ATE154010T1 - 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften - Google Patents
2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaftenInfo
- Publication number
- ATE154010T1 ATE154010T1 AT91920369T AT91920369T ATE154010T1 AT E154010 T1 ATE154010 T1 AT E154010T1 AT 91920369 T AT91920369 T AT 91920369T AT 91920369 T AT91920369 T AT 91920369T AT E154010 T1 ATE154010 T1 AT E154010T1
- Authority
- AT
- Austria
- Prior art keywords
- thienyl
- phenyl
- piperidine derivatives
- neuroprotective properties
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59714790A | 1990-10-15 | 1990-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE154010T1 true ATE154010T1 (de) | 1997-06-15 |
Family
ID=24390300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91920369T ATE154010T1 (de) | 1990-10-15 | 1991-10-11 | 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften |
Country Status (11)
Country | Link |
---|---|
US (1) | US5714500A (de) |
EP (1) | EP0553278B1 (de) |
JP (1) | JP3094450B2 (de) |
AT (1) | ATE154010T1 (de) |
DE (1) | DE69126438T2 (de) |
DK (1) | DK0553278T3 (de) |
ES (1) | ES2103832T3 (de) |
GR (1) | GR3024388T3 (de) |
IE (1) | IE913606A1 (de) |
PT (1) | PT99207B (de) |
WO (1) | WO1992006957A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW281670B (de) * | 1993-09-02 | 1996-07-21 | Hoffmann La Roche | |
US5563157B1 (en) * | 1994-10-31 | 1999-02-02 | Hoecst Marion Roussel Inc | Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof |
WO2002072542A2 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
KR20100045983A (ko) * | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 nmda 수용체 길항물질 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2524643A (en) * | 1947-12-04 | 1950-10-03 | Maltbie Lab Inc | 3-phenyl-2-piperidones |
US2636881A (en) * | 1951-01-06 | 1953-04-28 | Sharp & Dohme Inc | 3-substituted, 3-aryl, 2-pipecolines and salts thereof |
EP0317953A3 (de) * | 1987-11-24 | 1990-12-05 | G.D. Searle & Co. | N-(1-Thienylcycloalkyl)alkenylamine zur Behandlung von neurotoxischen Krankheiten |
EP0346791B1 (de) * | 1988-06-14 | 1994-04-06 | G.D. Searle & Co. | 1,2-Diarylethylamine zur Behandlung neurotoxischer Verletzungen |
US4924008A (en) * | 1989-05-04 | 1990-05-08 | American Home Products Corporation | Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents |
US5109017A (en) * | 1990-09-26 | 1992-04-28 | Fisons Corporation | (2-thienyl)alkylamine derivatives having neuroprotective properties |
-
1991
- 1991-10-11 JP JP03518577A patent/JP3094450B2/ja not_active Expired - Fee Related
- 1991-10-11 WO PCT/US1991/007522 patent/WO1992006957A1/en active IP Right Grant
- 1991-10-11 EP EP91920369A patent/EP0553278B1/de not_active Expired - Lifetime
- 1991-10-11 AT AT91920369T patent/ATE154010T1/de not_active IP Right Cessation
- 1991-10-11 DE DE69126438T patent/DE69126438T2/de not_active Expired - Fee Related
- 1991-10-11 DK DK91920369.5T patent/DK0553278T3/da active
- 1991-10-11 PT PT99207A patent/PT99207B/pt not_active IP Right Cessation
- 1991-10-11 ES ES91920369T patent/ES2103832T3/es not_active Expired - Lifetime
- 1991-10-16 IE IE360691A patent/IE913606A1/en not_active IP Right Cessation
-
1994
- 1994-03-04 US US08/039,221 patent/US5714500A/en not_active Expired - Fee Related
-
1997
- 1997-08-07 GR GR970402032T patent/GR3024388T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT99207B (pt) | 1999-04-30 |
IE913606A1 (en) | 1992-04-22 |
EP0553278B1 (de) | 1997-06-04 |
JP3094450B2 (ja) | 2000-10-03 |
GR3024388T3 (en) | 1997-11-28 |
JPH06501701A (ja) | 1994-02-24 |
PT99207A (pt) | 1992-09-30 |
EP0553278A1 (de) | 1993-08-04 |
DE69126438D1 (de) | 1997-07-10 |
WO1992006957A1 (en) | 1992-04-30 |
DK0553278T3 (da) | 1997-08-25 |
ES2103832T3 (es) | 1997-10-01 |
DE69126438T2 (de) | 1997-10-02 |
US5714500A (en) | 1998-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW347387B (en) | Piperidine derivatives | |
ES2114952T3 (es) | Agentes antianginales derivados de quinazolinona. | |
DK0646115T3 (da) | Heterocykliske/cykliske aminderivater | |
ATE188472T1 (de) | 4-arylmethyloxymethyl piperidine als tachykinin antagonisten | |
DE69433984D1 (de) | Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d | |
DE69312091D1 (de) | Piperazinderivate als 5-ht antagonisten | |
IT1250749B (it) | Composti eterociclici ad attivita' a ii antagonista | |
DE69208955D1 (de) | Pyrimidin-4-carboxamidderivate, ihre Herstellung und ihre Verwendung in der Therapie | |
DE69203911D1 (de) | Antihistaminische und nicht sedierende Benzimidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als Arzneimittel. | |
ATE171374T1 (de) | Verwendung von 1-(aminoalkyl)-3-quinoxalin-2-on derivaten zur herstellung von neuroprotektiven mitteln | |
ATE171949T1 (de) | Neue endothelin-antagonisten und ihre herstellung | |
DE69410509D1 (de) | Benzoxazinderivate, deren Herstellung und deren Verwendung in Therapie | |
ATE154010T1 (de) | 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften | |
ATE119878T1 (de) | Hydrazone. | |
DE69102762D1 (de) | Beta-phenylisoserinderivate, ihre herstellung und ihre anwendung. | |
DK0777653T3 (da) | Dihydropyridinderivater som bradykininantagonister | |
DE59206593D1 (de) | Verwendung von 2-Iminothiazolidin-4-onderivaten als neuartige Arzneimittelwirkstoffe | |
KR970706280A (ko) | 5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists) | |
ATE63309T1 (de) | 2,3-dihydro-2-oxo-3-benzofuranylessigs|urederivate und diese enthaltende arzneimittel. | |
PT98389A (pt) | Processo de preparacao de derivados de estreptogramina | |
DE69403896D1 (de) | 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten | |
ATE148459T1 (de) | Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften | |
KR930000501A (ko) | 피리디닐피페라진 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |