AR027782A1 - Nuevo procedimiento para la sintesis de los esteres de n-[(s)-1-carboxibutil]-(s)-alanina y su aplicacion en la sintesis del perindoprilo - Google Patents

Nuevo procedimiento para la sintesis de los esteres de n-[(s)-1-carboxibutil]-(s)-alanina y su aplicacion en la sintesis del perindoprilo

Info

Publication number
AR027782A1
AR027782A1 ARP010101670A ARP010101670A AR027782A1 AR 027782 A1 AR027782 A1 AR 027782A1 AR P010101670 A ARP010101670 A AR P010101670A AR P010101670 A ARP010101670 A AR P010101670A AR 027782 A1 AR027782 A1 AR 027782A1
Authority
AR
Argentina
Prior art keywords
synthesis
application
perindoprile
carboxibute
esteres
Prior art date
Application number
ARP010101670A
Other languages
English (en)
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR027782A1 publication Critical patent/AR027782A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un procedimiento estereoselectivo para la síntesis industrial de los compuestos de la formula (1) donde R representa un grupo alquilo (C1-6)lineal oramificado. Su aplicacion en la síntesis de perindoprilo y sus sales farmacéuticamente aceptables.
ARP010101670A 2000-04-11 2001-04-09 Nuevo procedimiento para la sintesis de los esteres de n-[(s)-1-carboxibutil]-(s)-alanina y su aplicacion en la sintesis del perindoprilo AR027782A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0004610A FR2807430B1 (fr) 2000-04-11 2000-04-11 Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
AR027782A1 true AR027782A1 (es) 2003-04-09

Family

ID=8849107

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101670A AR027782A1 (es) 2000-04-11 2001-04-09 Nuevo procedimiento para la sintesis de los esteres de n-[(s)-1-carboxibutil]-(s)-alanina y su aplicacion en la sintesis del perindoprilo

Country Status (36)

Country Link
US (1) US6774259B2 (es)
EP (1) EP1272454B1 (es)
JP (1) JP3872344B2 (es)
KR (1) KR100520700B1 (es)
CN (1) CN1176903C (es)
AP (1) AP1417A (es)
AR (1) AR027782A1 (es)
AT (1) ATE362913T1 (es)
AU (2) AU5046701A (es)
BG (1) BG65833B1 (es)
BR (1) BR0109963A (es)
CA (1) CA2405466C (es)
CY (1) CY1106720T1 (es)
CZ (1) CZ302603B6 (es)
DE (1) DE60128554T2 (es)
DK (1) DK1272454T3 (es)
EA (1) EA004265B1 (es)
EE (1) EE05030B1 (es)
ES (1) ES2287114T3 (es)
FR (1) FR2807430B1 (es)
GE (1) GEP20063798B (es)
HK (1) HK1053300A1 (es)
HR (1) HRP20020887B1 (es)
HU (1) HU229189B1 (es)
ME (1) ME00442B (es)
MX (1) MXPA02009888A (es)
NO (1) NO327970B1 (es)
NZ (1) NZ521846A (es)
OA (1) OA12246A (es)
PL (1) PL346553A1 (es)
PT (1) PT1272454E (es)
RS (1) RS50240B (es)
SK (1) SK287067B6 (es)
UA (1) UA72040C2 (es)
WO (1) WO2001056972A1 (es)
ZA (1) ZA200207689B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ATE395913T1 (de) 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
DK1362845T3 (da) * 2003-09-01 2010-01-18 Servier Lab Ny fremgangsmåde til fremstilling af estere af N-((S)-1-carboxybutyl)-(S)-alanin og deres anvendelse ved fremstilling af perindopril
EP1403278B1 (fr) * 2003-09-30 2005-06-08 Les Laboratoires Servier Procédé de synthèse de la N-((S)-1-carbéthoxybutyl)-(S)-alanine et application à la synthèse du perindopril
ES2256693T3 (es) * 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
EA011712B1 (ru) * 2004-03-29 2009-04-28 Ле Лаборатуар Сервье Способ производства твёрдой фармацевтической композиции
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
FI126564B (fi) 2011-02-28 2017-02-15 Andritz Oy Menetelmä ja laitteisto meesan polttamiseksi
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
KR20020093902A (ko) 2002-12-16
EP1272454B1 (fr) 2007-05-23
HUP0101337A3 (en) 2002-11-28
CY1106720T1 (el) 2012-05-23
NZ521846A (en) 2004-07-30
NO327970B1 (no) 2009-11-02
CA2405466A1 (fr) 2001-08-09
WO2001056972A1 (fr) 2001-08-09
BG107250A (bg) 2003-06-30
EA004265B1 (ru) 2004-02-26
PT1272454E (pt) 2007-08-01
HRP20020887B1 (en) 2011-03-31
BG65833B1 (bg) 2010-02-26
ES2287114T3 (es) 2007-12-16
NO20024811L (no) 2002-10-04
EE200200586A (et) 2004-04-15
JP3872344B2 (ja) 2007-01-24
EP1272454A1 (fr) 2003-01-08
ZA200207689B (en) 2003-09-25
JP2003521530A (ja) 2003-07-15
AU2001250467B2 (en) 2005-02-17
US20030109743A1 (en) 2003-06-12
NO20024811D0 (no) 2002-10-04
US6774259B2 (en) 2004-08-10
AP2002002639A0 (en) 2002-09-30
CZ20023323A3 (cs) 2003-01-15
HRP20020887A2 (en) 2004-02-29
CZ302603B6 (cs) 2011-08-03
OA12246A (en) 2003-12-08
CN1422245A (zh) 2003-06-04
KR100520700B1 (ko) 2005-10-17
HK1053300A1 (en) 2003-10-17
ATE362913T1 (de) 2007-06-15
FR2807430A1 (fr) 2001-10-12
FR2807430B1 (fr) 2002-05-17
GEP20063798B (en) 2006-04-25
DE60128554T2 (de) 2008-02-21
CA2405466C (fr) 2005-02-15
HU0101337D0 (en) 2001-06-28
BR0109963A (pt) 2003-08-05
AP1417A (en) 2005-05-24
DK1272454T3 (da) 2007-09-17
ME00442B (me) 2011-10-10
SK287067B6 (sk) 2009-11-05
HU229189B1 (hu) 2013-09-30
AU5046701A (en) 2001-08-14
HUP0101337A2 (hu) 2001-11-28
DE60128554D1 (de) 2007-07-05
EE05030B1 (et) 2008-06-16
CN1176903C (zh) 2004-11-24
EA200201049A1 (ru) 2003-02-27
PL346553A1 (en) 2001-09-10
RS50240B (sr) 2009-07-15
YU76702A (sh) 2006-05-25
MXPA02009888A (es) 2004-09-06
UA72040C2 (en) 2005-01-17
SK14572002A3 (sk) 2003-02-04

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee