NO20055921L - Heterocykliske metylsulfonderivater - Google Patents

Heterocykliske metylsulfonderivater

Info

Publication number
NO20055921L
NO20055921L NO20055921A NO20055921A NO20055921L NO 20055921 L NO20055921 L NO 20055921L NO 20055921 A NO20055921 A NO 20055921A NO 20055921 A NO20055921 A NO 20055921A NO 20055921 L NO20055921 L NO 20055921L
Authority
NO
Norway
Prior art keywords
substituent
heterocyclic
methylsulfone
derivatives
heterocyclic group
Prior art date
Application number
NO20055921A
Other languages
English (en)
Inventor
Hideki Kubota
Takanori Yasukouchi
Kayoko Motoki
Masanori Saito
Hitoshi Iimori
Satoru Miyauchi
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of NO20055921L publication Critical patent/NO20055921L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Det er tilveiebrakt en forbindelse som er i stand til inhibere produksjon eller sekresjon av P-amyloid-protein. Forbindelse representert ved den følgende formel (1): (hvor Rrepresenterer en heterocyklisk gruppe som kan ha en substituent, R2 representerer en cyklisk hydrokarbongruppe som kan ha en substituent eller en heterocyklisk gruppe som kan ha en substituent, Rrepresenterer en cyklisk hydrokarbongruppe som kan ha en substituent eller en heterocyklisk gruppe som kan ha en substituent, Rrepresenterer et hydrogenatom eller en C_alkylgnippe og X representerer -S-.-SO- eller -S0-); et N-oksyd eller S-oksyd derav; et salt derav; eller et solvat derav; og et medikament som inneholder hvilke som helst av disse.
NO20055921A 2003-06-30 2005-12-13 Heterocykliske metylsulfonderivater NO20055921L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003187796 2003-06-30
JP2004099151 2004-03-30
PCT/JP2004/009132 WO2005000798A1 (ja) 2003-06-30 2004-06-29 複素環メチルスルホン誘導体

Publications (1)

Publication Number Publication Date
NO20055921L true NO20055921L (no) 2006-01-24

Family

ID=33554493

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055921A NO20055921L (no) 2003-06-30 2005-12-13 Heterocykliske metylsulfonderivater

Country Status (14)

Country Link
US (1) US7932271B2 (no)
EP (1) EP1640366A4 (no)
JP (1) JP4523914B2 (no)
KR (1) KR20060066057A (no)
AU (1) AU2004251987C1 (no)
CA (1) CA2526487A1 (no)
HK (1) HK1090362A1 (no)
IL (1) IL172139A0 (no)
MX (1) MXPA05013631A (no)
NO (1) NO20055921L (no)
PL (1) PL379466A1 (no)
RU (1) RU2336270C2 (no)
TW (1) TWI328005B (no)
WO (1) WO2005000798A1 (no)

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SG173409A1 (en) * 2006-11-24 2011-08-29 Ac Immune Sa N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimers
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
AU2008307572A1 (en) * 2007-10-04 2009-04-09 Merck Sharp & Dohme Corp. Substituted aryl sulfone derivatives as calcium channel blockers
EP2311823A1 (en) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
US9120752B2 (en) 2010-07-16 2015-09-01 Purdue Pharma, L.P. Pyridine compounds as sodium channel blockers
US9206127B2 (en) 2012-03-16 2015-12-08 Purdue Pharm, L.P. Substituted pyridines as sodium channel blockers
EP2935257B1 (en) 2012-12-20 2018-02-07 Purdue Pharma LP Cyclic sulfonamides as sodium channel blockers
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
CN109071902B (zh) * 2016-03-30 2021-07-23 株式会社尼康 可固化组合物、固化制品及光学部件

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Also Published As

Publication number Publication date
AU2004251987B2 (en) 2010-07-01
JP4523914B2 (ja) 2010-08-11
RU2336270C2 (ru) 2008-10-20
IL172139A0 (en) 2006-04-10
WO2005000798A1 (ja) 2005-01-06
TWI328005B (en) 2010-08-01
AU2004251987A1 (en) 2005-01-06
TW200523251A (en) 2005-07-16
CA2526487A1 (en) 2005-01-06
US20060241302A1 (en) 2006-10-26
HK1090362A1 (en) 2006-12-22
JPWO2005000798A1 (ja) 2006-08-03
PL379466A1 (pl) 2006-09-18
MXPA05013631A (es) 2006-02-24
EP1640366A1 (en) 2006-03-29
RU2005141552A (ru) 2006-06-27
EP1640366A4 (en) 2009-05-13
KR20060066057A (ko) 2006-06-15
AU2004251987C1 (en) 2010-11-18
US7932271B2 (en) 2011-04-26
AU2004251987B8 (en) 2010-07-22

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