PT3374392T - Domínios variáveis de imunoglobulina que se ligam a albumina sérica melhorados - Google Patents
Domínios variáveis de imunoglobulina que se ligam a albumina sérica melhoradosInfo
- Publication number
- PT3374392T PT3374392T PT167909340T PT16790934T PT3374392T PT 3374392 T PT3374392 T PT 3374392T PT 167909340 T PT167909340 T PT 167909340T PT 16790934 T PT16790934 T PT 16790934T PT 3374392 T PT3374392 T PT 3374392T
- Authority
- PT
- Portugal
- Prior art keywords
- serum albumin
- variable domains
- immunoglobulin variable
- binding immunoglobulin
- improved serum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254813P | 2015-11-13 | 2015-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3374392T true PT3374392T (pt) | 2022-02-07 |
Family
ID=57233415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT167909340T PT3374392T (pt) | 2015-11-13 | 2016-10-28 | Domínios variáveis de imunoglobulina que se ligam a albumina sérica melhorados |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11142569B2 (pt) |
| EP (2) | EP3374392B1 (pt) |
| JP (2) | JP7195142B2 (pt) |
| CN (2) | CN115925919A (pt) |
| AU (1) | AU2016351710B2 (pt) |
| CA (1) | CA3005061A1 (pt) |
| DK (1) | DK3374392T3 (pt) |
| ES (1) | ES2905912T3 (pt) |
| HR (1) | HRP20220080T1 (pt) |
| HU (1) | HUE057241T2 (pt) |
| LT (1) | LT3374392T (pt) |
| PL (1) | PL3374392T3 (pt) |
| PT (1) | PT3374392T (pt) |
| RS (1) | RS62857B1 (pt) |
| SI (1) | SI3374392T1 (pt) |
| WO (1) | WO2017080850A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| SG10201805288QA (en) | 2014-05-16 | 2018-07-30 | Ablynx Nv | Improved immunoglobulin variable domains |
| PL3374392T3 (pl) * | 2015-11-13 | 2022-03-28 | Ablynx Nv | Ulepszone domeny zmienne immunoglobuliny wiążące albuminę surowicy |
| AU2018209151A1 (en) * | 2017-01-17 | 2019-07-25 | Ablynx Nv | Improved serum albumin binders |
| KR20200015912A (ko) | 2017-06-02 | 2020-02-13 | 메르크 파텐트 게엠베하 | Adamts5, mmp13 및 아그레칸 결합성 폴리펩타이드 |
| JP2020521804A (ja) * | 2017-06-02 | 2020-07-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｍｍｐ１３結合免疫グロブリン |
| JP2022520998A (ja) * | 2019-02-22 | 2022-04-04 | アンウィタ バイオサイエンシス， インク． | アルブミン結合抗体及びその使用 |
| AU2020396204A1 (en) | 2019-12-06 | 2022-07-28 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting TNFα and IL-23 |
| EP4069293A1 (en) | 2019-12-06 | 2022-10-12 | Ablynx N.V. | Polypeptides comprising immunoglobulin single variable domains targeting tnfa and ox40l |
| MX2022007035A (es) | 2019-12-09 | 2022-06-23 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y tslp. |
| US20230136595A1 (en) | 2020-03-30 | 2023-05-04 | Ablynx Nv | Method for the production and purification of multivalent immunoglobulin single variable domains |
| MX2023003522A (es) | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| KR20230122084A (ko) | 2020-12-18 | 2023-08-22 | 아블린쓰 엔.브이. | Tcr 알파/베타 반응성에 기초한 t 세포 동원 폴리펩타이드 |
| TW202241947A (zh) | 2020-12-18 | 2022-11-01 | 比利時商艾伯霖克斯公司 | 包含靶向磷脂醯肌醇蛋白聚糖—３和ｔ細胞受體的免疫球蛋白單可變結構域的多肽 |
| KR20230123497A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드 |
| TW202342508A (zh) | 2021-12-17 | 2023-11-01 | 比利時商艾伯霖克斯公司 | 包含靶向ＴＣＲαβ、ＣＤ３３和ＣＤ１２３的免疫球蛋白單可變結構域的多肽 |
| US20240109965A1 (en) | 2022-06-14 | 2024-04-04 | Ablynx N.V. | Immunoglobulin single variable domains targeting t cell receptor |
| WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| WO2024038112A1 (en) * | 2022-08-17 | 2024-02-22 | Institut National de la Santé et de la Recherche Médicale | Improved anti-albumin nanobodies and their uses |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| ATE461282T1 (de) | 1997-10-27 | 2010-04-15 | Bac Ip Bv | Multivalente antigenbindende proteine |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP1900753B1 (en) | 2002-11-08 | 2017-08-09 | Ablynx N.V. | Method of administering therapeutic polypeptides, and polypeptides therefor |
| CA2512545C (en) | 2003-01-10 | 2015-06-30 | Karen Silence | Recombinant vhh single domain antibody from camelidae against von willebrand factor (vwf) |
| JP2008521870A (ja) | 2004-12-02 | 2008-06-26 | ドマンティス リミテッド | 抗ｉｌ−１ｒ１単一ドメイン抗体および治療使用 |
| EP2949668B1 (en) | 2005-05-18 | 2019-08-14 | Ablynx N.V. | Improved nanobodies tm against tumor necrosis factor-alpha |
| CA2608873C (en) | 2005-05-20 | 2017-04-25 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
| JP2009517069A (ja) | 2005-12-01 | 2009-04-30 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する競合ドメイン抗体フォーマット |
| AU2006321364B2 (en) | 2005-12-01 | 2011-11-10 | Domantis Limited | Noncompetitive domain antibody formats that bind Interleukin 1 Receptor type 1 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| EP1976991A1 (en) | 2006-01-24 | 2008-10-08 | Domantis Limited | Fusion proteins that contain natural junctions |
| WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| RU2481355C2 (ru) | 2007-05-24 | 2013-05-10 | Аблинкс Н.В. | Аминокислотные последовательности, направленные на rank-l, и полипептиды, включающие их, для лечения заболеваний и нарушений костей |
| JP2011504740A (ja) | 2007-11-27 | 2011-02-17 | アブリンクス エン．ヴェー． | ヘテロ二量体サイトカイン及び／又はこれらの受容体に指向性を有するアミノ酸配列、並びにこれを含むポリペプチド |
| US9181327B2 (en) * | 2008-01-07 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-HIV domain antibodies and method of making and using same |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| CA2724208C (en) | 2008-05-16 | 2018-02-06 | Ablynx Nv | Amino acid sequences directed against cxcr4 and other gpcrs and compounds comprising the same |
| WO2010043650A2 (en) * | 2008-10-14 | 2010-04-22 | Ablynx Nv | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| BR112012001681A2 (pt) * | 2009-07-16 | 2019-09-24 | Graxo Group Ltd | domínios variáveis de ligação de anti-albumina sérica aperfeiçoados |
| EA201291009A1 (ru) * | 2010-05-20 | 2013-05-30 | Глаксо Груп Лимитед | Улучшенные связывающие варианты против сывороточного альбумина |
| US9012609B2 (en) * | 2010-08-13 | 2015-04-21 | Glaxosmithkline Intellectual Property Development Limited | Anti-serum albumin binding variants |
| EP2646467A2 (en) | 2010-12-01 | 2013-10-09 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| US9150651B2 (en) * | 2011-01-06 | 2015-10-06 | Glaxo Group Limited | Single variable domain immunoglobulins that bind TGF-beta receptor II |
