NL8102802A - N-(vinblastin-23-oyl)aminozuurderivaten. - Google Patents

N-(vinblastin-23-oyl)aminozuurderivaten. Download PDF

Info

Publication number
NL8102802A
NL8102802A NL8102802A NL8102802A NL8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A
Authority
NL
Netherlands
Prior art keywords
deacetyl
oyl
vinblastin
ethyl
tryptophanate
Prior art date
Application number
NL8102802A
Other languages
English (en)
Dutch (nl)
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of NL8102802A publication Critical patent/NL8102802A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8102802A 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten. NL8102802A (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU82514 1980-06-10
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
LU83034 1980-12-23

Publications (1)

Publication Number Publication Date
NL8102802A true NL8102802A (nl) 1982-01-04

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8102802A NL8102802A (nl) 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten.

Country Status (21)

Country Link
US (1) US4388305A (enExample)
EP (1) EP0041935B1 (enExample)
AT (2) AT390793B (enExample)
AU (1) AU541747B2 (enExample)
CA (1) CA1196326A (enExample)
DD (1) DD160417A5 (enExample)
DE (2) DE3122479A1 (enExample)
DK (1) DK160614C (enExample)
ES (1) ES8203385A1 (enExample)
FR (1) FR2483926A1 (enExample)
GB (1) GB2078730A (enExample)
GR (1) GR74565B (enExample)
HU (1) HU185261B (enExample)
IE (1) IE51403B1 (enExample)
IL (1) IL63038A0 (enExample)
IT (1) IT1144601B (enExample)
NL (1) NL8102802A (enExample)
NZ (1) NZ197299A (enExample)
OA (1) OA06421A (enExample)
PT (1) PT73161B (enExample)
SE (1) SE8103594L (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DE3483336D1 (de) * 1983-03-30 1990-11-08 Lilly Industries Ltd Vincaleukoblastin-derivate.
GR81790B (enExample) * 1983-04-29 1984-12-12 Omnichem Sa
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0233101A1 (fr) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Dérivés de vinblastine et composition pharmaceutique les contenant
DE3867039D1 (de) * 1987-11-11 1992-01-30 Akzo Nv Vincristin enthaltendes produkt.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
DE69535665T2 (de) 1994-08-19 2009-04-02 La Region Wallonne Konjugate enthaltend ein antitumorales mittel und deren verwendung
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) * 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AU2001266853B2 (en) 2000-06-14 2005-02-17 Medarex, Inc. Prodrug compounds with an oligopeptide having an isoleucine residue
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7235564B2 (en) * 2003-12-04 2007-06-26 Amr Technology, Inc. Vinorelbine derivatives
AU2004296191B2 (en) * 2003-12-04 2010-10-28 Albany Molecular Research, Inc. Vinca derivatives
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
BR112022025037A2 (pt) 2020-06-10 2023-02-14 Aligos Therapeutics Inc Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus
WO2023283256A1 (en) 2021-07-09 2023-01-12 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds
AU2023303408A1 (en) 2022-07-06 2024-12-19 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (enExample) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
EP0041935A1 (fr) 1981-12-16
PT73161A (fr) 1981-07-01
DE3122479A1 (de) 1982-06-16
AU7126281A (en) 1981-12-17
DD160417A5 (de) 1983-07-27
IE811275L (en) 1981-12-10
ES502644A0 (es) 1982-04-01
IL63038A0 (en) 1981-09-13
ES8203385A1 (es) 1982-04-01
GB2078730A (en) 1982-01-13
DE3166150D1 (en) 1984-10-25
ATA253881A (de) 1989-12-15
DK250181A (da) 1981-12-11
IT1144601B (it) 1986-10-29
OA06421A (fr) 1981-09-30
IE51403B1 (en) 1986-12-24
DK160614C (da) 1991-09-23
ATE9475T1 (de) 1984-10-15
IT8167782A0 (it) 1981-06-08
FR2483926A1 (fr) 1981-12-11
AT390793B (de) 1990-06-25
PT73161B (fr) 1982-07-16
EP0041935B1 (fr) 1984-09-19
AU541747B2 (en) 1985-01-17
FR2483926B1 (enExample) 1983-07-29
US4388305A (en) 1983-06-14
GR74565B (enExample) 1984-06-29
NZ197299A (en) 1985-10-11
CA1196326A (en) 1985-11-05
DK160614B (da) 1991-04-02
HU185261B (en) 1984-12-28
SE8103594L (sv) 1981-12-11

Similar Documents

Publication Publication Date Title
US4639456A (en) Vinblastin-23-oyl amino acid derivatives
US4388305A (en) Vinblastin-23-oyl amino acid derivatives for use as antitumor agents
ES2198421T3 (es) Derivados de la camptotecina unidos a polimeros.
CA2951049C (en) Peptide-drug conjugates
WO2015106599A1 (en) Conjugates and compositions for drug delivery
JPH0794456B2 (ja) 新規なテトラピロール化合物
ES2347878T3 (es) Derivados halogenados antimitoticos de los alcaloides de vinca.
KR100780991B1 (ko) 토포이소머라제 ⅰ 억제작용이 있는10,11-디플루오로메틸렌디옥시캄프토테신 화합물
Ouyang et al. Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation
NL8204711A (nl) N-(vinblastinoyl-23)derivaten van aminozuren, hun bereiding en therapeutische toepassing.
ES2735375T3 (es) Derivados funcionalizados de morfolinil antraciclina
JP2006504657A (ja) アンスラサイクリン−ペプチドコンジュゲートの合成方法
JPH0210836B2 (enExample)
JPS624398B2 (enExample)
CN109476605B (zh) 具有抗肿瘤活性的苯并-n-羟基酰胺化合物
HK110195A (en) Pradimicin derivatives
JP2026502619A (ja) 腎疾患の標的療法のためのペプチド薬物コンジュゲート
LU83034A1 (fr) Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
WO2026086886A1 (zh) 药物偶联物、药物组合物及其制备方法和用途
PL94203B1 (enExample)

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed