RS50614B - Derivati 4-fenil-5-okso-1,4,5,6,7,8-heksahidrokvinolina kao medikamenti za tretman neplodnosti - Google Patents
Derivati 4-fenil-5-okso-1,4,5,6,7,8-heksahidrokvinolina kao medikamenti za tretman neplodnostiInfo
- Publication number
- RS50614B RS50614B RSP-2008/0457A RSP20080457A RS50614B RS 50614 B RS50614 B RS 50614B RS P20080457 A RSP20080457 A RS P20080457A RS 50614 B RS50614 B RS 50614B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- group
- alkoxy
- phenyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivat 2-metil-4-fenil~5-okso-1,4,5,6,7,8-heksahidrokvinolina u skladu sa Formulom I naznačen time što:R1 je (l-6C)alkil. (2-6C)alkenil ili (2-6C)alkinil grupa; R2 je halogen;R3 je S02NR5R6 ili (l-4C)alkoksi grupa, opciono supstituisana sa jednim ili više atoma fluora; X je O ili NR7 grupa;R4 je R8-(2-8C)alkil, R8-(3-8C)alkenil, R8-(3-8C)alkinil ili R8-(2-4C)alkoksi- (2-4C)alkil grupa; Z je CN ili NO2 grupa;R5 i R6 su nezavisno H ili (l-4C)alkil grupa; iliR5 zajedno sa R6 i N za koji su vezani formiraju 3-8 člani zasićeni prsten koji opciono pored toga sadrži heteroatome izabrane od O i S;R8 je OH, (l-4C)alkoksi, NH2; NR9C(0)Rn, NR9S02RH ili C(0)NR9R10 grupa;R7 i R9 su nezavisno H ili (l-4C)alkil grupa;R10 je (l-4C)alkil,(l-4C)alkoksi(l-4C)alkil, ili fenil(l-4C)alkil ili (2-5C)heteroaril(l-4C)alkil grupa, obe opciono supstituisane na (hetero)aromatičnom prstenu sa jednim ili više supstituenata izabranih od OH, NH2, halogena, NO2, CF3, CN, (l-4C)alkil, (l-4C)alkoksi i (di)(l-4C)alkilamino grupe;R11 je (l-4C)alkil, (2-4C)alkenil, (2-4C)alkinil, (l-4C)alkoksi(l-4C)alkil, (3-6C)cikloalkil, (1-4C)alkoksi, (di)(l-4C) alkilamino ili fenil ili (2-5C)heteroaril grupa, obe opciono supstituisane na (hetero)aromatičnom prstenu sa jednim ili više supstituenata izabranih od OH, NH2, halogena, NO2, CF3, CN, (l-4C)alkil, (l-4C)alkoksi i (di)(l-4C)alkilamino grupe; ili njihova farmaceutski prihvatljiva so. Prijava sadrži još 8 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103741 | 2005-05-04 | ||
| PCT/EP2006/061978 WO2006117371A1 (en) | 2005-05-04 | 2006-05-02 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS50614B true RS50614B (sr) | 2010-06-30 |
Family
ID=34939698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2008/0457A RS50614B (sr) | 2005-05-04 | 2006-05-02 | Derivati 4-fenil-5-okso-1,4,5,6,7,8-heksahidrokvinolina kao medikamenti za tretman neplodnosti |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8017782B2 (sr) |
| EP (1) | EP1879581B1 (sr) |
| JP (1) | JP5118631B2 (sr) |
| KR (1) | KR20080010445A (sr) |
| CN (1) | CN101212971B (sr) |
| AR (1) | AR054109A1 (sr) |
| AT (1) | ATE406895T1 (sr) |
| AU (1) | AU2006243194B2 (sr) |
| BR (1) | BRPI0611124A2 (sr) |
| CA (1) | CA2607106C (sr) |
| CY (1) | CY1108584T1 (sr) |
| DE (1) | DE602006002608D1 (sr) |
| DK (1) | DK1879581T3 (sr) |
| ES (1) | ES2313667T3 (sr) |
| HK (1) | HK1110782A1 (sr) |
| HR (1) | HRP20080488T3 (sr) |
| IL (1) | IL186831A (sr) |
| MX (1) | MX2007013754A (sr) |
| MY (1) | MY144609A (sr) |
| NO (1) | NO20075637L (sr) |
| NZ (1) | NZ562804A (sr) |
| PE (1) | PE20061371A1 (sr) |
| PL (1) | PL1879581T3 (sr) |
| PT (1) | PT1879581E (sr) |
| RS (1) | RS50614B (sr) |
| RU (1) | RU2403249C2 (sr) |
| SI (1) | SI1879581T1 (sr) |
| TW (1) | TW200716553A (sr) |
| UA (1) | UA92009C2 (sr) |
| WO (1) | WO2006117371A1 (sr) |
| ZA (1) | ZA200709096B (sr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994189B2 (en) * | 2005-05-04 | 2011-08-09 | N.V. Organon | Dihydropyridine derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) * | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| DE4430639A1 (de) | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| EP0876349B1 (en) * | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| AU772373B2 (en) | 1998-08-07 | 2004-04-22 | Laboratoires Serono Sa | FSH mimetics for the treatment of infertility |
| WO2002009706A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| BR0210645A (pt) * | 2001-07-02 | 2004-10-05 | Akzo Nobel Nv | Composto derivado de tetraidroquinolina, composição farmacêutica, e, uso do composto. |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) * | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| US7994189B2 (en) * | 2005-05-04 | 2011-08-09 | N.V. Organon | Dihydropyridine derivatives |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
-
2006
- 2006-02-05 UA UAA200711804A patent/UA92009C2/ru unknown
- 2006-05-02 BR BRPI0611124-6A patent/BRPI0611124A2/pt not_active IP Right Cessation
- 2006-05-02 NZ NZ562804A patent/NZ562804A/en not_active IP Right Cessation
- 2006-05-02 PL PL06754954T patent/PL1879581T3/pl unknown
- 2006-05-02 CN CN2006800235439A patent/CN101212971B/zh not_active Expired - Fee Related
- 2006-05-02 AT AT06754954T patent/ATE406895T1/de active
- 2006-05-02 EP EP06754954A patent/EP1879581B1/en active Active
- 2006-05-02 WO PCT/EP2006/061978 patent/WO2006117371A1/en active Application Filing
- 2006-05-02 MX MX2007013754A patent/MX2007013754A/es active IP Right Grant
- 2006-05-02 US US11/912,756 patent/US8017782B2/en active Active
- 2006-05-02 CA CA2607106A patent/CA2607106C/en not_active Expired - Fee Related
- 2006-05-02 RU RU2007144984/04A patent/RU2403249C2/ru not_active IP Right Cessation
- 2006-05-02 SI SI200630120T patent/SI1879581T1/sl unknown
- 2006-05-02 KR KR1020077027874A patent/KR20080010445A/ko not_active Application Discontinuation
- 2006-05-02 JP JP2008509437A patent/JP5118631B2/ja not_active Expired - Fee Related
- 2006-05-02 ES ES06754954T patent/ES2313667T3/es active Active
- 2006-05-02 DK DK06754954T patent/DK1879581T3/da active
- 2006-05-02 DE DE602006002608T patent/DE602006002608D1/de active Active
- 2006-05-02 RS RSP-2008/0457A patent/RS50614B/sr unknown
- 2006-05-02 AU AU2006243194A patent/AU2006243194B2/en not_active Ceased
- 2006-05-02 PT PT06754954T patent/PT1879581E/pt unknown
- 2006-05-03 MY MYPI20062028A patent/MY144609A/en unknown
- 2006-05-03 TW TW095115776A patent/TW200716553A/zh unknown
- 2006-05-03 PE PE2006000466A patent/PE20061371A1/es not_active Application Discontinuation
- 2006-05-03 AR ARP060101781A patent/AR054109A1/es unknown
-
2007
- 2007-10-22 IL IL186831A patent/IL186831A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709096A patent/ZA200709096B/xx unknown
- 2007-11-06 NO NO20075637A patent/NO20075637L/no not_active Application Discontinuation
-
2008
- 2008-05-08 HK HK08105174A patent/HK1110782A1/xx not_active IP Right Cessation
- 2008-09-30 HR HR20080488T patent/HRP20080488T3/xx unknown
- 2008-11-20 CY CY20081101342T patent/CY1108584T1/el unknown
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