NO20074443L - Fremgangsmate for svak fordelingskromatografi - Google Patents

Fremgangsmate for svak fordelingskromatografi

Info

Publication number
NO20074443L
NO20074443L NO20074443A NO20074443A NO20074443L NO 20074443 L NO20074443 L NO 20074443L NO 20074443 A NO20074443 A NO 20074443A NO 20074443 A NO20074443 A NO 20074443A NO 20074443 L NO20074443 L NO 20074443L
Authority
NO
Norway
Prior art keywords
procedure
distribution chromatography
weak distribution
weak
chromatography
Prior art date
Application number
NO20074443A
Other languages
English (en)
Norwegian (no)
Inventor
Brian Kelley
Shujun Sun
Paul Brown
Jon Coffman
Ranganathan Godvarti
Tim Iskra
Suresh Vunnum
Tianning Yu
James Edward Booth
Mary Beth Switzer
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36992346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20074443(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20074443L publication Critical patent/NO20074443L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
NO20074443A 2005-03-11 2007-09-03 Fremgangsmate for svak fordelingskromatografi NO20074443L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66043705P 2005-03-11 2005-03-11
PCT/US2006/008919 WO2006099308A2 (en) 2005-03-11 2006-03-10 A method of weak partitioning chromatography

Publications (1)

Publication Number Publication Date
NO20074443L true NO20074443L (no) 2007-09-27

Family

ID=36992346

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074443A NO20074443L (no) 2005-03-11 2007-09-03 Fremgangsmate for svak fordelingskromatografi

Country Status (21)

