SE9000282L - 6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan - Google Patents

6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan

Info

Publication number
SE9000282L
SE9000282L SE9000282A SE9000282A SE9000282L SE 9000282 L SE9000282 L SE 9000282L SE 9000282 A SE9000282 A SE 9000282A SE 9000282 A SE9000282 A SE 9000282A SE 9000282 L SE9000282 L SE 9000282L
Authority
SE
Sweden
Prior art keywords
bromo
hydrochloride monohydrate
hydroxy
methyl
carboxylate
Prior art date
Application number
SE9000282A
Other languages
English (en)
Other versions
SE9000282D0 (sv
SE465462B (sv
Inventor
A N Grinev
Original Assignee
Le Nii Epidemiolognauchno I I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Nii Epidemiolognauchno I I filed Critical Le Nii Epidemiolognauchno I I
Publication of SE9000282D0 publication Critical patent/SE9000282D0/sv
Publication of SE9000282L publication Critical patent/SE9000282L/sv
Publication of SE465462B publication Critical patent/SE465462B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE9000282A 1989-01-12 1990-01-26 6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan SE465462B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SU1988/000272 WO1990008135A1 (en) 1989-01-12 1989-01-12 Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it

Publications (3)

Publication Number Publication Date
SE9000282D0 SE9000282D0 (sv) 1990-01-26
SE9000282L true SE9000282L (sv) 1991-07-27
SE465462B SE465462B (sv) 1991-09-16

Family

ID=21617367

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9000282A SE465462B (sv) 1989-01-12 1990-01-26 6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan

Country Status (10)

Country Link
US (1) US5198552A (sv)
BE (1) BE1003341A4 (sv)
CH (1) CH678726A5 (sv)
DE (2) DE3891468C2 (sv)
DK (1) DK15490A (sv)
FR (1) FR2650504B1 (sv)
GB (1) GB2234510B (sv)
NL (1) NL9000265A (sv)
SE (1) SE465462B (sv)
WO (1) WO1990008135A1 (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH678726A5 (sv) * 1989-01-12 1991-10-31 Vni Khim Farmatsevtichesky I I
AU2395095A (en) 1994-04-29 1995-11-29 G.D. Searle & Co. Method of using (h+/k+) atpase inhibitors as antiviral agents
CN100361975C (zh) * 2003-01-04 2008-01-16 沈阳药科大学 5－羟基－3－羧酸酯吲哚类衍生物及其制备方法
CN1560035A (zh) * 2004-03-12 2005-01-05 沈阳药科大学 5－羟基吲哚－3－羧酸脂类衍生物
CN100519523C (zh) * 2004-03-12 2009-07-29 沈阳药科大学 5-羟基吲哚-3-羧酸酯类衍生物及其用途
CN100364975C (zh) * 2005-04-26 2008-01-30 武汉大学 一种抗呼吸道病毒的药物及用途
CN1316968C (zh) * 2005-09-30 2007-05-23 青岛大学 吲哚－2,3－二酮在制备抗病毒或免疫增强剂药物中的应用
EP2036889A4 (en) 2006-05-23 2009-11-04 Alla Chem Llc SUBSTITUTED INDOLES AND PROCESS FOR PRODUCTION AND USE THEREOF
CN101070319B (zh) * 2007-05-29 2012-04-18 沈阳中海生物技术开发有限公司 一种抗乙肝病毒化合物的结晶形态以及它的制备方法和用途
EP2593430A1 (en) 2010-07-16 2013-05-22 Grindeks Derivatives of 1,4-dihydropyridine possessing antiviral efficacy
CN102786462B (zh) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 阿比朵尔盐酸盐晶b型及制法与在药品和保健品中应用
CN102786461B (zh) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 阿比朵尔盐酸盐晶e型及制法与在药品和保健品中应用
CN102351778A (zh) * 2011-08-17 2012-02-15 湖北华龙生物制药有限公司 一种盐酸阿比朵尔的制备方法
EP2578218A1 (en) 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
CN104193669B (zh) * 2014-08-01 2016-12-07 大连理工大学 一类阿比朵尔类似物或其盐、其制备方法及应用
CN106083691B (zh) * 2016-08-22 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种盐酸阿比朵尔一水合物的制备方法
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111533677A (zh) * 2020-05-13 2020-08-14 大连万福制药有限公司 一种合成盐酸阿比朵尔中间体的方法
CN116003308B (zh) * 2022-12-27 2023-09-29 石家庄中硕制药有限公司 阿比多尔结晶方法
CN117586173A (zh) * 2023-11-29 2024-02-23 石家庄中硕制药有限公司 一种阿比多尔的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124702A (en) * 1971-07-06 1978-11-07 Merck & Co., Inc. Polynucleotides active as inducers of interferon production in living animal cells
US4215137A (en) * 1978-06-26 1980-07-29 Sterling Drug Inc. Method of alleviating diseases by cell-mediated immune modulation
US4619942A (en) * 1982-04-08 1986-10-28 University Of North Carolina Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds
AU615877B2 (en) * 1986-04-17 1991-10-17 Oostven, Everardus Arnoldus Indoloquinone compounds
WO1988005432A1 (en) * 1987-01-23 1988-07-28 Yoshitomi Pharmaceutical Industries, Ltd. 5-hydroxyindole-3-carboxamide compound and medicinal use thereof
JPS63188665A (ja) * 1987-01-30 1988-08-04 Yoshitomi Pharmaceut Ind Ltd ５−ヒドロキシインド−ル−３−カルボン酸エステル化合物
CH678726A5 (sv) * 1989-01-12 1991-10-31 Vni Khim Farmatsevtichesky I I

Also Published As

Publication number Publication date
SE9000282D0 (sv) 1990-01-26
DK15490D0 (da) 1990-01-19
DE3891468C2 (de) 1994-02-24
FR2650504B1 (fr) 1993-12-24
US5198552A (en) 1993-03-30
GB2234510A (en) 1991-02-06
CH678726A5 (sv) 1991-10-31
GB9020370D0 (en) 1990-11-21
NL9000265A (nl) 1991-09-02
WO1990008135A1 (en) 1990-07-26
DE3891468T1 (de) 1991-02-21
DK15490A (da) 1991-07-20
SE465462B (sv) 1991-09-16
GB2234510B (en) 1992-03-25
BE1003341A4 (fr) 1992-03-03
FR2650504A1 (fr) 1991-02-08

Similar Documents

Publication Publication Date Title
SE9000282L (sv) 6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan
ES2125962T3 (es) Procedimiento de preparacion de monoesteres mayoritariamente en posicion 6' de la d-maltosa y su utilizacion en los campos cosmetico, bucodental, farmaceutico y alimenticio.
HUT59109A (en) Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
HUT57230A (en) Process for producing pyrimidine-nucleosides and pharmaceutical compositions containing them
EP0237051A3 (en) Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
KR940019708A (ko) 헤테로시클릭 치환된 페닐-시클로헥산-카르복실산 유도체
HU912768D0 (en) Process for producing codeinic salt of a substituted carboxylic acid as well as pharmaceutical preparative containing said compound
HUT46536A (en) Process for producing antianxietive pharmaceutical compositions
MX163528B (es) Productos de reaccion de poli(oxialquileno)de acido succinico hidrocarbilo-substituido y/o terminados de anhidrido amina y sistemas acuosos conteniendo los mismos
IL86080A (en) Substituted alkoxy-2-alkyl-indan and 1,2,3,4-tetrahydro-naphthol,process for the preparation thereof and pharmaceutical compositions comprising the same
KR960031442A (ko) 페닐시클로헥실카르복스아미드의 용도
GB2274283A (en) A process for preparing 4-isothiazolin-3-one
NO170154C (no) Fremgangsmaate for fremstilling av kinolincarboxylsyrer
HUT53880A (en) Process for preparation of 3-phenyl-5,6-dilhydrobenz (c)-acridine-carboxylic-acids and carboxylic-acid derivatives and for manufacturing of pharmaceutical composition containing these compounds as active ingredient
US3856848A (en) Process for preparing a protected arginine
BE904662A (fr) Derive antipsychotique du benzisothiazole s-oxyde.
HUT47398A (en) Antiparasitic compositions comprising 2,2-dimethyl-cyclopropanecarboxylic acid derivatives and process for producing the active ingredients and their intermediates
EP0669911B1 (en) Indole derivative having prolonged immunostimulating activity and pharmaceutical compositions therefrom
PT92848A (pt) Processo de preparacao de mono-hidrato de hidrocloreto de 6-bromo-5-hidroxi- -4-dimetilaminometil-1-metil-2-feniltiometilindole-3-carboxilato de etilo
ES2019022A6 (es) Un procedimiento para preparar hidrocloruro de 6-bromo-5-hidroxi-4-dimetilaminometil-1-metil-2-feniltiometil-indol-3-carboxilato de etilo monohidrato.
GB2008096A (en) (2-Oxo-pyrrolidine-1)- and (2-oxo- piperidine-1) carboxylic acid hydrazides, process for the manufacture thereof, and pharmaceutical preparations containing them
JPS57203049A (en) Preparation of amide derivative
CA2008911A1 (en) Process for preparing ethyl 6-bromo-5-hydroxy-4- dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3- carboxylate hydrochloride monohydrate and a pharmaceutical preparation containing the same having the antiviral, interferon-inducing and immunomodulatory effects
PT798297E (pt) "processo para a producao de 2-alcoxi-6-(trifluorometil)-pirimidin-4-ol"
JPS57175151A (en) Synthesis of diamino acid derivative

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 9000282-5

Format of ref document f/p: F