HUP0201045A2 - Antibiotikum- és antibiotikus készítmény késleltetett hatással - Google Patents

Antibiotikum- és antibiotikus készítmény késleltetett hatással

Info

Publication number
HUP0201045A2
HUP0201045A2 HU0201045A HUP0201045A HUP0201045A2 HU P0201045 A2 HUP0201045 A2 HU P0201045A2 HU 0201045 A HU0201045 A HU 0201045A HU P0201045 A HUP0201045 A HU P0201045A HU P0201045 A2 HUP0201045 A2 HU P0201045A2
Authority
HU
Hungary
Prior art keywords
antibiotic
sulfates
excipient component
appropriate
resorbable
Prior art date
Application number
HU0201045A
Other languages
English (en)
Inventor
Klaus-Dieter Kühn
Matthias Schnabelrauch
Sebastian Vogt
Original Assignee
Heraeus Kulzer Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer Gmbh & Co. Kg. filed Critical Heraeus Kulzer Gmbh & Co. Kg.
Publication of HU0201045D0 publication Critical patent/HU0201045D0/hu
Publication of HUP0201045A2 publication Critical patent/HUP0201045A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A találmány antibiotikum-/antibiotikus készítményre vonatkozik, mely ahumán- és állatgyógyászatban a szilárd- és lágyszövetek helyimikrobiális fertőzéseinek kezeléséhez reszorbeáló és nem reszorbeálóimplantátumokat biztosít. A találmány szerinti az antibiotikum-/antibiotikus készítmény keverék, mely legalább egy, a következőkközül választott amfifil vegyületből áll: alkilszulfátok,arilszulfátok, alkilarilszulfátok, cikloalkilszulfátok,alkilcikloalkilszulfátok, alkilszulfamátok, cikloalkilszulfamát,alkilcikloalkilszulfamátok, arilszulfamátok, alkilarilszulfamátok,alkilszulfonátok, zsírsav-2-szulfonátok, arilszulfonátok,alkilarilszulfonátok, cikloalkilszulfonátok,alkilcikloalkilszulfonátok, alkildiszulfátok, cikloalkildiszulfátok,alkildiszulfonátok, cikloalkildiszulfonátok, arildiszulfonátok,alkilarildiszulfonátok, ariltriszulfonátok és alkilariltriszulfonátok,valamint legalább egy antibiotikumot adnak hozzá, melyet a következőcsoportokból választanak ki: aminoglükozid antibiotikumok, lincosamidés tetraciklin antibiotikumok, és amely adott esetben legalább egyvízmentes szerves segédanyag komponenst, és adott esetben legalább egyszervetlen segédanyag komponenst, adott esetben legalább egybiológiailag aktív segédanyag komponenst tartalmaz. A találmányszerinti az antibiotikum-/ antibiotikus készítmény késleltetettfelszabadítású hatást biztosít. Ó
HU0201045A 2001-03-22 2002-03-21 Antibiotikum- és antibiotikus készítmény késleltetett hatással HUP0201045A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114244A DE10114244A1 (de) 2001-03-22 2001-03-22 Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Publications (2)

Publication Number Publication Date
HU0201045D0 HU0201045D0 (hu) 2002-05-29
HUP0201045A2 true HUP0201045A2 (hu) 2003-02-28

Family

ID=7678691

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201045A HUP0201045A2 (hu) 2001-03-22 2002-03-21 Antibiotikum- és antibiotikus készítmény késleltetett hatással

Country Status (32)

Country Link
US (1) US6913764B2 (hu)
EP (1) EP1243257B1 (hu)
JP (1) JP4181331B2 (hu)
CN (1) CN100486589C (hu)
AT (1) ATE258431T1 (hu)
AU (1) AU768962B2 (hu)
BG (1) BG65467B1 (hu)
BR (1) BR0200876A (hu)
CA (1) CA2378490C (hu)
CZ (1) CZ302690B6 (hu)
DE (2) DE10114244A1 (hu)
DK (1) DK1243257T3 (hu)
EE (1) EE200200153A (hu)
ES (1) ES2213717T3 (hu)
GE (1) GEP20053447B (hu)
HR (1) HRP20020240B1 (hu)
HU (1) HUP0201045A2 (hu)
IL (1) IL148703A (hu)
IS (2) IS2501B (hu)
MD (1) MD2550C2 (hu)
MX (1) MXPA02003007A (hu)
NO (1) NO331876B1 (hu)
NZ (1) NZ517922A (hu)
PL (1) PL204986B1 (hu)
PT (1) PT1243257E (hu)
RU (1) RU2264230C2 (hu)
SA (1) SA02230037B1 (hu)
SK (1) SK286493B6 (hu)
TR (1) TR200400244T4 (hu)
UA (1) UA71030C2 (hu)
YU (1) YU11802A (hu)
ZA (1) ZA200202254B (hu)

