NO163566C - 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater. - Google Patents

1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Info

Publication number
NO163566C
NO163566C NO863823A NO863823A NO163566C NO 163566 C NO163566 C NO 163566C NO 863823 A NO863823 A NO 863823A NO 863823 A NO863823 A NO 863823A NO 163566 C NO163566 C NO 163566C
Authority
NO
Norway
Prior art keywords
benzothiazepine derivatives
chloro
preparation
new
therapeutically active
Prior art date
Application number
NO863823A
Other languages
English (en)
Other versions
NO863823D0 (no
NO863823L (no
NO163566B (no
Inventor
Mikio Takeda
Tokuro Ohishi
Hiromichi Nakajima
Taku Nagao
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838315364A external-priority patent/GB8315364D0/en
Priority claimed from GB848400983A external-priority patent/GB8400983D0/en
Publication of NO863823L publication Critical patent/NO863823L/no
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Priority to NO863823A priority Critical patent/NO163566C/no
Publication of NO863823D0 publication Critical patent/NO863823D0/no
Publication of NO163566B publication Critical patent/NO163566B/no
Publication of NO163566C publication Critical patent/NO163566C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
    • C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
    • C09J123/04—Homopolymers or copolymers of ethene
    • C09J123/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
NO863823A 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater. NO163566C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB838315364A GB8315364D0 (en) 1983-06-03 1983-06-03 8-chloro-1 5-benzothiazepine derivatives
GB848400983A GB8400983D0 (en) 1984-01-14 1984-01-14 8-chloro-1,5-benzothiazepine derivatives
NO842203A NO162518C (no) 1983-06-03 1984-06-01 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Publications (4)

Publication Number Publication Date
NO863823L NO863823L (no) 1984-12-04
NO863823D0 NO863823D0 (no) 1986-09-25
NO163566B NO163566B (no) 1990-03-12
NO163566C true NO163566C (no) 1990-06-27

Family

ID=26286299

Family Applications (2)

Application Number Title Priority Date Filing Date
NO842203A NO162518C (no) 1983-06-03 1984-06-01 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO842203A NO162518C (no) 1983-06-03 1984-06-01 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.

Country Status (18)

Country Link
US (1) US4567175A (no)
EP (1) EP0127882B1 (no)
KR (1) KR900005697B1 (no)
AT (1) ATE22889T1 (no)
AU (1) AU563093B2 (no)
BG (2) BG40964A3 (no)
CA (2) CA1237719A (no)
DD (1) DD218619A5 (no)
DE (1) DE3460972D1 (no)
DK (2) DK167185B1 (no)
ES (2) ES533009A0 (no)
HK (1) HK81888A (no)
HU (2) HU193865B (no)
MY (1) MY101748A (no)
NO (2) NO162518C (no)
PH (1) PH21627A (no)
PT (1) PT78682B (no)
SU (2) SU1299508A3 (no)

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US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
JPS62161776A (ja) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
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US4778791A (en) * 1986-05-16 1988-10-18 Tanabe Seiyaku Co., Ltd. Pharmaceutical composition for improving constitution of lipids in blood
US4786634A (en) * 1986-05-23 1988-11-22 Tanabe Seikyaku Co., Ltd. Method for treating arteriosclerosis
ATE64925T1 (de) * 1986-08-20 1991-07-15 Mcneilab Inc Benzothiazepin-vasodilatoren mit aralkylsubstitution.
IL85257A (en) * 1987-02-10 1993-02-21 Tanabe Seiyaku Co Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
JPS6445376A (en) * 1987-08-12 1989-02-17 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
AT389446B (de) * 1987-10-08 1989-12-11 Tanabe Seiyaku Co Verwendung eines 8-chlorobenzothiazepins zur herstellung eines arzneimittels
US4808580A (en) * 1987-12-17 1989-02-28 Hoffmann-La Roche Inc. Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
US4879289A (en) * 1988-05-24 1989-11-07 Marion Laboratories, Inc. Method of ameliorating epileptic seizures
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5002942A (en) * 1988-07-25 1991-03-26 Sankyo Company, Limited 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1226301B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
AU628217B2 (en) * 1989-08-31 1992-09-10 Marion Merrell Dow Inc. Heterogeneous synthesis of azepinones from esters
US5250680A (en) * 1989-08-31 1993-10-05 Merrell Dow Pharmaceuticals Inc. Heterogeneous synthesis of azepinones from esters
JPH088879B2 (ja) * 1989-09-13 1996-01-31 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
CA2030160A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Benzothiazepine metastasis treatment
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
US5112969A (en) * 1990-04-02 1992-05-12 Merrell Dow Pharmaceuticals Inc. Cyano esters and azepinones
US5055575A (en) * 1990-04-12 1991-10-08 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
CA2049655C (en) * 1990-09-17 1996-11-12 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
DE69201793T2 (de) * 1991-05-20 1995-09-21 Marion Laboratories Inc Mehrschichtige zubereitung mit kontrollierter freisetzung.
US5378698A (en) * 1991-10-21 1995-01-03 Shionogi & Co., Ltd. Benzothiazepine derivatives
JP2712144B2 (ja) * 1992-02-06 1998-02-10 田辺製薬株式会社 血小板凝集抑制組成物
KR950003279A (ko) * 1993-07-29 1995-02-16 고사이 아끼오 플루오로알칸 카르복사미드 유도체의 제조방법
DE778272T1 (de) * 1995-12-05 1997-11-20 Tanabe Seiyaku Co Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung
US5705638A (en) * 1995-12-05 1998-01-06 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
CA2197816A1 (en) * 1996-02-23 1997-08-24 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
RS20050106A (en) 2002-08-19 2007-11-15 Pfizer Products Inc., Combination therapy for hyperproliferative diseases
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US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
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MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

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Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
BR6915295D0 (pt) * 1969-01-25 1973-04-12 Tanabe Seiyaku Co Indicador cronologico de evento em transmissao televisada

Also Published As

Publication number Publication date
NO842203L (no) 1984-12-04
DK272884A (da) 1984-12-04
HUT37929A (en) 1986-03-28
PT78682B (en) 1986-07-11
DK272884D0 (da) 1984-06-01
HK81888A (en) 1988-10-14
AU2887384A (en) 1984-12-06
BG40964A3 (en) 1987-03-14
DK104792A (da) 1992-08-24
KR850000033A (ko) 1985-02-25
SU1299508A3 (ru) 1987-03-23
ES8506677A1 (es) 1985-08-01
NO162518B (no) 1989-10-02
NO863823D0 (no) 1986-09-25
DD218619A5 (de) 1985-02-13
ES541557A0 (es) 1985-12-01
NO162518C (no) 1990-01-10
DK104792D0 (da) 1992-08-24
NO863823L (no) 1984-12-04
DE3460972D1 (en) 1986-11-20
EP0127882A1 (en) 1984-12-12
DK167186B1 (da) 1993-09-13
DK167185B1 (da) 1993-09-13
KR900005697B1 (ko) 1990-08-06
CA1231097A (en) 1988-01-05
ATE22889T1 (de) 1986-11-15
PT78682A (pt) 1985-01-01
PH21627A (en) 1987-12-11
CA1237719A (en) 1988-06-07
HU193865B (en) 1987-12-28
US4567175A (en) 1986-01-28
NO163566B (no) 1990-03-12
HU191933B (en) 1987-04-28
BG41130A3 (en) 1987-04-15
MY101748A (en) 1992-01-17
ES533009A0 (es) 1985-08-01
EP0127882B1 (en) 1986-10-15
ES8602720A1 (es) 1985-12-01
SU1362401A3 (ru) 1987-12-23
AU563093B2 (en) 1987-06-25

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