ES2046110B1 - Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol. - Google Patents
Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol.Info
- Publication number
- ES2046110B1 ES2046110B1 ES09200813A ES9200813A ES2046110B1 ES 2046110 B1 ES2046110 B1 ES 2046110B1 ES 09200813 A ES09200813 A ES 09200813A ES 9200813 A ES9200813 A ES 9200813A ES 2046110 B1 ES2046110 B1 ES 2046110B1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- alkyl
- hydroxyl
- aryl
- bencimidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS COMPUESTOS DERIVADOS DE BENCIMIDAZOL. CARACTERIZADO PORQUE COMPRENDE LA REACCION ENTRE UN COMPUESTO DE FORMULA GENERAL IIA CON OTRO DE FORMULA GENERAL III, OBTENIENDOSE DICHOS DERIVADOS DE BENCIMIDAZOL, DE FORMULA GENERAL Y SUS SALES TERAPEUTICAMENTE ACEPTABLES, CUYOS RADICALES REPRESENTAN: RSI1 SC Y RSI2 SC IGUALES O DIFERENTES, HIDROGENO, HALOGENO, ALQUILO INFERIOR HIDROXI, ALCOXI, CARBOXILATO DE ALQUILO, ARIL O ARIL SUSTITUIDO; N ES 0 O 1; M VALORES ENTRE 2 Y 4; X, Y, Z, W, IGUALES O DIFERENTES E INCLUSO FORMANDO PARTE DE OTRO CICLO, AROMATICO O NO, NITROGENO O CARBONO UNIDO A HIDROGENO, HALOGENO, ALQUILO, ARILO, CARBOXILALQUILO, CARBOXILICO, HIDROXILO, ALQUILHIDROXI, SULFONICO Y ALQUILSULFONICO; A, HALOGENO, O UN GRUPO ESCOGIDO ENTRE TOSILOXI O MESILOXI. DICHOS DERIVADOS DE BENCIMIDAZOL SON ANTIHISTAMINICOS EXENTOS DE EFECTOS SEDATIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9104171A FR2674856B1 (fr) | 1991-04-05 | 1991-04-05 | Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2046110A1 ES2046110A1 (es) | 1994-01-16 |
ES2046110B1 true ES2046110B1 (es) | 1994-08-01 |
Family
ID=9411523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09200813A Expired - Lifetime ES2046110B1 (es) | 1991-04-05 | 1992-04-03 | Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5214040A (es) |
EP (1) | EP0507696B1 (es) |
JP (1) | JP3060054B2 (es) |
KR (1) | KR970011298B1 (es) |
CN (1) | CN1028367C (es) |
AT (1) | ATE126228T1 (es) |
AU (1) | AU647904B2 (es) |
BG (1) | BG60678B1 (es) |
BR (1) | BR1100983A (es) |
CA (1) | CA2065061A1 (es) |
CZ (1) | CZ279506B6 (es) |
DE (1) | DE69203911T2 (es) |
DK (1) | DK0507696T3 (es) |
ES (1) | ES2046110B1 (es) |
FI (1) | FI99112C (es) |
FR (1) | FR2674856B1 (es) |
GR (1) | GR3017643T3 (es) |
HU (1) | HU214316B (es) |
IL (1) | IL101483A (es) |
IS (1) | IS1639B (es) |
MX (1) | MX9201556A (es) |
NO (1) | NO179552C (es) |
NZ (1) | NZ242208A (es) |
PL (1) | PL167720B1 (es) |
RO (1) | RO109198B1 (es) |
RU (1) | RU2099336C1 (es) |
TW (1) | TW208003B (es) |
YU (1) | YU48826B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1264456B1 (it) * | 1993-05-14 | 1996-09-23 | Dompe Farmaceutici Spa | Derivati del 2-(benzimidazol-2-il)-1,3-diaminopropano farmacologicamente attivi. |
FR2727865B1 (fr) * | 1994-12-08 | 1997-07-18 | Esteve Labor Dr | Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme |
US5773616A (en) * | 1995-02-15 | 1998-06-30 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
CA2213197C (en) * | 1995-02-15 | 2001-08-07 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
FR2731618B1 (fr) * | 1995-03-14 | 1997-08-01 | Esteve Labor Dr | Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique |
US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
US5998439A (en) | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
TWI225488B (en) * | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
HU230609B1 (hu) * | 2000-01-19 | 2017-03-28 | Cadila Healthcare Ltd. | Hipolipidémiás és hipokoleszterinémiás hatású szubsztituált pirrolszármazékok, azokat tartalmazó gyógyszerkészítmények, eljárás előállításukra, köztitermékek és alkalmazásuk |
CZ2003952A3 (cs) * | 2000-10-31 | 2003-11-12 | Basf Drucksysteme Gmbh | Použití hyperrozvětvených polyurethanů |
CA2473236A1 (en) * | 2002-01-10 | 2003-07-24 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues |
CN101089000B (zh) * | 2006-06-16 | 2011-01-05 | 北京大学 | 螺环哌嗪季铵盐类化合物及其制备方法和应用 |
MX2011013294A (es) * | 2009-06-11 | 2012-01-12 | Siena Biotech Spa | Antagonistas de la trayectoria de hedgehog y aplicaciones terapeuticas de los mismos. |
PT2938597T (pt) * | 2012-12-27 | 2016-12-09 | Université De Lille 2 Droit Et Santé | Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização |
KR102057075B1 (ko) * | 2018-11-30 | 2019-12-19 | 우승열 | 페트병에 장착되는 여과장치 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200641A (en) * | 1976-12-21 | 1980-04-29 | Janssen Pharmaceutica, N.V. | 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives |
DE3336409A1 (de) * | 1983-10-06 | 1985-04-18 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5010075A (en) * | 1987-04-24 | 1991-04-23 | Syntex Pharmaceuticals Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
CA1317939C (en) * | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
-
1991
- 1991-04-05 FR FR9104171A patent/FR2674856B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-31 YU YU33692A patent/YU48826B/sh unknown
- 1992-03-31 TW TW081102419A patent/TW208003B/zh active
- 1992-04-01 RU SU925011426A patent/RU2099336C1/ru active
- 1992-04-02 RO RO92-200447A patent/RO109198B1/ro unknown
- 1992-04-02 IS IS3832A patent/IS1639B/is unknown
- 1992-04-02 NZ NZ242208A patent/NZ242208A/en unknown
- 1992-04-02 AU AU13979/92A patent/AU647904B2/en not_active Ceased
- 1992-04-03 MX MX9201556A patent/MX9201556A/es unknown
- 1992-04-03 FI FI921473A patent/FI99112C/fi active
- 1992-04-03 IL IL10148392A patent/IL101483A/en not_active IP Right Cessation
- 1992-04-03 PL PL92294101A patent/PL167720B1/pl unknown
- 1992-04-03 NO NO921315A patent/NO179552C/no not_active IP Right Cessation
- 1992-04-03 CA CA002065061A patent/CA2065061A1/fr not_active Abandoned
- 1992-04-03 BG BG96180A patent/BG60678B1/bg unknown
- 1992-04-03 EP EP92400940A patent/EP0507696B1/fr not_active Expired - Lifetime
- 1992-04-03 US US07/863,208 patent/US5214040A/en not_active Expired - Fee Related
- 1992-04-03 DE DE69203911T patent/DE69203911T2/de not_active Expired - Fee Related
- 1992-04-03 AT AT92400940T patent/ATE126228T1/de not_active IP Right Cessation
- 1992-04-03 ES ES09200813A patent/ES2046110B1/es not_active Expired - Lifetime
- 1992-04-03 HU HU9201145A patent/HU214316B/hu not_active IP Right Cessation
- 1992-04-03 CZ CS921017A patent/CZ279506B6/cs not_active IP Right Cessation
- 1992-04-03 KR KR1019920005583A patent/KR970011298B1/ko not_active IP Right Cessation
- 1992-04-03 DK DK92400940.0T patent/DK0507696T3/da active
- 1992-04-04 CN CN92102353A patent/CN1028367C/zh not_active Expired - Fee Related
- 1992-04-06 JP JP4084230A patent/JP3060054B2/ja not_active Expired - Lifetime
-
1995
- 1995-10-04 GR GR950402756T patent/GR3017643T3/el unknown
-
1997
- 1997-05-14 BR BR1100983-7A patent/BR1100983A/pt active IP Right Grant
Also Published As
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Publication | Publication Date | Title |
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ES2046110B1 (es) | Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol. | |
GB2248616B (en) | Piperazine derivatives | |
DK0468884T5 (da) | Hidtil ukendte benzimidazolderivater, fremstilling heraf og anvendelse af disse som medikamenter |