 2011-06-23 | 2022-09-20 | Ablynx N.V | Técnicas para prever, detectar e reduzir interferência de proteína não especifica em ensaios envolvendo domínios variáveis únicos de imunoglobulina |
EP2944654A1 (en) | 2011-06-23 | 2015-11-18 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
US10808040B2 (en) * | 2011-08-17 | 2020-10-20 | Glaxo Group Limited | Modified proteins and peptides |
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ES2815572T3 (es) | 2014-05-16 | 2021-03-30 | Ablynx Nv | Dominios variables de inmunoglobulina |
NO2768984T3 (no) | 2015-11-12 | 2018-06-09 | ||
PT3374392T (pt) | 2015-11-13 | 2022-02-07 | Ablynx Nv | Domínios variáveis de imunoglobulina que se ligam a albumina sérica melhorados |
CA3005488A1 (en) | 2015-11-18 | 2017-05-26 | Ablynx Nv | Improved serum albumin binders |
US10501542B2 (en) | 2015-11-18 | 2019-12-10 | Merck Sharp & Dohme Corp. | CTLA4 binders |
WO2017210749A1 (en) * | 2016-06-10 | 2017-12-14 | Adelaide Research & Innovation Pty Ltd | Methods and products for treating autoimmune diseases |
EP4119944A1 (en) | 2016-06-23 | 2023-01-18 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
TWI797097B (zh) | 2016-11-28 | 2023-04-01 | 日商中外製藥股份有限公司 | 包含抗原結合域與運送部分的多胜肽 |
KR102616835B1 (ko) | 2016-12-07 | 2023-12-22 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합성 면역글로불린 단일 가변 도메인 |
WO2018134234A1 (en) | 2017-01-17 | 2018-07-26 | Ablynx Nv | Improved serum albumin binders |
CN117285623A (zh) | 2017-01-17 | 2023-12-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
US20220099682A9 (en) | 2017-03-31 | 2022-03-31 | Ablynx N.V. | Improved immunogenicity assays |
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US20210155701A1 (en) * | 2018-05-30 | 2021-05-27 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide comprising il-1r1 binding domain and carrying moiety |
CN109336977A (zh) * | 2018-10-11 | 2019-02-15 | 暨南大学 | 肿瘤干细胞标志分子EpCAM的结合蛋白及其应用 |
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-
2006
- 2006-11-30 TW TW095144416A patent/TW200730539A/zh unknown
- 2006-11-30 EA EA200801170A patent/EA200801170A1/ru unknown
- 2006-11-30 KR KR1020087015994A patent/KR20080077238A/ko not_active Application Discontinuation
- 2006-11-30 WO PCT/GB2006/004471 patent/WO2007063308A2/en active Application Filing
- 2006-11-30 JP JP2008542829A patent/JP2009519011A/ja active Pending
- 2006-11-30 BR BRPI0619225A patent/BRPI0619225A2/pt not_active IP Right Cessation
- 2006-11-30 CN CNA2006800518832A patent/CN101454344A/zh active Pending
- 2006-11-30 AU AU2006321364A patent/AU2006321364B2/en not_active Expired - Fee Related
- 2006-11-30 CA CA002632866A patent/CA2632866A1/en not_active Abandoned
- 2006-11-30 US US12/085,920 patent/US20090155283A1/en not_active Abandoned
- 2006-11-30 EP EP06820376A patent/EP1957536A2/en not_active Withdrawn
-
2008
- 2008-05-15 NO NO20082215A patent/NO20082215L/no not_active Application Discontinuation
- 2008-05-27 CR CR10022A patent/CR10022A/es not_active Application Discontinuation
- 2008-06-02 MA MA30984A patent/MA30300B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
CR10022A (es) | 2008-09-22 |
CA2632866A1 (en) | 2007-06-07 |
MA30300B1 (fr) | 2009-04-01 |
CN101454344A (zh) | 2009-06-10 |
AU2006321364B2 (en) | 2011-11-10 |
EP1957536A2 (en) | 2008-08-20 |
US20090155283A1 (en) | 2009-06-18 |
JP2009519011A (ja) | 2009-05-14 |
EA200801170A1 (ru) | 2008-12-30 |
KR20080077238A (ko) | 2008-08-21 |
BRPI0619225A2 (pt) | 2017-11-07 |
WO2007063308A3 (en) | 2007-09-20 |
AU2006321364A1 (en) | 2007-06-07 |
TW200730539A (en) | 2007-08-16 |
WO2007063308A2 (en) | 2007-06-07 |
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