NO20054453L - P38 inhibitorer og fremgangsmater for anvendelse derav - Google Patents
P38 inhibitorer og fremgangsmater for anvendelse deravInfo
- Publication number
- NO20054453L NO20054453L NO20054453A NO20054453A NO20054453L NO 20054453 L NO20054453 L NO 20054453L NO 20054453 A NO20054453 A NO 20054453A NO 20054453 A NO20054453 A NO 20054453A NO 20054453 L NO20054453 L NO 20054453L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/378,164 US7135575B2 (en) | 2003-03-03 | 2003-03-03 | P38 inhibitors and methods of use thereof |
US10/688,849 US20040180896A1 (en) | 2003-03-03 | 2003-10-15 | P38 inhibitors and methods of use thereof |
PCT/US2004/005693 WO2004078116A2 (en) | 2003-03-03 | 2004-02-25 | P38 inhibitors and methods of use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20054453D0 NO20054453D0 (no) | 2005-09-26 |
NO20054453L true NO20054453L (no) | 2005-11-29 |
NO328913B1 NO328913B1 (no) | 2010-06-14 |
Family
ID=32965317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20054453A NO328913B1 (no) | 2003-03-03 | 2005-09-26 | P38-inhibitorer, deres anvendelse og farmasoytiske sammensetninger omfattende forbindelsene |
Country Status (12)
Country | Link |
---|---|
US (1) | US7521447B2 (no) |
EP (1) | EP1606283B1 (no) |
JP (1) | JP4617299B2 (no) |
KR (1) | KR101099281B1 (no) |
AU (1) | AU2004218463B2 (no) |
CA (1) | CA2517517C (no) |
IS (1) | IS2675B (no) |
MX (1) | MXPA05009459A (no) |
NO (1) | NO328913B1 (no) |
PL (1) | PL214032B1 (no) |
RU (1) | RU2357957C2 (no) |
WO (1) | WO2004078116A2 (no) |
Families Citing this family (58)
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BR0315580A (pt) * | 2002-10-24 | 2005-08-30 | Merck Patent Gmbh | Derivados de metileno uréia |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
MXPA06002853A (es) * | 2003-09-11 | 2006-06-14 | Kemia Inc | Inhibidores citoquina. |
RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
EP1720878A1 (en) | 2004-02-27 | 2006-11-15 | F.Hoffmann-La Roche Ag | Heteroaryl-fused pyrazolo derivatives |
DE602005010714D1 (de) * | 2004-08-12 | 2008-12-11 | Pfizer | Der p38-map-kinase |
EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
RU2007114112A (ru) * | 2004-11-02 | 2008-12-10 | Пфайзер Инк. (US) | Способ получения индазольных соединений |
CN101052633A (zh) * | 2004-11-02 | 2007-10-10 | 辉瑞大药厂 | 制备吲唑化合物的方法 |
MX2007005291A (es) * | 2004-11-02 | 2007-07-19 | Pfizer | Metodos para preparar compuestos de indazol. |
UA95907C2 (en) * | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
WO2006122230A1 (en) * | 2005-05-11 | 2006-11-16 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
EP1919913A2 (en) * | 2005-08-25 | 2008-05-14 | F.Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
CA2620105A1 (en) | 2005-08-25 | 2007-03-01 | F. Hoffman-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
AU2006283935A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | Fused pyrazole as p38 MAP kinase inhibitors |
EP1934219A1 (en) | 2005-09-16 | 2008-06-25 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
WO2007031977A2 (en) * | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b]pyridines as phosphodiesterase inhibitors |
CN109053523B (zh) | 2005-10-07 | 2022-03-25 | 埃克塞利希斯股份有限公司 | 作为用于治疗增生性疾病的mek抑制剂的吖丁啶 |
CN101331120A (zh) * | 2005-10-13 | 2008-12-24 | 史密丝克莱恩比彻姆公司 | 作为阿片样物质受体调节剂的酚醚化合物 |
WO2007059219A1 (en) * | 2005-11-15 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Azaindazoles useful as inhibitors of kinases |
CA2636314A1 (en) * | 2005-11-29 | 2007-06-07 | Toray Industries, Inc. | Arylmethylene urea derivative and use thereof |
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US8026233B2 (en) * | 2006-03-29 | 2011-09-27 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
CA2927045A1 (en) * | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
AU2007334402B2 (en) * | 2006-12-14 | 2014-02-13 | Exelixis, Inc. | Methods of using MEK inhibitors |
US20080146549A1 (en) * | 2006-12-18 | 2008-06-19 | Coleman Peter R | Accelerated opiate dependence detoxification process |
JP2010513370A (ja) * | 2006-12-19 | 2010-04-30 | エフ.ホフマン−ラ ロシュ アーゲー | ピラゾロ[3,4−d]ピリミジンp38MAPキナーゼインヒビター |
EA017852B1 (ru) * | 2006-12-20 | 2013-03-29 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Производные замещенных индазолов, активные в качестве ингибиторов киназ |
WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
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WO2010006945A1 (en) * | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Substituted indolyl and indazolyl derivatives and uses thereof |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
BRPI0920707A2 (pt) | 2008-10-02 | 2015-12-29 | Respivert Ltd | compostos |
US8299074B2 (en) * | 2008-12-11 | 2012-10-30 | Respivert Ltd. | P38 MAP kinase inhibitors |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
AU2010314287A1 (en) * | 2009-10-12 | 2012-05-03 | F. Hoffmann-La Roche Ag | Combinations of a PI3K inhibitor and a MEK inhibitor |
KR20120120416A (ko) | 2010-02-11 | 2012-11-01 | 벤더르빌트 유니버시티 | Mglur4 알로스테릭 강화제로서 벤즈이속사졸 및 아자벤즈이속사졸, 조성물, 및 신경 기능이상을 치료하는 방법 |
EP2686314A1 (en) | 2011-03-16 | 2014-01-22 | F.Hoffmann-La Roche Ag | 6,5-heterocyclic propargylic alcohol compounds and uses therefor |
CN103974953B (zh) * | 2011-12-09 | 2016-06-29 | 奇斯药制品公司 | 激酶抑制剂 |
EP2819998B1 (en) * | 2012-03-01 | 2022-04-06 | Array BioPharma Inc. | Crystalline forms of 1-(3-tert-butyl-1-p-tolyl-1h-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1h-indazol-5-yloxy)benzyl)urea hydrochloride |
CA2883172A1 (en) * | 2012-08-29 | 2014-03-06 | Merck Patent Gmbh | Ddr2 inhibitors for the treatment of osteoarthritis |
CR20200237A (es) | 2012-10-12 | 2020-07-26 | Exelixis Inc | Proceso novedoso para la elaboración de compuestos para su uso en el tratamiento del cáncer (diviisional 2015-0245) |
CN105073739B (zh) | 2013-02-27 | 2017-10-24 | 阵列生物制药公司 | 用于制备吲唑衍生物的中间体及其制备方法 |
WO2014145485A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Map kinase modulators and uses thereof |
JP2016535012A (ja) * | 2013-10-18 | 2016-11-10 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経変性疾患の治療において使用するためのシクロプロパン化された不飽和脂肪酸のハロゲン化エステル |
CN104974160B (zh) * | 2014-04-08 | 2017-12-05 | 辰欣药业股份有限公司 | 2‑甲基吡唑并[1,5‑a]嘧啶‑6‑羧酸衍生物及其应用 |
EP3233797B1 (en) * | 2015-01-18 | 2019-05-08 | SRI International Inc. | Map4k4 (hgk) inhibitors |
RU2675496C1 (ru) * | 2017-03-31 | 2018-12-20 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения алкиловых эфиров гидроксибензойных кислот |
CN108947879B (zh) * | 2017-05-17 | 2022-06-28 | 中国科学院上海药物研究所 | Prmt i型抑制剂及其制备方法和用途 |
CA3077499C (en) | 2017-10-05 | 2021-09-21 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
AU2019242628A1 (en) | 2018-03-26 | 2020-09-24 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
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CN113354558B (zh) * | 2021-07-12 | 2022-03-11 | 无锡双启科技有限公司 | 一种2-氨基-5-氟苯腈的制备方法 |
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-
2004
- 2004-02-25 US US10/788,044 patent/US7521447B2/en active Active
- 2004-02-25 JP JP2006508838A patent/JP4617299B2/ja not_active Expired - Lifetime
- 2004-02-25 WO PCT/US2004/005693 patent/WO2004078116A2/en active Application Filing
- 2004-02-25 CA CA2517517A patent/CA2517517C/en not_active Expired - Lifetime
- 2004-02-25 AU AU2004218463A patent/AU2004218463B2/en not_active Expired
- 2004-02-25 EP EP04714621A patent/EP1606283B1/en not_active Expired - Lifetime
- 2004-02-25 RU RU2005131197/04A patent/RU2357957C2/ru active
- 2004-02-25 PL PL378432A patent/PL214032B1/pl unknown
- 2004-02-25 MX MXPA05009459A patent/MXPA05009459A/es active IP Right Grant
-
2005
- 2005-09-02 KR KR1020057016417A patent/KR101099281B1/ko active IP Right Grant
- 2005-09-21 IS IS8037A patent/IS2675B/is unknown
- 2005-09-26 NO NO20054453A patent/NO328913B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO2004078116A3 (en) | 2004-10-14 |
CA2517517C (en) | 2012-12-18 |
AU2004218463B2 (en) | 2009-07-16 |
US7521447B2 (en) | 2009-04-21 |
NO20054453D0 (no) | 2005-09-26 |
RU2357957C2 (ru) | 2009-06-10 |
EP1606283A4 (en) | 2007-05-23 |
EP1606283A2 (en) | 2005-12-21 |
IS8037A (is) | 2005-09-21 |
KR20050106484A (ko) | 2005-11-09 |
WO2004078116A9 (en) | 2008-09-12 |
NO328913B1 (no) | 2010-06-14 |
RU2005131197A (ru) | 2006-05-10 |
US20040192653A1 (en) | 2004-09-30 |
AU2004218463A1 (en) | 2004-09-16 |
PL378432A1 (pl) | 2006-04-03 |
PL214032B1 (pl) | 2013-06-28 |
WO2004078116A2 (en) | 2004-09-16 |
IS2675B (is) | 2010-09-15 |
JP4617299B2 (ja) | 2011-01-19 |
KR101099281B1 (ko) | 2011-12-26 |
EP1606283B1 (en) | 2008-10-08 |
MXPA05009459A (es) | 2006-05-17 |
CA2517517A1 (en) | 2004-09-16 |
JP2006519259A (ja) | 2006-08-24 |
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