NO174473C - Fremgangsmåte og ekspresjonsvektor til fremstilling av human TNF - Google Patents

Fremgangsmåte og ekspresjonsvektor til fremstilling av human TNF

Info

Publication number
NO174473C
NO174473C NO851400A NO851400A NO174473C NO 174473 C NO174473 C NO 174473C NO 851400 A NO851400 A NO 851400A NO 851400 A NO851400 A NO 851400A NO 174473 C NO174473 C NO 174473C
Authority
NO
Norway
Prior art keywords
preparation
expression vector
human tnf
tnf
human
Prior art date
Application number
NO851400A
Other languages
English (en)
Norwegian (no)
Other versions
NO174473B (no
NO851400L (no
Inventor
Robert Bruce Wallace
Hirataka Itoh
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Publication of NO851400L publication Critical patent/NO851400L/no
Publication of NO174473B publication Critical patent/NO174473B/no
Publication of NO174473C publication Critical patent/NO174473C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
NO851400A 1984-04-06 1985-04-03 Fremgangsmåte og ekspresjonsvektor til fremstilling av human TNF NO174473C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/597,372 US4879226A (en) 1984-04-06 1984-04-06 Novel human physiologically active polypeptide

Publications (3)

Publication Number Publication Date
NO851400L NO851400L (no) 1985-10-07
NO174473B NO174473B (no) 1994-01-31
NO174473C true NO174473C (no) 1994-05-11

Family

ID=24391235

Family Applications (1)

Application Number Title Priority Date Filing Date
NO851400A NO174473C (no) 1984-04-06 1985-04-03 Fremgangsmåte og ekspresjonsvektor til fremstilling av human TNF

Country Status (39)