| US9527925B2 (en) * | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| HUE047238T2 (hu) | 2011-06-23 | 2020-04-28 | Ablynx Nv | Szérumalbuminhoz kötõdõ fehérjék |
| IL229503B (en) | 2011-06-23 | 2022-06-01 | Ablynx Nv | Techniques for predicting, detecting and reducing interference of a-specific protein in tests involving single variable domains of immunoglobulin |
| KR102143506B1 (ko) | 2011-08-17 | 2020-08-12 | 글락소 그룹 리미티드 | 변형된 단백질 및 펩티드 |
| WO2014111550A1 (en) * | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| ES2815572T3 (es) | 2014-05-16 | 2021-03-30 | Ablynx Nv | Dominios variables de inmunoglobulina |
| SG10201805288QA (en) * | 2014-05-16 | 2018-07-30 | Ablynx Nv | Improved immunoglobulin variable domains |
| PL3374392T3 (pl) * | 2015-11-13 | 2022-03-28 | Ablynx Nv | Ulepszone domeny zmienne immunoglobuliny wiążące albuminę surowicy |
-
2016
- 2016-10-28 PL PL16790934T patent/PL3374392T3/pl unknown
- 2016-10-28 CA CA3005061A patent/CA3005061A1/en active Pending
- 2016-10-28 PT PT167909340T patent/PT3374392T/pt unknown
- 2016-10-28 JP JP2018524454A patent/JP7195142B2/ja active Active
- 2016-10-28 WO PCT/EP2016/076088 patent/WO2017080850A1/en active Application Filing
- 2016-10-28 ES ES16790934T patent/ES2905912T3/es active Active
- 2016-10-28 CN CN202210797845.2A patent/CN115925919A/zh active Pending
- 2016-10-28 EP EP16790934.0A patent/EP3374392B1/en active Active
- 2016-10-28 AU AU2016351710A patent/AU2016351710B2/en active Active
- 2016-10-28 US US15/769,800 patent/US11142569B2/en active Active
- 2016-10-28 DK DK16790934.0T patent/DK3374392T3/da active
- 2016-10-28 HU HUE16790934A patent/HUE057241T2/hu unknown
- 2016-10-28 RS RS20220086A patent/RS62857B1/sr unknown
- 2016-10-28 CN CN201680066246.6A patent/CN108290943A/zh active Pending
- 2016-10-28 LT LTEPPCT/EP2016/076088T patent/LT3374392T/lt unknown
- 2016-10-28 HR HRP20220080TT patent/HRP20220080T1/hr unknown
- 2016-10-28 SI SI201631451T patent/SI3374392T1/sl unknown
- 2016-10-28 EP EP21197952.1A patent/EP3974449A1/en active Pending
-
2021
- 2021-09-22 US US17/481,578 patent/US20220112275A1/en active Pending
-
2022
- 2022-12-13 JP JP2022198469A patent/JP2023027258A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7195142B2 (ja) | 2022-12-23 |
| HUE057241T2 (hu) | 2022-04-28 |
| JP2019502656A (ja) | 2019-01-31 |
| CA3005061A1 (en) | 2017-05-18 |
| DK3374392T3 (da) | 2022-02-14 |
| EP3374392B1 (en) | 2021-11-24 |
| EP3974449A1 (en) | 2022-03-30 |
| CN115925919A (zh) | 2023-04-07 |
| HRP20220080T1 (hr) | 2022-04-15 |
| AU2016351710B2 (en) | 2023-08-03 |
| SI3374392T1 (sl) | 2022-04-29 |
| AU2016351710A1 (en) | 2018-05-10 |
| LT3374392T (lt) | 2022-01-25 |
| US20220112275A1 (en) | 2022-04-14 |
| JP2023027258A (ja) | 2023-03-01 |
| ES2905912T3 (es) | 2022-04-12 |
| US11142569B2 (en) | 2021-10-12 |
| WO2017080850A1 (en) | 2017-05-18 |
| US20180312578A1 (en) | 2018-11-01 |
| RS62857B1 (sr) | 2022-02-28 |
| EP3374392A1 (en) | 2018-09-19 |
| PL3374392T3 (pl) | 2022-03-28 |
| CN108290943A (zh) | 2018-07-17 |
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