Country Link
US (3) US8067182B2 (ko)
EP (1) EP1869065B1 (ko)
JP (1) JP5199063B2 (ko)
KR (2) KR101482791B1 (ko)
CN (2) CN101175765A (ko)
AU (1) AU2006223180B2 (ko)
BR (1) BRPI0608584B8 (ko)
CA (1) CA2601062C (ko)
CR (1) CR9377A (ko)
DK (1) DK1869065T3 (ko)
ES (1) ES2797480T3 (ko)
HK (1) HK1210476A1 (ko)
HU (1) HUE049797T2 (ko)
IL (1) IL185687A (ko)
MX (1) MX2007011129A (ko)
NO (1) NO20074443L (ko)
PL (1) PL1869065T3 (ko)
PT (1) PT1869065T (ko)
RU (1) RU2457214C2 (ko)
SI (1) SI1869065T1 (ko)
WO (1) WO2006099308A2 (ko)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2457214C2 (ru) * 2005-03-11 2012-07-27 Вайет Способ хроматографии в режиме слабого распределения
WO2009017491A1 (en) * 2006-06-14 2009-02-05 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
FI2061803T4 (fi) 2006-08-28 2023-03-14 Process for the purification of fc-containing proteins
TW200821026A (en) * 2006-09-08 2008-05-16 Wyeth Corp Arginine wash in protein purification using affinity chromatography
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TW201516149A (zh) 2006-09-13 2015-05-01 Abbvie Inc 細胞培養改良
WO2008063892A2 (en) 2006-11-08 2008-05-29 Wyeth Rationally designed media for cell culture
SG175597A1 (en) * 2007-10-30 2011-11-28 Genentech Inc Antibody purification by cation exchange chromatography
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
ES2527943T5 (es) 2008-08-14 2019-03-07 Genentech Inc Métodos para eliminar un contaminante usando cromatografía de membrana de intercambio iónico de desplazamiento de proteínas
US20100069617A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
WO2010030222A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal with multimodal anion exchangers in the presence of protein-excluded zwitterions
JP5808249B2 (ja) * 2008-10-20 2015-11-10 アッヴィ・インコーポレイテッド プロテインａアフィニティークロマトグラフィーを用いる抗体の単離および精製
CN104974251A (zh) 2008-10-20 2015-10-14 Abbvie公司 在抗体纯化过程中的病毒灭活
US9393304B2 (en) 2008-10-29 2016-07-19 Ablynx N.V. Formulations of single domain antigen binding molecules
MX2011004558A (es) 2008-10-29 2011-06-01 Wyeth Llc Procedimientos para la purificacion de moleculas de union a antigeno de un unico dominio.
JP2012513425A (ja) 2008-12-22 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 免疫グロブリンの精製
WO2011073389A1 (en) * 2009-12-18 2011-06-23 Novartis Ag Wash solution and method for affinity chromatography
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
NZ603648A (en) * 2010-05-25 2014-12-24 Genentech Inc Methods of purifying polypeptides
EP2583973B1 (en) * 2010-06-21 2018-03-21 Kyowa Hakko Kirin Co., Ltd. Method for purifying protein using amino acid
GB201012603D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
ES2603396T3 (es) * 2010-07-30 2017-02-27 Pfizer Inc Purificación en tándem de proteínas
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
AU2011329053A1 (en) 2010-11-15 2013-06-06 Biogen Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
KR20140062469A (ko) 2011-07-20 2014-05-23 젭테온 인코포레이티드 폴리펩티드 분리 방법
CA2854330A1 (en) * 2011-11-02 2013-05-10 Genentech, Inc. Overload and elute chromatography
SG10201701224UA (en) 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
WO2013180933A1 (en) * 2012-05-30 2013-12-05 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
WO2013180647A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
AU2013309506A1 (en) 2012-09-02 2015-03-12 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
JP6348507B2 (ja) 2012-12-14 2018-06-27 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 充填ベッドクロマトグラフィーカラムの洗浄方法
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
PT2969099T (pt) * 2013-03-14 2018-07-05 Amgen Inc Remoção de ligandos escapados de cromatografia de afinidade
TW201940691A (zh) 2013-03-15 2019-10-16 美商艾爾德生物製藥股份有限公司 抗體純化及純度監測
AR096713A1 (es) * 2013-06-25 2016-01-27 Cadila Healthcare Ltd Proceso de purificación para anticuerpos monoclonales
EP3683232A1 (en) 2013-09-13 2020-07-22 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
KR102332302B1 (ko) 2013-09-13 2021-12-01 제넨테크, 인크. 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101975771B1 (ko) 2013-12-12 2019-05-09 이엠디 밀리포어 코포레이션 아크릴아미드 함유 필터를 사용한 단백질 분리
CN105407917B (zh) 2014-06-23 2021-07-06 生物辐射实验室股份有限公司 磷灰石原位恢复
US9802822B2 (en) 2014-06-23 2017-10-31 Bio-Rad Laboratories, Inc. Apatite pretreatment
US10688412B2 (en) 2016-07-25 2020-06-23 Cehpalon, Inc. Affinity chromatography wash buffer
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
WO2019224660A1 (ja) * 2018-05-24 2019-11-28 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 吸着剤の生産方法
US20220267369A1 (en) * 2018-07-25 2022-08-25 Merck Sharp & Dohme Corp. Methods of separating host cell lipases from a production protein in chromatographic processes
WO2020172658A1 (en) 2019-02-24 2020-08-27 Bristol-Myers Squibb Company Methods of isolating a protein
US20220387906A1 (en) 2019-03-21 2022-12-08 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
AU2021213153A1 (en) * 2020-01-29 2022-08-04 Merck Sharp & Dohme Llc Methods of separating host cell lipases from an anti-LAG3 antibody production
WO2022066934A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
WO2022066928A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
TW202323268A (zh) 2021-08-23 2023-06-16 美商建南德克公司 用於抗體藥物結合物之流通陽離子交換層析純化製程

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029583A (en) * 1975-02-28 1977-06-14 Purdue Research Foundation Chromatographic supports and methods and apparatus for preparing the same
JPS63126826A (ja) 1986-11-14 1988-05-30 Asahi Chem Ind Co Ltd プラスミノ−ゲン活性化因子誘導物質
WO1989003840A1 (en) * 1987-10-23 1989-05-05 Schering Corporation Method of purifying protein
US5451662A (en) * 1987-10-23 1995-09-19 Schering Corporation Method of purifying protein
US4983722A (en) * 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
ES2064412T3 (es) 1988-10-26 1995-02-01 American Cyanamid Co Procedimiento para reducir el contenido de aglomerado de materiales tipo hormona del crecimiento.
GB9022547D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Purified immunoglobulin
US5264555A (en) 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
FR2703049B1 (fr) 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
WO1995026977A1 (en) * 1994-04-01 1995-10-12 Unisyn Technologies, Inc. High salt binding buffer for immunoglobulin purification with a synthetic affinity ligand
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
RU2094077C1 (ru) * 1996-07-23 1997-10-27 Акционерное общество закрытого типа "Фосфосорб" Хроматографический способ выделения альфа-фетопротеина
TW505655B (en) * 1997-10-14 2002-10-11 Tanox Inc Enhanced aggregate removal from bulk-biologicals using ion exchange chromatography
US6504013B1 (en) 2000-02-01 2003-01-07 Idexx Laboratories, Inc. Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
WO2000015260A1 (en) 1998-09-16 2000-03-23 Tanox, Inc. Anti-ige gene therapy
DE69823889D1 (de) 1998-12-30 2004-06-17 Folke Tjerneld Trennungsmethode unter verwendung von flüssig-flüssig partition
DE60231651D1 (de) 2001-12-21 2009-04-30 Immunex Corp Proteinreinigungsverfahren
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
EP1601697B1 (en) * 2003-02-28 2007-05-30 Lonza Biologics plc Antibody purification by Protein A and ion exchange chromatography
JP4496168B2 (ja) * 2003-07-28 2010-07-07 株式会社リバース・プロテオミクス研究所 非特異的物質の除去方法
WO2005042569A1 (en) 2003-10-24 2005-05-12 Amgen, Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
AU2004286938B2 (en) * 2003-10-27 2011-06-30 Wyeth Removal of high molecular weight aggregates using hydroxyapatite chromatography
RU2457214C2 (ru) * 2005-03-11 2012-07-27 Вайет Способ хроматографии в режиме слабого распределения

Also Published As

Publication number Publication date
EP1869065A2 (en) 2007-12-26
US20070054390A1 (en) 2007-03-08
BRPI0608584B1 (pt) 2018-02-06
WO2006099308A3 (en) 2007-10-25
JP5199063B2 (ja) 2013-05-15
KR101660575B1 (ko) 2016-09-27
US20070060741A1 (en) 2007-03-15
CA2601062A1 (en) 2006-09-21
US8067182B2 (en) 2011-11-29
CN104610422A (zh) 2015-05-13
PL1869065T3 (pl) 2020-09-21
AU2006223180A1 (en) 2006-09-21
MX2007011129A (es) 2007-11-06
EP1869065A4 (en) 2012-07-04
BRPI0608584A2 (pt) 2010-01-19
BRPI0608584B8 (pt) 2021-05-25
CN101175765A (zh) 2008-05-07
KR20130128020A (ko) 2013-11-25
AU2006223180B2 (en) 2011-11-24
JP2008533473A (ja) 2008-08-21
CA2601062C (en) 2016-08-02
KR101482791B1 (ko) 2015-01-21
SI1869065T1 (sl) 2020-08-31
US20120138537A1 (en) 2012-06-07
WO2006099308A2 (en) 2006-09-21
HUE049797T2 (hu) 2020-10-28
ES2797480T3 (es) 2020-12-02
CR9377A (es) 2008-02-21
US9144755B2 (en) 2015-09-29
DK1869065T3 (da) 2020-06-08
IL185687A (en) 2015-05-31
RU2007132851A (ru) 2009-04-20
EP1869065B1 (en) 2020-05-06
KR20070121667A (ko) 2007-12-27
PT1869065T (pt) 2020-06-18
HK1210476A1 (en) 2016-04-22
RU2457214C2 (ru) 2012-07-27
IL185687A0 (en) 2008-01-06

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