Country Link
US (1) US4879226A (fr)
EP (2) EP0158286A3 (fr)
JP (1) JPS60252496A (fr)
KR (1) KR920007399B1 (fr)
AR (1) AR240475A1 (fr)
AU (2) AU595480B2 (fr)
BE (1) BE902119A (fr)
BG (1) BG43355A3 (fr)
BR (1) BR8501624A (fr)
CA (1) CA1341348C (fr)
CH (2) CH672790A5 (fr)
DD (1) DD251785A5 (fr)
DK (1) DK151985A (fr)
EG (1) EG17965A (fr)
ES (1) ES8704976A1 (fr)
FI (1) FI86992C (fr)
FR (1) FR2564097B1 (fr)
GB (1) GB2158829B (fr)
GR (1) GR850836B (fr)
HK (1) HK102192A (fr)
HU (1) HUT37813A (fr)
IE (1) IE58833B1 (fr)
IL (1) IL74804A (fr)
IN (1) IN163653B (fr)
IT (1) IT1218469B (fr)
JO (1) JO1365B1 (fr)
LU (1) LU85835A1 (fr)
MA (1) MA20402A1 (fr)
MT (1) MTP963B (fr)
MY (1) MY101887A (fr)
NO (1) NO174473C (fr)
NZ (2) NZ211666A (fr)
OA (1) OA07983A (fr)
PL (1) PL156392B1 (fr)
PT (1) PT80239B (fr)
RO (1) RO93650B (fr)
SG (1) SG77892G (fr)
YU (1) YU57885A (fr)
ZA (1) ZA852563B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
EP0155549B1 (fr) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. ADN codant pour le facteur humain de nécrose de tumeur et le polypeptide du facteur humain de nécrose de tumeur
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
JP2584206B2 (ja) * 1984-08-17 1997-02-26 大日本製薬株式会社 ヒト癌壊死因子
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
JPS60228297A (ja) * 1984-04-24 1985-11-13 株式会社　東京タツノ 給油装置
GR851626B (fr) * 1984-07-05 1985-11-26 Genentech Inc
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) * 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
DE3581730D1 (de) * 1984-10-15 1991-03-14 Cetus Corp Menschlicher tumornekrosisfaktor.
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0216786B1 (fr) * 1984-12-21 1992-03-18 Biogen, Inc. Purification, production et utilisation de facteurs necrotiques tumoraux
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
JPH0698004B2 (ja) * 1985-09-30 1994-12-07 サントリー株式会社 Ｔｎｆ発現用新規プラスミド
US5059530A (en) * 1985-09-30 1991-10-22 Suntory Ltd. Expression vector for human TNF
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
CA1310924C (fr) * 1986-04-24 1992-12-01 Francis P. Mccormick Systeme d'administration d'un medicament a l'aide de particules infectieuses
GB2194146A (en) * 1986-07-31 1988-03-02 Genentech Inc Treatment of retroviral infections
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
US5071834A (en) * 1988-09-16 1991-12-10 Genentech, Inc. Purified activin B composition
CA2003981C (fr) * 1988-12-27 2000-06-13 Hiroshi Ishimaru Composes pharmaceutiques utiles dans le traitement du psoriasis
US5342613A (en) * 1988-12-27 1994-08-30 Health Research Inc. Pharmaceutical compositions and use thereof in the treatment of psoriasis
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
WO1991002540A1 (fr) 1989-08-16 1991-03-07 Cetus Corporation Compositions pour l'inhibition de la formation d'hormones proteiques et emplois de celles-ci
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
WO1991006658A2 (fr) * 1989-10-24 1991-05-16 Cetus Corporation Systeme d'apport de proteines infectieuses
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
RU2139092C1 (ru) 1993-06-03 1999-10-10 Терапьютик Антибодиз Инк. Фрагменты антител в терапии
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
EP0749494A1 (fr) 1994-03-07 1996-12-27 Chiron Corporation Compositions pour l'inhibition de la formation des facteurs de necrose tumorale (tnf) et leur utilisation
NZ302638A (en) 1995-03-16 2001-04-27 Imutec Pharma Inc Immunomodulating composition from bile for the treatment of immune system disorders
FR2733421B1 (fr) * 1995-04-28 1997-06-06 Oreal Utilisation de derives de l'hormone stimulatrice des melanocytes de type alpha pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
US6001812A (en) * 1995-04-28 1999-12-14 Societe L'oreal S.A. Modulating body/cranial hair growth with derivatives of the α-type melanocyte-stimulating hormone
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6599710B1 (en) 1999-03-10 2003-07-29 The General Hospital Corporation Treatment of autoimmune disease
US7662367B2 (en) * 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US6579522B1 (en) * 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US20040198819A1 (en) * 2001-06-20 2004-10-07 Young Aiping H. Biological response modifier composition and uses thereof
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7628988B2 (en) 2002-06-27 2009-12-08 The General Hospital Corporation Methods and compositions for treating type 1 diabetes
US7582313B2 (en) * 2002-06-27 2009-09-01 The General Hospital Corporation Methods of organ regeneration using Hox 11-expressing pluripotent cells
US20040229785A1 (en) * 2002-11-15 2004-11-18 Denise Faustman Screening methods to identify treatments for autoimmune disease
RU2377253C2 (ru) 2002-12-02 2009-12-27 Амген Фремонт,Инк. Антитела, специфичные к фактору некроза опухолей, и их применение
US7101978B2 (en) * 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
EP2168603A1 (fr) 2003-11-14 2010-03-31 GenVec, Inc. Posologie thérapeutique pour le traitement du cancer
US7435799B2 (en) * 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
US20080102054A1 (en) * 2005-01-18 2008-05-01 Faustman Denise L Compositions Containing Agm Cells And Methods Of Use Thereof
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
EP2742127B1 (fr) * 2011-08-12 2019-10-09 Mello Biotechnology, Inc. Expression inductible dans des procaryotes d'un promoteur eucaryotique pol-2
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
PL2953634T3 (pl) 2013-02-07 2021-11-22 The General Hospital Corporation Sposoby namnażania lub zubożania limfocytów t-regulatorowych
US10906982B2 (en) 2015-05-15 2021-02-02 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor 2 antibodies
WO2017059132A1 (fr) 2015-09-29 2017-04-06 The General Hospital Corporation Méthodes de traitement et de diagnostic d'une maladie à l'aide de biomarqueurs pour thérapie par bcg
WO2017197331A2 (fr) 2016-05-13 2017-11-16 The General Hospital Corporation Anticorps antagonistes de la superfamille du récepteur du facteur de nécrose contre les tumeurs
NZ754407A (en) 2016-11-09 2023-01-27 Philogen Spa Il2 and tnf mutant immunoconjugates

