NL9000265A - Ethyl-6-broom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-fenylthiomethylindool-3-carboxylaat-hydrochloride-monohydraat, werkwijze voor de bereiding ervan en een farmaceutisch preparaat dat deze stof bevat, met antivirale, interferon inducerende en immunomodulatoire effecten. - Google Patents
Ethyl-6-broom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-fenylthiomethylindool-3-carboxylaat-hydrochloride-monohydraat, werkwijze voor de bereiding ervan en een farmaceutisch preparaat dat deze stof bevat, met antivirale, interferon inducerende en immunomodulatoire effecten. Download PDFInfo
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- NL9000265A NL9000265A NL9000265A NL9000265A NL9000265A NL 9000265 A NL9000265 A NL 9000265A NL 9000265 A NL9000265 A NL 9000265A NL 9000265 A NL9000265 A NL 9000265A NL 9000265 A NL9000265 A NL 9000265A
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- ethyl
- carboxylate
- methyl
- bromo
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- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 230000002024 thermoprotective effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 229960004626 umifenovir Drugs 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 208000005925 vesicular stomatitis Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SU1988/000272 WO1990008135A1 (fr) | 1989-01-12 | 1989-01-12 | Monohydrate d'hydrochlorure d'acide ethyle ester 6-brome-5-hydroxy-4-dimethyle-aminomethyle-1-methyle-2-phenylthiomethyle indole-3-carboxylique, son procede d'obtention et preparation pharmaceutique presentant une activite antivirale, de stimulation d'interferon et d'immunomodulation basee sur ledit compose |
| SU8800272 | 1989-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL9000265A true NL9000265A (nl) | 1991-09-02 |
Family
ID=21617367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9000265A NL9000265A (nl) | 1989-01-12 | 1990-02-02 | Ethyl-6-broom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-fenylthiomethylindool-3-carboxylaat-hydrochloride-monohydraat, werkwijze voor de bereiding ervan en een farmaceutisch preparaat dat deze stof bevat, met antivirale, interferon inducerende en immunomodulatoire effecten. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5198552A (cs) |
| BE (1) | BE1003341A4 (cs) |
| CH (1) | CH678726A5 (cs) |
| DE (2) | DE3891468C2 (cs) |
| DK (1) | DK15490A (cs) |
| FR (1) | FR2650504B1 (cs) |
| GB (1) | GB2234510B (cs) |
| NL (1) | NL9000265A (cs) |
| SE (1) | SE465462B (cs) |
| WO (1) | WO1990008135A1 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990008135A1 (fr) * | 1989-01-12 | 1990-07-26 | Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni S.Ordzhonikidze (Vnikhfi) | Monohydrate d'hydrochlorure d'acide ethyle ester 6-brome-5-hydroxy-4-dimethyle-aminomethyle-1-methyle-2-phenylthiomethyle indole-3-carboxylique, son procede d'obtention et preparation pharmaceutique presentant une activite antivirale, de stimulation d'interferon et d'immunomodulation basee sur ledit compose |
| AU2395095A (en) * | 1994-04-29 | 1995-11-29 | G.D. Searle & Co. | Method of using (h+/k+) atpase inhibitors as antiviral agents |
| CN100361975C (zh) * | 2003-01-04 | 2008-01-16 | 沈阳药科大学 | 5－羟基－3－羧酸酯吲哚类衍生物及其制备方法 |
| CN1560035A (zh) | 2004-03-12 | 2005-01-05 | 沈阳药科大学 | 5－羟基吲哚－3－羧酸脂类衍生物 |
| CN100519523C (zh) * | 2004-03-12 | 2009-07-29 | 沈阳药科大学 | 5-羟基吲哚-3-羧酸酯类衍生物及其用途 |
| CN100364975C (zh) * | 2005-04-26 | 2008-01-30 | 武汉大学 | 一种抗呼吸道病毒的药物及用途 |
| CN1316968C (zh) * | 2005-09-30 | 2007-05-23 | 青岛大学 | 吲哚－2,3－二酮在制备抗病毒或免疫增强剂药物中的应用 |
| EA016633B1 (ru) | 2006-05-23 | 2012-06-29 | Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" | Замещенные индолы, способ их получения и применения |
| CN101070319B (zh) * | 2007-05-29 | 2012-04-18 | 沈阳中海生物技术开发有限公司 | 一种抗乙肝病毒化合物的结晶形态以及它的制备方法和用途 |
| RU2422440C2 (ru) * | 2009-09-09 | 2011-06-27 | Российская Федерация, от имени которой выступает Министерство промышленности и торговли (Минпромторг России) | Способ выделения этилового эфира 1,2-диметил-5-ацетокси-3-индолилкарбоновой кислоты из реакционной массы |
| WO2012010276A1 (en) | 2010-07-16 | 2012-01-26 | Grindeks | Derivatives of 1,4-dihydropyridine possessing antiviral efficacy |
| CN102786462B (zh) * | 2011-05-18 | 2016-08-31 | 中国医学科学院药物研究所 | 阿比朵尔盐酸盐晶b型及制法与在药品和保健品中应用 |
| CN102786461B (zh) * | 2011-05-18 | 2016-08-31 | 中国医学科学院药物研究所 | 阿比朵尔盐酸盐晶e型及制法与在药品和保健品中应用 |
| CN102351778A (zh) * | 2011-08-17 | 2012-02-15 | 湖北华龙生物制药有限公司 | 一种盐酸阿比朵尔的制备方法 |
| EP2578218A1 (en) | 2011-10-06 | 2013-04-10 | Grindeks, A Joint Stock Company | Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives |
| CN104193669B (zh) * | 2014-08-01 | 2016-12-07 | 大连理工大学 | 一类阿比朵尔类似物或其盐、其制备方法及应用 |
| CN106083691B (zh) * | 2016-08-22 | 2018-11-27 | 山东罗欣药业集团恒欣药业有限公司 | 一种盐酸阿比朵尔一水合物的制备方法 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN111533677A (zh) * | 2020-05-13 | 2020-08-14 | 大连万福制药有限公司 | 一种合成盐酸阿比朵尔中间体的方法 |
| CN116003308B (zh) * | 2022-12-27 | 2023-09-29 | 石家庄中硕制药有限公司 | 阿比多尔结晶方法 |
| CN117586173B (zh) * | 2023-11-29 | 2024-07-12 | 石家庄中硕制药有限公司 | 一种阿比多尔的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124702A (en) * | 1971-07-06 | 1978-11-07 | Merck & Co., Inc. | Polynucleotides active as inducers of interferon production in living animal cells |
| US4215137A (en) * | 1978-06-26 | 1980-07-29 | Sterling Drug Inc. | Method of alleviating diseases by cell-mediated immune modulation |
| US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| DE3782938T2 (de) * | 1986-04-17 | 1993-10-21 | Everardus Arnoldus Oostveen | Indochinon-verbindungen. |
| US4874759A (en) * | 1987-01-23 | 1989-10-17 | Yoshitomi Pharmaceutical Industries, Ltd. | 5-Hydroxyindole-3-carboxylic acid amide compounds, pharmaceutical compositions and use |
| JPS63188665A (ja) * | 1987-01-30 | 1988-08-04 | Yoshitomi Pharmaceut Ind Ltd | ５−ヒドロキシインド−ル−３−カルボン酸エステル化合物 |
| WO1990008135A1 (fr) * | 1989-01-12 | 1990-07-26 | Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni S.Ordzhonikidze (Vnikhfi) | Monohydrate d'hydrochlorure d'acide ethyle ester 6-brome-5-hydroxy-4-dimethyle-aminomethyle-1-methyle-2-phenylthiomethyle indole-3-carboxylique, son procede d'obtention et preparation pharmaceutique presentant une activite antivirale, de stimulation d'interferon et d'immunomodulation basee sur ledit compose |
-
1989
- 1989-01-12 WO PCT/SU1988/000272 patent/WO1990008135A1/ru not_active Ceased
- 1989-01-12 DE DE3891468A patent/DE3891468C2/de not_active Expired - Fee Related
- 1989-01-12 US US07/576,444 patent/US5198552A/en not_active Expired - Fee Related
- 1989-01-12 CH CH3071/90A patent/CH678726A5/de not_active IP Right Cessation
- 1989-01-12 DE DE883891468T patent/DE3891468T1/de active Pending
- 1989-08-04 FR FR8910558A patent/FR2650504B1/fr not_active Expired - Fee Related
-
1990
- 1990-01-19 DK DK015490A patent/DK15490A/da not_active Application Discontinuation
- 1990-01-23 BE BE9000076A patent/BE1003341A4/fr not_active IP Right Cessation
- 1990-01-26 SE SE9000282A patent/SE465462B/sv unknown
- 1990-02-02 NL NL9000265A patent/NL9000265A/nl not_active Application Discontinuation
- 1990-09-11 GB GB9020370A patent/GB2234510B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BE1003341A4 (fr) | 1992-03-03 |
| GB9020370D0 (en) | 1990-11-21 |
| SE9000282L (sv) | 1991-07-27 |
| FR2650504A1 (fr) | 1991-02-08 |
| GB2234510B (en) | 1992-03-25 |
| WO1990008135A1 (fr) | 1990-07-26 |
| GB2234510A (en) | 1991-02-06 |
| SE465462B (sv) | 1991-09-16 |
| DE3891468T1 (de) | 1991-02-21 |
| FR2650504B1 (fr) | 1993-12-24 |
| DK15490D0 (da) | 1990-01-19 |
| DK15490A (da) | 1991-07-20 |
| DE3891468C2 (de) | 1994-02-24 |
| CH678726A5 (cs) | 1991-10-31 |
| US5198552A (en) | 1993-03-30 |
| SE9000282D0 (sv) | 1990-01-26 |
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| Date | Code | Title | Description |
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| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed |