NO174051C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive tetrazolyl-, triazolyl- og pyrazolylforbindelser - Google Patents
Analogifremgangsmåte ved fremstilling av terapeutisk aktive tetrazolyl-, triazolyl- og pyrazolylforbindelserInfo
- Publication number
- NO174051C NO174051C NO882799A NO882799A NO174051C NO 174051 C NO174051 C NO 174051C NO 882799 A NO882799 A NO 882799A NO 882799 A NO882799 A NO 882799A NO 174051 C NO174051 C NO 174051C
- Authority
- NO
- Norway
- Prior art keywords
- tetrazolyl
- triazolyl
- therapeutically active
- analogous process
- pyrazolyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878714789A GB8714789D0 (en) | 1987-06-24 | 1987-06-24 | Heterocyclic compounds |
Publications (4)
Publication Number | Publication Date |
---|---|
NO882799D0 NO882799D0 (no) | 1988-06-23 |
NO882799L NO882799L (no) | 1988-12-27 |
NO174051B NO174051B (no) | 1993-11-29 |
NO174051C true NO174051C (no) | 1994-03-09 |
Family
ID=10619472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO882799A NO174051C (no) | 1987-06-24 | 1988-06-23 | Analogifremgangsmåte ved fremstilling av terapeutisk aktive tetrazolyl-, triazolyl- og pyrazolylforbindelser |
Country Status (19)
Country | Link |
---|---|
US (3) | US4866077A (de) |
EP (1) | EP0296721B1 (de) |
JP (1) | JP2703268B2 (de) |
AU (1) | AU615917B2 (de) |
BR (1) | BR1100658A (de) |
CA (1) | CA1340458C (de) |
DE (1) | DE3881970T2 (de) |
DK (1) | DK168600B1 (de) |
ES (1) | ES2056928T3 (de) |
FI (1) | FI93356C (de) |
GB (1) | GB8714789D0 (de) |
HK (1) | HK84194A (de) |
HU (1) | HU210809A9 (de) |
IE (1) | IE61694B1 (de) |
IL (1) | IL86618A (de) |
NO (1) | NO174051C (de) |
NZ (1) | NZ224868A (de) |
PT (1) | PT87820B (de) |
ZA (1) | ZA884339B (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307141B1 (de) * | 1987-09-10 | 1993-01-13 | MERCK SHARP & DOHME LTD. | Oxazole und Thiazole zur Behandlung seniler Demenz |
IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
ATE87918T1 (de) * | 1988-02-19 | 1993-04-15 | Lilly Co Eli | Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren. |
DK162892C (da) * | 1988-07-04 | 1992-05-11 | Novo Nordisk As | 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
IT1229491B (it) * | 1988-12-28 | 1991-09-03 | Roussel Maestretti S P A Ora R | Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali |
JP3003148B2 (ja) * | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US5264444A (en) * | 1989-02-22 | 1993-11-23 | Novo Nordisk A/S | Piperidine compounds and use |
US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
US5328925A (en) * | 1989-02-22 | 1994-07-12 | Novo Nordisk A/S | Piperidine compounds and their use |
US5260311A (en) * | 1989-02-22 | 1993-11-09 | Novo Nordisk A/S | Piperidine compounds and their use |
EP0402056A3 (de) * | 1989-06-06 | 1991-09-04 | Beecham Group p.l.c. | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DE69026197T2 (de) * | 1989-10-07 | 1997-01-09 | Beecham Group Plc | Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
US5200419A (en) * | 1990-05-21 | 1993-04-06 | Warner-Lambert Company | Substituted tetrazoles and derivatives thereof acting at muscarinic receptors |
IE911994A1 (en) * | 1990-07-03 | 1992-01-15 | Akzo Nv | 5-isothiazolamine derivatives |
US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
USRE35822E (en) * | 1990-08-21 | 1998-06-09 | Novo Nordisk A/S | Heterocyclic compounds |
US5376668A (en) * | 1990-08-21 | 1994-12-27 | Novo Nordisk A/S | Heterocyclic compounds |
US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
DK198390D0 (da) | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
DK198490D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
EP0561913B1 (de) * | 1990-11-29 | 1998-04-01 | Allergan, Inc. | Verwendung von pyridine derivate zur behandlung der okulären hypertomie |
EP0576611A4 (en) * | 1991-03-13 | 1996-01-24 | Univ Minnesota | Radiopharmaceutical agents for the detection of alzheimer's disease |
IE922270A1 (en) * | 1991-07-26 | 1993-01-27 | Akzo Nv | Pyrazole derivatives |
US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
US5175166A (en) * | 1991-08-27 | 1992-12-29 | The University Of Toledo | Muscarinic agonists |
WO1993014089A1 (en) * | 1992-01-13 | 1993-07-22 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5330994A (en) * | 1992-03-24 | 1994-07-19 | Warner-Lambert Company | Tetrahydropyridine isoxazoline derivatives |
WO1994010145A1 (en) * | 1992-10-23 | 1994-05-11 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
US5753683A (en) * | 1993-08-19 | 1998-05-19 | Novo Nordisk A/S | Antipsychotic method |
US5612351A (en) * | 1994-11-08 | 1997-03-18 | Novo Nordisk A/S | Method of treating urinary bladder dysfunctions |
US5668148A (en) * | 1995-04-20 | 1997-09-16 | Merck & Co., Inc. | Alpha1a adrenergic receptor antagonists |
AU6299296A (en) * | 1995-06-29 | 1997-01-30 | Novo Nordisk A/S | Novel substituted azacyclic compounds |
EA000531B1 (ru) * | 1995-11-06 | 1999-10-28 | Х.Лундбекк А/С | Активное вещество при производстве фармацевтического препарата для лечения травматического повреждения головного мозга |
ATE250055T1 (de) * | 1996-04-24 | 2003-10-15 | Novo Nordisk As | Heterozyklische verbindungen, ihre herstellung und ihre anwendung |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
PT1014974E (pt) * | 1997-05-29 | 2004-12-31 | Lundbeck & Co As H | Tratamento da esquizofrenia e psicoses |
AR013096A1 (es) * | 1997-07-01 | 2000-12-13 | Lundbeck & Co As H | Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma. |
WO1999017771A1 (en) * | 1997-10-02 | 1999-04-15 | H. Lundbeck A/S | Granular preparations of 5-(2-ethyl- 2h-tetrazol- 5-yl)-1-methyl-1, 2,3,6-tetrahydropyridine |
HUP0102886A3 (en) * | 1998-07-27 | 2002-12-28 | Lilly Co Eli | Treatment of anxiety disorders |
AU6686700A (en) * | 1999-08-23 | 2001-03-19 | H. Lundbeck A/S | Treatment of urinary incontinence |
AU2001253418A1 (en) * | 2000-04-12 | 2001-10-30 | Smith Kline Beecham Corporation | Compounds and methods |
CA2439593C (en) * | 2001-04-05 | 2010-02-09 | Torrent Pharmaceuticals Ltd. | Heterocyclic compounds for aging-related and diabetic vascular complications |
US20030069597A1 (en) * | 2001-10-10 | 2003-04-10 | Scimed Life Systems, Inc. | Loading tool |
AU2002360403A1 (en) | 2001-11-19 | 2003-06-10 | Elan Pharmaceuticals, Inc. | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2003296308A1 (en) | 2002-12-18 | 2004-07-29 | Bayer Cropscience Ag | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines |
WO2004058148A2 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
EP1720874A4 (de) * | 2004-02-24 | 2010-03-03 | Bioaxone Therapeutique Inc | 4-substituierte piperidinderivate |
US20060224175A1 (en) * | 2005-03-29 | 2006-10-05 | Vrba Anthony C | Methods and apparatuses for disposition of a medical device onto an elongate medical device |
US7678363B2 (en) * | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP2010525020A (ja) * | 2007-04-24 | 2010-07-22 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | ムスカリン性受容体への親和性を有する複素環式化合物 |
US8084473B2 (en) | 2007-04-24 | 2011-12-27 | Solvay Pharmaceuticals B.V. | Heterocyclic compounds with affinity to muscarinic receptors |
JP2011520905A (ja) | 2008-05-15 | 2011-07-21 | ザ・ユニバーシティ・オブ・トレド | 向知性剤としてのムスカリンアゴニスト |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2427432A2 (de) * | 2009-05-07 | 2012-03-14 | Torrent Pharmaceuticals Limited | Neue heterozyklische verbindungen |
WO2012007500A2 (de) | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
WO2012052412A1 (de) | 2010-10-22 | 2012-04-26 | Bayer Cropscience Ag | Neue heterocylische verbindungen als schädlingsbekämpfungsmittel |
US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
CN103848850B (zh) * | 2013-08-28 | 2016-03-23 | 沈阳东瑞精细化工有限公司 | 一种舒巴坦的制备方法 |
US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US10149856B2 (en) | 2015-01-26 | 2018-12-11 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
