NO20075637L - 4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som medikamenter for behandling av infertilitet - Google Patents

4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som medikamenter for behandling av infertilitet

Info

Publication number
NO20075637L
NO20075637L NO20075637A NO20075637A NO20075637L NO 20075637 L NO20075637 L NO 20075637L NO 20075637 A NO20075637 A NO 20075637A NO 20075637 A NO20075637 A NO 20075637A NO 20075637 L NO20075637 L NO 20075637L
Authority
NO
Norway
Prior art keywords
oxo
phenyl
treatment
infertility
drugs
Prior art date
Application number
NO20075637A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of NO20075637L publication Critical patent/NO20075637L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

(I) Foreliggende oppfinnelse angår 2-metyl-4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som har den generelle formel (I), hvor substituentene er som beskrevet i beskrivelsen eller et farmasøytisk akseptabelt salt derav. Oppfinnelsen angår også farmasøytiske preparater omfattende nevnte derivater, så vel som anvendelse av disse 2-metyl-4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater i terapi, mer spesifikt for behandling av fertilitets-lidelser.
NO20075637A 2005-05-04 2007-11-06 4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som medikamenter for behandling av infertilitet NO20075637L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05103741 2005-05-04
PCT/EP2006/061978 WO2006117371A1 (en) 2005-05-04 2006-05-02 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

Publications (1)

Publication Number Publication Date
NO20075637L true NO20075637L (no) 2008-01-29

Family

ID=34939698

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075637A NO20075637L (no) 2005-05-04 2007-11-06 4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som medikamenter for behandling av infertilitet

Country Status (31)

Country Link
US (1) US8017782B2 (no)
EP (1) EP1879581B1 (no)
JP (1) JP5118631B2 (no)
KR (1) KR20080010445A (no)
CN (1) CN101212971B (no)
AR (1) AR054109A1 (no)
AT (1) ATE406895T1 (no)
AU (1) AU2006243194B2 (no)
BR (1) BRPI0611124A2 (no)
CA (1) CA2607106C (no)
CY (1) CY1108584T1 (no)
DE (1) DE602006002608D1 (no)
DK (1) DK1879581T3 (no)
ES (1) ES2313667T3 (no)
HK (1) HK1110782A1 (no)
HR (1) HRP20080488T3 (no)
IL (1) IL186831A (no)
MX (1) MX2007013754A (no)
MY (1) MY144609A (no)
NO (1) NO20075637L (no)
NZ (1) NZ562804A (no)
PE (1) PE20061371A1 (no)
PL (1) PL1879581T3 (no)
PT (1) PT1879581E (no)
RS (1) RS50614B (no)
RU (1) RU2403249C2 (no)
SI (1) SI1879581T1 (no)
TW (1) TW200716553A (no)
UA (1) UA92009C2 (no)
WO (1) WO2006117371A1 (no)
ZA (1) ZA200709096B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
US7994189B2 (en) * 2005-05-04 2011-08-09 N.V. Organon Dihydropyridine derivatives
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
DE1070162B (de) 1959-12-03 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd
US5455253A (en) * 1992-10-20 1995-10-03 Zeneca Limited Heterocyclic derivatives
GB9318935D0 (en) 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
GB9515445D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa Dihydropyridine and pyridine derivatives and process for their preparation
CN1200114A (zh) * 1995-10-19 1998-11-25 武田药品工业株式会社 作为gnrh拮抗剂的喹啉衍生物
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
DE69931975T2 (de) 1998-08-07 2006-10-05 Applied Research Systems Ars Holding N.V. FSH Mimetika zur Behandlung von Infertilität
AU2001278006A1 (en) 2000-07-27 2002-02-13 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
MXPA03011908A (es) * 2001-07-02 2004-06-03 Akzo Nobel Nv Derivados de tetrahidroquinolina.
JP2003026630A (ja) 2001-07-13 2003-01-29 Taoka Chem Co Ltd カラーカプラー中間体用カルボン酸クロリド類の製造法
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
US7994189B2 (en) * 2005-05-04 2011-08-09 N.V. Organon Dihydropyridine derivatives
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

Also Published As

Publication number Publication date
HRP20080488T3 (en) 2008-11-30
EP1879581B1 (en) 2008-09-03
PL1879581T3 (pl) 2009-02-27
AU2006243194A8 (en) 2006-11-09
IL186831A (en) 2011-08-31
CA2607106C (en) 2013-07-23
CN101212971A (zh) 2008-07-02
RU2007144984A (ru) 2009-06-10
JP2008540379A (ja) 2008-11-20
ES2313667T3 (es) 2009-03-01
NZ562804A (en) 2009-11-27
RS50614B (sr) 2010-06-30
UA92009C2 (ru) 2010-09-27
KR20080010445A (ko) 2008-01-30
SI1879581T1 (sl) 2009-02-28
MY144609A (en) 2011-10-14
PT1879581E (pt) 2008-11-13
AU2006243194A1 (en) 2006-11-09
AU2006243194B2 (en) 2011-07-21
US8017782B2 (en) 2011-09-13
IL186831A0 (en) 2008-02-09
US20080262033A1 (en) 2008-10-23
HK1110782A1 (en) 2008-07-25
ATE406895T1 (de) 2008-09-15
WO2006117371A1 (en) 2006-11-09
DK1879581T3 (da) 2008-12-15
CA2607106A1 (en) 2006-11-09
MX2007013754A (es) 2008-01-24
PE20061371A1 (es) 2006-12-19
AR054109A1 (es) 2007-06-06
BRPI0611124A2 (pt) 2010-11-09
CN101212971B (zh) 2010-12-08
EP1879581A1 (en) 2008-01-23
RU2403249C2 (ru) 2010-11-10
ZA200709096B (en) 2008-09-25
TW200716553A (en) 2007-05-01
DE602006002608D1 (de) 2008-10-16
JP5118631B2 (ja) 2013-01-16
CY1108584T1 (el) 2014-04-09

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