CO5180639A1 - Amidas de acidos carboxilicos medicamentos que contienen estos compuestos su utilizacion y su prepracion - Google Patents
Amidas de acidos carboxilicos medicamentos que contienen estos compuestos su utilizacion y su prepracionInfo
- Publication number
- CO5180639A1 CO5180639A1 CO00056547A CO00056547A CO5180639A1 CO 5180639 A1 CO5180639 A1 CO 5180639A1 CO 00056547 A CO00056547 A CO 00056547A CO 00056547 A CO00056547 A CO 00056547A CO 5180639 A1 CO5180639 A1 CO 5180639A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- amino
- substituted
- phenyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
1. Utilización de las amidas de ácidos carboxílicos de la fórmula general <EMI FILE="00056547_1" ID="1" IMF=JPEG >en la queR1 significa un átomo de hidrógeno, un grupo alquilo C1 3 o trifluorometilo, R2 significa un átomo de hidrógeno, flúor, cloro o bromo, un grupo alquilo C1 3, cicloalquilo C3 7 o alcoxi C1 3, o también, cuando R4 y R5 representan en cada caso un átomo de hidrógeno, R1 y R2 significan en común un grupo n alquileno C1 3 eventualmente sustituido con un grupo alquilo C1 3, R3 significa un átomo de hidrógeno o un grupo alquilo C1 5,R4 y R5 significan en cada caso un átomo de hidrógeno o en común otro enlace de carbono con carbono,A significa un grupo fenilo, naftilo o tetrahidronaftilo sustituido con un átomo de flúor, cloro, bromo o yodo, o con un grupo alquilo C1 6, cicloalquilo C3 7, fenilo, alcoxi C1 3, ciano, trifluorometilo o nitro, pudiendo los grupos fenilo y naftilo monosustituidos precedentemente mencionados estar sustituidos adicionalmente con un átomo de flúor, cloro o bromo, o con un grupo alquilo C1 3 o alcoxi C1 3, y pudiendo los grupos fenilo disustituidos precedentemente mencionados estar sustituidos adicionalmente con un grupo alquilo C1 3 o alcoxi C1 3, significa un grupo naftilo, significa un grupo de cromano o cromeno, en el que un grupo metileno puede estar reemplazado por un grupo carbonilo, significa un grupo heteroarilo de 5 ó 6 miembros, eventualmente sustituido en el entramado de carbonos con un átomo de flúor, cloro o bromo, o con un grupo alquilo C1 3 o alcoxi C1 3, conteniendo los grupos heteroarilo de 6 miembros uno, dos o tres átomos de nitrógeno y conteniendo los grupos heteroarilo de 5 miembros un grupo imino eventualmente sustituido con un grupo alquilo C1 3, un átomo de oxígeno o azufre o un grupo imino eventualmente sustituido con un grupo alquilo C1 3 y un átomo de oxígeno o azufre o uno o dos átomos de nitrógeno, y pudiendo estar condensado adicionalmente con los grupos heteroarilo monocíclicos precedentemente - 2 -mencionados a través de dos átomos de carbono contiguos un anillo de fenilo, que puede estar sustituido también en el entramado de carbonos con un átomo de flúor, cloro o bromo, o con un grupo alquilo C1 3 o alcoxi C1 3, significa un grupo fenil vinilo, o R1, en común con A y con el átomo de carbono situado entremedias, significa un grupo cicloalquilideno C5 7, con el que puede estar condensado a través de dos átomos de carbono contiguos un anillo de fenilo, que puede estar sustituido adicionalmente con uno o dos grupos alquilo C1 3 o alcoxi C1 3, pudiendo los sustituyentes ser iguales o diferentes, y B significa un grupo heteroarilo de 5 ó 6 miembros sustituido con un grupo carboxi o con un grupo transformable in vivo en un grupo carboxi,significa un grupo fenilo o naftilo, los cuales en cada caso pueden estar sustituidos con un grupo carboxi, con un grupo transformable in vivo en un grupo carboxi o con un grupo cargado negativamente en condiciones fisiológicas, pudiendo los grupos fenilo precedentemente mencionados estar sustituidos adicionalmente con un átomo de flúor, cloro, bromo o yodo, con un grupo alquilo C1 3, trifluorometilo, fenilo, hidroxi, alcoxi C1 3, alquil C1 3 sulfonil oxi, fenil sulfonil oxi, carboxi, alcoxi C1 3 carbonilo, formilo, alquil C1 3 carbonilo, alquil C1 3 sulfonilo, fenil sulfonilo, nitro, pirrolidino, piperidino, morfolino, N (alquil C1 3) piperazino, amino sulfonilo, alquil C1 3 amino sulfonilo o di (alquil C1 3) amino sulfonilo, con un grupo alquilo C1 3, que está sustituido con un grupo hidroxi, alcoxi C1 3, amino, alquil C1 4 amino, di (alquil C1 4) amino, cicloalquil C3 7 amino, pirrolidino, piperidino, morfolino, piperazino o N (alquil C1 3) piperazino, con un grupo alcoxi C2 3, alquenilo C2-3 o alquinilo C2-3 sustituido con un grupo di (alquil C1 3) amino en la posición 2 ó 3, con un grupo amino, con un grupo N (alquil C1 3) amino o N,N di (alquil C1 3) amino, en el que la parte de alquilo puede estar sustituida con un grupo alcoxi C1 3 en cada caso en la posición 2 ó 3, referida al átomo de nitrógeno, con un grupo N fenil amino, N (fenil alquil C1 3) amino o N (piridil alquil C1 3) amino, en los cuales en cada caso un átomo de hidrógeno de los grupos amino precedentemente mencionados puede estar reemplazado por un grupo alquil C1 3 sulfonilo, fenil alquil C1 3 sulfonilo o fenil sulfonilo, o con un grupo alquilo C1 7, que en las posiciones 2 a 5 puede estar reemplazado por un grupo alcoxi C1 3, ciano, amino, alquil C1 3 amino, di (alquil C1 3) amino o tetrazolilo, con un grupo amino carbonilo o alquil C1 3 amino carbonilo, los cuales en cada caso pueden estar sustituidos en el átomo de nitrógeno de amino con un grupo alquilo C1 4, que puede estar sustituido con un grupo vinilo, etinilo, fenilo, piridilo, imidazolilo, carboxi o trifluorometilo, o con excepción de la posición 2 referida al átomo de nitrógeno de amino carbonilo, puede estar sustituido con un grupo hidroxi, alcoxi C1 3, alquil C1 3 tio, amino, alquil C1 3 amino, di (alquil C1 3) amino, alcanoil C1 4 amino o alcoxi C1 5 carbonil amino, con un grupo cicloalquilo C3 7, aza bicicloalquilo C5 9, fenilo, piridilo, alcoxi C1 3 o di (alquil C1 3) amino, con un grupo alquilo C1 3, que está sustituido con un grupo piperidin 3 ilo o piperidin 4 ilo eventualmente sustituido en posición 1 con un grupo alquilo C1 3 o alcoxi C1 5 carbonilo, ocon un grupo amino, alquil C1 3 amino o fenil alquil C1 3 amino eventualmente sustituido en el átomo de nitrógeno de amino con un grupo alcanoílo C1 4, alcoxi C1 5 carbonilo, benzoílo, pirrolidino, piperidino, morfolino o N (alquil C1 3) piperazino, con un grupo carbonilo sustituido con un grupo pirrolidino, pirrolino, piperidino, morfolino o N (alquil C1 3) piperazino, con un grupo sulfonilo sustituido con un grupo amino, alquil C1 3 amino, di (alquil C1 3) amino, pirrolidino, piperidino, morfolino o N (alquil C1 3) piperazino, con un grupo amino o N (alquil C1 3) amino, que está sustituido en cada caso en el átomo de nitrógeno de amino con un grupo amino carbonilo, alquil C1 3 amino carbonilo, fenil alquil C1 3 amino carbonilo, fenil amino carbonilo, fenoxi fenil amino carbonilo, piridil amino carbonilo, pirrolidino carbonilo, piperidino carbonilo, morfolino carbonilo o - 3 -N (alquil C1 3) piperazino carbonilo, pudiendo un átomo de hidrógeno presente en los grupos amino carbonilo precedentemente mencionados estar sustituido adicionalmente con un grupo alquilo C1 3, con un grupo heteroarilo de 5 ó 6 miembros, con un grupo dihidro oxazolilo, dihidro imidazolilo, 2 oxo pirrolidino, 2 oxo piperidino o 2 oxo hexametilen imino, con los que puede estar condensado un anillo de fenilo a través de dos átomos de carbono contiguos, con un grupo etinilo sustituido con un grupo fenilo, hidroximetilo o dimetilamino, pudiendo los grupos fenilo mono o di sustituidos precedentemente mencionados estar sustituidos adicionalmente con otro átomo de flúor, cloro o bromo, o con uno o dos grupos alquilo C1 3 o alcoxi C1 3 adicionales y pudiendo dos grupos alcoxi C1 3 situados en posición o (= orto) estar reemplazados por un grupo metilendioxi,y los grupos heteroarilo de 6 miembros precedentemente mencionados contienen uno, dos o tres átomos de nitrógeno y los grupos heteroarilo de 5 miembros precedentemente mencionados contienen un grupo imino eventualmente sustituido con un grupo alquilo C1 3, un átomo de oxígeno o azufre o un grupo imino eventualmente sustituido con un grupo alquilo C1 3 y un átomo de oxígeno o azufre o uno o dos átomos de nitrógeno, y adicionalmente puede estar condensado con los grupos heteroarilo monocíclicos precedentemente mencionados a través de dos átomos de carbono contiguos un anillo de fenilo, que en el entramado de carbonos puede estar sustituido con un átomo de flúor, cloro o bromo, o con un grupo alquilo C1 3 o alcoxi C1 3, pudiendo los grupos heteroarilo monocíclicos de 5 miembros precedentemente mencionados estar sustituidos en el entramado de carbonos adicionalmente con un grupo alquilo C1 4, trifluorometilo, fenilo o furanilo y estar sustituidos con otro grupo alquilo C1 3, pudiendo los grupos amino e imino, mencionados con ocasión de la definición de los radicales precedentemente mencionados, estar sustituidos adicionalmente con un radical separable in vivo, sus isómeros y sus sales, especialmente sus sales fisiológicamente compatibles, para la inhibición de la telomerasa.
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Application Number | Priority Date | Filing Date | Title |
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DE19935219A DE19935219A1 (de) | 1999-07-27 | 1999-07-27 | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
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CO5180639A1 true CO5180639A1 (es) | 2002-07-30 |
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CO00056547A CO5180639A1 (es) | 1999-07-27 | 2000-07-27 | Amidas de acidos carboxilicos medicamentos que contienen estos compuestos su utilizacion y su prepracion |
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US (2) | US6362210B1 (es) |
EP (1) | EP1261321A2 (es) |
JP (1) | JP5010788B2 (es) |
KR (1) | KR20020032537A (es) |
CN (1) | CN1414849A (es) |
AR (1) | AR024944A1 (es) |
AU (1) | AU6436800A (es) |
BG (1) | BG106343A (es) |
BR (1) | BR0013184A (es) |
CA (1) | CA2378382C (es) |
CO (1) | CO5180639A1 (es) |
CZ (1) | CZ2002313A3 (es) |
DE (1) | DE19935219A1 (es) |
EA (1) | EA200200114A1 (es) |
EE (1) | EE200200041A (es) |
HR (1) | HRP20020072A2 (es) |
HU (1) | HUP0204373A3 (es) |
IL (1) | IL147707A0 (es) |
MX (1) | MXPA02000822A (es) |
NO (1) | NO20020374L (es) |
PL (1) | PL361335A1 (es) |
SK (1) | SK2962002A3 (es) |
TR (1) | TR200200226T2 (es) |
UY (1) | UY26256A1 (es) |
WO (1) | WO2001007020A2 (es) |
YU (1) | YU5502A (es) |
ZA (1) | ZA200200694B (es) |
Families Citing this family (28)
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US6645964B1 (en) * | 1999-11-29 | 2003-11-11 | Aventis Pharma S.A. | Chemical derivatives and their application as antitelomerase agent |
US20040043904A1 (en) * | 2000-09-22 | 2004-03-04 | Hiroshi Yamaguchi | N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same |
DE10065042A1 (de) * | 2000-12-23 | 2002-06-27 | Boehringer Ingelheim Pharma | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
US6887873B2 (en) | 2001-03-23 | 2005-05-03 | Aventis Pharma S.A. | Triazine derivatives and their application as antitelomerase agents |
CA2441274A1 (en) * | 2001-04-18 | 2002-10-24 | Pharmacia Italia S.P.A. | Aurones as telomerase inhibitors |
WO2002096903A2 (fr) * | 2001-05-28 | 2002-12-05 | Aventis Pharma S.A. | Derives chimiques et leur application comme agent antitelomerase |
FR2825090B1 (fr) * | 2001-05-28 | 2003-08-01 | Aventis Pharma Sa | Derives chimiques et leur application comme agent antitelomerase |
GB0127615D0 (en) * | 2001-07-09 | 2002-01-09 | Aventis Pharm Prod Inc | Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity |
WO2003049702A2 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
US20070232572A1 (en) * | 2003-02-07 | 2007-10-04 | Aventis Pharma S.A. | Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent |
JP2006520759A (ja) * | 2003-03-21 | 2006-09-14 | ハー・ルンドベック・アクチエゼルスカベット | 置換されたp−ジアミノベンゼン誘導体 |
GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
CN101083985A (zh) * | 2004-09-21 | 2007-12-05 | 幸讬制药公司 | 用于炎症及免疫相关用途的化合物 |
US8084492B2 (en) * | 2004-11-19 | 2011-12-27 | The New Industry Research Organization | Benzofuran compound and pharmaceutical composition containing the same |
