NL8701132A - Menselijk interleukine-2. - Google Patents

Menselijk interleukine-2. Download PDF

Info

Publication number
NL8701132A
NL8701132A NL8701132A NL8701132A NL8701132A NL 8701132 A NL8701132 A NL 8701132A NL 8701132 A NL8701132 A NL 8701132A NL 8701132 A NL8701132 A NL 8701132A NL 8701132 A NL8701132 A NL 8701132A
Authority
NL
Netherlands
Prior art keywords
gene
human
dna
mammalian cell
dna sequence
Prior art date
Application number
NL8701132A
Other languages
English (en)
Dutch (nl)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL8701132A publication Critical patent/NL8701132A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NL8701132A 1986-05-12 1987-05-12 Menselijk interleukine-2. NL8701132A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86208286 1986-05-12
US06/862,082 US4992367A (en) 1986-05-12 1986-05-12 Enhanced expression of human interleukin-2 in mammalian cells

Publications (1)

Publication Number Publication Date
NL8701132A true NL8701132A (nl) 1987-12-01

Family

ID=25337602

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8701132A NL8701132A (nl) 1986-05-12 1987-05-12 Menselijk interleukine-2.

Country Status (25)

Country Link
US (1) US4992367A (ja)
JP (1) JPS62278994A (ja)
AR (1) AR241794A1 (ja)
AT (1) AT389892B (ja)
AU (1) AU603576B2 (ja)
BE (1) BE1000717A5 (ja)
CH (1) CH675731A5 (ja)
DE (1) DE3715808A1 (ja)
DK (1) DK234087A (ja)
ES (2) ES2006476A6 (ja)
FI (1) FI872096A (ja)
FR (1) FR2598433B1 (ja)
GB (1) GB2190382B (ja)
GR (1) GR870727B (ja)
HU (1) HU205384B (ja)
IL (1) IL82475A0 (ja)
IT (1) IT1215478B (ja)
LU (1) LU86874A1 (ja)
MC (1) MC1821A1 (ja)
NL (1) NL8701132A (ja)
NO (1) NO871939L (ja)
NZ (1) NZ220246A (ja)
PT (1) PT84849B (ja)
SE (1) SE8701934L (ja)
ZA (1) ZA872768B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2220662A (en) * 1987-08-26 1990-01-17 Biogen Inc Biological materials,processes for producing biological materials and for using such materials in therapy
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
FR2636231A1 (fr) * 1988-09-09 1990-03-16 Sanofi Sa Cellules eucaryotes recombinees productrices d'interleukine-1 (beta) mature n-glycosylee, procede et vecteurs necessaires pour leur obtention et procede d'obtention d'interleukine-1 (beta) mature n-glycosylee
WO1990010069A1 (en) * 1989-02-28 1990-09-07 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr RECOMBINANT PLASMID DNA pAA 1213-23 AND pAC 262-33 CODING FOR SYNTHESIS OF HUMAN INTERLEUKIN-2, METHOD OF THEIR CONSTRUCTION AND STRAIN OF BACTERIA ESCHERICHIA COLI RRI/pAC 262-33 AS PRODUCER OF HUMAN INTERLEUKIN-2
CA2022983A1 (en) * 1989-08-11 1991-02-12 Mei-Huei Lai Expression of a functional insect specific toxin gene in mammalian cells
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5548075A (en) * 1993-08-30 1996-08-20 Utah State University DNA cassette and transgenic organisms carrying lytic peptide-encoding genes
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US5641665A (en) * 1994-11-28 1997-06-24 Vical Incorporated Plasmids suitable for IL-2 expression
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US6190901B1 (en) 1995-10-17 2001-02-20 Wayne State University Chicken interleukin-15 and uses thereof
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
AUPP655698A0 (en) 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
KR20020043448A (ko) * 2000-12-04 2002-06-10 리송알렉스인근 인터루킨-2 재조합 단백질 및 그의 제조방법
PL206976B1 (pl) * 2001-02-20 2010-10-29 Ortho Mcneil Pharm Inc Sposoby wytwarzania zawiesiny CD8⁺ do stosowania w leczeniu podmiotu z rakiem lub czerniakiem, sposób produkcji nie występującej naturalnie komórki i nie występująca naturalnie linia komórkowa
US20040071671A1 (en) * 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
US4405712A (en) * 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
AU556353B2 (en) * 1982-12-15 1986-10-30 Ajinomoto Co., Inc. Interleukin-2 polypeptide
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
IL71275A0 (en) * 1983-03-21 1984-06-29 Sparamedica Ag Human interleukin-2-and its preparation
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
WO1985002200A1 (en) * 1983-11-14 1985-05-23 Chiron Corporation Interleukin-2 production using cloned genes for interleukin-2 and yeast alpha-factor
FR2559782B1 (fr) * 1984-02-16 1986-07-18 Transgene Sa Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
EP0163603B1 (en) * 1984-05-08 1989-12-13 Genetics Institute, Inc. A human t-cell growth factor
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
EP0172619A1 (en) * 1984-06-20 1986-02-26 Takeda Chemical Industries, Ltd. Novel transformant and use thereof
CA1275954C (en) * 1984-08-31 1990-11-06 Hing Cheug Wong 3'-expression enhancing fragments and method
FR2583770B1 (fr) * 1985-06-21 1988-08-19 Transgene Sa Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices

