NO179552C - Nye ikke-sedative antihistaminer avledet fra benzimidazoler, anvendelse av dem og farmasöytiske blandinger - Google Patents

Nye ikke-sedative antihistaminer avledet fra benzimidazoler, anvendelse av dem og farmasöytiske blandinger

Info

Publication number
NO179552C
NO179552C NO921315A NO921315A NO179552C NO 179552 C NO179552 C NO 179552C NO 921315 A NO921315 A NO 921315A NO 921315 A NO921315 A NO 921315A NO 179552 C NO179552 C NO 179552C
Authority
NO
Norway
Prior art keywords
radical
alkyl
hydroxyl
benzimidazoles
derived
Prior art date
Application number
NO921315A
Other languages
English (en)
Other versions
NO921315L (no
NO179552B (no
NO921315D0 (no
Inventor
Maria Rosa Cuberes-Altisent
Jordi Frigola Constansa
Juan Pares Corominas
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NO921315D0 publication Critical patent/NO921315D0/no
Publication of NO921315L publication Critical patent/NO921315L/no
Publication of NO179552B publication Critical patent/NO179552B/no
Publication of NO179552C publication Critical patent/NO179552C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO921315A 1991-04-05 1992-04-03 Nye ikke-sedative antihistaminer avledet fra benzimidazoler, anvendelse av dem og farmasöytiske blandinger NO179552C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9104171A FR2674856B1 (fr) 1991-04-05 1991-04-05 Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.

Publications (4)

Publication Number Publication Date
NO921315D0 NO921315D0 (no) 1992-04-03
NO921315L NO921315L (no) 1992-10-06
NO179552B NO179552B (no) 1996-07-22
NO179552C true NO179552C (no) 1996-10-30

Family

ID=9411523

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921315A NO179552C (no) 1991-04-05 1992-04-03 Nye ikke-sedative antihistaminer avledet fra benzimidazoler, anvendelse av dem og farmasöytiske blandinger

Country Status (28)

Country Link
US (1) US5214040A (no)
EP (1) EP0507696B1 (no)
JP (1) JP3060054B2 (no)
KR (1) KR970011298B1 (no)
CN (1) CN1028367C (no)
AT (1) ATE126228T1 (no)
AU (1) AU647904B2 (no)
BG (1) BG60678B1 (no)
BR (1) BR1100983A (no)
CA (1) CA2065061A1 (no)
CZ (1) CZ279506B6 (no)
DE (1) DE69203911T2 (no)
DK (1) DK0507696T3 (no)
ES (1) ES2046110B1 (no)
FI (1) FI99112C (no)
FR (1) FR2674856B1 (no)
GR (1) GR3017643T3 (no)
HU (1) HU214316B (no)
IL (1) IL101483A (no)
IS (1) IS1639B (no)
MX (1) MX9201556A (no)
NO (1) NO179552C (no)
NZ (1) NZ242208A (no)
PL (1) PL167720B1 (no)
RO (1) RO109198B1 (no)
RU (1) RU2099336C1 (no)
TW (1) TW208003B (no)
YU (1) YU48826B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264456B1 (it) * 1993-05-14 1996-09-23 Dompe Farmaceutici Spa Derivati del 2-(benzimidazol-2-il)-1,3-diaminopropano farmacologicamente attivi.
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
CA2213197C (en) * 1995-02-15 2001-08-07 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
HU230609B1 (hu) * 2000-01-19 2017-03-28 Cadila Healthcare Ltd. Hipolipidémiás és hipokoleszterinémiás hatású szubsztituált pirrolszármazékok, azokat tartalmazó gyógyszerkészítmények, eljárás előállításukra, köztitermékek és alkalmazásuk
CZ2003952A3 (cs) * 2000-10-31 2003-11-12 Basf Drucksysteme Gmbh Použití hyperrozvětvených polyurethanů
CA2473236A1 (en) * 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
CN101089000B (zh) * 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
MX2011013294A (es) * 2009-06-11 2012-01-12 Siena Biotech Spa Antagonistas de la trayectoria de hedgehog y aplicaciones terapeuticas de los mismos.
PT2938597T (pt) * 2012-12-27 2016-12-09 Université De Lille 2 Droit Et Santé Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização
KR102057075B1 (ko) * 2018-11-30 2019-12-19 우승열 페트병에 장착되는 여과장치

