LU82082A1 - Carbamates de mercaptoacyl hydroxy prolines,a action antihypertensive - Google Patents
Carbamates de mercaptoacyl hydroxy prolines,a action antihypertensive Download PDFInfo
- Publication number
- LU82082A1 LU82082A1 LU82082A LU82082A LU82082A1 LU 82082 A1 LU82082 A1 LU 82082A1 LU 82082 A LU82082 A LU 82082A LU 82082 A LU82082 A LU 82082A LU 82082 A1 LU82082 A1 LU 82082A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- methyl
- proline
- oxy
- radical
- carbonyl
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title description 6
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical compound NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 description 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical group CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000029305 taxis Effects 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 229960000356 tienilic acid Drugs 0.000 description 1
- AGHANLSBXUWXTB-UHFFFAOYSA-N tienilic acid Chemical compound ClC1=C(Cl)C(OCC(=O)O)=CC=C1C(=O)C1=CC=CS1 AGHANLSBXUWXTB-UHFFFAOYSA-N 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- PMMYEEVYMWASQN-IUYQGCFVSA-N trans-4-hydroxy-D-proline Chemical compound O[C@@H]1CN[C@@H](C(O)=O)C1 PMMYEEVYMWASQN-IUYQGCFVSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 229960004813 trichlormethiazide Drugs 0.000 description 1
- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US317879A | 1979-01-15 | 1979-01-15 | |
| US317879 | 1979-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU82082A1 true LU82082A1 (fr) | 1980-04-23 |
Family
ID=21704564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU82082A LU82082A1 (fr) | 1979-01-15 | 1980-01-14 | Carbamates de mercaptoacyl hydroxy prolines,a action antihypertensive |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JPS5598161A (OSRAM) |
| AT (1) | AT364377B (OSRAM) |
| AU (1) | AU526767B2 (OSRAM) |
| BE (1) | BE881153A (OSRAM) |
| CA (1) | CA1138452A (OSRAM) |
| CH (2) | CH646950A5 (OSRAM) |
| DE (1) | DE3001113A1 (OSRAM) |
| DK (1) | DK14980A (OSRAM) |
| FR (1) | FR2446281A1 (OSRAM) |
| GB (2) | GB2088875B (OSRAM) |
| GR (1) | GR73002B (OSRAM) |
| HU (2) | HU182778B (OSRAM) |
| IE (1) | IE49357B1 (OSRAM) |
| IT (1) | IT1140505B (OSRAM) |
| LU (1) | LU82082A1 (OSRAM) |
| NL (1) | NL8000206A (OSRAM) |
| NO (1) | NO800077L (OSRAM) |
| NZ (1) | NZ192522A (OSRAM) |
| PH (2) | PH14946A (OSRAM) |
| SE (1) | SE8000298L (OSRAM) |
| ZA (1) | ZA8035B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
| CA1258853A (en) * | 1982-04-30 | 1989-08-29 | Rudiger D. Haugwitz | Substituted 4-phenoxy prolines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1980
- 1980-01-02 CA CA000342899A patent/CA1138452A/en not_active Expired
- 1980-01-03 AU AU54327/80A patent/AU526767B2/en not_active Ceased
- 1980-01-03 ZA ZA00800035A patent/ZA8035B/xx unknown
- 1980-01-04 NZ NZ192522A patent/NZ192522A/xx unknown
- 1980-01-10 IE IE48/80A patent/IE49357B1/en unknown
- 1980-01-10 FR FR8000500A patent/FR2446281A1/fr active Granted
- 1980-01-11 GR GR60934A patent/GR73002B/el unknown
- 1980-01-11 PH PH23504A patent/PH14946A/en unknown
- 1980-01-11 CH CH24080A patent/CH646950A5/de not_active IP Right Cessation
- 1980-01-14 HU HU813412A patent/HU182778B/hu not_active IP Right Cessation
- 1980-01-14 LU LU82082A patent/LU82082A1/fr unknown
- 1980-01-14 DE DE19803001113 patent/DE3001113A1/de not_active Ceased
- 1980-01-14 NL NL8000206A patent/NL8000206A/nl not_active Application Discontinuation
- 1980-01-14 NO NO800077A patent/NO800077L/no unknown
- 1980-01-14 IT IT19209/80A patent/IT1140505B/it active
- 1980-01-14 HU HU808065A patent/HU179621B/hu not_active IP Right Cessation
- 1980-01-14 SE SE8000298A patent/SE8000298L/xx not_active Application Discontinuation
- 1980-01-14 GB GB8200442A patent/GB2088875B/en not_active Expired
- 1980-01-14 DK DK14980A patent/DK14980A/da unknown
- 1980-01-14 JP JP300580A patent/JPS5598161A/ja active Granted
- 1980-01-14 GB GB8001117A patent/GB2040937B/en not_active Expired
- 1980-01-15 BE BE0/198972A patent/BE881153A/fr not_active IP Right Cessation
- 1980-01-15 AT AT0019080A patent/AT364377B/de not_active IP Right Cessation
- 1980-08-13 PH PH24438A patent/PH15318A/en unknown
-
1983
- 1983-11-17 CH CH619383A patent/CH646690A5/de not_active IP Right Cessation
-
1988
- 1988-12-16 JP JP63319342A patent/JPH01301656A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AT364377B (de) | 1981-10-12 |
| SE8000298L (sv) | 1980-07-16 |
| ZA8035B (en) | 1980-12-31 |
| HU182778B (en) | 1984-03-28 |
| GB2088875A (en) | 1982-06-16 |
| GB2040937B (en) | 1982-11-24 |
| JPH0125744B2 (OSRAM) | 1989-05-19 |
| JPH01301656A (ja) | 1989-12-05 |
| ATA19080A (de) | 1981-03-15 |
| CH646690A5 (de) | 1984-12-14 |
| NZ192522A (en) | 1982-06-29 |
| DK14980A (da) | 1980-07-16 |
| BE881153A (fr) | 1980-07-15 |
| PH15318A (en) | 1982-11-18 |
| IE800048L (en) | 1980-07-15 |
| CA1138452A (en) | 1982-12-28 |
| NL8000206A (nl) | 1980-07-17 |
| GB2040937A (en) | 1980-09-03 |
| GB2088875B (en) | 1983-06-08 |
| DE3001113A1 (de) | 1980-07-24 |
| CH646950A5 (de) | 1984-12-28 |
| IT8019209A0 (it) | 1980-01-14 |
| JPH0378378B2 (OSRAM) | 1991-12-13 |
| PH14946A (en) | 1982-02-02 |
| JPS5598161A (en) | 1980-07-25 |
| IT1140505B (it) | 1986-10-01 |
| AU526767B2 (en) | 1983-01-27 |
| AU5432780A (en) | 1980-07-24 |
| FR2446281B1 (OSRAM) | 1984-01-20 |
| HU179621B (en) | 1982-11-29 |
| NO800077L (no) | 1980-07-16 |
| GR73002B (OSRAM) | 1984-01-24 |
| FR2446281A1 (fr) | 1980-08-08 |
| IE49357B1 (en) | 1985-09-18 |
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