EA200801170A1 - Форматы неконкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа - Google Patents
Форматы неконкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типаInfo
- Publication number
- EA200801170A1 EA200801170A1 EA200801170A EA200801170A EA200801170A1 EA 200801170 A1 EA200801170 A1 EA 200801170A1 EA 200801170 A EA200801170 A EA 200801170A EA 200801170 A EA200801170 A EA 200801170A EA 200801170 A1 EA200801170 A1 EA 200801170A1
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- EA
- Eurasian Patent Office
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Abstract
Изобретение относится к мономерам доменного антитела (dAb), которые связываются с IL-1R1 и ингибируют связывание IL-1 (например IL-1α и/или IL-1β) с рецептором, но не ингибируют связывание IL-1 ra с IL-1R1, и к лигандам, содержащим такие мономеры dAb. Изобретение также относится к мономерам dAb, устойчивым к протеазе, и к лигандам, содержащим мономеры dAb, устойчивые к протеазе. Изобретение также относится к нуклеиновым кислотам, включающим векторы, которые кодируют мономеры dAb и лиганд, к клеткам-хозяевам, содержащим нуклеиновые кислоты, и к способу продуцирования мономера dAb или лиганда. Изобретение также относится к фармацевтическим композициям, содержащим мономеры dAb или лиганды, и к терапевтическим способам, включающим введение мономера dAb или лиганда.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74206205P | 2005-12-01 | 2005-12-01 | |
PCT/GB2006/004471 WO2007063308A2 (en) | 2005-12-01 | 2006-11-30 | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
Publications (1)
Publication Number | Publication Date |
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EA200801170A1 true EA200801170A1 (ru) | 2008-12-30 |
Family
ID=37885775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801170A EA200801170A1 (ru) | 2005-12-01 | 2006-11-30 | Форматы неконкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090155283A1 (ru) |
EP (1) | EP1957536A2 (ru) |
JP (1) | JP2009519011A (ru) |
KR (1) | KR20080077238A (ru) |
CN (1) | CN101454344A (ru) |
AU (1) | AU2006321364B2 (ru) |
BR (1) | BRPI0619225A2 (ru) |
CA (1) | CA2632866A1 (ru) |
CR (1) | CR10022A (ru) |
EA (1) | EA200801170A1 (ru) |
MA (1) | MA30300B1 (ru) |
NO (1) | NO20082215L (ru) |
TW (1) | TW200730539A (ru) |
WO (1) | WO2007063308A2 (ru) |
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-
2006
- 2006-11-30 TW TW095144416A patent/TW200730539A/zh unknown
- 2006-11-30 JP JP2008542829A patent/JP2009519011A/ja active Pending
- 2006-11-30 WO PCT/GB2006/004471 patent/WO2007063308A2/en active Application Filing
- 2006-11-30 CA CA002632866A patent/CA2632866A1/en not_active Abandoned
- 2006-11-30 CN CNA2006800518832A patent/CN101454344A/zh active Pending
- 2006-11-30 EA EA200801170A patent/EA200801170A1/ru unknown
- 2006-11-30 KR KR1020087015994A patent/KR20080077238A/ko not_active Application Discontinuation
- 2006-11-30 AU AU2006321364A patent/AU2006321364B2/en not_active Expired - Fee Related
- 2006-11-30 EP EP06820376A patent/EP1957536A2/en not_active Withdrawn
- 2006-11-30 BR BRPI0619225A patent/BRPI0619225A2/pt not_active IP Right Cessation
- 2006-11-30 US US12/085,920 patent/US20090155283A1/en not_active Abandoned
-
2008
- 2008-05-15 NO NO20082215A patent/NO20082215L/no not_active Application Discontinuation
- 2008-05-27 CR CR10022A patent/CR10022A/es not_active Application Discontinuation
- 2008-06-02 MA MA30984A patent/MA30300B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
TW200730539A (en) | 2007-08-16 |
NO20082215L (no) | 2008-08-14 |
KR20080077238A (ko) | 2008-08-21 |
AU2006321364B2 (en) | 2011-11-10 |
CN101454344A (zh) | 2009-06-10 |
JP2009519011A (ja) | 2009-05-14 |
MA30300B1 (fr) | 2009-04-01 |
BRPI0619225A2 (pt) | 2017-11-07 |
WO2007063308A3 (en) | 2007-09-20 |
EP1957536A2 (en) | 2008-08-20 |
CR10022A (es) | 2008-09-22 |
AU2006321364A1 (en) | 2007-06-07 |
WO2007063308A2 (en) | 2007-06-07 |
US20090155283A1 (en) | 2009-06-18 |
CA2632866A1 (en) | 2007-06-07 |
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