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5010075A (en) * 1987-04-24 1991-04-23 Syntex Pharmaceuticals Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Also Published As

Publication number Publication date
HU9201145D0 (en) 1992-06-29
HUT60732A (en) 1992-10-28
JPH0597846A (ja) 1993-04-20
CZ279506B6 (cs) 1995-05-17
FI921473A (fi) 1992-10-06
PL167720B1 (pl) 1995-10-31
IL101483A (en) 1995-12-08
MX9201556A (es) 1992-10-01
AU1397992A (en) 1992-10-08
HU214316B (hu) 1998-03-02
ES2046110A1 (es) 1994-01-16
NO921315L (no) 1992-10-06
CS101792A3 (en) 1992-10-14
ES2046110B1 (es) 1994-08-01
FR2674856B1 (fr) 1993-07-30
YU48826B (sh) 2002-03-18
RU2099336C1 (ru) 1997-12-20
GR3017643T3 (en) 1996-01-31
ATE126228T1 (de) 1995-08-15
CN1028367C (zh) 1995-05-10
BG60678B1 (bg) 1995-12-29
EP0507696B1 (fr) 1995-08-09
IS3832A (is) 1992-10-06
AU647904B2 (en) 1994-03-31
US5214040A (en) 1993-05-25
FR2674856A1 (fr) 1992-10-09
DK0507696T3 (da) 1995-09-18
DE69203911D1 (de) 1995-09-14
CN1065460A (zh) 1992-10-21
EP0507696A1 (fr) 1992-10-07
NZ242208A (en) 1993-10-26
IS1639B (is) 1997-03-25
KR970011298B1 (ko) 1997-07-09
NO179552B (no) 1996-07-22
KR920019781A (ko) 1992-11-20
PL294101A1 (en) 1992-11-30
JP3060054B2 (ja) 2000-07-04
FI99112C (fi) 1997-10-10
NO921315D0 (no) 1992-04-03
CA2065061A1 (fr) 1992-10-06
IL101483A0 (en) 1992-12-30
FI921473A0 (fi) 1992-04-03
DE69203911T2 (de) 1995-12-07
RO109198B1 (ro) 1994-12-30
TW208003B (no) 1993-06-21
YU33692A (sh) 1995-03-27
BR1100983A (pt) 1999-10-13
FI99112B (fi) 1997-06-30

Similar Documents

Publication Publication Date Title
NO179552C (no) Nye ikke-sedative antihistaminer avledet fra benzimidazoler, anvendelse av dem og farmasöytiske blandinger
ATE204873T1 (de) Naphthyridinderivate als angiotensin-ii- antagonist-inhibitoren
DK0513379T3 (da) 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne
CY1110863T1 (el) Παραγωγα του 2-(8,9-διοξο-2,6-διαζαδικυκλο (5.2.0)-εννε-1(7)-εν-2-υλ)αλκυλ-φωσφονικου οξεος και η χρηση τους ως ανταγωνιστων του ν-μεθυλ- d-ασπαρτικου (nmda) υποδοχεα
CY1110240T1 (el) Νεα παραγωγα 2η-πυριδαζινο-3-ονης, φαρμακευτικες συνθεσεις που τα περιεχουν και μεθοδος για την παρασκευη του δραστικου συστατικου
NO20000572L (no) Indolderivater som MCP-1 reseptor antagonister
ATE109481T1 (de) Diazinderivate als angiotensin ii rezeptor antagonisten.
NO912669D0 (no) Nye derivater av benzimidazol, deres fremstilling og anvendelse som legemidler.
NO961797L (no) Anvendelse av benzopyranderivater for fremstilling av farmasöytiske sammensetninger beregnet for behandling av patologier forbundet med den Na+-uavhengige C1-HCO3-utbytter
HUT63626A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
NZ225528A (en) Benzimidazoles substituted in the 2 position by n(4-n-guanidyl) piperidinyl radicals; preparations thereof; pharmaceutical compositions
ATE154010T1 (de) 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften
DE3862660D1 (de) 2,3-dihydro-2-oxo-3-benzofuranyl-essigsaeurederivate und diese enthaltende arzneimittel.
ECSP982623A (es) Derivados del 2-( 4-aril - o heteroaril - piperazin -1- ilmetil) -1h-indol

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN OCTOBER 2001