AU541747B2 - N-(vinblastinoyl-23)derivatives of amino acid and peptides - Google Patents

N-(vinblastinoyl-23)derivatives of amino acid and peptides

Info

Publication number
AU541747B2
AU541747B2 AU71262/81A AU7126281A AU541747B2 AU 541747 B2 AU541747 B2 AU 541747B2 AU 71262/81 A AU71262/81 A AU 71262/81A AU 7126281 A AU7126281 A AU 7126281A AU 541747 B2 AU541747 B2 AU 541747B2
Authority
AU
Australia
Prior art keywords
deacetyl
ethyl
oyl
vinblastin
spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU71262/81A
Other languages
English (en)
Other versions
AU7126281A (en
Inventor
Jean Alfred Alphonse Hannart
Kandukuri Sivaprasada Bushana Rao
Andrebenoit Leon Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem SA filed Critical Omnichem SA
Publication of AU7126281A publication Critical patent/AU7126281A/en
Application granted granted Critical
Publication of AU541747B2 publication Critical patent/AU541747B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU71262/81A 1980-06-10 1981-06-02 N-(vinblastinoyl-23)derivatives of amino acid and peptides Ceased AU541747B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU82514 1980-06-10
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
LU83034 1980-12-23

Publications (2)

Publication Number Publication Date
AU7126281A AU7126281A (en) 1981-12-17
AU541747B2 true AU541747B2 (en) 1985-01-17

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71262/81A Ceased AU541747B2 (en) 1980-06-10 1981-06-02 N-(vinblastinoyl-23)derivatives of amino acid and peptides

Country Status (21)

Country Link
US (1) US4388305A (enExample)
EP (1) EP0041935B1 (enExample)
AT (2) AT390793B (enExample)
AU (1) AU541747B2 (enExample)
CA (1) CA1196326A (enExample)
DD (1) DD160417A5 (enExample)
DE (2) DE3122479A1 (enExample)
DK (1) DK160614C (enExample)
ES (1) ES8203385A1 (enExample)
FR (1) FR2483926A1 (enExample)
GB (1) GB2078730A (enExample)
GR (1) GR74565B (enExample)
HU (1) HU185261B (enExample)
IE (1) IE51403B1 (enExample)
IL (1) IL63038A0 (enExample)
IT (1) IT1144601B (enExample)
NL (1) NL8102802A (enExample)
NZ (1) NZ197299A (enExample)
OA (1) OA06421A (enExample)
PT (1) PT73161B (enExample)
SE (1) SE8103594L (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DE3483336D1 (de) * 1983-03-30 1990-11-08 Lilly Industries Ltd Vincaleukoblastin-derivate.
GR81790B (enExample) * 1983-04-29 1984-12-12 Omnichem Sa
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0233101A1 (fr) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Dérivés de vinblastine et composition pharmaceutique les contenant
DE3867039D1 (de) * 1987-11-11 1992-01-30 Akzo Nv Vincristin enthaltendes produkt.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
DE69535665T2 (de) 1994-08-19 2009-04-02 La Region Wallonne Konjugate enthaltend ein antitumorales mittel und deren verwendung
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) * 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AU2001266853B2 (en) 2000-06-14 2005-02-17 Medarex, Inc. Prodrug compounds with an oligopeptide having an isoleucine residue
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7235564B2 (en) * 2003-12-04 2007-06-26 Amr Technology, Inc. Vinorelbine derivatives
AU2004296191B2 (en) * 2003-12-04 2010-10-28 Albany Molecular Research, Inc. Vinca derivatives
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
BR112022025037A2 (pt) 2020-06-10 2023-02-14 Aligos Therapeutics Inc Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus
WO2023283256A1 (en) 2021-07-09 2023-01-12 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds
AU2023303408A1 (en) 2022-07-06 2024-12-19 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (enExample) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
EP0041935A1 (fr) 1981-12-16
PT73161A (fr) 1981-07-01
DE3122479A1 (de) 1982-06-16
AU7126281A (en) 1981-12-17
DD160417A5 (de) 1983-07-27
IE811275L (en) 1981-12-10
ES502644A0 (es) 1982-04-01
IL63038A0 (en) 1981-09-13
ES8203385A1 (es) 1982-04-01
GB2078730A (en) 1982-01-13
DE3166150D1 (en) 1984-10-25
ATA253881A (de) 1989-12-15
DK250181A (da) 1981-12-11
IT1144601B (it) 1986-10-29
OA06421A (fr) 1981-09-30
IE51403B1 (en) 1986-12-24
DK160614C (da) 1991-09-23
NL8102802A (nl) 1982-01-04
ATE9475T1 (de) 1984-10-15
IT8167782A0 (it) 1981-06-08
FR2483926A1 (fr) 1981-12-11
AT390793B (de) 1990-06-25
PT73161B (fr) 1982-07-16
EP0041935B1 (fr) 1984-09-19
FR2483926B1 (enExample) 1983-07-29
US4388305A (en) 1983-06-14
GR74565B (enExample) 1984-06-29
NZ197299A (en) 1985-10-11
CA1196326A (en) 1985-11-05
DK160614B (da) 1991-04-02
HU185261B (en) 1984-12-28
SE8103594L (sv) 1981-12-11

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