ES8801230A1 - Un procedimiento para preparar un derivado de 1,5-benzotiazepina - Google Patents

Un procedimiento para preparar un derivado de 1,5-benzotiazepina

Info

Publication number
ES8801230A1
ES8801230A1 ES557061A ES557061A ES8801230A1 ES 8801230 A1 ES8801230 A1 ES 8801230A1 ES 557061 A ES557061 A ES 557061A ES 557061 A ES557061 A ES 557061A ES 8801230 A1 ES8801230 A1 ES 8801230A1
Authority
ES
Spain
Prior art keywords
derivatives
hydrogen
benzothiazephine
preparing
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557061A
Other languages
English (en)
Other versions
ES557061A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES557061A0 publication Critical patent/ES557061A0/es
Publication of ES8801230A1 publication Critical patent/ES8801230A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE 1,5-BENZOTIAZEPINA, DE F''ORULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN DESACILAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R2 ES ALQUILO INFERIOR; Q ES HIDROGENO O UN GRUPO PROTECTOR; R3 ES HIDROGENO O ALQUILO INFERIOR; Y R4 Y R5 SON HIDROGENO UNO DE ELLOS Y EL OTRO ES CLORO, CON UN AGENTE ALCALINO TAL COMO HIDROXIDO DE METAL ALCALINO O UN CARBONATO DE METAL ALCALINO, EN UN DISOLVENTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 100 GRADOS, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). OPCIONALMENTE SE DESALQUILA EL PRODUCTO ASI OBTENIDO O UNA SAL DEL MISMO CON TRIHALURO DE BORO EN UN DISOLVENTE A UNA TEMPERATURA COMPRENDIDA ENTRE LOS 50 Y LOS 25 GRADOS. DE APLICACION EN MEDICINA POR SU ACTIVIDAD INHIBIDORA DE LA AGREGACION DE PLAQUETAS.
ES557061A 1984-04-10 1986-09-11 Un procedimiento para preparar un derivado de 1,5-benzotiazepina Expired ES8801230A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8409258 1984-04-10

Publications (2)

Publication Number Publication Date
ES557061A0 ES557061A0 (es) 1988-01-01
ES8801230A1 true ES8801230A1 (es) 1988-01-01

Family

ID=10559475

Family Applications (2)

Application Number Title Priority Date Filing Date
ES542125A Expired ES8705408A1 (es) 1984-04-10 1985-04-10 Un procedimiento para preparar un derivado de 1,5-benzotiazepina.
ES557061A Expired ES8801230A1 (es) 1984-04-10 1986-09-11 Un procedimiento para preparar un derivado de 1,5-benzotiazepina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542125A Expired ES8705408A1 (es) 1984-04-10 1985-04-10 Un procedimiento para preparar un derivado de 1,5-benzotiazepina.

Country Status (12)

Country Link
US (1) US4585768A (es)
EP (1) EP0158339B1 (es)
JP (1) JPS60226866A (es)
KR (1) KR910005414B1 (es)
AT (1) ATE40126T1 (es)
AU (1) AU572978B2 (es)
CA (1) CA1218991A (es)
DE (1) DE3567650D1 (es)
DK (1) DK172257B1 (es)
ES (2) ES8705408A1 (es)
HU (1) HU191785B (es)
SU (2) SU1632372A3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
JPS62161776A (ja) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
US4786634A (en) * 1986-05-23 1988-11-22 Tanabe Seikyaku Co., Ltd. Method for treating arteriosclerosis
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
FR2630107B1 (fr) * 1988-04-19 1990-06-08 Synthelabo Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
US5274300A (en) 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
FR2642425A1 (fr) * 1989-01-30 1990-08-03 Sanofi Sa Procede de preparation de derives de benzothiazepine-1,5 one-4
JP2674232B2 (ja) * 1989-08-31 1997-11-12 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体
JPH088879B2 (ja) * 1989-09-13 1996-01-31 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
JP2643798B2 (ja) * 1992-10-23 1997-08-20 田辺製薬株式会社 末梢動脈血流増加剤
FR2704848B1 (fr) * 1993-05-03 1995-07-21 Prod Chim Auxil Synthese Précurseur liquide pour la production de revêtements d'oxyde d'étain dopé au fluor et procédé de revêtement correspondant.
US5580867A (en) * 1994-09-09 1996-12-03 Universite De Montreal Myocardial protection during ischemia and reperfusion

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US3341519A (en) * 1965-04-28 1967-09-12 Squibb & Sons Inc Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS56156218A (en) * 1980-05-02 1981-12-02 Tanabe Seiyaku Co Ltd Inhibitor against blood platelet agglutination
JPS56156217A (en) * 1980-05-02 1981-12-02 Tanabe Seiyaku Co Ltd Inhibitor against blood platelet agglutination
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
CH665909A5 (fr) * 1985-05-15 1988-06-15 Matix Ind Sa Procede et dispositif de detection par ultrasons des defauts internes d'un rail de chemin de fer situes dans les bords du champignon de ce rail, utilisation du dispositif.
US5708066A (en) * 1995-03-01 1998-01-13 E. I. Du Pont De Nemours And Company Reaction curable composition and solid surface material

Also Published As

Publication number Publication date
HUT37411A (en) 1985-12-28
AU4039285A (en) 1985-10-17
EP0158339B1 (en) 1989-01-18
EP0158339A2 (en) 1985-10-16
CA1218991A (en) 1987-03-10
KR910005414B1 (ko) 1991-07-29
AU572978B2 (en) 1988-05-19
EP0158339A3 (en) 1986-06-11
DK172257B1 (da) 1998-02-09
ES542125A0 (es) 1987-05-01
ATE40126T1 (de) 1989-02-15
JPH0374659B2 (es) 1991-11-27
DE3567650D1 (en) 1989-02-23
ES557061A0 (es) 1988-01-01
KR850007248A (ko) 1985-12-02
JPS60226866A (ja) 1985-11-12
US4585768A (en) 1986-04-29
SU1632372A3 (ru) 1991-02-28
DK157785A (da) 1985-10-11
ES8705408A1 (es) 1987-05-01
DK157785D0 (da) 1985-04-09
SU1358784A3 (ru) 1987-12-07
HU191785B (en) 1987-04-28

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