ATE218582T1 - Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen - Google Patents
Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungenInfo
- Publication number
- ATE218582T1 ATE218582T1 AT97952999T AT97952999T ATE218582T1 AT E218582 T1 ATE218582 T1 AT E218582T1 AT 97952999 T AT97952999 T AT 97952999T AT 97952999 T AT97952999 T AT 97952999T AT E218582 T1 ATE218582 T1 AT E218582T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- pharmaceutical compositions
- cyclosporine derivatives
- derivatives
- cyclosporine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9615955A FR2757521B1 (fr) | 1996-12-24 | 1996-12-24 | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
PCT/FR1997/002406 WO1998028330A1 (fr) | 1996-12-24 | 1997-12-23 | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE218582T1 true ATE218582T1 (de) | 2002-06-15 |
Family
ID=9499088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97952999T ATE218582T1 (de) | 1996-12-24 | 1997-12-23 | Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen |
Country Status (14)
Country | Link |
---|---|
US (1) | US5994299A (de) |
EP (1) | EP0951474B1 (de) |
JP (1) | JP4146518B2 (de) |
AT (1) | ATE218582T1 (de) |
AU (1) | AU5669398A (de) |
DE (1) | DE69713152D1 (de) |
DK (1) | DK0951474T3 (de) |
ES (1) | ES2178038T3 (de) |
FR (1) | FR2757521B1 (de) |
MA (1) | MA26458A1 (de) |
PT (1) | PT951474E (de) |
TN (1) | TNSN97212A1 (de) |
WO (1) | WO1998028330A1 (de) |
ZA (1) | ZA9711607B (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010052766A (ko) * | 1998-06-12 | 2001-06-25 | 침머만 다니엘 | 신규한 사이클로스포린 |
FR2780061B1 (fr) * | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
DK1091975T3 (da) | 1998-07-01 | 2006-04-18 | Debiopharm Sa | Ny cyclosporin med forbedret aktivitetsprofil |
US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
AU769315B2 (en) | 1999-08-24 | 2004-01-22 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
KR100465012B1 (ko) * | 2001-05-11 | 2005-01-13 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
DK1435910T3 (da) * | 2001-10-19 | 2009-11-09 | Isotechnika Inc | Nye cyclosporinanaloge mikroemulsionsprækoncentrater |
BRPI0213658A8 (pt) | 2001-10-19 | 2016-12-06 | F Hoffmann La Roche Ltd | Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a |
US6987090B2 (en) * | 2002-05-09 | 2006-01-17 | Lg Household & Health Care Ltd. | Use of 3-position cyclosporin derivatives for hair growth |
KR20040039622A (ko) * | 2002-11-04 | 2004-05-12 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
AU2004222306A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
GB0320638D0 (en) * | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
ES2359925T3 (es) * | 2004-07-14 | 2011-05-30 | Novartis Ag | Uso de una combinación de ciclosporina e interferones pegilados para tratar la hepatitis c (hcv). |
KR100597309B1 (ko) | 2004-09-17 | 2006-07-05 | 주식회사 핸슨바이오텍 | 세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법 |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
US7378391B2 (en) * | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
AU2005292162B2 (en) * | 2004-10-01 | 2011-11-10 | Scynexis, Inc | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
JP2008515886A (ja) * | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキンおよびそれらの医用薬剤としての有用性 |
US7691812B2 (en) | 2004-11-04 | 2010-04-06 | Trustees Of The University Of Pennsylvania | Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine A or other cyclophilin inhibitors |
BRPI0519355A2 (pt) * | 2004-12-23 | 2009-01-20 | Novartis Ag | compostos para tratamento contra flaviviridae |
EP1830871A1 (de) * | 2004-12-23 | 2007-09-12 | Novartis AG | Zusammensetzunge zur hcv-behandlung |
NZ567262A (en) * | 2005-09-30 | 2011-12-22 | Scynexis Inc | Cyclosporin derivatives and their use for the treatment and prevention of hepatitis C infection |
ATE498630T1 (de) | 2005-09-30 | 2011-03-15 | Scynexis Inc | Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion |
CN101316606B (zh) * | 2005-09-30 | 2015-05-27 | 西尼克斯公司 | 治疗和预防丙型肝炎感染的方法和药物组合物 |
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
ATE502633T1 (de) | 2006-05-19 | 2011-04-15 | Scynexis Inc | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen |
CN101502196A (zh) * | 2006-06-02 | 2009-08-05 | 克洛德·安妮·佩里西恩 | 激活电子的管理 |
