ATE9475T1 - Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung. - Google Patents

Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung.

Info

Publication number
ATE9475T1
ATE9475T1 AT81870028T AT81870028T ATE9475T1 AT E9475 T1 ATE9475 T1 AT E9475T1 AT 81870028 T AT81870028 T AT 81870028T AT 81870028 T AT81870028 T AT 81870028T AT E9475 T1 ATE9475 T1 AT E9475T1
Authority
AT
Austria
Prior art keywords
derivatives
preparation
amino acid
vinblastinoyl
peptide
Prior art date
Application number
AT81870028T
Other languages
English (en)
Inventor
Andre Benoit Leon Trouet
Kandukuri Sivaprasada Bushana Rao
Jean Alfred Alphonse Hannart
Original Assignee
Omnichem Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Societe Anonyme filed Critical Omnichem Societe Anonyme
Application granted granted Critical
Publication of ATE9475T1 publication Critical patent/ATE9475T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
AT81870028T 1980-06-10 1981-06-09 Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung. ATE9475T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
EP81870028A EP0041935B1 (de) 1980-06-10 1981-06-09 Aminosäure- und Peptid-N-(vinblastinoyl-23)-Derivate und ihre Herstellung

Publications (1)

Publication Number Publication Date
ATE9475T1 true ATE9475T1 (de) 1984-10-15

Family

ID=26640267

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0253881A AT390793B (de) 1980-06-10 1981-06-05 Verfahren zur herstellung von neuen n-(vinblastin-23-oyl)-aminosaeurederivaten und von deren saeureadditionssalzen
AT81870028T ATE9475T1 (de) 1980-06-10 1981-06-09 Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT0253881A AT390793B (de) 1980-06-10 1981-06-05 Verfahren zur herstellung von neuen n-(vinblastin-23-oyl)-aminosaeurederivaten und von deren saeureadditionssalzen

Country Status (21)

Country Link
US (1) US4388305A (de)
EP (1) EP0041935B1 (de)
AT (2) AT390793B (de)
AU (1) AU541747B2 (de)
CA (1) CA1196326A (de)
DD (1) DD160417A5 (de)
DE (2) DE3122479A1 (de)
DK (1) DK160614C (de)
ES (1) ES8203385A1 (de)
FR (1) FR2483926A1 (de)
GB (1) GB2078730A (de)
GR (1) GR74565B (de)
HU (1) HU185261B (de)
IE (1) IE51403B1 (de)
IL (1) IL63038A0 (de)
IT (1) IT1144601B (de)
NL (1) NL8102802A (de)
NZ (1) NZ197299A (de)
OA (1) OA06421A (de)
PT (1) PT73161B (de)
SE (1) SE8103594L (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
US4596676A (en) * 1983-03-30 1986-06-24 Lilly Industries Limited Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids
GR81790B (de) * 1983-04-29 1984-12-12 Omnichem Sa
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (de) * 1985-12-16 1988-04-06 La Region Wallonne Konjugate des Vinblastins und seiner Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
EP0233101A1 (de) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Vinblastin-Derivate und diese enthaltende Arzneimittel
ATE70454T1 (de) * 1987-11-11 1992-01-15 Akzo Nv Vincristin enthaltendes produkt.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
EP1880737A1 (de) * 1994-08-19 2008-01-23 La Region Wallonne Verbindungen, pharmazeutische Zusammensetzung und diese umfassende Diagnosevorrichtung und deren Einsatz
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2000006582A1 (en) * 1998-07-31 2000-02-10 Goldsmith Seeds, Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
JP2004510702A (ja) * 2000-06-14 2004-04-08 メダレックス，インコーポレイティド イソロイシンを有するプロドラッグ化合物
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7238704B2 (en) * 2003-12-04 2007-07-03 Amr Technology, Inc. Vinca derivatives
EP1694330A4 (de) * 2003-12-04 2009-06-24 Amr Technology Inc Vinorelbin-derivate
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
US11952365B2 (en) 2020-06-10 2024-04-09 Aligos Therapeutics, Inc. Anti-viral compounds
US11851422B2 (en) 2021-07-09 2023-12-26 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (de) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
OA06421A (fr) 1981-09-30
CA1196326A (en) 1985-11-05
IT1144601B (it) 1986-10-29
NZ197299A (en) 1985-10-11
HU185261B (en) 1984-12-28
EP0041935B1 (de) 1984-09-19
FR2483926B1 (de) 1983-07-29
US4388305A (en) 1983-06-14
GR74565B (de) 1984-06-29
ATA253881A (de) 1989-12-15
AU7126281A (en) 1981-12-17
PT73161A (fr) 1981-07-01
DK250181A (da) 1981-12-11
AT390793B (de) 1990-06-25
IE51403B1 (en) 1986-12-24
DK160614B (da) 1991-04-02
IT8167782A0 (it) 1981-06-08
DK160614C (da) 1991-09-23
ES502644A0 (es) 1982-04-01
DE3122479A1 (de) 1982-06-16
GB2078730A (en) 1982-01-13
AU541747B2 (en) 1985-01-17
IL63038A0 (en) 1981-09-13
EP0041935A1 (de) 1981-12-16
PT73161B (fr) 1982-07-16
DE3166150D1 (en) 1984-10-25
ES8203385A1 (es) 1982-04-01
FR2483926A1 (fr) 1981-12-11
DD160417A5 (de) 1983-07-27
IE811275L (en) 1981-12-10
NL8102802A (nl) 1982-01-04
SE8103594L (sv) 1981-12-11

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