Also Published As

Publication number Publication date
AT389892B (de) 1990-02-12
ATA263787A (de) 1989-07-15
HU205384B (en) 1992-04-28
MC1821A1 (fr) 1988-03-18
JPS62278994A (ja) 1987-12-03
ES2006476A6 (es) 1989-05-01
DK234087A (da) 1987-11-13
GR870727B (en) 1987-09-21
AR241794A1 (es) 1992-12-30
FI872096A (fi) 1987-11-13
HUT45558A (en) 1988-07-28
BE1000717A5 (fr) 1989-03-21
GB2190382B (en) 1990-08-15
DK234087D0 (da) 1987-05-08
DE3715808A1 (de) 1987-12-10
FI872096A0 (fi) 1987-05-12
IT1215478B (it) 1990-02-14
GB8711072D0 (en) 1987-06-17
SE8701934D0 (sv) 1987-05-11
NZ220246A (en) 1990-07-26
FR2598433A1 (fr) 1987-11-13
LU86874A1 (fr) 1988-06-13
PT84849A (pt) 1987-06-01
IT8720479A0 (it) 1987-05-12
NO871939L (no) 1987-11-13
ZA872768B (en) 1988-04-27
AU603576B2 (en) 1990-11-22
PT84849B (pt) 1990-02-08
NO871939D0 (no) 1987-05-11
CH675731A5 (ja) 1990-10-31
FR2598433B1 (fr) 1990-09-21
GB2190382A (en) 1987-11-18
IL82475A0 (en) 1987-11-30
AU7270387A (en) 1987-11-19
ES2012940A6 (es) 1990-04-16
SE8701934L (sv) 1987-11-13
US4992367A (en) 1991-02-12

Similar Documents

Publication Publication Date Title
Oliviero et al. The human haptoglobin gene promoter: interleukin‐6‐responsive elements interact with a DNA‐binding protein induced by interleukin‐6.
NL8701132A (nl) Menselijk interleukine-2.
Shaw et al. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Myers et al. Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.
US4929554A (en) Human immune interferon
McKnight et al. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region
US5096705A (en) Human immune interferon
EP0256843A1 (en) Expression of g-csf and muteins thereof and their use
JP2721139B2 (ja) 動物のインターフェロン
NL8103151A (nl) Polypeptiden, farmaceutische preparaten, die deze poly- peptiden bevatten en werkwijzen ter bereiding ervan.
EP0136489A1 (en) Analogs of human interleukin II and their preparation
US5582824A (en) Recombinant DES-CYS-TYR-CYS human immune interferon
CA2069746A1 (en) Hybrid growth factors
Kaushansky Control of granulocyte-macrophage colony-stimulating factor production in normal endothelial cells by positive and negative regulatory elements.
Windle et al. Two distant and precisely positioned domains promote transcription of Xenopus laevis rRNA genes: analysis with linker-scanning mutants
KR0142675B1 (ko) 유전자 발현 조절인자
Dijkmans et al. Molecular cloning of murine interferon gamma (MuIFN-γ) cDNA and its expression in heterologous mammalian cells
Maquat et al. A β°-thalassemic β-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells
US5002874A (en) Genetically engineered eucaryotic host cells capable of expressing modified forms of eIF-2α
Kulke et al. Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptor
Prescott et al. A single base change at 726 in 16S rRNA radically alters the pattern of proteins synthesized in vivo.
JPH02195888A (ja) ヒトインターロイキン２活性を有するポリペプチドをコードする遺伝子を含有する組換えｄｎａ体および該組換えｄｎａ体により形質転換された原核生物細胞
Jean-Francois et al. Post-transcriptional defects in the synthesis of the mitochondrial H+-ATPase subunit 6 in yeast mutants with lesions in the subunit 9 structural gene
CA1321766C (en) Process for producing cell having high productivity of protein and process for preparing protein by using the cell
JP2530632B2 (ja) ヒトインタ―フェロンの生産方法

Legal Events

Date Code Title Description
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: HOFFMANN-LA ROCHE AG. F. -

BV The patent application has lapsed