NL8000206A - Carbamaatderivaten van mercaptoacylhydroxyprolinen, alsmede werkwijzen voor het bereiden en toepassen van deze prolinen. - Google Patents
Carbamaatderivaten van mercaptoacylhydroxyprolinen, alsmede werkwijzen voor het bereiden en toepassen van deze prolinen. Download PDFInfo
- Publication number
- NL8000206A NL8000206A NL8000206A NL8000206A NL8000206A NL 8000206 A NL8000206 A NL 8000206A NL 8000206 A NL8000206 A NL 8000206A NL 8000206 A NL8000206 A NL 8000206A NL 8000206 A NL8000206 A NL 8000206A
- Authority
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- Netherlands
- Prior art keywords
- methyl
- proline
- group
- trans
- compounds according
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 52
- 150000004657 carbamic acid derivatives Chemical class 0.000 title description 3
- 229960002429 proline Drugs 0.000 claims description 93
- -1 (methylamino) carbonyl Chemical group 0.000 claims description 62
- 150000001875 compounds Chemical class 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
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- 239000003814 drug Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
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- 230000036772 blood pressure Effects 0.000 claims description 5
- 206010020772 Hypertension Diseases 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000001589 carboacyl group Chemical group 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
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- 125000003368 amide group Chemical group 0.000 claims 1
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- 230000001631 hypertensive effect Effects 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
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- WWVCWLBEARZMAH-MNOVXSKESA-N (2s,4r)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid Chemical compound C1[C@H](O)C[C@@H](C(O)=O)N1C(=O)OCC1=CC=CC=C1 WWVCWLBEARZMAH-MNOVXSKESA-N 0.000 description 4
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- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 4
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
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- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 4
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- 125000005843 halogen group Chemical group 0.000 description 3
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US317879A | 1979-01-15 | 1979-01-15 | |
| US317879 | 1979-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8000206A true NL8000206A (nl) | 1980-07-17 |
Family
ID=21704564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8000206A NL8000206A (nl) | 1979-01-15 | 1980-01-14 | Carbamaatderivaten van mercaptoacylhydroxyprolinen, alsmede werkwijzen voor het bereiden en toepassen van deze prolinen. |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JPS5598161A (OSRAM) |
| AT (1) | AT364377B (OSRAM) |
| AU (1) | AU526767B2 (OSRAM) |
| BE (1) | BE881153A (OSRAM) |
| CA (1) | CA1138452A (OSRAM) |
| CH (2) | CH646950A5 (OSRAM) |
| DE (1) | DE3001113A1 (OSRAM) |
| DK (1) | DK14980A (OSRAM) |
| FR (1) | FR2446281A1 (OSRAM) |
| GB (2) | GB2088875B (OSRAM) |
| GR (1) | GR73002B (OSRAM) |
| HU (2) | HU182778B (OSRAM) |
| IE (1) | IE49357B1 (OSRAM) |
| IT (1) | IT1140505B (OSRAM) |
| LU (1) | LU82082A1 (OSRAM) |
| NL (1) | NL8000206A (OSRAM) |
| NO (1) | NO800077L (OSRAM) |
| NZ (1) | NZ192522A (OSRAM) |
| PH (2) | PH14946A (OSRAM) |
| SE (1) | SE8000298L (OSRAM) |
| ZA (1) | ZA8035B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
| CA1258853A (en) * | 1982-04-30 | 1989-08-29 | Rudiger D. Haugwitz | Substituted 4-phenoxy prolines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1980
- 1980-01-02 CA CA000342899A patent/CA1138452A/en not_active Expired
- 1980-01-03 AU AU54327/80A patent/AU526767B2/en not_active Ceased
- 1980-01-03 ZA ZA00800035A patent/ZA8035B/xx unknown
- 1980-01-04 NZ NZ192522A patent/NZ192522A/xx unknown
- 1980-01-10 IE IE48/80A patent/IE49357B1/en unknown
- 1980-01-10 FR FR8000500A patent/FR2446281A1/fr active Granted
- 1980-01-11 GR GR60934A patent/GR73002B/el unknown
- 1980-01-11 PH PH23504A patent/PH14946A/en unknown
- 1980-01-11 CH CH24080A patent/CH646950A5/de not_active IP Right Cessation
- 1980-01-14 HU HU813412A patent/HU182778B/hu not_active IP Right Cessation
- 1980-01-14 LU LU82082A patent/LU82082A1/fr unknown
- 1980-01-14 DE DE19803001113 patent/DE3001113A1/de not_active Ceased
- 1980-01-14 NL NL8000206A patent/NL8000206A/nl not_active Application Discontinuation
- 1980-01-14 NO NO800077A patent/NO800077L/no unknown
- 1980-01-14 IT IT19209/80A patent/IT1140505B/it active
- 1980-01-14 HU HU808065A patent/HU179621B/hu not_active IP Right Cessation
- 1980-01-14 SE SE8000298A patent/SE8000298L/xx not_active Application Discontinuation
- 1980-01-14 GB GB8200442A patent/GB2088875B/en not_active Expired
- 1980-01-14 DK DK14980A patent/DK14980A/da unknown
- 1980-01-14 JP JP300580A patent/JPS5598161A/ja active Granted
- 1980-01-14 GB GB8001117A patent/GB2040937B/en not_active Expired
- 1980-01-15 BE BE0/198972A patent/BE881153A/fr not_active IP Right Cessation
- 1980-01-15 AT AT0019080A patent/AT364377B/de not_active IP Right Cessation
- 1980-08-13 PH PH24438A patent/PH15318A/en unknown
-
1983
- 1983-11-17 CH CH619383A patent/CH646690A5/de not_active IP Right Cessation
-
1988
- 1988-12-16 JP JP63319342A patent/JPH01301656A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AT364377B (de) | 1981-10-12 |
| SE8000298L (sv) | 1980-07-16 |
| ZA8035B (en) | 1980-12-31 |
| HU182778B (en) | 1984-03-28 |
| GB2088875A (en) | 1982-06-16 |
| GB2040937B (en) | 1982-11-24 |
| JPH0125744B2 (OSRAM) | 1989-05-19 |
| JPH01301656A (ja) | 1989-12-05 |
| ATA19080A (de) | 1981-03-15 |
| CH646690A5 (de) | 1984-12-14 |
| NZ192522A (en) | 1982-06-29 |
| DK14980A (da) | 1980-07-16 |
| BE881153A (fr) | 1980-07-15 |
| PH15318A (en) | 1982-11-18 |
| LU82082A1 (fr) | 1980-04-23 |
| IE800048L (en) | 1980-07-15 |
| CA1138452A (en) | 1982-12-28 |
| GB2040937A (en) | 1980-09-03 |
| GB2088875B (en) | 1983-06-08 |
| DE3001113A1 (de) | 1980-07-24 |
| CH646950A5 (de) | 1984-12-28 |
| IT8019209A0 (it) | 1980-01-14 |
| JPH0378378B2 (OSRAM) | 1991-12-13 |
| PH14946A (en) | 1982-02-02 |
| JPS5598161A (en) | 1980-07-25 |
| IT1140505B (it) | 1986-10-01 |
| AU526767B2 (en) | 1983-01-27 |
| AU5432780A (en) | 1980-07-24 |
| FR2446281B1 (OSRAM) | 1984-01-20 |
| HU179621B (en) | 1982-11-29 |
| NO800077L (no) | 1980-07-16 |
| GR73002B (OSRAM) | 1984-01-24 |
| FR2446281A1 (fr) | 1980-08-08 |
| IE49357B1 (en) | 1985-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed |