NO20075091L - Fremgangsmate for rensing av antistoffer - Google Patents
Fremgangsmate for rensing av antistofferInfo
- Publication number
- NO20075091L NO20075091L NO20075091A NO20075091A NO20075091L NO 20075091 L NO20075091 L NO 20075091L NO 20075091 A NO20075091 A NO 20075091A NO 20075091 A NO20075091 A NO 20075091A NO 20075091 L NO20075091 L NO 20075091L
- Authority
- NO
- Norway
- Prior art keywords
- procedure
- ion exchange
- purifying antibodies
- immunoglobulin
- purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
Abstract
En fremgangsmåte for rensing av immunglobuliner ved ionebytterkromatografi er beskrevet. Den kromatografiske metoden anvender en svak ionebytteresin og en ett trinns elueringsmetode for rensing av et immunglobulin. I tillegg er en fremgangsmåte for bestemmelse av saltkonsentrasjonen for ett trinns eluering av et immunglobulin fra en ionebytteresin beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05011302 | 2005-05-25 | ||
PCT/EP2006/004863 WO2006125599A2 (en) | 2005-05-25 | 2006-05-23 | Method for the purification of antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20075091L true NO20075091L (no) | 2008-01-23 |
NO345362B1 NO345362B1 (no) | 2020-12-28 |
Family
ID=34936911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075091A NO345362B1 (no) | 2005-05-25 | 2007-10-09 | Fremgangsmåte for rensing av antistoffer |
Country Status (18)
Country | Link |
---|---|
US (3) | US20090098660A1 (no) |
EP (2) | EP1888636B2 (no) |
JP (1) | JP4852602B2 (no) |
KR (1) | KR100967778B1 (no) |
CN (1) | CN101180317B (no) |
AT (1) | ATE525087T1 (no) |
AU (1) | AU2006251307B2 (no) |
BR (1) | BRPI0610201B8 (no) |
CA (1) | CA2607375C (no) |
DK (1) | DK1888636T4 (no) |
ES (2) | ES2373402T5 (no) |
FI (1) | FI1888636T4 (no) |
IL (2) | IL186338A (no) |
MX (1) | MX2007014269A (no) |
NO (1) | NO345362B1 (no) |
PL (1) | PL1888636T5 (no) |
TW (2) | TWI320788B (no) |
WO (1) | WO2006125599A2 (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI320788B (en) | 2005-05-25 | 2010-02-21 | Hoffmann La Roche | Method for the purification of antibodies |
RU2009148891A (ru) | 2007-06-01 | 2011-07-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Очистка иммуноглобулина |
AR067536A1 (es) | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea |
AR067537A1 (es) | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
CN102171237A (zh) * | 2008-08-14 | 2011-08-31 | 默沙东公司 | 使用蛋白a亲和色谱法纯化抗体的方法 |
KR101555740B1 (ko) | 2010-03-10 | 2015-09-25 | 에프. 호프만-라 로슈 아게 | 면역글로불린 용액 정제 방법 |
MX2012011737A (es) * | 2010-04-14 | 2012-11-16 | Hoffmann La Roche | Remocion de agregado de inmunoglobulina. |
KR20130142128A (ko) * | 2010-10-11 | 2013-12-27 | 애브비 인코포레이티드 | 단백질의 정제 방법 |
WO2012084829A1 (en) | 2010-12-21 | 2012-06-28 | F. Hoffmann-La Roche Ag | Isoform enriched antibody preparation and method for obtaining it |
EP3318571B1 (en) * | 2011-03-16 | 2021-02-17 | F. Hoffmann-La Roche AG | Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase |
EP2726496B1 (en) | 2011-07-01 | 2018-04-04 | F.Hoffmann-La Roche Ag | Method for separation of monomeric polypeptides from aggregated polypeptides |
US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
EP3048109A4 (en) * | 2013-09-17 | 2017-04-19 | Kaneka Corporation | Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom |
KR101700580B1 (ko) | 2013-10-30 | 2017-02-13 | (주)셀트리온 | 양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법 |
CA2960797A1 (en) | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn-binding and methods of use |
GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
BR112018009881A2 (pt) * | 2015-11-18 | 2018-11-13 | Merck Patent Gmbh | separação de proteína aperfeiçoada em cromatografia de troca iônica |
CA3005484A1 (en) * | 2015-11-18 | 2017-05-26 | Merck Patent Gmbh | Opposite ph-salt gradients for improved protein separations |
CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
EP3773969A1 (en) * | 2018-04-03 | 2021-02-17 | Merck Patent GmbH | Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds |
CN111068361B (zh) * | 2018-10-22 | 2022-02-11 | 中国石油化工股份有限公司 | 一种己内酰胺离子交换装置及其再生方法 |
CN110066314B (zh) * | 2019-04-01 | 2023-10-27 | 上海药明生物技术有限公司 | 一种高效提高多聚体分离分辨率的亲和纯化工艺 |
TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4136094A (en) * | 1977-08-31 | 1979-01-23 | The Regents Of The University Of Minnesota | Preparation of intravenous human and animal gamma globulins and isolation of albumin |
JPS5598117A (en) | 1979-01-17 | 1980-07-25 | Chemo Sero Therapeut Res Inst | Purification of gamma-globulin derivative |
DE3271181D1 (en) * | 1982-02-08 | 1986-06-19 | Schweiz Serum & Impfinst | Intravenously administrable human immunoglobuline and process for its preparation |
JPS6042336A (ja) * | 1983-08-18 | 1985-03-06 | Nippon Seiyaku Kk | 免疫グロブリンの製造方法 |
DE3640513A1 (de) | 1986-11-27 | 1988-06-09 | Biotest Pharma Gmbh | Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates |
US5118796A (en) * | 1987-12-09 | 1992-06-02 | Centocor, Incorporated | Efficient large-scale purification of immunoglobulins and derivatives |
US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
US5177194A (en) | 1990-02-01 | 1993-01-05 | Baxter International, Inc. | Process for purifying immune serum globulins |
ATE122054T1 (de) * | 1990-03-22 | 1995-05-15 | Biotest Pharma Gmbh | Verfahren zur herstellung eines intravenös verträglichen immunglobulin-g-präparates. |
WO1992014832A1 (en) * | 1991-02-26 | 1992-09-03 | Ajinomoto Co., Inc. | Processes for purifying human bcdf |
DE69214709T2 (de) | 1991-04-26 | 1997-02-20 | Surface Active Ltd | Neue Antikörper und Verfahren zu ihrer Verwendung |
DE4118912C1 (no) | 1991-06-08 | 1992-07-02 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
CA2113813C (en) | 1991-08-14 | 2005-04-12 | Paula M. Jardieu | Immunoglobulin variants for specific fc epsilon receptors |
DE69328135D1 (de) | 1992-06-26 | 2000-04-27 | Aetsrn | Menschliche monoklonale Antikörper gegen Rhesus D und Zellinien die diese produzieren |
FR2706466B1 (fr) * | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
IT1271461B (it) | 1993-12-01 | 1997-05-28 | Menarini Ricerche Sud Spa | Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. |
ES2129076T5 (es) | 1993-12-27 | 2003-05-16 | Zlb Bioplasma Ag | Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. |
US5429746A (en) † | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
FI952196A0 (fi) * | 1995-05-08 | 1995-05-08 | Suomen Punainen Risti Veripalv | Framstaellning av immunoglobulin |
IL121900A (en) | 1997-10-07 | 2001-12-23 | Omrix Biopharmaceuticals Ltd | A method for the purification of immunoglobulins |
UA64742C2 (uk) | 1997-12-24 | 2004-03-15 | Альфа Терапевтик Корпорейшн | СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ) |
US6162904A (en) * | 1997-12-24 | 2000-12-19 | Alpha Therapeutic Corporation | Manufacturing method for intraveneously administrable immune globulin and resultant product |
ATE321066T1 (de) † | 1998-05-06 | 2006-04-15 | Genentech Inc | Anti-her2 antikörperzusammensetzung |
WO1999062936A1 (en) * | 1998-06-01 | 1999-12-09 | Genentech, Inc. | Separation of protein monomers from aggregates by use of ion-exchange chromatography |
ES2527915T3 (es) * | 1998-06-09 | 2015-02-02 | Csl Behring Ag | Producto de inmunoglobulina G (IgG) líquido |
DK1084147T3 (da) | 1998-06-09 | 2004-10-25 | Statens Seruminstitut | Fremgangsmåde til fremstilling af immunglobuliner til administration og andre immunglobulinprodukter |
US6441144B1 (en) * | 1999-05-20 | 2002-08-27 | Alpha Therapeutic Corporation | Method for repairing dual virally inactivated immune globulin for intravenous administration |
AU2001249574A1 (en) † | 2000-03-29 | 2001-10-08 | Ecokasa Incorporated | Nitrogen reduction wastewater treatment system |
SE0001128D0 (sv) | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
US6962700B1 (en) * | 2000-09-13 | 2005-11-08 | Atopix Pharmaceuticals Corporation | Method of manufacturing immune globulin |
CA2478925C (en) * | 2002-04-26 | 2016-06-07 | Robert Lee Fahrner | Non-affinity purification of proteins |
ES2629602T5 (es) | 2002-09-11 | 2021-06-08 | Genentech Inc | Purificación de proteínas |
CN1490334A (zh) * | 2002-10-18 | 2004-04-21 | 缪金明 | 基因特异性抗体的亲和纯化方法 |
EP1601697B1 (en) | 2003-02-28 | 2007-05-30 | Lonza Biologics plc | Antibody purification by Protein A and ion exchange chromatography |
AR045614A1 (es) | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
NZ551180A (en) * | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
TWI320788B (en) | 2005-05-25 | 2010-02-21 | Hoffmann La Roche | Method for the purification of antibodies |
-
2006
- 2006-05-19 TW TW095118030A patent/TWI320788B/zh active
- 2006-05-19 TW TW098127045A patent/TWI391399B/zh active
- 2006-05-23 JP JP2008512752A patent/JP4852602B2/ja active Active
- 2006-05-23 BR BRPI0610201A patent/BRPI0610201B8/pt active IP Right Grant
- 2006-05-23 CN CN200680017966XA patent/CN101180317B/zh active Active
- 2006-05-23 KR KR1020077027285A patent/KR100967778B1/ko active IP Right Grant
- 2006-05-23 ES ES06753791T patent/ES2373402T5/es active Active
- 2006-05-23 EP EP06753791.0A patent/EP1888636B2/en active Active
- 2006-05-23 EP EP10175706.0A patent/EP2261252B2/en active Active
- 2006-05-23 MX MX2007014269A patent/MX2007014269A/es active IP Right Grant
- 2006-05-23 CA CA2607375A patent/CA2607375C/en active Active
- 2006-05-23 US US11/920,288 patent/US20090098660A1/en not_active Abandoned
- 2006-05-23 DK DK06753791.0T patent/DK1888636T4/da active
- 2006-05-23 AT AT06753791T patent/ATE525087T1/de active
- 2006-05-23 FI FIEP06753791.0T patent/FI1888636T4/fi active
- 2006-05-23 AU AU2006251307A patent/AU2006251307B2/en active Active
- 2006-05-23 WO PCT/EP2006/004863 patent/WO2006125599A2/en active Application Filing
- 2006-05-23 PL PL06753791.0T patent/PL1888636T5/pl unknown
- 2006-05-23 ES ES10175706T patent/ES2389641T5/es active Active
-
2007
- 2007-10-07 IL IL186338A patent/IL186338A/en active IP Right Grant
- 2007-10-09 NO NO20075091A patent/NO345362B1/no unknown
-
2010
- 2010-07-14 IL IL206993A patent/IL206993A0/en active IP Right Grant
-
2014
- 2014-05-06 US US14/271,058 patent/US9631007B2/en active Active
-
2017
- 2017-03-14 US US15/458,368 patent/US11034754B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20075091L (no) | Fremgangsmate for rensing av antistoffer | |
WO2010048192A3 (en) | Viral inactivation during purification of antibodies | |
ATE363491T1 (de) | Reinigung von antikörpern durch protein a und ionenaustauschromatographie | |
EA201592192A1 (ru) | Способ очистки моноклональных антител | |
ATE425989T1 (de) | Proteinreinigungsverfahren | |
DE602005022239D1 (de) | Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten | |
EP1568710A3 (en) | Antibody purification method | |
SE0400501D0 (sv) | Antibody purification | |
ATE384742T1 (de) | Verfahren zur reinigung von preproinsulin | |
WO2011146179A3 (en) | Apparatus and process of purification of proteins | |
WO2005090403A3 (en) | Method and apparatus for antibody purification | |
WO2011090719A3 (en) | Protein purification by ion exchange | |
DE602004023626D1 (de) | Trennung von polypeptiden mit einer racemisierten aminosäure | |
EP1780537A4 (en) | PROTEOMANALYSIS PROCESS FOR PHOSPHORYLATED PROTEIN | |
SE0300791D0 (sv) | Use of ph-responsive polymers | |
NO20080131L (no) | Fremgangsmate for rensing av IL-18 bindende protein | |
ATE461199T1 (de) | Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie | |
WO2012099949A3 (en) | Antibody purification via affinity chromatography | |
DK1558622T3 (da) | Fremgangsmåde til oprensning af macrolider | |
HRP20080408T3 (en) | Method for the purification of a non-immunoglobulin protein comprising an immunoglobulin-like (ig-like) domain | |
DK1371665T3 (da) | Fremgangsmåde for selektivt at isolere IgY-antistoffer fra æggeblomme af en andefugl | |
DE602004018674D1 (de) | Grosstechnisches verfahren zur abtrennung und aufreinigung von fentanyl durch präparative umkehrphasenchromatographie | |
DK1471355T3 (da) | Fremgangsmåde til fastgörelse af biomolekyle til bærer | |
EP2129461A4 (en) | CLEANING OF IMMUNOGLOBULINS | |
RU2008138372A (ru) | СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО ФАКТОРА VIIa ЧЕЛОВЕКА |