CN101557819A (zh) * | 2006-10-12 | 2009-10-14 | 诺瓦提斯公司 | 修饰的环孢素的用途 |
WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
US20080255038A1 (en) * | 2007-04-11 | 2008-10-16 | Samuel Earl Hopkins | Pharmaceutical compositions |
US8394763B2 (en) | 2007-09-26 | 2013-03-12 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
CN102083852A (zh) * | 2008-06-06 | 2011-06-01 | 西尼克斯公司 | 环孢菌素类似物及其在治疗hcv感染中的应用 |
WO2009148615A1 (en) * | 2008-06-06 | 2009-12-10 | Scynexis, Inc. | Cyclosporin analogs and their use in the treatment of hcv infections |
CA2730108A1 (en) * | 2008-07-10 | 2010-01-14 | Allergan, Inc. | Cyclosporin derivatives for treating ocular and dermal diseases and conditions |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
CA2748389A1 (en) | 2008-12-31 | 2010-07-08 | Scynexis, Inc. | Derivatives of cyclosporin a |
MX2011007195A (es) * | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
CA2763207A1 (en) | 2009-05-27 | 2010-12-02 | Allergan, Inc. | Cyclosporin derivatives for treating inflammatory diseases and conditions |
EP2519538A1 (de) | 2009-12-30 | 2012-11-07 | Scynexis, Inc. | Cyclosporin-analoga |
US9217015B2 (en) | 2010-07-16 | 2015-12-22 | S&T Global Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
WO2012021796A2 (en) | 2010-08-12 | 2012-02-16 | S&T Global, Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
MX2013004062A (es) * | 2010-10-12 | 2013-07-22 | Allergan Inc | Analogos de ciclosporina. |
RU2013119869A (ru) * | 2010-10-12 | 2014-11-20 | Аллерган, Инк. | Аналоги циклоспорина |
US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
NZ611620A (en) | 2010-12-15 | 2016-02-26 | Ciclofilin Pharmaceuticals Corp | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
EP2705856A1 (de) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Verbindungen zur Behandlung von neurodegenerativen Erkrankungen |
WO2020037530A1 (en) * | 2018-08-22 | 2020-02-27 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Crystalline form of compound and uses thereof in medicine |
WO2020118715A1 (en) * | 2018-12-14 | 2020-06-18 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Salts of scy-635 and uses thereof in medicine |
WO2020118714A1 (en) * | 2018-12-14 | 2020-06-18 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Maleate of scy-635 and uses thereof in medicine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972B1 (de) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Cyclosporine |
US4814323A (en) * | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
SK278808B6 (sk) * | 1990-11-02 | 1998-03-04 | Novartis Ag | Cyklosporíny, ich použitie pri príprave liečiva na |
US5948884A (en) * | 1995-07-17 | 1999-09-07 | C-Chem Ag | Cyclosporin derivatives with anti-HIV effect |
-
1996
- 1996-12-24 FR FR9615955A patent/FR2757521B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-19 MA MA24907A patent/MA26458A1/fr unknown
- 1997-12-23 DK DK97952999T patent/DK0951474T3/da active
- 1997-12-23 PT PT97952999T patent/PT951474E/pt unknown
- 1997-12-23 AT AT97952999T patent/ATE218582T1/de not_active IP Right Cessation
- 1997-12-23 EP EP97952999A patent/EP0951474B1/de not_active Expired - Lifetime
- 1997-12-23 US US08/997,612 patent/US5994299A/en not_active Expired - Lifetime
- 1997-12-23 ES ES97952999T patent/ES2178038T3/es not_active Expired - Lifetime
- 1997-12-23 AU AU56693/98A patent/AU5669398A/en not_active Abandoned
- 1997-12-23 ZA ZA9711607A patent/ZA9711607B/xx unknown
- 1997-12-23 TN TNTNSN97212A patent/TNSN97212A1/fr unknown
- 1997-12-23 JP JP52849098A patent/JP4146518B2/ja not_active Expired - Lifetime
- 1997-12-23 DE DE69713152T patent/DE69713152D1/de not_active Expired - Lifetime
- 1997-12-23 WO PCT/FR1997/002406 patent/WO1998028330A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
FR2757521A1 (fr) | 1998-06-26 |
ZA9711607B (en) | 1998-06-24 |
JP2001507347A (ja) | 2001-06-05 |
JP4146518B2 (ja) | 2008-09-10 |
WO1998028330A1 (fr) | 1998-07-02 |
US5994299A (en) | 1999-11-30 |
EP0951474A1 (de) | 1999-10-27 |
DK0951474T3 (da) | 2002-09-16 |
TNSN97212A1 (fr) | 2005-03-15 |
PT951474E (pt) | 2002-11-29 |
FR2757521B1 (fr) | 1999-01-29 |
MA26458A1 (fr) | 2004-12-20 |
DE69713152D1 (de) | 2002-07-11 |
AU5669398A (en) | 1998-07-17 |
EP0951474B1 (de) | 2002-06-05 |
ES2178038T3 (es) | 2002-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |