NL8801733A - Nieuwe toepassing van 5 ht-3 antagonisten. - Google Patents
Nieuwe toepassing van 5 ht-3 antagonisten. Download PDFInfo
- Publication number
- NL8801733A NL8801733A NL8801733A NL8801733A NL8801733A NL 8801733 A NL8801733 A NL 8801733A NL 8801733 A NL8801733 A NL 8801733A NL 8801733 A NL8801733 A NL 8801733A NL 8801733 A NL8801733 A NL 8801733A
- Authority
- NL
- Netherlands
- Prior art keywords
- group
- antagonist
- addiction
- carbon atoms
- inducing agent
- Prior art date
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- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 title claims description 42
- 206010012335 Dependence Diseases 0.000 claims description 57
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- 230000001939 inductive effect Effects 0.000 claims description 31
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- 125000000217 alkyl group Chemical group 0.000 claims description 19
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Classifications
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- Life Sciences & Earth Sciences (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3722959 | 1987-07-11 | ||
| DE3722959 | 1987-07-11 | ||
| DE3735719 | 1987-10-22 | ||
| DE3735719 | 1987-10-22 | ||
| CH451087 | 1987-11-19 | ||
| CH451087 | 1987-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8801733A true NL8801733A (nl) | 1989-02-01 |
Family
ID=27174878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8801733A NL8801733A (nl) | 1987-07-11 | 1988-07-08 | Nieuwe toepassing van 5 ht-3 antagonisten. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5039680A (enExample) |
| EP (1) | EP0302008A3 (enExample) |
| JP (1) | JPS6431729A (enExample) |
| KR (1) | KR890001537A (enExample) |
| AT (1) | AT401615B (enExample) |
| AU (3) | AU618008B2 (enExample) |
| BE (1) | BE1004835A5 (enExample) |
| DE (1) | DE3822792C2 (enExample) |
| DK (1) | DK385388A (enExample) |
| FR (1) | FR2617713A1 (enExample) |
| GB (2) | GB2206788B (enExample) |
| HU (1) | HU206042B (enExample) |
| IT (1) | IT1226632B (enExample) |
| MY (1) | MY103536A (enExample) |
| NL (1) | NL8801733A (enExample) |
| PH (1) | PH27002A (enExample) |
| PT (1) | PT87958B (enExample) |
| SE (1) | SE8802570L (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198447A (en) * | 1986-11-21 | 1993-03-30 | Glaxo Group Limited | Medicaments |
| GB8627909D0 (en) * | 1986-11-21 | 1986-12-31 | Glaxo Group Ltd | Medicaments |
| WO1988003801A1 (en) * | 1986-11-21 | 1988-06-02 | Glaxo Group Limited | Medicaments for treatment or prevention of withdrawal syndrome |
| DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
| US5166341A (en) * | 1988-07-29 | 1992-11-24 | Dainippon Pharmaceutical Co., Ltd. | 6-amino-1,4-hexahydro-1H-diazepine derivatives |
| GB8820650D0 (en) * | 1988-09-01 | 1988-10-05 | Glaxo Group Ltd | Medicaments |
| US4999382A (en) * | 1988-10-26 | 1991-03-12 | Massachusetts Institute Of Technology | Compositions for treating tobacco withdrawal symptoms and methods for their use |
| US5276050A (en) * | 1989-08-01 | 1994-01-04 | Glaxo Group Limited | Medicaments |
| WO1993000074A1 (en) * | 1991-06-26 | 1993-01-07 | Sepracor, Inc. | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
| JPH05310732A (ja) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−３−カルボン酸誘導体 |
| JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔３，２−ｂ〕ピリジン誘導体 |
| US6109269A (en) * | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
| US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
| US20040092511A1 (en) * | 1999-12-10 | 2004-05-13 | Billstein Stephan Anthony | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders |
| US6486172B2 (en) | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| AU2001282874A1 (en) | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| US6599916B2 (en) | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| WO2003018585A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
| US20030069296A1 (en) * | 2001-08-24 | 2003-04-10 | Wishka Donn G. | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| BR0212477A (pt) * | 2001-09-12 | 2004-08-24 | Upjohn Co | 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças |
| NZ531786A (en) | 2001-10-02 | 2006-10-27 | Upjohn Co | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| MXPA04004464A (es) * | 2001-11-08 | 2004-08-11 | Upjohn Co | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. |
| WO2003042210A1 (en) | 2001-11-09 | 2003-05-22 | Pharmacia & Upjohn Company | Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands |
| US7071335B2 (en) | 2002-02-01 | 2006-07-04 | Euro-Celtique S.A. | 2-pyridinyl-1-piperazine therapeutic agents useful for treating pain |
| US6852716B2 (en) | 2002-02-15 | 2005-02-08 | Pfizer Inc | Substituted-aryl compounds for treatment of disease |
| MXPA04008152A (es) * | 2002-02-19 | 2005-09-08 | Upjohn Co | Compuestos azabiciclicos para el tratamiento de enfermedades. |
| JP2005523288A (ja) * | 2002-02-19 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド |
| US7001900B2 (en) * | 2002-02-20 | 2006-02-21 | Pfizer Inc. | Azabicyclic compounds for the treatment of disease |
| US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| US6864261B2 (en) * | 2002-05-02 | 2005-03-08 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| NZ537292A (en) * | 2002-06-28 | 2006-08-31 | Euroceltique S | Therapeutic piperazine derivatives useful for treating pain |
| US7262194B2 (en) * | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US20080081834A1 (en) | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
| EP1542999A1 (en) * | 2002-08-01 | 2005-06-22 | Pharmacia & Upjohn Company LLC | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| US7157462B2 (en) * | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| BR0315056A (pt) * | 2002-11-01 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central |
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| EP1641775B1 (en) * | 2003-07-03 | 2009-02-18 | Euro-Celtique S.A. | 2-pyridine alkyne derivatives useful for treating pain |
| DE602004017316D1 (de) * | 2003-07-24 | 2008-12-04 | Euro Celtique Sa | Heteroaryl-tetrahydropyridylverbindungen, die sich für die behandlung bzw. die prävention von schmerzen eignen |
| KR100954415B1 (ko) * | 2003-07-24 | 2010-04-26 | 유로-셀띠끄 소시에떼 아노님 | 피페리딘 화합물 및 그들을 포함하는 약학적 조성물 |
| PL1867644T3 (pl) | 2003-07-24 | 2009-10-30 | Euro Celtique Sa | Związki heteroarylo-tetrahydropiperydylowe przydatne w leczeniu lub zapobieganiu bólu |
| PT1942106E (pt) | 2003-08-01 | 2011-12-22 | Euro Celtique Sa | Agentes terapêuticos úteis para o tratamento da dor |
| ES2317052T3 (es) * | 2003-09-22 | 2009-04-16 | Euro-Celtique S.A. | Agentes terapeuticos utiles para el tratamiento del dolor. |
| DK1664041T3 (da) | 2003-09-22 | 2008-10-27 | Euro Celtique Sa | Phenylcarboxamidforbindelser, der er egnede til behandling af smerter |
| KR100867188B1 (ko) * | 2003-12-30 | 2008-11-06 | 유로-셀띠끄 소시에떼 아노님 | 통증 치료에 유용한 피페라진 |
| US20070043100A1 (en) * | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| US20060100263A1 (en) * | 2004-11-05 | 2006-05-11 | Anthony Basile | Antipyretic compositions and methods |
| AU2006275870B2 (en) * | 2005-07-27 | 2013-01-10 | Otsuka America Pharmaceutical, Inc. | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| US8138377B2 (en) * | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US8389549B2 (en) * | 2007-04-27 | 2013-03-05 | Purdue Pharma L.P. | Substituted pyridines useful for treating pain |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| EP2167083B1 (en) * | 2007-06-06 | 2015-10-28 | Euthymics Bioscience, Inc. | 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| WO2011085389A1 (en) | 2010-01-11 | 2011-07-14 | Astraea Therapeutics, Llc | Nicotinic acetylcholine receptor modulators |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| PL3083616T3 (pl) | 2013-12-20 | 2021-12-06 | Astex Therapeutics Limited | Bicykliczne związki heterocykliczne i ich zastosowania w terapii |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
| FI74707C (fi) * | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
| BE897117A (fr) * | 1982-06-29 | 1983-12-23 | Sandoz Sa | Nouveaux derives de la piperidine leur preparation et leur utilisation comme medicaments |
| DE3429830A1 (de) * | 1983-08-26 | 1985-03-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Automatische carbonsaeure- und sulfonsaeureester oder -amide |
| FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
| PT79890B (en) * | 1984-01-25 | 1987-02-03 | Glaxo Group Ltd | Process for preparing tetrahydro-methylimidazolylcarbazolones |
| DE3689974T2 (de) * | 1985-03-14 | 1994-11-03 | Beecham Group Plc | Arzneimittel zur Behandlung von Emesis. |
| DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| GR861128B (en) * | 1985-05-06 | 1986-08-26 | Sandoz Ag | New use of dopamine agonists |
| GB8516083D0 (en) * | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8520616D0 (en) * | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
| GB8701494D0 (en) * | 1987-01-23 | 1987-02-25 | Glaxo Group Ltd | Chemical compounds |
| GB8627909D0 (en) * | 1986-11-21 | 1986-12-31 | Glaxo Group Ltd | Medicaments |
| WO1988003801A1 (en) * | 1986-11-21 | 1988-06-02 | Glaxo Group Limited | Medicaments for treatment or prevention of withdrawal syndrome |
| GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
| GB8630080D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
| DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| EP0306323B1 (en) * | 1987-09-03 | 1994-09-21 | Glaxo Group Limited | Lactam derivatives |
| ZA886585B (en) * | 1987-09-08 | 1990-05-30 | Lilly Co Eli | Specific 5-ht,antagonists |
| GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
| US4985420A (en) * | 1987-12-10 | 1991-01-15 | Duphar International Research B.V. | 1,7-annelated indolecarboxylic acid esters and -amides |
| EP0336759A1 (en) * | 1988-04-07 | 1989-10-11 | Glaxo Group Limited | Imidazole derivatives |
-
1988
- 1988-07-06 DE DE3822792A patent/DE3822792C2/de not_active Expired - Fee Related
- 1988-07-07 EP EP19880810470 patent/EP0302008A3/en not_active Withdrawn
- 1988-07-08 DK DK385388A patent/DK385388A/da not_active Application Discontinuation
- 1988-07-08 GB GB8816298A patent/GB2206788B/en not_active Expired - Lifetime
- 1988-07-08 FR FR8809350A patent/FR2617713A1/fr active Granted
- 1988-07-08 AT AT0177688A patent/AT401615B/de not_active IP Right Cessation
- 1988-07-08 MY MYPI88000755A patent/MY103536A/en unknown
- 1988-07-08 HU HU883610A patent/HU206042B/hu not_active IP Right Cessation
- 1988-07-08 NL NL8801733A patent/NL8801733A/nl not_active Application Discontinuation
- 1988-07-08 PT PT87958A patent/PT87958B/pt not_active IP Right Cessation
- 1988-07-08 SE SE8802570A patent/SE8802570L/xx not_active Application Discontinuation
- 1988-07-09 JP JP63171704A patent/JPS6431729A/ja active Pending
- 1988-07-09 KR KR1019880008589A patent/KR890001537A/ko not_active Ceased
- 1988-07-11 IT IT8848172A patent/IT1226632B/it active
- 1988-07-11 BE BE8800802A patent/BE1004835A5/fr not_active IP Right Cessation
- 1988-07-11 PH PH37205A patent/PH27002A/en unknown
- 1988-07-11 AU AU18920/88A patent/AU618008B2/en not_active Ceased
-
1990
- 1990-01-19 US US07/467,598 patent/US5039680A/en not_active Expired - Fee Related
-
1991
- 1991-03-05 GB GB9104598A patent/GB2240475B/en not_active Expired - Lifetime
- 1991-10-07 AU AU85628/91A patent/AU633762B2/en not_active Ceased
- 1991-10-07 AU AU85630/91A patent/AU643075B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1892088A (en) | 1989-01-12 |
| FR2617713A1 (fr) | 1989-01-13 |
| SE8802570L (sv) | 1989-03-28 |
| DK385388D0 (da) | 1988-07-08 |
| AU643075B2 (en) | 1993-11-04 |
| GB2206788B (en) | 1992-03-25 |
| EP0302008A2 (en) | 1989-02-01 |
| PH27002A (en) | 1993-02-01 |
| PT87958B (pt) | 1995-03-01 |
| DE3822792C2 (de) | 1997-11-27 |
| GB2240475A (en) | 1991-08-07 |
| US5039680A (en) | 1991-08-13 |
| HUT50038A (en) | 1989-12-28 |
| JPS6431729A (en) | 1989-02-02 |
| DE3822792A1 (de) | 1989-01-19 |
| EP0302008A3 (en) | 1992-12-23 |
| PT87958A (pt) | 1989-06-30 |
| IT8848172A0 (it) | 1988-07-11 |
| AU8563091A (en) | 1991-12-12 |
| AU8562891A (en) | 1991-12-05 |
| AU633762B2 (en) | 1993-02-04 |
| IT1226632B (it) | 1991-01-28 |
| GB8816298D0 (en) | 1988-08-10 |
| BE1004835A5 (fr) | 1993-02-09 |
| HU206042B (en) | 1992-08-28 |
| AU618008B2 (en) | 1991-12-12 |
| KR890001537A (ko) | 1989-03-27 |
| SE8802570D0 (sv) | 1988-07-08 |
| GB2240475B (en) | 1992-03-18 |
| GB9104598D0 (en) | 1991-04-17 |
| DK385388A (da) | 1989-01-12 |
| MY103536A (en) | 1993-07-31 |
| AT401615B (de) | 1996-10-25 |
| GB2206788A (en) | 1989-01-18 |
| FR2617713B1 (enExample) | 1994-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |