ATE171949T1 - Neue endothelin-antagonisten und ihre herstellung - Google Patents
Neue endothelin-antagonisten und ihre herstellungInfo
- Publication number
- ATE171949T1 ATE171949T1 AT92923203T AT92923203T ATE171949T1 AT E171949 T1 ATE171949 T1 AT E171949T1 AT 92923203 T AT92923203 T AT 92923203T AT 92923203 T AT92923203 T AT 92923203T AT E171949 T1 ATE171949 T1 AT E171949T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- production
- date
- endothelin antagonists
- sec
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title abstract 2
- 108050009340 Endothelin Proteins 0.000 title abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919123967A GB9123967D0 (en) | 1991-11-12 | 1991-11-12 | New compound and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE171949T1 true ATE171949T1 (de) | 1998-10-15 |
Family
ID=10704459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92923203T ATE171949T1 (de) | 1991-11-12 | 1992-10-30 | Neue endothelin-antagonisten und ihre herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5538950A (de) |
| EP (1) | EP0621867B1 (de) |
| JP (1) | JPH07501071A (de) |
| AT (1) | ATE171949T1 (de) |
| CA (1) | CA2123395A1 (de) |
| DE (1) | DE69227258T2 (de) |
| GB (1) | GB9123967D0 (de) |
| WO (1) | WO1993010144A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430022A (en) * | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
| US5614498A (en) * | 1990-06-07 | 1997-03-25 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| US5496928A (en) * | 1990-06-07 | 1996-03-05 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| CA2043741C (en) * | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
| TW217417B (de) * | 1991-12-04 | 1993-12-11 | Manyu Seiyaku Kk | |
| US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
| US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US5811416A (en) * | 1994-06-06 | 1998-09-22 | Board Of Regents The University Of Texas System | Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate |
| US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
| US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
| US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
| US5906987A (en) * | 1997-03-10 | 1999-05-25 | Schering Aktiengesellschaft And Board Of Regents | Treatment of male climacteric disorders with nitric oxide synthase substrates and/or donors, in combination with androgens and/or aromatase inhibitors |
| AU4572999A (en) * | 1998-06-18 | 2000-01-05 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
| AU2001239896A1 (en) * | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
| CN101279955B (zh) * | 2007-04-03 | 2012-11-28 | 北京摩力克科技有限公司 | 作为二肽肽激酶-iv抑制剂的n-取代硫吗啉衍生物及其医药用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187156A (en) * | 1988-03-16 | 1993-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
| WO1991012266A1 (fr) * | 1990-02-15 | 1991-08-22 | Fujisawa Pharmaceutical Co., Ltd. | Compose peptidique |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
-
1991
- 1991-11-12 GB GB919123967A patent/GB9123967D0/en active Pending
-
1992
- 1992-10-30 US US08/232,156 patent/US5538950A/en not_active Expired - Fee Related
- 1992-10-30 CA CA002123395A patent/CA2123395A1/en not_active Abandoned
- 1992-10-30 JP JP5509138A patent/JPH07501071A/ja active Pending
- 1992-10-30 EP EP92923203A patent/EP0621867B1/de not_active Expired - Lifetime
- 1992-10-30 DE DE69227258T patent/DE69227258T2/de not_active Expired - Fee Related
- 1992-10-30 AT AT92923203T patent/ATE171949T1/de not_active IP Right Cessation
- 1992-10-30 WO PCT/JP1992/001405 patent/WO1993010144A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0621867B1 (de) | 1998-10-07 |
| GB9123967D0 (en) | 1992-01-02 |
| WO1993010144A1 (en) | 1993-05-27 |
| DE69227258D1 (de) | 1998-11-12 |
| US5538950A (en) | 1996-07-23 |
| JPH07501071A (ja) | 1995-02-02 |
| DE69227258T2 (de) | 1999-04-01 |
| CA2123395A1 (en) | 1993-05-27 |
| EP0621867A1 (de) | 1994-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE171949T1 (de) | Neue endothelin-antagonisten und ihre herstellung | |
| DE69327541D1 (en) | 4-arylmethyloxymethyl piperidine als tachykinin antagonisten | |
| DK0597088T3 (da) | Nye imidazolderivater, deres fremstilling og terapeutiske anvendelser | |
| DE69103636D1 (de) | Biaromatische verbindungen und ihre anwendung in menschen- und tierheilkunde und in der kosmetik. | |
| DK0674624T3 (da) | Pyrazoler med CRF-antagonistisk aktivitet | |
| ATE188379T1 (de) | Fibrinogenrezeptor-antagonisten | |
| NO940737L (de) | ||
| DE69505968D1 (de) | Azolidindion-derivate und ihre anwendung als antihyperglykämika | |
| AU1070895A (en) | Indole-derived arylpiperazines as ligands for 5HT1-like receptors 5HT1B and 5HT1D | |
| ES2122258T3 (es) | 4-azaesteroides 15 sustituidos. | |
| MX9203100A (es) | Nuevos peptidos, su preparacion y su aplicacion. | |
| MY102135A (en) | A benzoylurea derivative and its production and use. | |
| DE69522332D1 (de) | 1,4-dihydropyridine als bradykinin antagonisten | |
| DK0689534T3 (da) | Amidderivater som 5-HT1A-ligander | |
| DE69226931D1 (de) | Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten | |
| PT100891A (pt) | Per-hidro-1h-pirido {1,2-a} pirazinas 2-substituidas neurolepticas | |
| ES2139247T3 (es) | Derivados de 6-polifluoralcoxi y de 6-polifluoralquilo-2-aminobenzotiazoles. | |
| DE69131353D1 (de) | Indolderivate | |
| ATE123025T1 (de) | 2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica. | |
| ATE154010T1 (de) | 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften | |
| EP0313311A3 (de) | Herbizide Sulfonamide | |
| ES2032251A1 (es) | Agentes para el deshojado de plantas de algodon. | |
| MY110894A (en) | New pyrazolylpryrazoles, processes for their preparation, as well as intermediates, and thier use as herbicides | |
| MX9800052A (es) | Compuestos 1,3-dioxan-5-ilamino-heterociclicos sustituidos, procedimientos para su preparacion y su uso como composiciones para controlar plagas. | |
| DE69200523D1 (de) | Polyglukosiden aus Hydroxyalkylsorbit. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |