AU618008B2 - Improvements in or relating to organic compounds - Google Patents

Improvements in or relating to organic compounds Download PDF

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Publication number
AU618008B2
AU618008B2 AU18920/88A AU1892088A AU618008B2 AU 618008 B2 AU618008 B2 AU 618008B2 AU 18920/88 A AU18920/88 A AU 18920/88A AU 1892088 A AU1892088 A AU 1892088A AU 618008 B2 AU618008 B2 AU 618008B2
Authority
AU
Australia
Prior art keywords
dependency
inducing agent
compound
salt form
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18920/88A
Other languages
English (en)
Other versions
AU1892088A (en
Inventor
Assunta Imperato
Dietmar Romer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU1892088A publication Critical patent/AU1892088A/en
Application granted granted Critical
Publication of AU618008B2 publication Critical patent/AU618008B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU18920/88A 1987-07-11 1988-07-11 Improvements in or relating to organic compounds Ceased AU618008B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE3722959 1987-07-11
DE3722959 1987-07-11
DE3735719 1987-10-22
DE3735719 1987-10-22
CH4510/87 1987-11-19
CH451087 1987-11-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU85628/91A Division AU633762B2 (en) 1987-07-11 1991-10-07 5ht-3 antagonist for the prevention or reduction of dependence
AU85630/91A Division AU643075B2 (en) 1987-07-11 1991-10-07 5HT-3 antagonists for the prevention or reduction of dependence

Publications (2)

Publication Number Publication Date
AU1892088A AU1892088A (en) 1989-01-12
AU618008B2 true AU618008B2 (en) 1991-12-12

Family

ID=27174878

Family Applications (3)

Application Number Title Priority Date Filing Date
AU18920/88A Ceased AU618008B2 (en) 1987-07-11 1988-07-11 Improvements in or relating to organic compounds
AU85628/91A Ceased AU633762B2 (en) 1987-07-11 1991-10-07 5ht-3 antagonist for the prevention or reduction of dependence
AU85630/91A Ceased AU643075B2 (en) 1987-07-11 1991-10-07 5HT-3 antagonists for the prevention or reduction of dependence

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU85628/91A Ceased AU633762B2 (en) 1987-07-11 1991-10-07 5ht-3 antagonist for the prevention or reduction of dependence
AU85630/91A Ceased AU643075B2 (en) 1987-07-11 1991-10-07 5HT-3 antagonists for the prevention or reduction of dependence

Country Status (18)

Country Link
US (1) US5039680A (enExample)
EP (1) EP0302008A3 (enExample)
JP (1) JPS6431729A (enExample)
KR (1) KR890001537A (enExample)
AT (1) AT401615B (enExample)
AU (3) AU618008B2 (enExample)
BE (1) BE1004835A5 (enExample)
DE (1) DE3822792C2 (enExample)
DK (1) DK385388A (enExample)
FR (1) FR2617713A1 (enExample)
GB (2) GB2206788B (enExample)
HU (1) HU206042B (enExample)
IT (1) IT1226632B (enExample)
MY (1) MY103536A (enExample)
NL (1) NL8801733A (enExample)
PH (1) PH27002A (enExample)
PT (1) PT87958B (enExample)
SE (1) SE8802570L (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643075B2 (en) * 1987-07-11 1993-11-04 Sandoz Ltd. 5HT-3 antagonists for the prevention or reduction of dependence

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US5198447A (en) * 1986-11-21 1993-03-30 Glaxo Group Limited Medicaments
EP0279114B2 (en) * 1986-11-21 1995-08-23 Glaxo Group Limited Medicaments for the treatment or prevention of the withdrawal syndrome
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
US4999382A (en) * 1988-10-26 1991-03-12 Massachusetts Institute Of Technology Compositions for treating tobacco withdrawal symptoms and methods for their use
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
WO1993000074A1 (en) * 1991-06-26 1993-01-07 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
US6109269A (en) * 1999-04-30 2000-08-29 Medtronic, Inc. Method of treating addiction by brain infusion
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
US20040092511A1 (en) * 1999-12-10 2004-05-13 Billstein Stephan Anthony Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001282874A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
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US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
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CN115368356B (zh) 2013-12-20 2025-05-09 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途

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AU7619087A (en) * 1986-07-30 1988-02-04 Novartis Ag Therapeutic use of indol-3-yl-carboxylic acid endo-8-methyl- 8-aza-bicyclo{3,2,1}oct-3-yl ester
AU8261587A (en) * 1986-12-17 1988-06-23 Glaxo Group Limited Medicaments
AU2191688A (en) * 1987-09-08 1989-03-09 Eli Lilly And Company Improvements in or relating to specific 5-ht3 antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643075B2 (en) * 1987-07-11 1993-11-04 Sandoz Ltd. 5HT-3 antagonists for the prevention or reduction of dependence

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DK385388A (da) 1989-01-12
PT87958B (pt) 1995-03-01
IT8848172A0 (it) 1988-07-11
US5039680A (en) 1991-08-13
AU8563091A (en) 1991-12-12
NL8801733A (nl) 1989-02-01
AU1892088A (en) 1989-01-12
FR2617713A1 (fr) 1989-01-13
HUT50038A (en) 1989-12-28
IT1226632B (it) 1991-01-28
JPS6431729A (en) 1989-02-02
EP0302008A2 (en) 1989-02-01
MY103536A (en) 1993-07-31
KR890001537A (ko) 1989-03-27
GB2206788B (en) 1992-03-25
SE8802570L (sv) 1989-03-28
DE3822792A1 (de) 1989-01-19
AT401615B (de) 1996-10-25
BE1004835A5 (fr) 1993-02-09
AU633762B2 (en) 1993-02-04
PH27002A (en) 1993-02-01
DK385388D0 (da) 1988-07-08
HU206042B (en) 1992-08-28
DE3822792C2 (de) 1997-11-27
GB8816298D0 (en) 1988-08-10
SE8802570D0 (sv) 1988-07-08
EP0302008A3 (en) 1992-12-23
GB2240475B (en) 1992-03-18
GB2206788A (en) 1989-01-18
AU643075B2 (en) 1993-11-04
GB2240475A (en) 1991-08-07
AU8562891A (en) 1991-12-05
GB9104598D0 (en) 1991-04-17
PT87958A (pt) 1989-06-30
FR2617713B1 (enExample) 1994-08-19

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