NO20045507L - Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner - Google Patents

Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner

Info

Publication number
NO20045507L
NO20045507L NO20045507A NO20045507A NO20045507L NO 20045507 L NO20045507 L NO 20045507L NO 20045507 A NO20045507 A NO 20045507A NO 20045507 A NO20045507 A NO 20045507A NO 20045507 L NO20045507 L NO 20045507L
Authority
NO
Norway
Prior art keywords
delivery
hyaluronic acid
osteogenic proteins
injectable
osteogenic
Prior art date
Application number
NO20045507A
Other languages
English (en)
Norwegian (no)
Inventor
Rebecca Hung-Mei Li
Hyun Kim
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of NO20045507L publication Critical patent/NO20045507L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
NO20045507A 2002-05-17 2004-12-16 Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner NO20045507L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38159002P 2002-05-17 2002-05-17
PCT/US2003/014609 WO2003099992A2 (en) 2002-05-17 2003-05-12 Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins

Publications (1)

Publication Number Publication Date
NO20045507L true NO20045507L (no) 2004-12-16

Family

ID=29584319

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045507A NO20045507L (no) 2002-05-17 2004-12-16 Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner

Country Status (17)

Country Link
US (2) US20050287135A1 (de)
EP (1) EP1519744A4 (de)
JP (1) JP4879482B2 (de)
CN (1) CN1665525A (de)
AR (1) AR039548A1 (de)
AU (1) AU2003228958C1 (de)
BR (1) BR0310087A (de)
CA (1) CA2486113A1 (de)
CO (1) CO5631458A2 (de)
EA (1) EA008354B1 (de)
IL (1) IL165077A0 (de)
MX (1) MXPA04011337A (de)
NO (1) NO20045507L (de)
NZ (1) NZ536478A (de)
TW (2) TW200638946A (de)
WO (1) WO2003099992A2 (de)
ZA (1) ZA200409096B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69421832D1 (de) * 1993-01-11 2000-01-05 Canon Kk Farbanzeigevorrichtung
JP4703926B2 (ja) * 1999-10-15 2011-06-15 ジェネティクス インスティテュート,エルエルシー 骨形成蛋白をデリバリーするためのヒアルロン酸の処方
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
EP1675608B1 (de) * 2003-09-12 2007-03-21 Wyeth Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
CZ13928U1 (cs) * 2003-10-08 2004-01-20 Cpn Spol. S R.O. Dietetický přípravek pro prevenci a léčbu osteoporózy
AR046773A1 (es) * 2003-12-23 2005-12-21 Novartis Ag Formulaciones farmaceuticas de bisfosfonatos
CN101022812A (zh) * 2004-08-23 2007-08-22 特瓦制药工业有限公司 固体和晶体伊班膦酸钠及其制备方法
ITMI20052515A1 (it) * 2005-12-29 2007-06-30 Abiogen Pharma Spa Formulazione farmaceutica per il trattamento della osteoartrite
CA2616421A1 (en) * 2006-05-23 2007-11-29 Mathys Ag Bettlach Solid precursor for the preparation of a pasty bone replacement material by admixture of a liquid.
US20100047306A1 (en) * 2006-10-05 2010-02-25 Novartis Ag Pharmaceutical compositions comprising bisphosponates
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
EP2288371A1 (de) * 2008-04-14 2011-03-02 Adocia Osteogene zusammensetzung mit einem wachstumsfaktor, einem löslichen kationensalz und einem organischen substrat
MX2010011267A (es) * 2008-04-14 2010-12-21 Adocia Composicion osteogenica que comprende un complejo del factor de crecimiento/polimero anfifilico, una sal de cation soluble y un soporte organico.
JP5542687B2 (ja) 2008-11-05 2014-07-09 国立大学法人 東京医科歯科大学 ヒアルロン酸誘導体、およびその医薬組成物
EP3067016A1 (de) 2009-07-10 2016-09-14 Kirk Promotion LTD. Implantierbare medizinische vorrichtung zum schmieren einer künstlichen kontaktfläche
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
KR102016745B1 (ko) * 2013-02-01 2019-09-02 아이진 주식회사 Bmp―7 및 부형제를 포함하는 흉터 형성의 감소 또는 억제용 조성물
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
JP2020502218A (ja) 2016-12-21 2020-01-23 メレオ バイオファーマ 3 リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
MX2021002889A (es) * 2018-09-14 2021-06-04 Orthocell Ltd Periostio artificial.

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465257A (en) * 1945-09-12 1949-03-22 Universal Moulded Products Cor Laminated tubular article
CH563767A5 (de) * 1973-01-30 1975-07-15 Pheulpin Jean
DE2657370C2 (de) * 1976-12-17 1982-11-11 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten
DE2732848A1 (de) * 1977-07-18 1979-02-08 Schering Ag Diurethane, herbizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4727028A (en) * 1981-06-22 1988-02-23 Eli Lilly And Company Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4804744A (en) * 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
US4662884A (en) * 1984-04-25 1987-05-05 University Of Utah Research Foundation Prostheses and methods for promoting nerve regeneration
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
CA1341617C (en) * 1984-06-08 2011-06-28 Henry George Burger Inhibin isolated from ovarian follicular fluid
EP0169016B2 (de) * 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4843063A (en) * 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
AU598455B2 (en) * 1984-12-27 1990-06-28 Suntory Limited Method for purifying an interferon
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4798885A (en) * 1986-02-07 1989-01-17 Genentech, Inc. Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain
US5215893A (en) * 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5089396A (en) * 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5133755A (en) * 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
US4737578A (en) * 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
US4758233A (en) * 1986-04-22 1988-07-19 N.J. Phillips TPY. Limited Cream applicator
NL8601328A (nl) * 1986-05-23 1987-12-16 Langen Research Inrichting voor het met een massa, in het bijzonder pasteuze massa, injekteren van vlees.
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US6432919B1 (en) * 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5631142A (en) * 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
US5019087A (en) * 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US5202120A (en) * 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US4920962A (en) * 1988-11-23 1990-05-01 Claude Proulx Splint-like element for use in end-to-end nerve suture
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
WO1991000103A1 (en) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
WO1991017777A2 (en) 1990-05-22 1991-11-28 University Of Florida Injectable bioactive glass compositions and methods for tissue reconstruction
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
ATE238417T1 (de) * 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
SE469653B (sv) * 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
JPH07504106A (ja) * 1992-02-28 1995-05-11 コラーゲン コーポレイション 注射可能なセラミック組成物及びそれらの製造及び使用のための方法
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1259100B (it) * 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
SK329592A3 (en) 1992-11-03 1995-03-08 Stu Chemickotechnologicka Method of preparation of bioactive material
US6221958B1 (en) * 1993-01-06 2001-04-24 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
EP2272959A1 (de) * 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 Zusammenstellungen
ATE326234T1 (de) * 1993-08-26 2006-06-15 Genetics Inst Llc Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
WO1995016035A2 (en) * 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
HU222664B1 (hu) * 1995-06-05 2003-09-29 Genetics Institute, Llc Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására
US5716413A (en) * 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
WO1997032591A1 (en) 1996-03-05 1997-09-12 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
NZ331238A (en) * 1996-03-05 2000-05-26 Orquest Inc Method of promoting bone growth with hyaluronic acid and growth factors (bFGF)
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
IT1288290B1 (it) 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
DE69814352T3 (de) * 1997-02-07 2009-08-13 Stryker Corp., Kalamazoo Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6015801A (en) * 1997-07-22 2000-01-18 Merck & Co., Inc. Method for inhibiting bone resorption
IT1296689B1 (it) 1997-11-06 1999-07-14 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
JP4211108B2 (ja) * 1999-01-13 2009-01-21 生化学工業株式会社 高粘弾性物質の注入器具
JP4703926B2 (ja) * 1999-10-15 2011-06-15 ジェネティクス インスティテュート,エルエルシー 骨形成蛋白をデリバリーするためのヒアルロン酸の処方

