NL8102802A - N-(vinblastin-23-oyl)aminozuurderivaten. - Google Patents

N-(vinblastin-23-oyl)aminozuurderivaten. Download PDF

Info

Publication number
NL8102802A
NL8102802A NL8102802A NL8102802A NL8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A
Authority
NL
Netherlands
Prior art keywords
deacetyl
oyl
vinblastin
ethyl
tryptophanate
Prior art date
Application number
NL8102802A
Other languages
English (en)
Dutch (nl)
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of NL8102802A publication Critical patent/NL8102802A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
NL8102802A 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten. NL8102802A (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU82514 1980-06-10
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
LU83034 1980-12-23

Publications (1)

Publication Number Publication Date
NL8102802A true NL8102802A (nl) 1982-01-04

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8102802A NL8102802A (nl) 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten.

Country Status (21)

Country Link
US (1) US4388305A (enExample)
EP (1) EP0041935B1 (enExample)
AT (2) AT390793B (enExample)
AU (1) AU541747B2 (enExample)
CA (1) CA1196326A (enExample)
DD (1) DD160417A5 (enExample)
DE (2) DE3122479A1 (enExample)
DK (1) DK160614C (enExample)
ES (1) ES8203385A1 (enExample)
FR (1) FR2483926A1 (enExample)
GB (1) GB2078730A (enExample)
GR (1) GR74565B (enExample)
HU (1) HU185261B (enExample)
IE (1) IE51403B1 (enExample)
IL (1) IL63038A0 (enExample)
IT (1) IT1144601B (enExample)
NL (1) NL8102802A (enExample)
NZ (1) NZ197299A (enExample)
OA (1) OA06421A (enExample)
PT (1) PT73161B (enExample)
SE (1) SE8103594L (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
ATE64396T1 (de) * 1983-04-29 1991-06-15 Omnichem Sa Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant
ATE70454T1 (de) * 1987-11-11 1992-01-15 Akzo Nv Vincristin enthaltendes produkt.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
NZ291368A (en) * 1994-08-19 1999-04-29 Wallone Region A compound comprising a marker or a therapeutic agent linked to a ligand containing amino acids wherein the marker or agent is cleaved from the ligand to permit entry into the cell of the marker or agent, medicaments for treating tumours; diagnostic devices
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) * 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AU6685301A (en) * 2000-06-14 2001-12-24 Corixa Corp Prodrug compounds with isoleucine
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7235564B2 (en) * 2003-12-04 2007-06-26 Amr Technology, Inc. Vinorelbine derivatives
AU2004296191B2 (en) * 2003-12-04 2010-10-28 Albany Molecular Research, Inc. Vinca derivatives
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
CN116096714A (zh) 2020-06-10 2023-05-09 安力高医药股份有限公司 用于治疗冠状病毒、小核糖核酸病毒和诺罗病毒感染的抗病毒化合物
KR20240035513A (ko) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 항바이러스 화합물
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (enExample) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
CA1196326A (en) 1985-11-05
AU7126281A (en) 1981-12-17
FR2483926A1 (fr) 1981-12-11
EP0041935B1 (fr) 1984-09-19
IT8167782A0 (it) 1981-06-08
AT390793B (de) 1990-06-25
FR2483926B1 (enExample) 1983-07-29
IE51403B1 (en) 1986-12-24
DE3122479A1 (de) 1982-06-16
GR74565B (enExample) 1984-06-29
GB2078730A (en) 1982-01-13
SE8103594L (sv) 1981-12-11
IT1144601B (it) 1986-10-29
NZ197299A (en) 1985-10-11
ATA253881A (de) 1989-12-15
IL63038A0 (en) 1981-09-13
HU185261B (en) 1984-12-28
IE811275L (en) 1981-12-10
OA06421A (fr) 1981-09-30
US4388305A (en) 1983-06-14
DK250181A (da) 1981-12-11
ES502644A0 (es) 1982-04-01
ATE9475T1 (de) 1984-10-15
PT73161A (fr) 1981-07-01
EP0041935A1 (fr) 1981-12-16
AU541747B2 (en) 1985-01-17
ES8203385A1 (es) 1982-04-01
DD160417A5 (de) 1983-07-27
DK160614B (da) 1991-04-02
PT73161B (fr) 1982-07-16
DK160614C (da) 1991-09-23
DE3166150D1 (en) 1984-10-25

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed