US4146715A
(en)
|
1975-08-27 |
1979-03-27 |
Burroughs Wellcome Co. |
2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
|
US4060616A
(en)
*
|
1976-03-01 |
1977-11-29 |
Burroughs Wellcome Co. |
Purine derivatives with repeating unit
|
US4287188A
(en)
|
1977-02-24 |
1981-09-01 |
Burroughs Wellcome Co. |
Purine derivatives
|
AU521577B2
(en)
*
|
1977-02-24 |
1982-04-22 |
Wellcome Foundation Limited, The |
9-hydroxyethoxymethyl guanine phosphates
|
KR830005852A
(ko)
*
|
1980-07-18 |
1983-09-14 |
미첼 페터 잭슨 |
피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
|
US5157120A
(en)
*
|
1980-09-16 |
1992-10-20 |
Syntex (U.S.A.) Inc. |
Guanine derivatives
|
US4347360A
(en)
*
|
1980-09-16 |
1982-08-31 |
Ens Bio Logicals Inc. |
Ring open nucleoside analogues
|
JPS57102818A
(en)
*
|
1980-10-15 |
1982-06-26 |
Wellcome Found |
Treatment for fish virus diseases
|
US4355032B2
(en)
*
|
1981-05-21 |
1990-10-30 |
|
9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
|
US4423050A
(en)
*
|
1981-05-21 |
1983-12-27 |
Syntex (U.S.A.) Inc. |
9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
|
US4603219A
(en)
*
|
1981-05-21 |
1986-07-29 |
Syntex (U.S.A.) Inc. |
1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine
|
KR880002276B1
(ko)
*
|
1981-08-11 |
1988-10-21 |
더 웰컴 화운데이션 리미티드 |
항비루스성 화합물의 제조방법
|
AU564576B2
(en)
*
|
1981-09-24 |
1987-08-20 |
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. |
Purine derivatives
|
US5250535A
(en)
*
|
1982-02-01 |
1993-10-05 |
Syntex Inc. |
Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
|
JPS59500317A
(ja)
*
|
1982-02-12 |
1984-03-01 |
シンテツクス (ユー・エス・エイ) インコーポレイテツド |
抗ウイルス性組成物
|
SE8203855D0
(sv)
*
|
1982-06-21 |
1982-06-21 |
Astra Laekemedel Ab |
Novel derivatives of guanine i
|
SE8203856D0
(sv)
*
|
1982-06-21 |
1982-06-21 |
Astra Laekemedel Ab |
Novel derivatives of guanine ii
|
NL8202626A
(nl)
*
|
1982-06-29 |
1984-01-16 |
Stichting Rega V Z W |
Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
|
DE3376325D1
(en)
*
|
1982-10-14 |
1988-05-26 |
Wellcome Found |
Antiviral purine derivatives
|
US4745119A
(en)
*
|
1982-10-14 |
1988-05-17 |
Burroughs Wellcome Co. |
Method for using purine derivatives
|
US5059604A
(en)
*
|
1982-10-14 |
1991-10-22 |
Burroughs Wellcome Co. |
2-amino purine derivatives
|
US4649140A
(en)
*
|
1982-10-14 |
1987-03-10 |
Burroughs Wellcome Co. |
Purine derivatives
|
US4609662A
(en)
*
|
1982-10-14 |
1986-09-02 |
Burroughs Wellcome Co. |
Method for using purine derivatives
|
US4612314A
(en)
*
|
1982-12-22 |
1986-09-16 |
Syntex (U.S.A.) Inc. |
Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
|
US4461757A
(en)
*
|
1983-02-23 |
1984-07-24 |
Ens Bio Logicals Inc. |
Dimethylaminomethylenated anti-herpes compounds
|
ES520140A0
(es)
*
|
1983-02-25 |
1984-04-01 |
Ind Farma Especial |
Un procedimiento para la preparacion de acicloguanosina.
|
US5047533A
(en)
*
|
1983-05-24 |
1991-09-10 |
Sri International |
Acyclic purine phosphonate nucleotide analogs
|
US4557934A
(en)
|
1983-06-21 |
1985-12-10 |
The Procter & Gamble Company |
Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
|
JPS6023380A
(ja)
*
|
1983-06-24 |
1985-02-05 |
メルク・エンド・カムパニー・インコーポレーテッド |
抗ウイルス剤
|
US4880820A
(en)
*
|
1983-06-24 |
1989-11-14 |
Merck & Co., Inc. |
Guanine derivatives
|
US5684153A
(en)
*
|
1984-08-16 |
1997-11-04 |
Beecham Group Plc |
Process for the preparation of purine derivatives
|
US4897479A
(en)
*
|
1983-09-30 |
1990-01-30 |
Merck & Co., Inc. |
Arylsulfonyloxy purine intermediates
|
JPS6094992A
(ja)
*
|
1983-10-28 |
1985-05-28 |
Sankyo Co Ltd |
グリゼオ−ル酸誘導体
|
US4918219A
(en)
*
|
1983-10-31 |
1990-04-17 |
Warner-Lambert Company |
Glycerine derivatives
|
US4806642A
(en)
*
|
1984-10-05 |
1989-02-21 |
Warner-Lambert Company |
Purine derivatives
|
ZA848080B
(en)
*
|
1983-10-31 |
1985-06-26 |
Warner Lambert Co |
Purine derivatives
|
IE842642L
(en)
*
|
1983-10-31 |
1985-04-30 |
Harvard College |
Purine Derivatives
|
US4579849A
(en)
*
|
1984-04-06 |
1986-04-01 |
Merck & Co., Inc. |
N-alkylguanine acyclonucleosides as antiviral agents
|
US4617304A
(en)
*
|
1984-04-10 |
1986-10-14 |
Merck & Co., Inc. |
Purine derivatives
|
DK163985A
(da)
*
|
1984-04-13 |
1985-10-14 |
Wellcome Found |
Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
|
US4636507A
(en)
*
|
1984-04-30 |
1987-01-13 |
Hoechst-Roussel Pharmaceuticals Inc. |
Host defense mechanism enhancement
|
EP0167385B1
(en)
|
1984-07-03 |
1992-03-18 |
The Wellcome Foundation Limited |
Antiviral compounds, treatment and formulations
|
WO1986000901A1
(en)
*
|
1984-07-20 |
1986-02-13 |
Gauntt Charles O |
Immunoregulatory and anti-viral compound
|
SE8406538D0
(sv)
*
|
1984-12-21 |
1984-12-21 |
Astra Laekemedel Ab |
Novel derivatives of purine
|
US5683990A
(en)
*
|
1985-03-16 |
1997-11-04 |
Glaxo Wellcome Inc. |
Treatment of human viral infections
|
US4724232A
(en)
*
|
1985-03-16 |
1988-02-09 |
Burroughs Wellcome Co. |
Treatment of human viral infections
|
CS263951B1
(en)
*
|
1985-04-25 |
1989-05-12 |
Antonin Holy |
9-(phosponylmethoxyalkyl)adenines and method of their preparation
|
CS263952B1
(en)
*
|
1985-04-25 |
1989-05-12 |
Holy Antonin |
Remedy with antiviral effect
|
EP0203736B1
(en)
|
1985-05-02 |
1989-11-23 |
The Wellcome Foundation Limited |
Antiviral compounds
|
IL78643A0
(en)
*
|
1985-05-02 |
1986-08-31 |
Wellcome Found |
Purine derivatives,their preparation and pharmaceutical compositions containing them
|
DE3529497A1
(de)
*
|
1985-08-17 |
1987-02-26 |
Boehringer Mannheim Gmbh |
N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
|
DE3627024A1
(de)
*
|
1985-09-24 |
1987-04-02 |
Hoechst Ag |
In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
|
IT1207507B
(it)
*
|
1985-10-21 |
1989-05-25 |
Baldacci Lab Spa |
Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
|
AU618723B2
(en)
*
|
1986-10-06 |
1992-01-09 |
University Of Virginia Alumni Patents Foundation, The |
Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
|
EP0290630A4
(de)
*
|
1986-11-25 |
1990-02-26 |
Inst Organicheskogo Sinteza Ak |
9-substituierte guanine.
|
US4978655A
(en)
*
|
1986-12-17 |
1990-12-18 |
Yale University |
Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
|
US4829055A
(en)
*
|
1987-01-23 |
1989-05-09 |
Naficy Sadeque S |
Method of treatment for herpes infections of external tissues
|
US5565566A
(en)
*
|
1987-04-24 |
1996-10-15 |
Discovery Therapeutics, Inc. |
N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
|
US4835104A
(en)
*
|
1987-06-16 |
1989-05-30 |
Ajinomoto Co., Inc., Patent & Licensing Department |
Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
|
US6306647B1
(en)
|
1987-06-16 |
2001-10-23 |
Ajinomoto Co., Inc. |
Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
|
GB8725939D0
(en)
*
|
1987-11-05 |
1987-12-09 |
Wellcome Found |
Therapeutic compounds
|
GB8719367D0
(en)
*
|
1987-08-15 |
1987-09-23 |
Wellcome Found |
Therapeutic compounds
|
CA1302887C
(en)
*
|
1987-11-24 |
1992-06-09 |
Yves Langelier |
Combination of acyclovir or a derivative thereof and bacitracin
|
JPH01121424U
(da)
*
|
1988-02-10 |
1989-08-17 |
|
|
GB8815241D0
(en)
*
|
1988-06-27 |
1988-08-03 |
Wellcome Found |
Antiviral combinations & compounds therefor
|
US5164395A
(en)
*
|
1988-06-27 |
1992-11-17 |
Burroughs Wellcome Co. |
Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
|
GB8816760D0
(en)
*
|
1988-07-14 |
1988-08-17 |
Wellcome Found |
Therapeutic compounds
|
EP0366385B1
(en)
*
|
1988-10-24 |
1993-06-09 |
The Wellcome Foundation Limited |
Guanine derivatives having antiviral activity and their pharmaceutically acceptable salts
|
WO1990009178A1
(en)
*
|
1989-01-31 |
1990-08-23 |
Whitby Research, Inc. |
N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
|
US4966895A
(en)
*
|
1989-02-02 |
1990-10-30 |
Merck & Co. Inc. |
Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
|
GB8907173D0
(en)
*
|
1989-03-30 |
1989-05-10 |
Beecham Group Plc |
Novel compounds
|
GB8912043D0
(en)
*
|
1989-05-25 |
1989-07-12 |
Beecham Group Plc |
Novel compounds
|
GB9001886D0
(en)
*
|
1990-01-26 |
1990-03-28 |
Beecham Group Plc |
Pharmaceutical formulation
|
DE4008858A1
(de)
*
|
1990-03-20 |
1991-09-26 |
Hoechst Ag |
Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
|
CA2033447C
(en)
*
|
1990-12-31 |
1999-08-31 |
Robert Deziel |
Synergistic combination for treating herpes infections
|
US5879700A
(en)
*
|
1991-10-15 |
1999-03-09 |
Hostetler; Karl Y. |
Nucleoside analogue phosphates for topical use
|
US5580571A
(en)
*
|
1991-10-15 |
1996-12-03 |
Hostetler; Karl Y. |
Nucleoside analogues
|
CA2091732C
(en)
*
|
1992-07-08 |
1998-07-21 |
Anica Markovac |
A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
|
DK169121B1
(da)
|
1992-09-09 |
1994-08-22 |
Gea Farmaceutisk Fabrik As |
Antiviralt virksom farmaceutisk olie-i-vand-emulsion indeholdende 9-[(2-hydroxyethoxy)methyl]guanin (acyclovir) eller et salt eller en ester deraf
|
EP0589335B1
(de)
*
|
1992-09-24 |
2003-06-18 |
Hoechst Aktiengesellschaft |
N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
|
US6015573A
(en)
*
|
1993-05-12 |
2000-01-18 |
Hostetler; Karl Y. |
Nucleoside phosphate therapy for viral infection
|
US5654286A
(en)
*
|
1993-05-12 |
1997-08-05 |
Hostetler; Karl Y. |
Nucleotides for topical treatment of psoriasis, and methods for using same
|
IT1264599B1
(it)
*
|
1993-06-14 |
1996-10-04 |
Solar Chem Sa |
Processo per la sintesi della 9-(2-idrossietossimetil)- guanina
|
US5567816A
(en)
*
|
1994-07-26 |
1996-10-22 |
Syntex (U.S.A.) Inc. |
Preparation of acyclovir using 1,3 dioxolane
|
US5543414A
(en)
*
|
1994-07-28 |
1996-08-06 |
Syntex (Usa) Inc. |
Achiral amino acid acyl esters of ganciclovir and its derivatives
|
US5856481A
(en)
*
|
1994-07-28 |
1999-01-05 |
Syntex (U.S.A.) Inc. |
2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
|
US5565565A
(en)
|
1994-08-04 |
1996-10-15 |
Syntex (U.S.A.) Inc. |
Preparation of N-9 substituted guanine compounds
|
US5627185A
(en)
*
|
1994-11-23 |
1997-05-06 |
Gosselin; Gilles |
Acyclovir derivatives as antiviral agents
|
US5700936A
(en)
*
|
1996-01-26 |
1997-12-23 |
Syntex (U.S.A.) Inc. |
Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
|
US5840890A
(en)
*
|
1996-01-26 |
1998-11-24 |
Syntex (U.S.A.) Inc. |
Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
|
US5756736A
(en)
*
|
1996-01-26 |
1998-05-26 |
Syntex (U.S.A.) Inc. |
Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
|
US6040446A
(en)
|
1996-01-26 |
2000-03-21 |
Syntex (U.S.A.) Inc. |
Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
|
IN179493B
(da)
*
|
1996-02-22 |
1997-10-11 |
Lupin Laboraties Ltd |
|
US5789589A
(en)
*
|
1996-04-22 |
1998-08-04 |
Drug Innovation & Design, Inc. |
Guanine analog phosphates
|
US6440980B1
(en)
*
|
1996-09-17 |
2002-08-27 |
Avanir Pharmaceuticals |
Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
|
WO1998051692A1
(en)
|
1997-05-15 |
1998-11-19 |
Drug Innovation & Design, Inc. |
Acyclovir diester derivatives
|
US6180790B1
(en)
|
1997-05-15 |
2001-01-30 |
Drug Innovation And Design, Inc. |
Methods of preparing acyclovir prodrugs
|
EP1436006A4
(en)
*
|
2001-10-16 |
2006-06-07 |
Avanir Pharmaceuticals |
VIRAL INHIBITION BY N-DOCOSANOL
|
EP1440072A4
(en)
*
|
2001-10-30 |
2005-02-02 |
Conforma Therapeutic Corp |
PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
|
US20070129334A1
(en)
*
|
2001-10-30 |
2007-06-07 |
Conforma Therapeutics Corporation |
Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
|
US7078524B2
(en)
|
2002-11-22 |
2006-07-18 |
Ranbaxy Laboratories Limited |
Process for the synthesis of ganciclovir
|
SI1583542T1
(sl)
|
2003-01-14 |
2008-12-31 |
Gilead Sciences Inc |
Sestavki in postopki za kombinacijsko antivirusnoterapijo
|
US20040200730A1
(en)
*
|
2003-04-14 |
2004-10-14 |
Kyo Jibiki |
Hydrometallurgical copper recovery process
|
US20080132527A1
(en)
|
2004-05-19 |
2008-06-05 |
Emisphere Technologies, Inc. |
Compositions For Delivering Acyclovir
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
EP2001488A4
(en)
*
|
2006-03-14 |
2009-11-25 |
Alt Solutions Inc |
PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
EP2376515A1
(en)
|
2008-12-23 |
2011-10-19 |
Pharmasset, Inc. |
Synthesis of purine nucleosides
|
SG172361A1
(en)
|
2008-12-23 |
2011-07-28 |
Pharmasset Inc |
Nucleoside analogs
|
AR074897A1
(es)
|
2008-12-23 |
2011-02-23 |
Pharmasset Inc |
Fosforamidatos de nucleosidos
|
PT3290428T
(pt)
|
2010-03-31 |
2021-12-27 |
Gilead Pharmasset Llc |
Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
|
GB201819418D0
(en)
|
2018-11-29 |
2019-01-16 |
Daniel Calladine Ltd |
Anti-viral compositions
|
US20230218644A1
(en)
|
2020-04-16 |
2023-07-13 |
Som Innovation Biotech, S.A. |
Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
|