Also Published As

Publication number Publication date
WO2003099992A2 (en) 2003-12-04
CA2486113A1 (en) 2003-12-04
JP2005532335A (ja) 2005-10-27
TWI282283B (en) 2007-06-11
EP1519744A4 (de) 2007-10-03
CO5631458A2 (es) 2006-04-28
MXPA04011337A (es) 2005-07-01
AR039548A1 (es) 2005-02-23
ZA200409096B (en) 2006-06-28
WO2003099992A3 (en) 2004-05-27
AU2003228958A2 (en) 2003-12-12
EA200401502A1 (ru) 2005-08-25
BR0310087A (pt) 2005-08-16
AU2003228958A1 (en) 2003-12-12
TW200638946A (en) 2006-11-16
US7875590B2 (en) 2011-01-25
IL165077A0 (en) 2005-12-18
JP4879482B2 (ja) 2012-02-22
US20050287135A1 (en) 2005-12-29
AU2003228958C1 (en) 2009-01-08
TW200307559A (en) 2003-12-16
NZ536478A (en) 2008-02-29
EP1519744A2 (de) 2005-04-06
AU2003228958B2 (en) 2008-05-01
EA008354B1 (ru) 2007-04-27
CN1665525A (zh) 2005-09-07
US20090181058A1 (en) 2009-07-16

Similar Documents

Publication Publication Date Title
NO20045507L (no) Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner
Foster et al. The influence of biomechanical stability on bone healing and fracture-related infection: the legacy of Stephan Perren.
Rodriguez-Merchan et al. Nonunion: general principles and experimental data
CA2085750C (en) Osteoinductive pharmaceutical formulations
NO20061547L (no) Injiserbare kalsiumfosfat faste staver eller masser for levering av osteogene proteiner
Kanakaris et al. Biological enhancement of tibial diaphyseal aseptic non-unions: the efficacy of autologous bone grafting, BMPs and reaming by-products
DE60012557D1 (de) Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
DK2907522T1 (da) Fremgangsmåde til øgning af knoglesejhed og -stivhed og nedsættelse af frakturer
ATE255367T1 (de) Marknagelsystem zur frakturheilung bzw. knochenverlängerung
MX2009003569A (es) Metodo de administracion de farmacos para la proteina anabolica osea.
MD2353B2 (en) Antibiotic preparation, process for obtaining and use thereof
MD2550C2 (ro) Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia
BRPI0417621A (pt) terapia de combinação contìnua com agonistas seletivos do receptor ep4 de prostaglandina e um estrogênio para o tratamento de estados que se apresentem com baixa massa óssea
MXPA03010679A (es) Una composicion para acelerar la cicatrizacion de fractura osea.
AU2003270196A1 (en) Method for preventing or reducing secondary fractures after hip fracture
AU2003251728A1 (en) Placental growth factor as a target for the treatment of osteoporosis
ATE367828T1 (de) Igf-enthaltende injizierbare formulierungen enthaltend succinate als puffermittel
GB9930768D0 (en) Composition
Pinholt et al. Osteoinductive potential of demineralized rat bone increases with increasing donor age from birth to adulthood
Bos et al. Reconstruction of congenital tibial pseudarthrosis by revascularized fibular transplants
FI970715A0 (fi) Menetelmä luun parantamiseksi ja murtuman korjaamiseksi
Markatos An invited commentary on “Four interventions for pediatric femoral shaft fractures: Network meta-analysis of randomized trials”[Int. J. Surg. 80 (2020) 53–60]
Gupta et al. Functional outcome of long proximal femoral nail versus short proximal femoral nail in peritrochanteric fractures
Seng et al. Critical size bone defects managed with modern techniques of bone transport: An update
MD2000F1 (en) Method of reconstruction of viciously consolidated distal humerus metaphyseal fractures to children

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application