US10537567B2 (en) | 2017-07-11 | 2020-01-21 | BioAxone BioSciences, Inc. | Kinase inhibitors for treatment of disease |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2659739A (en) | 1950-04-14 | 1953-11-17 | Eastman Kodak Co | 1-hydroxy-4-beta-cyanopropylamino-anthraquinone and process for preparing same |
BE845612A (fr) * | 1976-03-23 | 1977-02-28 | Derives de tetrazole-5-carboxamide et leur preparation | |
US4431653A (en) | 1982-03-18 | 1984-02-14 | Hoffmann-La Roche Inc. | Penicillanic acid derivatives |
DE3421072A1 (de) * | 1984-06-06 | 1985-12-12 | Heinrich Mack Nachf., 7918 Illertissen | 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4650805A (en) * | 1985-12-02 | 1987-03-17 | Warner-Lambert Company | 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity |
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
IL83275A (en) * | 1986-09-08 | 1994-02-27 | Novo Nordisk As | Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them |
IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
EP0372125A1 (de) * | 1988-11-08 | 1990-06-13 | Akzo N.V. | Oxazol und Thiazol-Derivate |
-
1987
- 1987-06-24 GB GB878714789A patent/GB8714789D0/en active Pending
-
1988
- 1988-05-27 ES ES88304899T patent/ES2056928T3/es not_active Expired - Lifetime
- 1988-05-27 DE DE88304899T patent/DE3881970T2/de not_active Expired - Lifetime
- 1988-05-27 EP EP88304899A patent/EP0296721B1/de not_active Expired - Lifetime
- 1988-05-30 IE IE163188A patent/IE61694B1/en not_active IP Right Cessation
- 1988-06-01 NZ NZ224868A patent/NZ224868A/en unknown
- 1988-06-03 IL IL86618A patent/IL86618A/xx not_active IP Right Cessation
- 1988-06-13 DK DK321688A patent/DK168600B1/da not_active IP Right Cessation
- 1988-06-17 ZA ZA884339A patent/ZA884339B/xx unknown
- 1988-06-22 US US07/209,994 patent/US4866077A/en not_active Ceased
- 1988-06-22 CA CA000570135A patent/CA1340458C/en not_active Expired - Lifetime
- 1988-06-23 FI FI883064A patent/FI93356C/fi active IP Right Grant
- 1988-06-23 AU AU18282/88A patent/AU615917B2/en not_active Expired
- 1988-06-23 NO NO882799A patent/NO174051C/no not_active IP Right Cessation
- 1988-06-24 PT PT87820A patent/PT87820B/pt not_active IP Right Cessation
- 1988-06-24 JP JP63155095A patent/JP2703268B2/ja not_active Expired - Lifetime
-
1989
- 1989-04-26 US US07/343,848 patent/US4925858A/en not_active Expired - Lifetime
-
1994
- 1994-08-18 HK HK84194A patent/HK84194A/xx not_active IP Right Cessation
-
1995
- 1995-03-08 HU HU95P/P00089P patent/HU210809A9/hu unknown
-
1996
- 1996-05-13 US US08/648,240 patent/USRE36374E/en not_active Expired - Lifetime
-
1997
- 1997-05-07 BR BR1100658-7A patent/BR1100658A/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
IE881631L (en) | 1988-12-24 |
AU1828288A (en) | 1989-01-05 |
HU210809A9 (en) | 1995-08-28 |
EP0296721A2 (de) | 1988-12-28 |
EP0296721B1 (de) | 1993-06-23 |
USRE36374E (en) | 1999-11-02 |
EP0296721A3 (en) | 1990-04-25 |
PT87820B (pt) | 1992-10-30 |
BR1100658A (pt) | 1999-08-31 |
FI883064A0 (fi) | 1988-06-23 |
ES2056928T3 (es) | 1994-10-16 |
DK168600B1 (da) | 1994-05-02 |
DE3881970D1 (de) | 1993-07-29 |
ZA884339B (en) | 1989-05-30 |
NO174051B (no) | 1993-11-29 |
FI93356C (fi) | 1995-03-27 |
IE61694B1 (en) | 1994-11-16 |
JP2703268B2 (ja) | 1998-01-26 |
NO882799L (no) | 1988-12-27 |
GB8714789D0 (en) | 1987-07-29 |
NZ224868A (en) | 1990-07-26 |
FI883064A (fi) | 1988-12-25 |
US4866077A (en) | 1989-09-12 |
PT87820A (pt) | 1989-05-31 |
NO882799D0 (no) | 1988-06-23 |
FI93356B (fi) | 1994-12-15 |
JPS6422869A (en) | 1989-01-25 |
AU615917B2 (en) | 1991-10-17 |
CA1340458C (en) | 1999-03-23 |
DE3881970T2 (de) | 1993-11-11 |
IL86618A0 (en) | 1988-11-30 |
IL86618A (en) | 1992-07-15 |
HK84194A (en) | 1994-08-26 |
DK321688A (da) | 1988-12-25 |
US4925858A (en) | 1990-05-15 |
DK321688D0 (da) | 1988-06-13 |
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