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DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
US7981871B2 (en) * 2003-12-04 2011-07-19 University Of Utah Research Foundation Modified macromolescules and associated methods of synthesis and use
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
ES2507552T3 (es) * 2005-10-27 2014-10-15 Nexilis Ag Implante que contiene amino-bisfosfonatos y procedimiento para su producción
US8940320B2 (en) * 2005-10-27 2015-01-27 Thommen Medical Ag Dental implant and production method for said implant
US20070213835A1 (en) * 2005-11-04 2007-09-13 Markus Wimmer Plastic implant impregnated with an antibiotic
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DE102006037362B3 (de) * 2006-08-09 2007-09-20 Heraeus Kulzer Gmbh Knochenersatzmaterial
US7923021B2 (en) * 2007-07-24 2011-04-12 University Of Memphis Research Foundation Local delivery method and composition
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
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US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
EA202090748A1 (ru) * 2017-06-16 2020-08-11 Борис Славинович ФАРБЕР Биологически активные комбинаторные производные полисахаридов
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IL256312A (en) * 2017-12-14 2018-01-31 Omrix Biopharmaceuticals Ltd Antibacterial preparations containing minocycline and oxidized cellulose

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Also Published As

Publication number Publication date
NO331876B1 (no) 2012-04-23
US20020182251A1 (en) 2002-12-05
IL148703A (en) 2006-07-05
SK3892002A3 (en) 2002-10-08
EP1243257B1 (de) 2004-01-28
PL204986B1 (pl) 2010-02-26
AU768962B2 (en) 2004-01-08
CZ2002871A3 (cs) 2002-11-13
HU0201045D0 (hu) 2002-05-29
IS2501B (is) 2009-03-15
HRP20020240A2 (en) 2002-12-31
DE50200223D1 (de) 2004-03-04
US6913764B2 (en) 2005-07-05
CA2378490A1 (en) 2002-09-22
PT1243257E (pt) 2004-06-30
MXPA02003007A (es) 2003-08-20
HRP20020240B1 (en) 2005-04-30
MD2550C2 (ro) 2005-04-30
YU11802A (sh) 2004-12-31
MD2550B2 (en) 2004-09-30
ZA200202254B (en) 2002-10-10
NZ517922A (en) 2003-08-29
DE10114244A1 (de) 2002-10-02
IL148703A0 (en) 2002-11-10
MD20020075A (en) 2002-11-30
ATE258431T1 (de) 2004-02-15
BR0200876A (pt) 2003-03-11
IS6269A (is) 2002-09-22
SK286493B6 (sk) 2008-11-06
IS6270A (is) 2002-09-22
DK1243257T3 (da) 2004-05-10
AU2755402A (en) 2002-09-26
CN100486589C (zh) 2009-05-13
CZ302690B6 (cs) 2011-09-07
CN1376469A (zh) 2002-10-30
SA02230037B1 (ar) 2007-04-15
RU2264230C2 (ru) 2005-11-20
JP4181331B2 (ja) 2008-11-12
CA2378490C (en) 2008-05-13
BG65467B1 (bg) 2008-09-30
PL352920A1 (en) 2002-09-23
TR200400244T4 (tr) 2004-04-21
NO20021390D0 (no) 2002-03-20
EP1243257A1 (de) 2002-09-25
NO20021390L (no) 2002-09-23
BG106454A (en) 2002-10-31
JP2002322097A (ja) 2002-11-08
UA71030C2 (uk) 2004-11-15
GEP20053447B (en) 2005-02-25
EE200200153A (et) 2002-12-16
ES2213717T3 (es) 2004-09-01

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