NO20075936L - Fuserte heterocykliske forbindelser - Google Patents
Fuserte heterocykliske forbindelserInfo
- Publication number
- NO20075936L NO20075936L NO20075936A NO20075936A NO20075936L NO 20075936 L NO20075936 L NO 20075936L NO 20075936 A NO20075936 A NO 20075936A NO 20075936 A NO20075936 A NO 20075936A NO 20075936 L NO20075936 L NO 20075936L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- acyl
- hydrocarbyl
- heterocyclic compounds
- fused heterocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er tilveiebrakt en CRF-reseptorantagonist omfattende en forbindelse med formelen (I): hvori R1 er en eventuelt substituert hydrokarbyl, en eventuelt substituert C-tilknyttet heterosyklisk gruppe, en eventuelt substituert N-tilknyttet heteroarylgruppe, cyano eller acyl; R2 er en eventuelt substituert syklisk hydrokarbyl eller en eventuelt substituert heterosyklisk gruppe; X er oksygen, svovel eller -NR3- (hvori R3 er hydrogen, en eventuelt substituert hydrokarbyl eller acyl); Y1, Y2 og Y3 er hver en eventuelt substituert karbon eller et nitrogen, forutsatt at én eller ingen av Y1, Y2 og Y3 er nitrogen; og Z er en binding, -CO-, oksygen, svovel, -SO-, -SO2-, -NR4-, -NR4-alk-, -CONR4- eller -NR4CO- (hvori alk er en eventuelt substituert Ci_4 alkylen, og R4 er hydrogen, en eventuelt substituert hydrokarbyl eller acyl); eller et salt derav eller en prodroge derav.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67511305P | 2005-04-27 | 2005-04-27 | |
US74210105P | 2005-12-02 | 2005-12-02 | |
PCT/US2006/015646 WO2006116412A2 (en) | 2005-04-27 | 2006-04-26 | Fused heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20075936L true NO20075936L (no) | 2007-11-19 |
Family
ID=37215421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075936A NO20075936L (no) | 2005-04-27 | 2007-11-19 | Fuserte heterocykliske forbindelser |
Country Status (19)
Country | Link |
---|---|
US (1) | US8163935B2 (no) |
EP (1) | EP1874736A4 (no) |
JP (1) | JP5061097B2 (no) |
KR (1) | KR101368037B1 (no) |
AR (1) | AR053859A1 (no) |
AU (1) | AU2006241210B2 (no) |
BR (1) | BRPI0610150A2 (no) |
CA (1) | CA2605453A1 (no) |
CR (1) | CR9421A (no) |
GE (1) | GEP20104962B (no) |
IL (1) | IL186407A (no) |
MA (1) | MA29486B1 (no) |
MX (1) | MX2007013154A (no) |
NO (1) | NO20075936L (no) |
NZ (1) | NZ562235A (no) |
PE (1) | PE20061377A1 (no) |
RU (1) | RU2408586C2 (no) |
TW (1) | TWI370820B (no) |
WO (1) | WO2006116412A2 (no) |
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JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
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WO2005077936A1 (en) | 2004-02-11 | 2005-08-25 | Ulkar Kimya Sanayii Ve Ticaret A.S. | Pyridine benzimidazole sulfoxides with high purity |
US7429608B2 (en) * | 2005-01-20 | 2008-09-30 | Amgen Inc. | Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments |
CN101142194B (zh) | 2005-03-14 | 2012-10-10 | 顶点制药有限责任公司 | 吲哚衍生物,组合物及用作β-分泌酶抑制剂的方法 |
WO2008013270A1 (en) | 2006-07-28 | 2008-01-31 | Ono Pharmaceutical Co., Ltd. | Method for diagnosis of neuropsychiatric disease |
JP2010514672A (ja) * | 2006-12-29 | 2010-05-06 | 武田薬品工業株式会社 | Crfアンタゴニスト活性を有する縮合複素環化合物 |
AU2009206936A1 (en) * | 2008-01-22 | 2009-07-30 | Takeda Pharmaceutical Company Limited | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them |
AR073010A1 (es) * | 2008-08-12 | 2010-10-06 | Takeda Pharmaceutical | Compuesto amida con actividad agonista del gpr52 |
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- 2006-04-26 PE PE2006000437A patent/PE20061377A1/es not_active Application Discontinuation
- 2006-04-26 US US11/919,435 patent/US8163935B2/en not_active Expired - Fee Related
- 2006-04-26 MX MX2007013154A patent/MX2007013154A/es active IP Right Grant
- 2006-04-26 RU RU2007143966/04A patent/RU2408586C2/ru not_active IP Right Cessation
- 2006-04-26 KR KR1020077024873A patent/KR101368037B1/ko not_active IP Right Cessation
- 2006-04-26 WO PCT/US2006/015646 patent/WO2006116412A2/en active Application Filing
- 2006-04-26 AR ARP060101661A patent/AR053859A1/es unknown
- 2006-04-26 AU AU2006241210A patent/AU2006241210B2/en not_active Ceased
- 2006-04-26 EP EP06751379A patent/EP1874736A4/en not_active Withdrawn
- 2006-04-26 CA CA002605453A patent/CA2605453A1/en not_active Abandoned
- 2006-04-26 NZ NZ562235A patent/NZ562235A/xx not_active IP Right Cessation
- 2006-04-26 BR BRPI0610150-0A patent/BRPI0610150A2/pt not_active IP Right Cessation
- 2006-04-26 JP JP2008509045A patent/JP5061097B2/ja not_active Expired - Fee Related
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- 2007-10-07 IL IL186407A patent/IL186407A/en not_active IP Right Cessation
- 2007-10-08 CR CR9421A patent/CR9421A/es unknown
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Also Published As
Publication number | Publication date |
---|---|
BRPI0610150A2 (pt) | 2012-09-25 |
CR9421A (es) | 2007-12-12 |
AU2006241210A1 (en) | 2006-11-02 |
RU2408586C2 (ru) | 2011-01-10 |
CA2605453A1 (en) | 2006-11-02 |
RU2007143966A (ru) | 2009-06-10 |
EP1874736A4 (en) | 2008-08-20 |
NZ562235A (en) | 2010-03-26 |
US20090312383A1 (en) | 2009-12-17 |
MA29486B1 (fr) | 2008-05-02 |
US8163935B2 (en) | 2012-04-24 |
GEP20104962B (en) | 2010-04-26 |
TW200716639A (en) | 2007-05-01 |
WO2006116412A2 (en) | 2006-11-02 |
JP5061097B2 (ja) | 2012-10-31 |
IL186407A (en) | 2014-04-30 |
PE20061377A1 (es) | 2007-01-18 |
IL186407A0 (en) | 2008-01-20 |
AU2006241210B2 (en) | 2011-11-17 |
WO2006116412A3 (en) | 2007-06-28 |
MX2007013154A (es) | 2008-01-21 |
AR053859A1 (es) | 2007-05-23 |
JP2008539247A (ja) | 2008-11-13 |
EP1874736A2 (en) | 2008-01-09 |
KR20080000625A (ko) | 2008-01-02 |
KR101368037B1 (ko) | 2014-02-26 |
WO2006116412A8 (en) | 2007-03-01 |
TWI370820B (en) | 2012-08-21 |
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