MD2550C2 - Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia - Google Patents

Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia Download PDF

Info

Publication number
MD2550C2
MD2550C2 MDA20020075A MD20020075A MD2550C2 MD 2550 C2 MD2550 C2 MD 2550C2 MD A20020075 A MDA20020075 A MD A20020075A MD 20020075 A MD20020075 A MD 20020075A MD 2550 C2 MD2550 C2 MD 2550C2
Authority
MD
Moldova
Prior art keywords
slow release
active ingredient
antibiotic
component
preparation
Prior art date
Application number
MDA20020075A
Other languages
English (en)
Russian (ru)
Other versions
MD20020075A (ro
MD2550B2 (ro
Inventor
Себастиан ВОГТ
Маттиас ШНАБЕЛЬРАУХ
Клаус-Дитер КУН
Original Assignee
ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ filed Critical ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Publication of MD20020075A publication Critical patent/MD20020075A/ro
Publication of MD2550B2 publication Critical patent/MD2550B2/ro
Publication of MD2550C2 publication Critical patent/MD2550C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Invenţia se referă la preparate antibiotice utilizate pentru implanturi în medicină şi medicina veterinară pentru tratamentul infecţiilor microbiene locale în ţesuturile tari şi moi.Preparatul revendicat prezintă un amestec constând din cel puţin un component amfifilic, care este reprezentat de sulfaţi, sulfamaţi sau sulfonaţi, precum şi din cel puţin un component antibiotic din grupa aminoglicozidelor, lincosamidelor, 4-chinolonelor sau tetraciclinelor şi, eventual, din cel puţin un component auxiliar organic anhidru şi/sau anorganic şi un component biologic activ.Preparatul revendicat posedă o acţiune de eliberare încetinită a componentului biologic activ.
MDA20020075A 2001-03-22 2002-02-13 Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia MD2550C2 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114244A DE10114244A1 (de) 2001-03-22 2001-03-22 Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Publications (3)

Publication Number Publication Date
MD20020075A MD20020075A (ro) 2002-11-30
MD2550B2 MD2550B2 (ro) 2004-09-30
MD2550C2 true MD2550C2 (ro) 2005-04-30

Family

ID=7678691

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20020075A MD2550C2 (ro) 2001-03-22 2002-02-13 Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia

Country Status (32)

Country Link
US (1) US6913764B2 (ro)
EP (1) EP1243257B1 (ro)
JP (1) JP4181331B2 (ro)
CN (1) CN100486589C (ro)
AT (1) ATE258431T1 (ro)
AU (1) AU768962B2 (ro)
BG (1) BG65467B1 (ro)
BR (1) BR0200876A (ro)
CA (1) CA2378490C (ro)
CZ (1) CZ302690B6 (ro)
DE (2) DE10114244A1 (ro)
DK (1) DK1243257T3 (ro)
EE (1) EE200200153A (ro)
ES (1) ES2213717T3 (ro)
GE (1) GEP20053447B (ro)
HR (1) HRP20020240B1 (ro)
HU (1) HUP0201045A2 (ro)
IL (1) IL148703A (ro)
IS (2) IS2501B (ro)
MD (1) MD2550C2 (ro)
MX (1) MXPA02003007A (ro)
NO (1) NO331876B1 (ro)
NZ (1) NZ517922A (ro)
PL (1) PL204986B1 (ro)
PT (1) PT1243257E (ro)
RU (1) RU2264230C2 (ro)
SA (1) SA02230037B1 (ro)
SK (1) SK286493B6 (ro)
TR (1) TR200400244T4 (ro)
UA (1) UA71030C2 (ro)
YU (1) YU11802A (ro)
ZA (1) ZA200202254B (ro)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
JP4993465B2 (ja) * 2003-12-04 2012-08-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション 変性された高分子ならびにその製造方法および使用方法
AU2005325213B2 (en) 2004-08-04 2010-10-07 Evonik Operations Gmbh Methods for manufacturing delivery devices and devices thereof
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) * 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
US9050391B2 (en) * 2005-10-27 2015-06-09 Nexilis Ag Implant and production method for said implant
EP1940339B1 (de) * 2005-10-27 2011-12-21 Thommen Medical Ag Dentalimplantat und verfahren zu dessen herstellung
WO2007056667A2 (en) * 2005-11-04 2007-05-18 Rush University Medical Center Plastic implant impregnated with an antibiotic
DE102006007245A1 (de) 2006-02-15 2007-08-23 Heraeus Kulzer Gmbh Implantatmaterial
RU2335510C2 (ru) * 2006-02-22 2008-10-10 Институт высокомолекулярных соединений РАН Водорастворимые полимерные комплексы антибиотиков-аминогликозидов
DE102006037362B3 (de) * 2006-08-09 2007-09-20 Heraeus Kulzer Gmbh Knochenersatzmaterial
WO2009015197A1 (en) * 2007-07-24 2009-01-29 University Of Memphis Research Foundation Local delivery method and composition
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
CN101758337B (zh) * 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
US20210361696A1 (en) * 2017-06-16 2021-11-25 Boris Farber Biologically active combinatorial polysaccharide derivatives
AU2018297348B2 (en) 2017-07-07 2024-07-25 Epicentrx, Inc. Compositions for parenteral administration of therapeutic agents
IL256312A (en) 2017-12-14 2018-01-31 Omrix Biopharmaceuticals Ltd Antibacterial preparations containing minocycline and oxidized cellulose

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4617293A (en) * 1981-05-13 1986-10-14 Merck Patent Gesellschaft Mit Beschraenkter Haftung Flavonoid phosphate salts of aminoglycoside antibiotics

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US356759A (en) * 1887-02-01 Paul gmehlikt
US3091572A (en) 1962-07-16 1963-05-28 Schering Corp Gentamycin and method of production
GB1120992A (en) * 1965-04-24 1968-07-24 Fisons Pharmaceuticals Ltd Aerosol compositions
ES315101A1 (es) 1965-07-08 1966-01-01 Folch Vazquez Conrado Procedimiento de preparaciën de nuevos derivados de tetraciclina
FR6476M (ro) 1967-06-06 1968-11-18
DE2320373B2 (de) * 1973-04-21 1978-04-06 Merck Patent Gmbh, 6100 Darmstadt Antibioticahaltiges Mittel und seine Verwendung als chirurgisches Kunststoffmaterial
FR2272680B1 (ro) * 1974-05-29 1978-07-21 Hosbon Sa Lab
DE2511122B2 (de) * 1975-03-14 1977-06-08 Vorprodukt fuer die zubereitung von knochenzement
AR216922A1 (es) * 1976-11-11 1980-02-15 Merck Patent Gmbh Procedimiento para la fabricacion de un medio quirurgico
JPS5391113A (en) * 1977-01-21 1978-08-10 Meiji Seika Kaisha Ltd Preparation of suppository of antibiotics
EP0052916B1 (en) * 1980-11-10 1985-01-02 Alza Corporation Erodible polymer containing erosion rate modifier
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US5035891A (en) * 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
CA1337279C (en) * 1989-06-06 1995-10-10 Robert J. Borgman Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US5709875A (en) 1990-10-26 1998-01-20 Centre National De La Rechierche Scientifique (C.N.R.S) Implantable biodegradable material and process for its production
FR2668367B1 (fr) * 1990-10-26 1994-05-13 Centre Nal Recherc Scientifique Medicament implantable a effet prolonge.
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
CN2108030U (zh) * 1991-07-13 1992-06-24 河北霸州市水利局下河口冲压件厂 折叠式爬楼拉液化气罐车
FR2697539B1 (fr) * 1992-11-03 1994-12-02 Pechiney Recherche Méthode, dispositif et appareil de traitement de surface de corps de boîtes métalliques, en particulier an al ou ses alliages.
DE4404018A1 (de) * 1994-02-09 1995-08-10 Merck Patent Gmbh Protrahiert freisetzende Darreichungsformen enthaltend Clindamycin-Palmitat
AU6439094A (en) * 1994-04-06 1995-10-30 Aktsionernoe Obschestvo Zakrytogo Tipa Firma "Assol" (Firma "Assol") Pharmaceutical agent for local application and a method of obtaining same
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5674142A (en) * 1996-04-16 1997-10-07 Sram Corporation Control cable adjustment device
US5670142A (en) * 1996-07-08 1997-09-23 Donald Neudecker Treatment for itch of chicken pox
DE19713229A1 (de) * 1997-04-01 1998-10-08 Merck Patent Gmbh Antibiotikumhaltige Knochenzementpaste
WO2000024377A1 (en) * 1998-10-23 2000-05-04 Idea Innovative Dermale Applikationen Gmbh Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4617293A (en) * 1981-05-13 1986-10-14 Merck Patent Gesellschaft Mit Beschraenkter Haftung Flavonoid phosphate salts of aminoglycoside antibiotics

Also Published As

Publication number Publication date
SA02230037B1 (ar) 2007-04-15
US20020182251A1 (en) 2002-12-05
HUP0201045A2 (hu) 2003-02-28
DE50200223D1 (de) 2004-03-04
US6913764B2 (en) 2005-07-05
NO20021390L (no) 2002-09-23
IL148703A0 (en) 2002-11-10
UA71030C2 (uk) 2004-11-15
CN100486589C (zh) 2009-05-13
IS6269A (is) 2002-09-22
AU768962B2 (en) 2004-01-08
JP4181331B2 (ja) 2008-11-12
EE200200153A (et) 2002-12-16
EP1243257B1 (de) 2004-01-28
BG106454A (en) 2002-10-31
MD20020075A (ro) 2002-11-30
CZ2002871A3 (cs) 2002-11-13
SK3892002A3 (en) 2002-10-08
CA2378490C (en) 2008-05-13
NO331876B1 (no) 2012-04-23
BG65467B1 (bg) 2008-09-30
JP2002322097A (ja) 2002-11-08
AU2755402A (en) 2002-09-26
PL352920A1 (en) 2002-09-23
DK1243257T3 (da) 2004-05-10
PL204986B1 (pl) 2010-02-26
IS2501B (is) 2009-03-15
ES2213717T3 (es) 2004-09-01
HRP20020240A2 (en) 2002-12-31
DE10114244A1 (de) 2002-10-02
MD2550B2 (ro) 2004-09-30
IS6270A (is) 2002-09-22
TR200400244T4 (tr) 2004-04-21
SK286493B6 (sk) 2008-11-06
RU2264230C2 (ru) 2005-11-20
CZ302690B6 (cs) 2011-09-07
GEP20053447B (en) 2005-02-25
YU11802A (sh) 2004-12-31
MXPA02003007A (es) 2003-08-20
HRP20020240B1 (en) 2005-04-30
HU0201045D0 (ro) 2002-05-29
NO20021390D0 (no) 2002-03-20
ZA200202254B (en) 2002-10-10
EP1243257A1 (de) 2002-09-25
CN1376469A (zh) 2002-10-30
IL148703A (en) 2006-07-05
ATE258431T1 (de) 2004-02-15
CA2378490A1 (en) 2002-09-22
NZ517922A (en) 2003-08-29
PT1243257E (pt) 2004-06-30
BR0200876A (pt) 2003-03-11

Similar Documents

Publication Publication Date Title
MD2550C2 (ro) Preparat antibiotic cu eliberare lenta a ingredientului activ şi utilizare a acestuia
MD20020073A (ro) Procedeu de obtinere a preparatului antimicrobian si utilizarea lui
BRPI0412526A (pt) composto, uso de um composto, composição farmacêutica, formulação em aerossol farmacêutica, e, método para o tratamento de um paciente humano ou animal com uma condição anti-inflamatória e/ou alérgica
AP1818A (en) Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
EP1024145A3 (en) Novel azalides and methods of making same
ATE218582T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
NZ552047A (en) Method of treatment of endobronchial infections
WO2001092288A3 (en) Cobalamin compounds useful as antibiotic agents and as imaging agents
ATE218581T1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
BG66093B1 (bg) Състави с контролирано освобождаване, съдържащи нимесулид
MXPA02005173A (es) Composicion farmaceutica para el tratamiento de enfermedades asociadas con disminucion de masa osea.
UA88463C2 (ru) Фармацевтическая композиция, которая содержит соединение 1, и процесс лечения вич-инфекции
BR0100558A (pt) Composições e métodos para tratar a osteoporose
NO20045507L (no) Injiserbare faste hyaluronsyrebaerere for levering av osteogene proteiner
MD2517C2 (ro) Procedeu de producere a compozitelor antibiotice si utilizarea lor
NO20061468L (no) Anvendelse av tigecyklin, alene eller i kombinasjonmed rifampin for behandling av osteomyelitt og/eller septisk artritt
PL376413A1 (en) Pharmaceutical formulation of olanzapine
ECSP003859A (es) Composicion para el tratamiento de tejidos dañados
BR0011845A (pt) Complexo farmacêutico
WO2002057281A3 (en) Aminoglycosides as antibiotics
AR037543A1 (es) Metodo para la terapia del cancer y composicion farmaceutica
SE9902673D0 (sv) New composition
BR0215352A (pt) Composição farmacêutica que compreende um inibidor de alfa-glicosidase e um ácido 4-oxobutanóico, e seu uso para tratar diabetes
SE9902674D0 (sv) New composition
UA32315A (uk) Спосіб накладання шкірного шва

Legal Events

Date Code Title Description
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees