HRP20080488T3 - 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QCIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY - Google Patents
4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QCIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITYInfo
- Publication number
- HRP20080488T3 HRP20080488T3 HR20080488T HRP20080488T HRP20080488T3 HR P20080488 T3 HRP20080488 T3 HR P20080488T3 HR 20080488 T HR20080488 T HR 20080488T HR P20080488 T HRP20080488 T HR P20080488T HR P20080488 T3 HRP20080488 T3 HR P20080488T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- alkylamino
- alkynyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 208000000509 infertility Diseases 0.000 title 1
- 230000036512 infertility Effects 0.000 title 1
- 231100000535 infertility Toxicity 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- KHNADQLNEYSCBM-UHFFFAOYSA-N 2-methyl-4-phenyl-4,6,7,8-tetrahydro-1h-quinolin-5-one Chemical class C1CCC(=O)C2=C1NC(C)=CC2C1=CC=CC=C1 KHNADQLNEYSCBM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103741 | 2005-05-04 | ||
| PCT/EP2006/061978 WO2006117371A1 (en) | 2005-05-04 | 2006-05-02 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080488T3 true HRP20080488T3 (en) | 2008-11-30 |
Family
ID=34939698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080488T HRP20080488T3 (en) | 2005-05-04 | 2008-09-30 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QCIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8017782B2 (no) |
| EP (1) | EP1879581B1 (no) |
| JP (1) | JP5118631B2 (no) |
| KR (1) | KR20080010445A (no) |
| CN (1) | CN101212971B (no) |
| AR (1) | AR054109A1 (no) |
| AT (1) | ATE406895T1 (no) |
| AU (1) | AU2006243194B2 (no) |
| BR (1) | BRPI0611124A2 (no) |
| CA (1) | CA2607106C (no) |
| CY (1) | CY1108584T1 (no) |
| DE (1) | DE602006002608D1 (no) |
| DK (1) | DK1879581T3 (no) |
| ES (1) | ES2313667T3 (no) |
| HK (1) | HK1110782A1 (no) |
| HR (1) | HRP20080488T3 (no) |
| IL (1) | IL186831A (no) |
| MX (1) | MX2007013754A (no) |
| MY (1) | MY144609A (no) |
| NO (1) | NO20075637L (no) |
| NZ (1) | NZ562804A (no) |
| PE (1) | PE20061371A1 (no) |
| PL (1) | PL1879581T3 (no) |
| PT (1) | PT1879581E (no) |
| RS (1) | RS50614B (no) |
| RU (1) | RU2403249C2 (no) |
| SI (1) | SI1879581T1 (no) |
| TW (1) | TW200716553A (no) |
| UA (1) | UA92009C2 (no) |
| WO (1) | WO2006117371A1 (no) |
| ZA (1) | ZA200709096B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994189B2 (en) * | 2005-05-04 | 2011-08-09 | N.V. Organon | Dihydropyridine derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) * | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| DE4430639A1 (de) | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| EP0876349B1 (en) * | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| AU772373B2 (en) | 1998-08-07 | 2004-04-22 | Laboratoires Serono Sa | FSH mimetics for the treatment of infertility |
| WO2002009706A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| BR0210645A (pt) * | 2001-07-02 | 2004-10-05 | Akzo Nobel Nv | Composto derivado de tetraidroquinolina, composição farmacêutica, e, uso do composto. |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) * | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| US7994189B2 (en) * | 2005-05-04 | 2011-08-09 | N.V. Organon | Dihydropyridine derivatives |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
-
2006
- 2006-02-05 UA UAA200711804A patent/UA92009C2/ru unknown
- 2006-05-02 BR BRPI0611124-6A patent/BRPI0611124A2/pt not_active IP Right Cessation
- 2006-05-02 NZ NZ562804A patent/NZ562804A/en not_active IP Right Cessation
- 2006-05-02 PL PL06754954T patent/PL1879581T3/pl unknown
- 2006-05-02 CN CN2006800235439A patent/CN101212971B/zh not_active Expired - Fee Related
- 2006-05-02 AT AT06754954T patent/ATE406895T1/de active
- 2006-05-02 EP EP06754954A patent/EP1879581B1/en active Active
- 2006-05-02 WO PCT/EP2006/061978 patent/WO2006117371A1/en active Application Filing
- 2006-05-02 MX MX2007013754A patent/MX2007013754A/es active IP Right Grant
- 2006-05-02 US US11/912,756 patent/US8017782B2/en active Active
- 2006-05-02 CA CA2607106A patent/CA2607106C/en not_active Expired - Fee Related
- 2006-05-02 RU RU2007144984/04A patent/RU2403249C2/ru not_active IP Right Cessation
- 2006-05-02 SI SI200630120T patent/SI1879581T1/sl unknown
- 2006-05-02 KR KR1020077027874A patent/KR20080010445A/ko not_active Application Discontinuation
- 2006-05-02 JP JP2008509437A patent/JP5118631B2/ja not_active Expired - Fee Related
- 2006-05-02 ES ES06754954T patent/ES2313667T3/es active Active
- 2006-05-02 DK DK06754954T patent/DK1879581T3/da active
- 2006-05-02 DE DE602006002608T patent/DE602006002608D1/de active Active
- 2006-05-02 RS RSP-2008/0457A patent/RS50614B/sr unknown
- 2006-05-02 AU AU2006243194A patent/AU2006243194B2/en not_active Ceased
- 2006-05-02 PT PT06754954T patent/PT1879581E/pt unknown
- 2006-05-03 MY MYPI20062028A patent/MY144609A/en unknown
- 2006-05-03 TW TW095115776A patent/TW200716553A/zh unknown
- 2006-05-03 PE PE2006000466A patent/PE20061371A1/es not_active Application Discontinuation
- 2006-05-03 AR ARP060101781A patent/AR054109A1/es unknown
-
2007
- 2007-10-22 IL IL186831A patent/IL186831A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709096A patent/ZA200709096B/xx unknown
- 2007-11-06 NO NO20075637A patent/NO20075637L/no not_active Application Discontinuation
-
2008
- 2008-05-08 HK HK08105174A patent/HK1110782A1/xx not_active IP Right Cessation
- 2008-09-30 HR HR20080488T patent/HRP20080488T3/xx unknown
- 2008-11-20 CY CY20081101342T patent/CY1108584T1/el unknown
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