US20070072873A1 (en) * | 2005-09-27 | 2007-03-29 | Henrietta Dehmlow | Novel thiophene derivatives which are HM74A agonists |
PL2035369T3 (pl) * | 2006-07-05 | 2015-02-27 | Fibrotech Therapeutics Pty Ltd | Związki terapeutyczne |
NZ601866A (en) | 2007-06-29 | 2013-12-20 | Acucela Inc | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
KR20100046107A (ko) | 2007-07-24 | 2010-05-06 | 아스텔라스세이야쿠 가부시키가이샤 | 벤즈이미다졸 유도체 |
JP5730578B2 (ja) * | 2007-12-21 | 2015-06-10 | フィブロテック セラピューティクス プロプライエタリー リミテッド | 抗線維症剤のハロゲン化類似体 |
WO2009100323A2 (en) * | 2008-02-08 | 2009-08-13 | Grand Valley State University | Methods of using carboxylic amides as antimicrobial agents |
JPWO2010087319A1 (ja) | 2009-01-27 | 2012-08-02 | アステラス製薬株式会社 | 前立腺癌治療剤として有効な物質のスクリーニング方法 |
WO2010144959A1 (en) * | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
EP2758041B1 (de) | 2011-09-20 | 2021-01-13 | Basf Se | Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung |
WO2013091011A1 (en) * | 2011-12-21 | 2013-06-27 | Biota Europe Ltd | Heterocyclic urea compounds |
MX2019009235A (es) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd | Compuestos antifibroticos. |
CN110357789B (zh) * | 2018-04-11 | 2022-09-30 | 华东理工大学 | 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途 |
CN114831977B (zh) * | 2021-02-02 | 2023-12-19 | 北京大学 | 苯甲酸类衍生物作为trpm2蛋白抑制剂的用途 |
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JPS5640710B2 (es) | 1973-01-18 | 1981-09-22 | ||
JPS5848545B2 (ja) * | 1974-04-18 | 1983-10-28 | キツセイヤクヒンコウギヨウ カブシキガイシヤ | シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ |
JPS6097946A (ja) * | 1983-11-01 | 1985-05-31 | Ono Pharmaceut Co Ltd | カルボキサミド誘導体 |
JPS60139646A (ja) * | 1983-12-27 | 1985-07-24 | Otsuka Pharmaceut Factory Inc | ナフタレン誘導体 |
JPS60146855A (ja) * | 1984-01-11 | 1985-08-02 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
JPS61170528A (ja) | 1985-01-22 | 1986-08-01 | Sutaaroi Sangyo Kk | コバルトの剥離回収方法 |
CA2062587A1 (en) * | 1991-03-11 | 1992-09-12 | Toshiaki Kumazawa | Indole derivatives |
JPH0578315A (ja) * | 1991-03-11 | 1993-03-30 | Kyowa Hakko Kogyo Co Ltd | インドール誘導体 |
JPH0672866A (ja) * | 1992-07-02 | 1994-03-15 | Chugoku Igakuka Gakuin Yakubutsu Kenkyusho | 分化誘導剤 |
IT1276462B1 (it) | 1995-07-03 | 1997-10-31 | Rotta Research Lab | Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico |
JPH09154575A (ja) * | 1995-10-04 | 1997-06-17 | Soosei:Kk | テロメラーゼ |
IT1286141B1 (it) | 1996-07-02 | 1998-07-07 | Rotta Research Lab | Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico. |
FR2759368B1 (fr) | 1997-02-10 | 2001-06-01 | Galderma Rech Dermatologique | Composes biaromatiques, compositions les contenant et utilisations |
JPH1149676A (ja) * | 1997-07-31 | 1999-02-23 | Geron Corp | ピリジン系テロメラーゼ阻害剤 |
AU8684598A (en) * | 1997-08-05 | 1999-03-01 | American Home Products Corporation | Anthranilic acid analogs |
AU2160899A (en) | 1997-12-11 | 1999-06-28 | Janssen Pharmaceutica N.V. | Retinoic acid mimetic anilides |
JP2002521441A (ja) | 1998-07-28 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | Ccr5モジュレーターとしてのプロペンアミド |
EP1127054A4 (en) | 1998-10-29 | 2006-11-02 | Bristol Myers Squibb Co | INHIBITORS OF IMPDH ENZYME |
-
1999
- 1999-07-27 DE DE19935219A patent/DE19935219A1/de not_active Withdrawn
-
2000
- 2000-07-18 US US09/618,702 patent/US6362210B1/en not_active Expired - Lifetime
- 2000-07-22 HU HU0204373A patent/HUP0204373A3/hu unknown
- 2000-07-22 MX MXPA02000822A patent/MXPA02000822A/es unknown
- 2000-07-22 IL IL14770700A patent/IL147707A0/xx unknown
- 2000-07-22 EE EEP200200041A patent/EE200200041A/xx unknown
- 2000-07-22 CN CN00812829A patent/CN1414849A/zh active Pending
- 2000-07-22 BR BR0013184-9A patent/BR0013184A/pt not_active Expired - Fee Related
- 2000-07-22 PL PL36133500A patent/PL361335A1/xx not_active Application Discontinuation
- 2000-07-22 WO PCT/EP2000/007057 patent/WO2001007020A2/de not_active Application Discontinuation
- 2000-07-22 YU YU5502A patent/YU5502A/sh unknown
- 2000-07-22 CZ CZ2002313A patent/CZ2002313A3/cs unknown
- 2000-07-22 TR TR2002/00226T patent/TR200200226T2/xx unknown
- 2000-07-22 KR KR1020027001103A patent/KR20020032537A/ko not_active Application Discontinuation
- 2000-07-22 AU AU64368/00A patent/AU6436800A/en not_active Abandoned
- 2000-07-22 EA EA200200114A patent/EA200200114A1/ru unknown
- 2000-07-22 SK SK296-2002A patent/SK2962002A3/sk not_active Application Discontinuation
- 2000-07-22 EP EP00951431A patent/EP1261321A2/de not_active Withdrawn
- 2000-07-22 JP JP2001511906A patent/JP5010788B2/ja not_active Expired - Fee Related
- 2000-07-22 CA CA002378382A patent/CA2378382C/en not_active Expired - Fee Related
- 2000-07-25 UY UY26256A patent/UY26256A1/es not_active Application Discontinuation
- 2000-07-26 AR ARP000103858A patent/AR024944A1/es not_active Withdrawn
- 2000-07-27 CO CO00056547A patent/CO5180639A1/es not_active Application Discontinuation
-
2002
- 2002-01-03 US US10/037,555 patent/US6727250B2/en not_active Expired - Lifetime
- 2002-01-23 BG BG106343A patent/BG106343A/xx active Pending
- 2002-01-24 NO NO20020374A patent/NO20020374L/no not_active Application Discontinuation
- 2002-01-25 ZA ZA200200694A patent/ZA200200694B/en unknown
- 2002-01-25 HR HR20020072A patent/HRP20020072A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6727250B2 (en) | 2004-04-27 |
CN1414849A (zh) | 2003-04-30 |
DE19935219A1 (de) | 2001-02-01 |
ZA200200694B (en) | 2003-09-23 |
NO20020374D0 (no) | 2002-01-24 |
MXPA02000822A (es) | 2002-10-23 |
CA2378382C (en) | 2008-09-23 |
UY26256A1 (es) | 2001-03-16 |
HUP0204373A3 (en) | 2004-12-28 |
US6362210B1 (en) | 2002-03-26 |
SK2962002A3 (en) | 2002-06-04 |
US20020099089A1 (en) | 2002-07-25 |
NO20020374L (no) | 2002-01-24 |
WO2001007020A3 (de) | 2002-09-19 |
HRP20020072A2 (en) | 2003-10-31 |
PL361335A1 (en) | 2004-10-04 |
CA2378382A1 (en) | 2001-02-01 |
JP2003518475A (ja) | 2003-06-10 |
TR200200226T2 (tr) | 2002-09-23 |
WO2001007020A2 (de) | 2001-02-01 |
EP1261321A2 (de) | 2002-12-04 |
KR20020032537A (ko) | 2002-05-03 |
JP5010788B2 (ja) | 2012-08-29 |
IL147707A0 (en) | 2002-08-14 |
HUP0204373A2 (hu) | 2003-03-28 |
BR0013184A (pt) | 2003-07-01 |
AR024944A1 (es) | 2002-10-30 |
CZ2002313A3 (cs) | 2002-06-12 |
EA200200114A1 (ru) | 2002-12-26 |
EE200200041A (et) | 2003-04-15 |
YU5502A (sh) | 2005-06-10 |
BG106343A (en) | 2002-08-30 |
AU6436800A (en) | 2001-02-13 |
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