NL8102802A - N-(vinblastin-23-oyl)aminozuurderivaten. - Google Patents

N-(vinblastin-23-oyl)aminozuurderivaten. Download PDF

Info

Publication number
NL8102802A
NL8102802A NL8102802A NL8102802A NL8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A
Authority
NL
Netherlands
Prior art keywords
deacetyl
oyl
vinblastin
ethyl
tryptophanate
Prior art date
Application number
NL8102802A
Other languages
English (en)
Dutch (nl)
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of NL8102802A publication Critical patent/NL8102802A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
NL8102802A 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten. NL8102802A (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU82514 1980-06-10
LU83034 1980-12-23
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique

Publications (1)

Publication Number Publication Date
NL8102802A true NL8102802A (nl) 1982-01-04

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8102802A NL8102802A (nl) 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten.

Country Status (21)

Country Link
US (1) US4388305A (enExample)
EP (1) EP0041935B1 (enExample)
AT (2) AT390793B (enExample)
AU (1) AU541747B2 (enExample)
CA (1) CA1196326A (enExample)
DD (1) DD160417A5 (enExample)
DE (2) DE3122479A1 (enExample)
DK (1) DK160614C (enExample)
ES (1) ES8203385A1 (enExample)
FR (1) FR2483926A1 (enExample)
GB (1) GB2078730A (enExample)
GR (1) GR74565B (enExample)
HU (1) HU185261B (enExample)
IE (1) IE51403B1 (enExample)
IL (1) IL63038A0 (enExample)
IT (1) IT1144601B (enExample)
NL (1) NL8102802A (enExample)
NZ (1) NZ197299A (enExample)
OA (1) OA06421A (enExample)
PT (1) PT73161B (enExample)
SE (1) SE8103594L (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
US4596676A (en) * 1983-03-30 1986-06-24 Lilly Industries Limited Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids
EP0124502B1 (fr) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Nouveaux conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques contenant ces conjugués
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant
DE3867039D1 (de) * 1987-11-11 1992-01-30 Akzo Nv Vincristin enthaltendes produkt.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
ATE380559T1 (de) * 1994-08-19 2007-12-15 Wallone Region Konjugate enthaltend ein antitumorales mittel und deren verwendung
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AU2001266853B2 (en) * 2000-06-14 2005-02-17 Medarex, Inc. Prodrug compounds with an oligopeptide having an isoleucine residue
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
EP1694330A4 (en) * 2003-12-04 2009-06-24 Amr Technology Inc DERIVATIVES OF VINORELBINE
JP5448299B2 (ja) * 2003-12-04 2014-03-19 アルバニー モレキュラー リサーチ， インコーポレイテッド ビンカ誘導体
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
IL298324A (en) 2020-06-10 2023-01-01 Aligos Therapeutics Inc Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (enExample) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
AT390793B (de) 1990-06-25
GR74565B (enExample) 1984-06-29
PT73161A (fr) 1981-07-01
ATA253881A (de) 1989-12-15
GB2078730A (en) 1982-01-13
FR2483926A1 (fr) 1981-12-11
ES502644A0 (es) 1982-04-01
AU541747B2 (en) 1985-01-17
IE51403B1 (en) 1986-12-24
ES8203385A1 (es) 1982-04-01
DE3122479A1 (de) 1982-06-16
IL63038A0 (en) 1981-09-13
DK160614B (da) 1991-04-02
PT73161B (fr) 1982-07-16
DK250181A (da) 1981-12-11
IE811275L (en) 1981-12-10
IT8167782A0 (it) 1981-06-08
EP0041935B1 (fr) 1984-09-19
CA1196326A (en) 1985-11-05
DE3166150D1 (en) 1984-10-25
HU185261B (en) 1984-12-28
AU7126281A (en) 1981-12-17
ATE9475T1 (de) 1984-10-15
DD160417A5 (de) 1983-07-27
OA06421A (fr) 1981-09-30
IT1144601B (it) 1986-10-29
SE8103594L (sv) 1981-12-11
DK160614C (da) 1991-09-23
FR2483926B1 (enExample) 1983-07-29
EP0041935A1 (fr) 1981-12-16
NZ197299A (en) 1985-10-11
US4388305A (en) 1983-06-14

Similar Documents

Publication Publication Date Title
US4639456A (en) Vinblastin-23-oyl amino acid derivatives
US4388305A (en) Vinblastin-23-oyl amino acid derivatives for use as antitumor agents
ES2198421T3 (es) Derivados de la camptotecina unidos a polimeros.
CA2951049C (en) Peptide-drug conjugates
WO2015106599A1 (en) Conjugates and compositions for drug delivery
JPH0794456B2 (ja) 新規なテトラピロール化合物
ES2347878T3 (es) Derivados halogenados antimitoticos de los alcaloides de vinca.
KR100780991B1 (ko) 토포이소머라제 ⅰ 억제작용이 있는10,11-디플루오로메틸렌디옥시캄프토테신 화합물
Ouyang et al. Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation
NL8204711A (nl) N-(vinblastinoyl-23)derivaten van aminozuren, hun bereiding en therapeutische toepassing.
ES2735375T3 (es) Derivados funcionalizados de morfolinil antraciclina
JP2006504657A (ja) アンスラサイクリン−ペプチドコンジュゲートの合成方法
JPH0210836B2 (enExample)
JPS624398B2 (enExample)
CN109476605B (zh) 具有抗肿瘤活性的苯并-n-羟基酰胺化合物
HK110195A (en) Pradimicin derivatives
JP2026502619A (ja) 腎疾患の標的療法のためのペプチド薬物コンジュゲート
LU83034A1 (fr) Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
WO2026086886A1 (zh) 药物偶联物、药物组合物及其制备方法和用途
PL94203B1 (enExample)

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed