NO178929C - Indolopyrolkarbazol-derivater - Google Patents
Indolopyrolkarbazol-derivaterInfo
- Publication number
- NO178929C NO178929C NO924593A NO924593A NO178929C NO 178929 C NO178929 C NO 178929C NO 924593 A NO924593 A NO 924593A NO 924593 A NO924593 A NO 924593A NO 178929 C NO178929 C NO 178929C
- Authority
- NO
- Norway
- Prior art keywords
- substd
- opt
- carboxyl
- alkyl
- carbamoyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 alkenyl alkynyl Chemical group 0.000 abstract 4
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002402 hexoses Chemical class 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 150000002972 pentoses Chemical class 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34191691 | 1991-11-29 | ||
| JP6926992 | 1992-02-18 | ||
| JP25730692 | 1992-09-01 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO924593D0 NO924593D0 (no) | 1992-11-27 |
| NO924593L NO924593L (no) | 1993-06-01 |
| NO178929B NO178929B (no) | 1996-03-25 |
| NO178929C true NO178929C (no) | 1996-07-03 |
Family
ID=27300000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924593A NO178929C (no) | 1991-11-29 | 1992-11-27 | Indolopyrolkarbazol-derivater |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0545195B1 (OSRAM) |
| JP (1) | JP2629542B2 (OSRAM) |
| KR (1) | KR100275976B1 (OSRAM) |
| AT (1) | ATE130617T1 (OSRAM) |
| AU (1) | AU650376B2 (OSRAM) |
| BG (1) | BG61036B1 (OSRAM) |
| CA (1) | CA2083534C (OSRAM) |
| CZ (1) | CZ287304B6 (OSRAM) |
| DE (1) | DE69206242T2 (OSRAM) |
| DK (1) | DK0545195T3 (OSRAM) |
| DZ (1) | DZ1634A1 (OSRAM) |
| ES (1) | ES2079774T3 (OSRAM) |
| FI (1) | FI106864B (OSRAM) |
| GR (1) | GR3018527T3 (OSRAM) |
| HU (3) | HU217611B (OSRAM) |
| IL (1) | IL103844A (OSRAM) |
| MX (1) | MX9206847A (OSRAM) |
| MY (1) | MY114655A (OSRAM) |
| NO (1) | NO178929C (OSRAM) |
| NZ (1) | NZ245203A (OSRAM) |
| PL (1) | PL171468B1 (OSRAM) |
| RO (1) | RO113469B1 (OSRAM) |
| RU (1) | RU2117671C1 (OSRAM) |
| SA (1) | SA93130351B1 (OSRAM) |
| TW (1) | TW224469B (OSRAM) |
| WO (1) | WO1993011145A1 (OSRAM) |
| YU (1) | YU48963B (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995030682A1 (en) * | 1994-05-09 | 1995-11-16 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyprolocarbazole derivative |
| CA2190007C (en) * | 1994-05-09 | 2003-04-15 | Katsuhisa Kojiri | Antitumor indolopyrrolocarbazole derivatives |
| AU2575395A (en) * | 1994-06-13 | 1996-01-05 | Banyu Pharmaceutical Co., Ltd. | Gene coding for glycosyltransferase and use thereof |
| AU3086495A (en) * | 1994-08-02 | 1996-03-04 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazoles |
| US5591855A (en) * | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
| US5594009A (en) * | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| WO1997009339A1 (fr) * | 1995-09-05 | 1997-03-13 | Banyu Pharmaceutical Co., Ltd. | Derives antitumoraux d'indolopyrrolocarbazole |
| US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
| HUP9903931A3 (en) * | 1996-08-22 | 2000-09-28 | Bristol Myers Squibb Co Wallin | Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles |
| GB9811624D0 (en) * | 1998-05-29 | 1998-07-29 | Merck Sharp & Dohme | Therapeutic use |
| US6013646A (en) * | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6703373B1 (en) | 1999-09-10 | 2004-03-09 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives and antitumor agents |
| FR2801054B1 (fr) * | 1999-11-17 | 2003-06-13 | Adir | Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TR200302314T4 (tr) | 2000-02-24 | 2004-01-21 | Banyu Pharmaceutical Co., Ltd. | İndolopirolokarbazol türevinin hazırlanması için bir işlem, hazırlık işlemindeki ara ürünler ve ara ürünlerin hazırlanmsı için bir işlem. |
| US6653290B2 (en) | 2000-10-06 | 2003-11-25 | Bristol-Myers Squibb Company | Tumor proliferation inhibitors |
| US6677450B2 (en) | 2000-10-06 | 2004-01-13 | Bristol-Myers Squibb Company | Topoisomerase inhibitors |
| US6610727B2 (en) | 2000-10-06 | 2003-08-26 | Bristol-Myers Squibb Company | Anhydro sugar derivatives of indolocarbazoles |
| US6555677B2 (en) | 2000-10-31 | 2003-04-29 | Merck & Co., Inc. | Phase transfer catalyzed glycosidation of an indolocarbazole |
| JP2004534006A (ja) | 2001-03-22 | 2004-11-11 | ブリストル−マイヤーズ スクイブ カンパニー | インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体 |
| US6559299B2 (en) | 2001-03-29 | 2003-05-06 | Merck & Co., Inc. | Preparation and isolation of indolocarbazole glycosides |
| MXPA04009324A (es) * | 2002-03-26 | 2005-01-25 | Banyu Pharma Co Ltd | Uso de derivado de indolopirrolocarbazol y otro agente anticanceroso en combinacion. |
| CA2398828A1 (en) | 2002-08-09 | 2004-02-09 | Merck & Co., Inc. | A pharmaceutical composition containing an indolopyrrolocarbazole derivative |
| CA2496479A1 (en) * | 2002-08-23 | 2004-03-04 | Banyu Pharmaceutical Co., Ltd. | Process for producing indolopyrrolocarbazole derivative |
| WO2005010017A1 (ja) * | 2003-07-24 | 2005-02-03 | Banyu Pharmaceutical Co., Ltd | インドロピロロカルバゾール誘導体及び抗腫瘍剤 |
| CN1852914A (zh) * | 2003-09-16 | 2006-10-25 | 万有制药株式会社 | 抗肿瘤性新型吲哚并吡咯并咔唑衍生物 |
| US7169802B2 (en) | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US7241779B2 (en) | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| RU2255089C1 (ru) * | 2003-12-26 | 2005-06-27 | Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" | Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью |
| ES2326459B1 (es) | 2008-04-08 | 2010-05-28 | Universidad De Oviedo | Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos. |
| MX2011005055A (es) | 2008-11-19 | 2011-05-31 | Cephalon Inc | Nuevas formas de un compuesto de indazolo [5,4-a]pirrolo[3,4-c]car bazol. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| EP0445736A1 (en) * | 1990-03-06 | 1991-09-11 | Bristol-Myers Squibb Company | Rebeccamycin analog and pharmaceutical composition containing it |
| IL97233A (en) * | 1990-03-06 | 1995-03-30 | Bristol Myers Squibb Co | Rebeccamycin analogs, their production and pharmaceutical compositions containing them |
| MX9201643A (es) * | 1991-04-11 | 1992-10-01 | Schering Corp | Agentes contra tumores y anti-psoriasicos. |
-
1992
- 1992-11-20 NZ NZ245203A patent/NZ245203A/en not_active IP Right Cessation
- 1992-11-22 DZ DZ920145A patent/DZ1634A1/fr active
- 1992-11-23 CA CA002083534A patent/CA2083534C/en not_active Expired - Fee Related
- 1992-11-23 EP EP92119904A patent/EP0545195B1/en not_active Expired - Lifetime
- 1992-11-23 DK DK92119904.8T patent/DK0545195T3/da active
- 1992-11-23 DE DE69206242T patent/DE69206242T2/de not_active Expired - Fee Related
- 1992-11-23 AT AT92119904T patent/ATE130617T1/de not_active IP Right Cessation
- 1992-11-23 ES ES92119904T patent/ES2079774T3/es not_active Expired - Lifetime
- 1992-11-23 IL IL103844A patent/IL103844A/xx not_active IP Right Cessation
- 1992-11-24 JP JP4336560A patent/JP2629542B2/ja not_active Expired - Fee Related
- 1992-11-25 MY MYPI92002167A patent/MY114655A/en unknown
- 1992-11-25 TW TW081109448A patent/TW224469B/zh active
- 1992-11-26 AU AU29637/92A patent/AU650376B2/en not_active Ceased
- 1992-11-27 CZ CS19923508A patent/CZ287304B6/cs not_active IP Right Cessation
- 1992-11-27 RU RU93050130A patent/RU2117671C1/ru not_active IP Right Cessation
- 1992-11-27 FI FI925422A patent/FI106864B/fi active
- 1992-11-27 RO RO93-01067A patent/RO113469B1/ro unknown
- 1992-11-27 HU HU9203754A patent/HU217611B/hu not_active IP Right Cessation
- 1992-11-27 MX MX9206847A patent/MX9206847A/es unknown
- 1992-11-27 NO NO924593A patent/NO178929C/no not_active IP Right Cessation
- 1992-11-27 HU HU9203754A patent/HU9203754D0/hu unknown
- 1992-11-27 WO PCT/JP1992/001549 patent/WO1993011145A1/en not_active Ceased
- 1992-11-27 PL PL92304729A patent/PL171468B1/pl not_active IP Right Cessation
- 1992-11-27 YU YU102692A patent/YU48963B/sh unknown
- 1992-11-28 KR KR1019920022729A patent/KR100275976B1/ko not_active Expired - Fee Related
-
1993
- 1993-01-30 SA SA93130351A patent/SA93130351B1/ar unknown
- 1993-07-20 BG BG97970A patent/BG61036B1/bg unknown
-
1995
- 1995-06-08 HU HU95P/P00172P patent/HU211254A9/hu unknown
- 1995-12-22 GR GR950403667T patent/GR3018527T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0545195T3 (da) | Indolopyrrolocarbazolderivater | |
| ES470134A1 (es) | Un procedimiento para la produccion de derivados sustituidosde ciclohexano-1,3-diona | |
| ES414279A1 (es) | Procedimiento para la preparacion de 1,4-benzodiazepinas. | |
| NZ233735A (en) | Heterocyclic substituted aminophenol derivatives | |
| GB1402498A (en) | Triazine derivatives their production and their medicinal use | |
| NZ514662A (en) | Amine derivatives | |
| MX9306110A (es) | Fenoxi y fenopxialquil-piperidinas como agentes anti-virales. | |
| ES2002012A6 (es) | Procedimiento para preparar (1,2,4)triazol (1,5-c)pirimidinas e-fusionadas | |
| MX9700928A (es) | Derivado de triazian y medicina que lo contiene. | |
| ES435819A1 (es) | Procedimiento para preparar derivados de 1-(4-fenoxi-fenil)-1, 3, 5-triazina. | |
| EA200100422A1 (ru) | Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью | |
| ES2021182A6 (es) | Procedimiento para preparar derivados de capsaicina. | |
| ES433462A1 (es) | Un procedimiento de produccion de un derivado de pirazina. | |
| YU72992A (sh) | Derivati cikloheksana i tetrahidropirana | |
| ATE196137T1 (de) | Thiazolin-derivate | |
| ES8707718A1 (es) | Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles | |
| DE59404557D1 (de) | Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate | |
| GB1341884A (en) | Herbicidal 1,2,4-thiadiazolyl derivatives | |
| DE3473270D1 (de) | 2-amino alkenyl sulfonyl ureas | |
| ES454501A1 (es) | Un procedimiento para la preparacion de acidos pirrolidon- carboxilicos sustituidos en n. | |
| ES8306099A1 (es) | Un procedimiento para la preparacion de derivados de acido 2-(2-cianoetil)-2-benzoilamino-alcanoicos. | |
| ES2133376T3 (es) | Derivados de imidazol y su uso como agentes agroquimicos. | |
| ES478049A1 (es) | Procedimiento para preparar derivados de trifluormetilimino-tiazolidina. | |
| TH5599A (th) | อนุพันธุ์ของคาร์บาโมอิลลอกซีไธโอฟีน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |