NL8503213A - Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. - Google Patents
Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. Download PDFInfo
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- NL8503213A NL8503213A NL8503213A NL8503213A NL8503213A NL 8503213 A NL8503213 A NL 8503213A NL 8503213 A NL8503213 A NL 8503213A NL 8503213 A NL8503213 A NL 8503213A NL 8503213 A NL8503213 A NL 8503213A
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- Prior art keywords
- group
- formula
- prostaglandin analog
- carbon atoms
- hydrogen atom
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- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
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- HEPKWABQTOCTFQ-CXTOUWENSA-N methyl (5e)-5-[(3ar,4r,5r,6as)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoate Chemical compound O1\C(=C\CCCC(=O)OC)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 HEPKWABQTOCTFQ-CXTOUWENSA-N 0.000 description 1
- IVYMDQDVHDERHD-UHFFFAOYSA-N methyl 5-(6a-silyloxy-3a,4,5,6-tetrahydro-1H-pentalen-2-yl)-5-oxopentanoate Chemical compound [SiH3]OC12CCCC2C=C(C1)C(CCCC(=O)OC)=O IVYMDQDVHDERHD-UHFFFAOYSA-N 0.000 description 1
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- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
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- 159000000000 sodium salts Chemical class 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
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- 239000008223 sterile water Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
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- 125000004434 sulfur atom Chemical group 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- DRDCQJADRSJFFD-UHFFFAOYSA-N tris-hydroxymethyl-methyl-ammonium Chemical compound OC[N+](C)(CO)CO DRDCQJADRSJFFD-UHFFFAOYSA-N 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848429545A GB8429545D0 (en) | 1984-11-22 | 1984-11-22 | Compositions of matter |
| GB8429545 | 1984-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8503213A true NL8503213A (nl) | 1986-06-16 |
Family
ID=10570117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8503213A NL8503213A (nl) | 1984-11-22 | 1985-11-21 | Prostaglandine-analogen, werkwijzen ter bereiding ervan alsmede farmaceutische preparaten, die de prostaglandine-analogen bevatten. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4698363A (it) |
| JP (1) | JPS61129146A (it) |
| BE (1) | BE903687A (it) |
| DE (1) | DE3541384A1 (it) |
| FR (1) | FR2573422B1 (it) |
| GB (2) | GB8429545D0 (it) |
| IT (1) | IT1207509B (it) |
| NL (1) | NL8503213A (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0680027B2 (ja) * | 1985-09-18 | 1994-10-12 | 財団法人相模中央化学研究所 | プロスタサイクリン類及びこれらを含有する薬剤 |
| AU782869B2 (en) | 1999-08-05 | 2005-09-08 | Teijin Limited | Neuropathy improvers containing nitrogenous compounds as the active ingredient |
| US6906046B2 (en) | 2000-12-22 | 2005-06-14 | Celltech R & D Inc. | Pharmaceutical uses and synthesis of benzobicyclooctanes |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4192891A (en) * | 1979-04-25 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction |
| US4254041A (en) * | 1979-07-05 | 1981-03-03 | The Upjohn Company | 19-Hydroxy-5-hydroxy-PGI compounds |
| JPS56150039A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Clathrate compound of prostacycline derivative |
| JPS58216140A (ja) * | 1982-05-28 | 1983-12-15 | メイ・アンド・ベイカ−・リミテツド | 新規なプロスタグランジン類似体 |
| JPS59137445A (ja) * | 1983-01-27 | 1984-08-07 | Teijin Ltd | プロスタサイクリン類及びその製法 |
| JPS59210044A (ja) * | 1983-05-13 | 1984-11-28 | Teijin Ltd | プロスタサイクリン類の製法 |
| JPS6028943A (ja) * | 1983-07-26 | 1985-02-14 | Sankyo Co Ltd | カルバサイクリン類縁体 |
| EP0136779B1 (en) * | 1983-07-26 | 1988-09-14 | Sankyo Company Limited | New carbacyclin derivatives, processes for their preparation and compositions containing them |
| EP0134153B1 (en) * | 1983-08-19 | 1989-04-19 | Sagami Chemical Research Center | Bicyclo[3.3.0]octane derivative and preparation thereof |
| JPS60202840A (ja) * | 1984-03-28 | 1985-10-14 | Sagami Chem Res Center | （３’−アルコキシ−１’−アルケニル）−シス−ビシクロ〔３．３．０〕オクテン誘導体 |
| JPS6130549A (ja) * | 1984-07-23 | 1986-02-12 | Sankyo Co Ltd | ビシクロオクタン化合物 |
| EP0171992B1 (en) * | 1984-08-09 | 1990-06-06 | Mitsubishi Kasei Corporation | Pharmaceuticals containing prostaglandin i2 |
| JPS6185346A (ja) * | 1984-10-03 | 1986-04-30 | Sagami Chem Res Center | ビシクロ〔３．３．０〕オクタン誘導体 |
| JPS6185348A (ja) * | 1984-10-03 | 1986-04-30 | Sagami Chem Res Center | ビシクロ〔３．３．０〕オクタノン誘導体 |
| JPS61122292A (ja) * | 1984-11-16 | 1986-06-10 | Teijin Ltd | 新規カルバサイクリン中間体の製法 |
| JPH11539A (ja) * | 1997-06-12 | 1999-01-06 | Asahi Chem Ind Co Ltd | ポリアクリロニトリル系膜およびその製造方法 |
-
1984
- 1984-11-22 GB GB848429545A patent/GB8429545D0/en active Pending
-
1985
- 1985-11-19 FR FR8517058A patent/FR2573422B1/fr not_active Expired
- 1985-11-20 US US06/799,796 patent/US4698363A/en not_active Expired - Fee Related
- 1985-11-20 GB GB8528522A patent/GB2167415B/en not_active Expired
- 1985-11-21 BE BE0/215899A patent/BE903687A/fr not_active IP Right Cessation
- 1985-11-21 NL NL8503213A patent/NL8503213A/nl not_active Application Discontinuation
- 1985-11-22 IT IT8522959A patent/IT1207509B/it active
- 1985-11-22 JP JP60261613A patent/JPS61129146A/ja active Pending
- 1985-11-22 DE DE19853541384 patent/DE3541384A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB8528522D0 (en) | 1985-12-24 |
| US4698363A (en) | 1987-10-06 |
| JPS61129146A (ja) | 1986-06-17 |
| FR2573422B1 (fr) | 1988-08-26 |
| IT1207509B (it) | 1989-05-25 |
| DE3541384A1 (de) | 1986-05-22 |
| GB8429545D0 (en) | 1985-01-03 |
| BE903687A (fr) | 1986-05-21 |
| FR2573422A1 (fr) | 1986-05-23 |
| IT8522959A0 (it) | 1985-11-22 |
| GB2167415B (en) | 1989-06-07 |
| GB2167415A (en) | 1986-05-29 |
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| BV | The patent application has lapsed |