NO20024811L - FremgangsmÕte ved syntese av N-[(S)-1-karboksybutyl]-(S)- alaninestere og anvendelse i syntesen av perindopril - Google Patents

FremgangsmÕte ved syntese av N-[(S)-1-karboksybutyl]-(S)- alaninestere og anvendelse i syntesen av perindopril

Info

Publication number
NO20024811L
NO20024811L NO20024811A NO20024811A NO20024811L NO 20024811 L NO20024811 L NO 20024811L NO 20024811 A NO20024811 A NO 20024811A NO 20024811 A NO20024811 A NO 20024811A NO 20024811 L NO20024811 L NO 20024811L
Authority
NO
Norway
Prior art keywords
synthesis
perindopril
carboxybutyl
alanine esters
alanine
Prior art date
Application number
NO20024811A
Other languages
English (en)
Other versions
NO20024811D0 (no
NO327970B1 (no
Inventor
Jean-Claude Souvie
Alain Renaud
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20024811D0 publication Critical patent/NO20024811D0/no
Publication of NO20024811L publication Critical patent/NO20024811L/no
Publication of NO327970B1 publication Critical patent/NO327970B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen vedrører en stereoselektiv fremgangsmåte for den industrielle syntese av forbindelser med formel (I):. hvori R representerer en lineær eller forgrenet (Q-C) alkylgruppe. Oppfinnelsen er nyttig for syntesen av perindopril og de farmasøytisk akseptable salter derav.
NO20024811A 2000-04-11 2002-10-04 Fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntesen av perindopril NO327970B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004610A FR2807430B1 (fr) 2000-04-11 2000-04-11 Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
PCT/FR2001/001088 WO2001056972A1 (fr) 2000-04-11 2001-04-10 Nouveau procede de synthese des esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (3)

Publication Number Publication Date
NO20024811D0 NO20024811D0 (no) 2002-10-04
NO20024811L true NO20024811L (no) 2002-10-04
NO327970B1 NO327970B1 (no) 2009-11-02

Family

ID=8849107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024811A NO327970B1 (no) 2000-04-11 2002-10-04 Fremgangsmate ved syntese av N-[(S)-1-karboksybutyl]-(S)-alaninestere og anvendelse i syntesen av perindopril

Country Status (36)

Country Link
US (1) US6774259B2 (no)
EP (1) EP1272454B1 (no)
JP (1) JP3872344B2 (no)
KR (1) KR100520700B1 (no)
CN (1) CN1176903C (no)
AP (1) AP1417A (no)
AR (1) AR027782A1 (no)
AT (1) ATE362913T1 (no)
AU (2) AU5046701A (no)
BG (1) BG65833B1 (no)
BR (1) BR0109963A (no)
CA (1) CA2405466C (no)
CY (1) CY1106720T1 (no)
CZ (1) CZ302603B6 (no)
DE (1) DE60128554T2 (no)
DK (1) DK1272454T3 (no)
EA (1) EA004265B1 (no)
EE (1) EE05030B1 (no)
ES (1) ES2287114T3 (no)
FR (1) FR2807430B1 (no)
GE (1) GEP20063798B (no)
HK (1) HK1053300A1 (no)
HR (1) HRP20020887B1 (no)
HU (1) HU229189B1 (no)
ME (1) ME00442B (no)
MX (1) MXPA02009888A (no)
NO (1) NO327970B1 (no)
NZ (1) NZ521846A (no)
OA (1) OA12246A (no)
PL (1) PL346553A1 (no)
PT (1) PT1272454E (no)
RS (1) RS50240B (no)
SK (1) SK287067B6 (no)
UA (1) UA72040C2 (no)
WO (1) WO2001056972A1 (no)
ZA (1) ZA200207689B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf
ES2334900T3 (es) * 2003-09-01 2010-03-17 Les Laboratoires Servier Nuevo procedimiento de sintesis de esteres de n-((s)-1-carboxibutil)-(s)-alanina y su aplicacion a la sintesis de perindopril.
ES2256693T3 (es) * 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
PT1403278E (pt) * 2003-09-30 2005-09-30 Servier Lab Processo de sintese da n-((s)-1-carbetoxibutil)-(s)-alanina e aplicacao a sintese do perindopril
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
FI126564B (fi) 2011-02-28 2017-02-15 Andritz Oy Menetelmä ja laitteisto meesan polttamiseksi
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
EA004265B1 (ru) 2004-02-26
CN1422245A (zh) 2003-06-04
AP2002002639A0 (en) 2002-09-30
EE200200586A (et) 2004-04-15
BG107250A (bg) 2003-06-30
HU0101337D0 (en) 2001-06-28
EE05030B1 (et) 2008-06-16
ME00442B (me) 2011-10-10
CA2405466C (fr) 2005-02-15
CN1176903C (zh) 2004-11-24
EA200201049A1 (ru) 2003-02-27
NZ521846A (en) 2004-07-30
ATE362913T1 (de) 2007-06-15
PT1272454E (pt) 2007-08-01
DK1272454T3 (da) 2007-09-17
AR027782A1 (es) 2003-04-09
SK14572002A3 (sk) 2003-02-04
DE60128554T2 (de) 2008-02-21
US20030109743A1 (en) 2003-06-12
CZ20023323A3 (cs) 2003-01-15
FR2807430A1 (fr) 2001-10-12
FR2807430B1 (fr) 2002-05-17
ZA200207689B (en) 2003-09-25
AP1417A (en) 2005-05-24
OA12246A (en) 2003-12-08
JP2003521530A (ja) 2003-07-15
MXPA02009888A (es) 2004-09-06
UA72040C2 (en) 2005-01-17
NO20024811D0 (no) 2002-10-04
PL346553A1 (en) 2001-09-10
HK1053300A1 (en) 2003-10-17
HUP0101337A3 (en) 2002-11-28
EP1272454A1 (fr) 2003-01-08
EP1272454B1 (fr) 2007-05-23
BG65833B1 (bg) 2010-02-26
DE60128554D1 (de) 2007-07-05
RS50240B (sr) 2009-07-15
CY1106720T1 (el) 2012-05-23
GEP20063798B (en) 2006-04-25
NO327970B1 (no) 2009-11-02
HU229189B1 (hu) 2013-09-30
SK287067B6 (sk) 2009-11-05
AU2001250467B2 (en) 2005-02-17
YU76702A (sh) 2006-05-25
ES2287114T3 (es) 2007-12-16
AU5046701A (en) 2001-08-14
HUP0101337A2 (hu) 2001-11-28
HRP20020887B1 (en) 2011-03-31
KR20020093902A (ko) 2002-12-16
JP3872344B2 (ja) 2007-01-24
CZ302603B6 (cs) 2011-08-03
CA2405466A1 (fr) 2001-08-09
HRP20020887A2 (en) 2004-02-29
KR100520700B1 (ko) 2005-10-17
US6774259B2 (en) 2004-08-10
WO2001056972A1 (fr) 2001-08-09
BR0109963A (pt) 2003-08-05

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