NO20034345D0 - Pyridazinon aldose reduktase inhibitorer - Google Patents

Pyridazinon aldose reduktase inhibitorer

Info

Publication number
NO20034345D0
NO20034345D0 NO20034345A NO20034345A NO20034345D0 NO 20034345 D0 NO20034345 D0 NO 20034345D0 NO 20034345 A NO20034345 A NO 20034345A NO 20034345 A NO20034345 A NO 20034345A NO 20034345 D0 NO20034345 D0 NO 20034345D0
Authority
NO
Norway
Prior art keywords
reductase inhibitors
aldose reductase
pyridazinone aldose
pyridazinone
inhibitors
Prior art date
Application number
NO20034345A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034345L (no
Inventor
Banavara Lakshman Mylari
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20034345L publication Critical patent/NO20034345L/no
Publication of NO20034345D0 publication Critical patent/NO20034345D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20034345A 2001-03-30 2003-09-29 Pyridazinon aldose reduktase inhibitorer NO20034345D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28005101P 2001-03-30 2001-03-30
PCT/IB2002/000320 WO2002079198A1 (en) 2001-03-30 2002-01-31 Pyridazinone aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
NO20034345L NO20034345L (no) 2003-09-29
NO20034345D0 true NO20034345D0 (no) 2003-09-29

Family

ID=23071435

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034345A NO20034345D0 (no) 2001-03-30 2003-09-29 Pyridazinon aldose reduktase inhibitorer

Country Status (44)

Country Link
US (2) US6579879B2 (uk)
EP (3) EP1373259B1 (uk)
JP (1) JP2004528319A (uk)
KR (1) KR100586138B1 (uk)
CN (1) CN1215067C (uk)
AP (1) AP2002002461A0 (uk)
AR (1) AR035798A1 (uk)
AT (3) ATE348100T1 (uk)
AU (1) AU2002226634B2 (uk)
BG (1) BG108179A (uk)
BR (1) BR0208571A (uk)
CA (1) CA2442476A1 (uk)
CZ (1) CZ20032563A3 (uk)
DE (3) DE60217930T2 (uk)
DK (2) DK1491540T3 (uk)
EA (1) EA006023B1 (uk)
EC (1) ECSP034671A (uk)
EE (1) EE200300470A (uk)
ES (2) ES2231681T3 (uk)
GE (1) GEP20053675B (uk)
HK (1) HK1061678A1 (uk)
HR (1) HRP20030752A2 (uk)
HU (1) HUP0303644A3 (uk)
IL (1) IL156462A0 (uk)
IS (3) IS2205B (uk)
MA (1) MA27003A1 (uk)
MX (1) MXPA03008850A (uk)
MY (1) MY134304A (uk)
NO (1) NO20034345D0 (uk)
NZ (1) NZ528406A (uk)
OA (1) OA12453A (uk)
PA (1) PA8541801A1 (uk)
PE (1) PE20030007A1 (uk)
PL (1) PL365294A1 (uk)
PT (2) PT1491540E (uk)
SI (1) SI1373259T1 (uk)
SK (1) SK11852003A3 (uk)
TN (1) TNSN02037A1 (uk)
TW (1) TWI245762B (uk)
UA (1) UA73236C2 (uk)
UY (1) UY27237A1 (uk)
WO (1) WO2002079198A1 (uk)
YU (1) YU71403A (uk)
ZA (1) ZA200304671B (uk)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT934061E (pt) 1996-07-24 2003-10-31 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
DE60204611T2 (de) * 2001-02-28 2006-05-11 Pfizer Products Inc., Groton Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren
IL156462A0 (en) * 2001-03-30 2004-01-04 Pfizer Prod Inc Pyridazinone aldose reductase inhibitors
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
TWI250980B (en) 2002-01-09 2006-03-11 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents
US7419981B2 (en) * 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US20040092522A1 (en) * 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
US6872833B2 (en) * 2003-04-14 2005-03-29 Hoffmann-La Roche Inc. Adenosine receptor ligands
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060035251A1 (en) * 2004-06-30 2006-02-16 Whitehead Institute For Biomedical Research Novel methods for high-throughput genome-wide location analysis
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7645752B2 (en) * 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
PE20080993A1 (es) 2006-06-27 2008-10-06 Takeda Pharmaceutical Compuestos ciclicos fusionados como moduladores del receptor gpr40
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
US9296692B2 (en) * 2011-09-15 2016-03-29 Taipei Medical University Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体
CN103739547B (zh) * 2014-01-03 2015-09-02 沈阳药科大学 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JP2018511616A (ja) * 2015-04-14 2018-04-26 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物および方法
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
BR112018076244A2 (pt) 2016-06-21 2019-03-26 The Trustees Of Columbia University In The City Of New York inibidores da aldose redutase e métodos de uso destes
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
WO2018058109A1 (en) * 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
PL3658142T3 (pl) 2017-07-28 2024-08-26 Applied Therapeutics, Inc. Związki i sposoby leczenia galaktozemii
JP7128969B2 (ja) 2019-01-18 2022-08-31 アストラゼネカ・アクチエボラーグ Pcsk9阻害剤及びその使用方法
SG11202111822QA (en) 2019-05-07 2021-11-29 Univ Miami Treatment and detection of inherited neuropathies and associated disorders
KR20220030222A (ko) 2019-05-31 2022-03-10 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
US11458149B1 (en) 2019-05-31 2022-10-04 Ikena Oncology, Inc. TEAD inhibitors and uses thereof
WO2022120353A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
US4996204A (en) 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
KR950001039B1 (ko) * 1990-11-30 1995-02-08 가부시끼가이샤 쓰무라 크로몬 유도체 및 이 화합물을 유효성분으로 하는 아르도스 리덕타제 저해제
EP0582643A1 (en) 1991-03-28 1994-02-16 Pfizer Inc. Pyridazinone acetic acids
US5834466A (en) 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
NZ503044A (en) * 1997-09-24 2001-08-31 Orion Corp Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
IL156462A0 (en) * 2001-03-30 2004-01-04 Pfizer Prod Inc Pyridazinone aldose reductase inhibitors
JP2004528344A (ja) * 2001-04-30 2004-09-16 ファイザー・プロダクツ・インク アルドースレダクターゼ阻害薬とシクロオキシゲナーゼ−2阻害薬の併用
TWI250980B (en) * 2002-01-09 2006-03-11 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents

Also Published As

Publication number Publication date
IL156462A0 (en) 2004-01-04
NZ528406A (en) 2004-03-26
TWI245762B (en) 2005-12-21
DE60202452T2 (de) 2006-02-09
DE60202452C5 (de) 2006-11-23
IS6845A (is) 2003-06-16
DE60217930D1 (de) 2007-03-15
TNSN02037A1 (fr) 2005-12-23
EP1373259A1 (en) 2004-01-02
EA200300673A1 (ru) 2003-12-25
DE60217930T2 (de) 2007-10-18
CN1500087A (zh) 2004-05-26
DK1491540T3 (da) 2007-03-26
EP1491541B1 (en) 2007-01-24
HUP0303644A3 (en) 2008-06-30
EP1373259B1 (en) 2004-12-29
US20020143017A1 (en) 2002-10-03
CZ20032563A3 (cs) 2004-05-12
SI1373259T1 (en) 2005-04-30
CN1215067C (zh) 2005-08-17
CA2442476A1 (en) 2002-10-10
AP2002002461A0 (en) 2002-06-30
ECSP034671A (es) 2003-08-29
AU2002226634B2 (en) 2007-01-25
NO20034345L (no) 2003-09-29
JP2004528319A (ja) 2004-09-16
KR100586138B1 (ko) 2006-06-07
PL365294A1 (en) 2004-12-27
ES2231681T3 (es) 2005-05-16
ES2274369T3 (es) 2007-05-16
EP1491540A1 (en) 2004-12-29
DK1373259T3 (da) 2005-03-29
HK1061678A1 (en) 2004-09-30
ZA200304671B (en) 2004-06-25
BR0208571A (pt) 2004-03-23
IS8251A (is) 2006-01-23
HUP0303644A2 (hu) 2004-03-01
BG108179A (en) 2004-09-30
AR035798A1 (es) 2004-07-14
PT1491540E (pt) 2007-01-31
ATE348100T1 (de) 2007-01-15
ATE352551T1 (de) 2007-02-15
DE60202452D1 (de) 2005-02-03
KR20030088484A (ko) 2003-11-19
UA73236C2 (en) 2005-06-15
WO2002079198A1 (en) 2002-10-10
HRP20030752A2 (en) 2005-06-30
YU71403A (sh) 2006-05-25
IS8250A (is) 2006-01-23
PA8541801A1 (es) 2002-10-28
US20030162784A1 (en) 2003-08-28
MY134304A (en) 2007-12-31
PT1373259E (pt) 2005-03-31
EA006023B1 (ru) 2005-08-25
UY27237A1 (es) 2002-12-31
GEP20053675B (en) 2005-11-25
MA27003A1 (fr) 2004-12-20
MXPA03008850A (es) 2003-12-04
EE200300470A (et) 2004-02-16
SK11852003A3 (sk) 2004-07-07
ATE286049T1 (de) 2005-01-15
EP1491541A1 (en) 2004-12-29
EP1491540B1 (en) 2006-12-13
PE20030007A1 (es) 2003-01-28
IS2205B (is) 2007-02-15
US6849629B2 (en) 2005-02-01
DE60216823D1 (de) 2007-01-25
US6579879B2 (en) 2003-06-17
DE60216823T2 (de) 2007-10-04
OA12453A (en) 2006-05-24

Similar Documents

Publication Publication Date Title
ATE352551T1 (de) Pyridazinon aldose reductase inhibitoren
CY2015028I1 (el) Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης
DE60234125D1 (de) E inhibitoren
ATE397925T1 (de) Cis-imidazoline als mdm2-hemmer
PT1370553E (pt) Inibidores de rhoquinase
DE60218138D1 (de) Rho-kinase inhibitoren
DE60301683D1 (de) Leseverstärker
ATE368651T1 (de) Pyridazinon-derivate als gsk-3beta-hemmer
NO20041983D0 (no) C-5-modifiserte indazolylprrolotriaziner
ATE452891T1 (de) Pyrimidopyrimidone als kinaseinhibitoren
ATE484496T1 (de) Metalloproteinaseinhibitoren
EE200300439A (et) Metalloproteinaasi inhibiitorid
NO20042742L (no) Pyrimidinforbindelser
EE200300450A (et) Metalloproteinaasi inhibiitorid
DE60239456D1 (de) Amplifizierungsverfahren
DE60201856D1 (de) Klasse-D Verstärker
DE60222443D1 (de) Vorverstärkungsschaltung
SE0100694D0 (sv) DHFR inhibitors
ITVA20020070A1 (it) Composizioni farmaceutico-dietetiche comprendenti inibitori della hmg-coa reduttasi e/o polielettroliti.
ATE270267T1 (de) Scyphostatin-analoga als smase-inhibitoren
UA5096S (uk) Суцільнометалевий піввагон
FI20010995A0 (fi) Audiovahvistin
FI20011758A0 (fi) Henkilökohtainen virtsauslaite