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309418A (en) * 1980-03-25 1982-01-05 Sloan-Kettering Research Institute For Cancer Anti-tumor agent from human serum and process
US4359415A (en) * 1981-06-03 1982-11-16 University Of Tennessee Research Corporation Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine
FR2513124B1 (fr) * 1981-07-21 1989-11-17 Hayashibara Biochem Lab Production et applications du facteur de lyse des cellules-cibles
JPS5821621A (ja) * 1981-07-31 1983-02-08 Hayashibara Biochem Lab Inc ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
JPS6011890B2 (ja) * 1981-12-21 1985-03-28 株式会社林原生物化学研究所 ツモアネクロシスフアクタ−の製造方法
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action
JPS58141785A (ja) * 1982-02-16 1983-08-23 Nippon Shinyaku Co Ltd 抗腫瘍物質の製法
US4481137A (en) * 1982-02-26 1984-11-06 Mochida Pharmaceutical Co., Ltd. Glycoproteins and processes for their production
US4447355A (en) * 1982-04-07 1984-05-08 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same
JPS591288A (ja) * 1982-06-29 1984-01-06 Sato :Kk 連続値札印字装置
AU8956582A (en) * 1982-10-06 1984-04-24 Makitsubo, T. Process for extracting tumor necrosis factor from macrophage
JPS59169492A (ja) * 1983-03-15 1984-09-25 Asahi Chem Ind Co Ltd ヒト融合細胞からの生理活性物質の産生方法
CA1265444A (fr) * 1983-06-27 1990-02-06 Lloyd J. Old Effet du facteur humain de necrose des tumeurs et de l'interferon humain sur des cellules cancereuses humaines et methodes utilisees
JPS6019719A (ja) * 1983-07-15 1985-01-31 Asahi Chem Ind Co Ltd 抗腫瘍活性を有する蛋白質
JPS5943617Y2 (ja) * 1983-08-26 1984-12-25 株式会社潤工社 広い周波数帯域において均一な特性を有する伝送線路用導体
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
JPS60185799A (ja) * 1984-03-06 1985-09-21 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子
EP0155549B1 (fr) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. ADN codant pour le facteur humain de nécrose de tumeur et le polypeptide du facteur humain de nécrose de tumeur
JPS60260522A (ja) * 1984-06-07 1985-12-23 Asahi Chem Ind Co Ltd 遺伝子組換体が生産する生理活性物質の安定化法
DE3423234A1 (de) * 1984-06-23 1986-02-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Synergistische mischungen von interferonen und tumor-nekrose-faktor
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法

Also Published As

Publication number Publication date
FI86992C (fi) 1992-11-10
JPS60252496A (ja) 1985-12-13
JPH025760B2 (fr) 1990-02-05
HUT37813A (en) 1986-02-28
FI86992B (fi) 1992-07-31
HK102192A (en) 1992-12-24
EP0158286A3 (fr) 1987-05-13
FR2564097B1 (fr) 1989-09-22
IE58833B1 (en) 1993-11-17
OA07983A (en) 1987-01-31
AU595480B2 (en) 1990-04-05
PT80239A (en) 1985-05-01
NZ211666A (en) 1990-01-29
RO93650A (fr) 1988-03-30
BE902119A (fr) 1985-10-04
GB8508864D0 (en) 1985-05-09
CH672790A5 (fr) 1989-12-29
KR850007273A (ko) 1985-12-02
NO174473B (no) 1994-01-31
AU4088285A (en) 1985-10-10
ES541920A0 (es) 1987-05-01
GB2158829B (en) 1992-04-22
RO93650B (ro) 1988-03-31
GR850836B (fr) 1985-06-26
CH675423A5 (fr) 1990-09-28
IE850863L (en) 1985-10-06
MY101887A (en) 1992-02-15
GB2158829A (en) 1985-11-20
NZ231317A (en) 1991-01-29
AU4016289A (en) 1989-12-07
JO1365B1 (en) 1986-11-30
US4879226A (en) 1989-11-07
IL74804A (en) 1991-06-30
PL252807A1 (en) 1986-02-25
EG17965A (en) 1994-01-30
MA20402A1 (fr) 1985-12-31
MTP963B (en) 1985-11-25
SG77892G (en) 1992-10-02
EP0354592A1 (fr) 1990-02-14
BG43355A3 (en) 1988-05-16
CA1341348C (fr) 2002-03-19
IL74804A0 (en) 1985-07-31
IT1218469B (it) 1990-04-19
DK151985D0 (da) 1985-04-03
ES8704976A1 (es) 1987-05-01
NO851400L (no) 1985-10-07
YU57885A (en) 1989-02-28
AU637054B2 (en) 1993-05-20
PT80239B (pt) 1988-02-17
FI851336A0 (fi) 1985-04-03
FR2564097A1 (fr) 1985-11-15
EP0158286A2 (fr) 1985-10-16
LU85835A1 (fr) 1985-12-16
IN163653B (fr) 1988-10-22
DK151985A (da) 1985-10-07
FI851336L (fi) 1985-10-07
BR8501624A (pt) 1985-12-03
KR920007399B1 (ko) 1992-08-31
IT8520242A0 (it) 1985-04-05
AR240475A1 (es) 1990-04-30
ZA852563B (en) 1986-05-28
DD251785A5 (de) 1987-11-25
PL156392B1 (pl) 1992-03-31

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