NO20021781L - Heteroalkylamino-substituerte bicykliske nitrogenheterocykler som inhibitorer for P38-proteinkinase - Google Patents
Heteroalkylamino-substituerte bicykliske nitrogenheterocykler som inhibitorer for P38-proteinkinaseInfo
- Publication number
- NO20021781L NO20021781L NO20021781A NO20021781A NO20021781L NO 20021781 L NO20021781 L NO 20021781L NO 20021781 A NO20021781 A NO 20021781A NO 20021781 A NO20021781 A NO 20021781A NO 20021781 L NO20021781 L NO 20021781L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- heteroalkylamino
- protein kinase
- substituted bicyclic
- nitrogen heterocycles
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000012826 P38 inhibitor Substances 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16080399P | 1999-10-21 | 1999-10-21 | |
| US21374300P | 2000-06-22 | 2000-06-22 | |
| PCT/EP2000/010088 WO2001029042A1 (en) | 1999-10-21 | 2000-10-13 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20021781D0 NO20021781D0 (no) | 2002-04-16 |
| NO20021781L true NO20021781L (no) | 2002-04-18 |
Family
ID=26857240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021781A NO20021781L (no) | 1999-10-21 | 2002-04-16 | Heteroalkylamino-substituerte bicykliske nitrogenheterocykler som inhibitorer for P38-proteinkinase |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6451804B1 (de) |
| EP (1) | EP1228070B1 (de) |
| JP (1) | JP3961830B2 (de) |
| KR (1) | KR100523120B1 (de) |
| CN (1) | CN1171889C (de) |
| AR (1) | AR026084A1 (de) |
| AT (1) | ATE353329T1 (de) |
| AU (1) | AU776250B2 (de) |
| BR (1) | BR0015243A (de) |
| CA (1) | CA2388142C (de) |
| CZ (1) | CZ20021744A3 (de) |
| DE (1) | DE60033307T2 (de) |
| ES (1) | ES2280247T3 (de) |
| HR (1) | HRP20020328A2 (de) |
| HU (1) | HUP0203564A3 (de) |
| IL (1) | IL149100A0 (de) |
| MA (1) | MA26837A1 (de) |
| MX (1) | MXPA02003950A (de) |
| NO (1) | NO20021781L (de) |
| NZ (1) | NZ518119A (de) |
| PE (1) | PE20010758A1 (de) |
| PL (1) | PL357502A1 (de) |
| RU (1) | RU2265606C2 (de) |
| TR (1) | TR200201057T2 (de) |
| WO (1) | WO2001029042A1 (de) |
| YU (1) | YU29102A (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU763839B2 (en) | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| EP1492790A1 (de) * | 2002-04-03 | 2005-01-05 | F. Hoffmann-La Roche Ag | Imidazokondensierte verbindungen |
| KR20040103972A (ko) * | 2002-04-19 | 2004-12-09 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
| DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| CA2492112A1 (en) * | 2002-08-06 | 2004-02-19 | F. Hoffmann-La Roche Ag | 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors |
| US7084270B2 (en) * | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| BR0316375A (pt) * | 2002-11-18 | 2005-10-04 | Hoffmann La Roche | Diazinopirimidinas |
| JP2006522756A (ja) | 2003-04-10 | 2006-10-05 | エフ．ホフマン−ラ ロシュ アーゲー | ピリミド化合物 |
| MXPA06001098A (es) | 2003-07-29 | 2006-04-24 | Irm Llc | Compuestos y composiciones utiles como inhibidores de proteina cinasa. |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| KR100853974B1 (ko) | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 7-아미노-3-페닐 디히드로피리미도[4,5-ｄ]피리미디논의아미드 유도체, 그의 제조 방법 및 약학제로서의 용도 |
| BRPI0514738A (pt) | 2004-08-31 | 2008-06-24 | Hoffmann La Roche | derivados de amida de 3-fenil-diidropirimido[4,5-d]pirimidinonas, sua fabricação e aplicação como agentes farmacêuticos |
| WO2006038112A1 (en) * | 2004-10-01 | 2006-04-13 | Warner-Lambert Company Llc | Use of kinase inhibitors to promote neochondrogenesis |
| EP1831215A1 (de) * | 2004-11-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Pyrido[2,3-d]pyrimidine als entzüngungshemmende mittel |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1846403A1 (de) * | 2005-02-02 | 2007-10-24 | Ranbaxy Laboratories Limited | Azabicycloderivate als entzündungshemmende mittel |
| CN101341116A (zh) * | 2005-12-22 | 2009-01-07 | 巴斯夫欧洲公司 | 制备o-烷基化环状氨基醇的方法 |
| JP2009525292A (ja) | 2006-01-31 | 2009-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
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| GB8814352D0 (en) | 1988-06-16 | 1988-07-20 | Smith Kline French Lab | Chemical compounds |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| ES2221213T3 (es) * | 1997-10-20 | 2004-12-16 | F. Hoffmann-La Roche Ag | Inhibidores de kinasa biciclicos. |
| AU763839B2 (en) * | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| NZ510760A (en) * | 1998-10-23 | 2003-08-29 | F | Bicyclic nitrogen heterocycles |
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