PT3143042T - Domínios variáveis de imunoglobulina - Google Patents
Domínios variáveis de imunoglobulinaInfo
- Publication number
- PT3143042T PT3143042T PT157222118T PT15722211T PT3143042T PT 3143042 T PT3143042 T PT 3143042T PT 157222118 T PT157222118 T PT 157222118T PT 15722211 T PT15722211 T PT 15722211T PT 3143042 T PT3143042 T PT 3143042T
- Authority
- PT
- Portugal
- Prior art keywords
- variable domains
- immunoglobulin variable
- improved immunoglobulin
- improved
- domains
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461994552P | 2014-05-16 | 2014-05-16 | |
| US201461014015P | 2014-06-18 | 2014-06-18 | |
| US201462040167P | 2014-08-21 | 2014-08-21 | |
| US201462047560P | 2014-09-08 | 2014-09-08 | |
| US201562133600P | 2015-03-16 | 2015-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3143042T true PT3143042T (pt) | 2020-09-01 |
Family
ID=53175523
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT171789902T PT3248986T (pt) | 2014-05-16 | 2015-05-13 | Domínios variáveis de imunoglobulina |
| PT157222118T PT3143042T (pt) | 2014-05-16 | 2015-05-13 | Domínios variáveis de imunoglobulina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT171789902T PT3248986T (pt) | 2014-05-16 | 2015-05-13 | Domínios variáveis de imunoglobulina |
Country Status (14)
| Country | Link |
|---|---|
| EP (4) | EP3248986B1 (pt) |
| AU (6) | AU2015261536B2 (pt) |
| BR (2) | BR122018009619B1 (pt) |
| CA (1) | CA2948076A1 (pt) |
| DK (2) | DK3143042T3 (pt) |
| ES (2) | ES2912069T3 (pt) |
| HR (2) | HRP20220400T1 (pt) |
| HU (2) | HUE058008T2 (pt) |
| LT (2) | LT3248986T (pt) |
| PL (2) | PL3143042T3 (pt) |
| PT (2) | PT3248986T (pt) |
| RS (2) | RS63085B1 (pt) |
| SI (2) | SI3143042T1 (pt) |
| WO (1) | WO2015173325A2 (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3248986T (pt) | 2014-05-16 | 2022-04-05 | Ablynx Nv | Domínios variáveis de imunoglobulina |
| WO2016118733A1 (en) | 2015-01-21 | 2016-07-28 | Inhibrx Biopharma LLC | Non-immunogenic single domain antibodies |
| NO2768984T3 (pt) | 2015-11-12 | 2018-06-09 | ||
| CN108431039B (zh) | 2015-11-12 | 2022-06-28 | 埃博灵克斯股份有限公司 | 改进的p2x7受体结合剂和包含其的多肽 |
| CA3005061A1 (en) | 2015-11-13 | 2017-05-18 | Ablynx Nv | Improved serum albumin-binding immunoglobulin variable domains |
| EP3377526A1 (en) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme Corp. | PD1/CTLA4 Binders |
| CR20180279A (es) | 2015-11-18 | 2018-08-24 | Merck Sharp & Dohme | Enlazadores de ctla4 |
| EP3377525A2 (en) * | 2015-11-18 | 2018-09-26 | Ablynx NV | Improved serum albumin binders |
| IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
| AU2017216864B2 (en) | 2016-02-12 | 2023-06-22 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
| CN107400166A (zh) * | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | 针对ctla4的单域抗体及其衍生蛋白 |
| KR102374912B1 (ko) | 2016-06-23 | 2022-03-16 | 아블린쓰 엔.브이. | 면역글로불린 단일 가변 도메인에 대한 개선된 약동학적 어세이 |
| CA3043515A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
| WO2018104444A1 (en) * | 2016-12-07 | 2018-06-14 | Ablynx Nv | Improved serum albumin binding immunoglobulin single variable domains |
| KR102653724B1 (ko) | 2017-01-17 | 2024-04-02 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합제 |
| US11414481B2 (en) | 2017-01-17 | 2022-08-16 | Ablynx N.V. | Serum albumin binders |
| US11261260B2 (en) | 2017-06-02 | 2022-03-01 | Merck Patent Gmbh | ADAMTS binding immunoglobulins |
| WO2019016237A1 (en) | 2017-07-19 | 2019-01-24 | Vib Vzw | AGENTS FOR CONNECTING TO SERUM ALBUMIN |
| US11873347B2 (en) | 2017-10-31 | 2024-01-16 | Vib Vzw | Antigen-binding chimeric proteins and methods and uses thereof |
| EP3962599A1 (en) | 2019-04-30 | 2022-03-09 | Vib Vzw | Cystic fibrosis transmembrane conductance regulator stabilizing agents |
| US20220411495A1 (en) | 2019-11-27 | 2022-12-29 | Vib Vzw | Positive allosteric modulators of the calcium-sensing receptor |
| BR112022010231A2 (pt) | 2019-12-06 | 2022-09-06 | Ablynx Nv | Polipeptídeos compreendendo domínios variáveis únicos de imunoglobulina direcionados a tnfalfa e ox40l |
| CA3163877A1 (en) | 2019-12-06 | 2021-06-10 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting tnf.alpha. and il-23 |
| MX2022007035A (es) | 2019-12-09 | 2022-06-23 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y tslp. |
| AR120698A1 (es) | 2019-12-09 | 2022-03-09 | Ablynx Nv | Polipéptidos que comprenden dominios variables únicos de inmunoglobulina que se dirigen a il-13 y tslp |
| WO2021123360A1 (en) | 2019-12-20 | 2021-06-24 | Vib Vzw | Nanobody exchange chromatography |
| WO2021156490A2 (en) | 2020-02-06 | 2021-08-12 | Vib Vzw | Corona virus binders |
| IL295892A (en) | 2020-02-25 | 2022-10-01 | Vib Vzw | Leucine-rich repeat kinase 2 allosteric modulators |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| WO2022003156A1 (en) | 2020-07-02 | 2022-01-06 | Oncurious Nv | Ccr8 non-blocking binders |
| IL301581A (en) | 2020-09-25 | 2023-05-01 | Ablynx Nv | Polypeptides comprising single immunoglobulin variable sites targeting 13-IL and OX40L |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| WO2022117572A2 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | An ltbr agonist in combination therapy against cancer |
| CA3201219A1 (en) | 2020-12-04 | 2022-06-09 | Mir Ali | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
| EP4262985A1 (en) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
| WO2022129572A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| WO2022129637A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| GB202020502D0 (en) | 2020-12-23 | 2021-02-03 | Vib Vzw | Antibody composistion for treatment of corona virus infection |
| US20240101647A1 (en) | 2021-02-05 | 2024-03-28 | Vib Vzw | Sarbecovirus binders |
| CN117794566A (zh) | 2021-02-05 | 2024-03-29 | Vib研究所 | 沙贝病毒结合剂 |
| EP4294516A1 (en) | 2021-02-19 | 2023-12-27 | Vib Vzw | Cation-independent mannose-6-phosphate receptor binders |
| WO2023016828A2 (en) | 2021-07-30 | 2023-02-16 | Vib Vzw | Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation |
| WO2023093899A1 (zh) * | 2021-11-29 | 2023-06-01 | 江苏恒瑞医药股份有限公司 | 经修饰的蛋白或多肽 |
| WO2023111266A1 (en) | 2021-12-17 | 2023-06-22 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
| WO2023135198A1 (en) | 2022-01-12 | 2023-07-20 | Vib Vzw | Human ntcp binders for therapeutic use and liver-specific targeted delivery |
| WO2023198848A1 (en) | 2022-04-13 | 2023-10-19 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| WO2023222825A1 (en) | 2022-05-18 | 2023-11-23 | Vib Vzw | Sarbecovirus spike s2 subunit binders |
| US20240002331A1 (en) | 2022-06-08 | 2024-01-04 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
| US20240109965A1 (en) | 2022-06-14 | 2024-04-04 | Ablynx N.V. | Immunoglobulin single variable domains targeting t cell receptor |
| WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| WO2024068744A1 (en) | 2022-09-27 | 2024-04-04 | Vib Vzw | Antivirals against human parainfluenza virus |
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| US20100081792A1 (en) | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
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| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| PT1517921E (pt) | 2002-06-28 | 2006-09-29 | Domantis Ltd | Ligandos duplamente especificos com semi-vida no soro aumentada |
| FR2846667B1 (fr) | 2002-11-06 | 2004-12-31 | Pasteur Institut | Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives |
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| EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
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| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
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| WO2007063311A2 (en) | 2005-12-01 | 2007-06-07 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
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| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
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| WO2010142534A1 (en) | 2009-05-27 | 2010-12-16 | Ablynx Nv | Biparatopic protein constructs directed against il-23 |
| HUE051430T2 (hu) | 2009-07-10 | 2021-03-01 | Ablynx Nv | Eljárás variábilis domének elõállítására |
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| WO2011042398A1 (en) | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
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| AR080446A1 (es) | 2010-03-03 | 2012-04-11 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta (beta amiloide) |
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| US9667316B2 (en) | 2013-05-17 | 2017-05-30 | The Boeing Company | Aircraft data transmission using phase separation |
| PT3248986T (pt) | 2014-05-16 | 2022-04-05 | Ablynx Nv | Domínios variáveis de imunoglobulina |
-
2015
- 2015-05-13 PT PT171789902T patent/PT3248986T/pt unknown
- 2015-05-13 LT LTEP17178990.2T patent/LT3248986T/lt unknown
- 2015-05-13 EP EP17178990.2A patent/EP3248986B1/en active Active
- 2015-05-13 EP EP15722211.8A patent/EP3143042B1/en active Active
- 2015-05-13 DK DK15722211.8T patent/DK3143042T3/da active
- 2015-05-13 HR HRP20220400TT patent/HRP20220400T1/hr unknown
- 2015-05-13 PL PL15722211T patent/PL3143042T3/pl unknown
- 2015-05-13 BR BR122018009619-5A patent/BR122018009619B1/pt active IP Right Grant
- 2015-05-13 PL PL17178990T patent/PL3248986T3/pl unknown
- 2015-05-13 ES ES17178990T patent/ES2912069T3/es active Active
- 2015-05-13 DK DK17178990.2T patent/DK3248986T3/da active
- 2015-05-13 EP EP20163286.6A patent/EP3693386A1/en active Pending
- 2015-05-13 LT LTEP15722211.8T patent/LT3143042T/lt unknown
- 2015-05-13 SI SI201531267T patent/SI3143042T1/sl unknown
- 2015-05-13 HU HUE17178990A patent/HUE058008T2/hu unknown
- 2015-05-13 EP EP20167969.3A patent/EP3702369A1/en active Pending
- 2015-05-13 SI SI201531807T patent/SI3248986T1/sl unknown
- 2015-05-13 RS RS20220328A patent/RS63085B1/sr unknown
- 2015-05-13 BR BR112016026773A patent/BR112016026773A2/pt not_active Application Discontinuation
- 2015-05-13 WO PCT/EP2015/060643 patent/WO2015173325A2/en active Application Filing
- 2015-05-13 AU AU2015261536A patent/AU2015261536B2/en active Active
- 2015-05-13 HU HUE15722211A patent/HUE050007T2/hu unknown
- 2015-05-13 CA CA2948076A patent/CA2948076A1/en active Pending
- 2015-05-13 ES ES15722211T patent/ES2815572T3/es active Active
- 2015-05-13 RS RS20201034A patent/RS60717B1/sr unknown
- 2015-05-13 PT PT157222118T patent/PT3143042T/pt unknown
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2018
- 2018-06-14 AU AU2018204226A patent/AU2018204226A1/en not_active Abandoned
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2020
- 2020-04-16 AU AU2020202570A patent/AU2020202570B2/en active Active
- 2020-04-30 AU AU2020202855A patent/AU2020202855B2/en active Active
- 2020-06-18 HR HRP20200966TT patent/HRP20200966T1/hr unknown
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2022
- 2022-11-28 AU AU2022279374A patent/AU2022279374A1/en active Pending
- 2022-11-28 AU AU2022279373A patent/AU2022279373A1/en active Pending
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