NO20020374D0 - Karboksylsyreamider, medikamenter inneholdende disse forbindelser, deres anvendelse og fremstilling - Google Patents

Karboksylsyreamider, medikamenter inneholdende disse forbindelser, deres anvendelse og fremstilling

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Publication number
NO20020374D0
NO20020374D0 NO20020374A NO20020374A NO20020374D0 NO 20020374 D0 NO20020374 D0 NO 20020374D0 NO 20020374 A NO20020374 A NO 20020374A NO 20020374 A NO20020374 A NO 20020374A NO 20020374 D0 NO20020374 D0 NO 20020374D0
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NO
Norway
Prior art keywords
compounds
preparation
carboxylic acid
acid amides
drugs containing
Prior art date
Application number
NO20020374A
Other languages
English (en)
Norwegian (no)
Other versions
NO20020374L (no
Inventor
Norbert Hauel
Henning Priepke
Klaus Damm
Andreas Schnapp
Original Assignee
Boehringer Ingelheim Pharma
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Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20020374L publication Critical patent/NO20020374L/no
Publication of NO20020374D0 publication Critical patent/NO20020374D0/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C271/06—Esters of carbamic acids
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645964B1 (en) * 1999-11-29 2003-11-11 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agent
EP1319657A4 (fr) * 2000-09-22 2005-03-02 Nihon Nohyaku Co Ltd Derives de n-(4-pyrazolyl amide, produits chimiques pour utilisation agricole et horticole et applications desdits derives
DE10065042A1 (de) * 2000-12-23 2002-06-27 Boehringer Ingelheim Pharma Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
US6887873B2 (en) * 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US20040132807A1 (en) * 2001-04-18 2004-07-08 Dario Ballinari Aurones as telomerase inhibitors
FR2825090B1 (fr) * 2001-05-28 2003-08-01 Aventis Pharma Sa Derives chimiques et leur application comme agent antitelomerase
WO2002096903A2 (fr) * 2001-05-28 2002-12-05 Aventis Pharma S.A. Derives chimiques et leur application comme agent antitelomerase
GB0127615D0 (en) * 2001-07-09 2002-01-09 Aventis Pharm Prod Inc Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity
EP1463714A4 (fr) * 2001-12-10 2005-10-19 Amgen Inc Ligands de recepteur vanilloide et utilisation de ceux-ci dans des traitements
US20070232572A1 (en) * 2003-02-07 2007-10-04 Aventis Pharma S.A. Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent
WO2004082677A1 (fr) * 2003-03-21 2004-09-30 H. Lundbeck A/S Derives de para-diaminobenzene substitues
GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
CA2580852A1 (fr) * 2004-09-21 2006-03-30 Synta Pharmaceutical Corp. Composes pour l'inflammation et applications associees aux troubles immuns
JPWO2006054793A1 (ja) * 2004-11-19 2008-06-05 財団法人新産業創造研究機構 ベンゾフラン化合物、およびそれを含有してなる医薬組成物
US20070072873A1 (en) * 2005-09-27 2007-03-29 Henrietta Dehmlow Novel thiophene derivatives which are HM74A agonists
DK2799427T3 (en) * 2006-07-05 2018-10-22 Fibrotech Therapeutics Pty Ltd Therapeutic compounds
RU2470910C9 (ru) 2007-06-29 2013-05-20 Акьюсела, Инк. Соединения, представляющие собой алкинилфенильные производные, для лечения офтальмических заболеваний и расстройств
CN101835747A (zh) 2007-07-24 2010-09-15 安斯泰来制药有限公司 苯并咪唑衍生物
US8624056B2 (en) * 2007-12-21 2014-01-07 Fibrotech Therapeutics Pty Ltd Halogenated analogues of anti-fibrotic agents
WO2009100323A2 (fr) * 2008-02-08 2009-08-13 Grand Valley State University Procédés d'utilisation d'amides carboxyliques comme agents antimicrobiens
EP2383573A4 (fr) 2009-01-27 2012-10-24 Astellas Pharma Inc Procédé de criblage de substance utile en tant qu'agent pour le cancer de la prostate
WO2010144959A1 (fr) * 2009-06-18 2010-12-23 Fibrotech Therapeutics Pty Ltd Analogues d'agents antifibrotiques
US9062076B2 (en) 2009-10-22 2015-06-23 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
WO2013041621A1 (fr) 2011-09-20 2013-03-28 Basf Se Modulateurs à faible masse moléculaire du récepteur sensible au froid et au menthol trpm8, et leur utilisation
WO2013091011A1 (fr) * 2011-12-21 2013-06-27 Biota Europe Ltd Composés hétérocycliques d'urée
US11014873B2 (en) 2017-02-03 2021-05-25 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
CN110357789B (zh) * 2018-04-11 2022-09-30 华东理工大学 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途
CN114831977B (zh) * 2021-02-02 2023-12-19 北京大学 苯甲酸类衍生物作为trpm2蛋白抑制剂的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640710B2 (fr) 1973-01-18 1981-09-22
JPS5848545B2 (ja) * 1974-04-18 1983-10-28 キツセイヤクヒンコウギヨウ カブシキガイシヤ シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ
JPS6097946A (ja) * 1983-11-01 1985-05-31 Ono Pharmaceut Co Ltd カルボキサミド誘導体
JPS60139646A (ja) * 1983-12-27 1985-07-24 Otsuka Pharmaceut Factory Inc ナフタレン誘導体
JPS60146855A (ja) * 1984-01-11 1985-08-02 Ono Pharmaceut Co Ltd アニリン誘導体
JPS61170528A (ja) 1985-01-22 1986-08-01 Sutaaroi Sangyo Kk コバルトの剥離回収方法
JPH0578315A (ja) * 1991-03-11 1993-03-30 Kyowa Hakko Kogyo Co Ltd インドール誘導体
DE69212058T2 (de) * 1991-03-11 1997-01-09 Kyowa Hakko Kogyo Kk Indol-Derivate
JPH0672866A (ja) * 1992-07-02 1994-03-15 Chugoku Igakuka Gakuin Yakubutsu Kenkyusho 分化誘導剤
IT1276462B1 (it) 1995-07-03 1997-10-31 Rotta Research Lab Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
JPH09154575A (ja) * 1995-10-04 1997-06-17 Soosei:Kk テロメラーゼ
IT1286141B1 (it) 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
FR2759368B1 (fr) 1997-02-10 2001-06-01 Galderma Rech Dermatologique Composes biaromatiques, compositions les contenant et utilisations
JPH1149676A (ja) * 1997-07-31 1999-02-23 Geron Corp ピリジン系テロメラーゼ阻害剤
BR9811845A (pt) * 1997-08-05 2000-08-08 American Home Prod Análogos do ácido antranìlico
WO1999029674A1 (fr) 1997-12-11 1999-06-17 Janssen Pharmaceutica N.V. Anilides mimetiques de l'acide retinoique
CA2338804A1 (fr) 1998-07-28 2000-02-10 Smithkline Beecham Corporation Propenamides tenant lieu de modulateurs de ccr5
EP1127054A4 (fr) 1998-10-29 2006-11-02 Bristol Myers Squibb Co Nouveaux inhibiteurs de l'enzyme impdh

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ZA200200694B (en) 2003-09-23
CN1414849A (zh) 2003-04-30
AU6436800A (en) 2001-02-13
PL361335A1 (en) 2004-10-04
US20020099089A1 (en) 2002-07-25
JP2003518475A (ja) 2003-06-10
US6362210B1 (en) 2002-03-26
TR200200226T2 (tr) 2002-09-23
US6727250B2 (en) 2004-04-27
HUP0204373A2 (hu) 2003-03-28
BR0013184A (pt) 2003-07-01
WO2001007020A3 (fr) 2002-09-19
DE19935219A1 (de) 2001-02-01
HRP20020072A2 (en) 2003-10-31
EE200200041A (et) 2003-04-15
BG106343A (en) 2002-08-30
CA2378382A1 (fr) 2001-02-01
CA2378382C (fr) 2008-09-23
CO5180639A1 (es) 2002-07-30
NO20020374L (no) 2002-01-24
EA200200114A1 (ru) 2002-12-26
CZ2002313A3 (cs) 2002-06-12
SK2962002A3 (en) 2002-06-04
KR20020032537A (ko) 2002-05-03
WO2001007020A2 (fr) 2001-02-01
IL147707A0 (en) 2002-08-14
EP1261321A2 (fr) 2002-12-04
HUP0204373A3 (en) 2004-12-28
JP5010788B2 (ja) 2012-08-29
YU5502A (sh) 2005-06-10
AR024944A1 (es) 2002-10-30
MXPA02000822A (es) 2002-10-23
UY26256A1 (es) 2001-03-16

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